Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HII4_LEIBR

TriTrypDb:

LbrM.30.2480 , LBRM2903_300031200

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HII4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.438
CLV_NRD_NRD_1	34	36	PF00675	0.635
CLV_PCSK_KEX2_1	148	150	PF00082	0.437
CLV_PCSK_KEX2_1	34	36	PF00082	0.635
CLV_PCSK_SKI1_1	158	162	PF00082	0.193
CLV_PCSK_SKI1_1	186	190	PF00082	0.631
CLV_PCSK_SKI1_1	38	42	PF00082	0.336
DEG_APCC_DBOX_1	37	45	PF00400	0.358
DOC_CKS1_1	46	51	PF01111	0.279
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.482
DOC_MAPK_gen_1	146	155	PF00069	0.618
DOC_PP4_FxxP_1	46	49	PF00568	0.298
DOC_USP7_MATH_1	121	125	PF00917	0.411
DOC_USP7_MATH_1	16	20	PF00917	0.442
DOC_USP7_MATH_1	5	9	PF00917	0.436
DOC_WW_Pin1_4	45	50	PF00397	0.311
DOC_WW_Pin1_4	54	59	PF00397	0.247
LIG_14-3-3_CanoR_1	75	83	PF00244	0.465
LIG_Actin_WH2_2	47	63	PF00022	0.199
LIG_BIR_III_4	25	29	PF00653	0.418
LIG_BRCT_BRCA1_1	128	132	PF00533	0.261
LIG_BRCT_BRCA1_1	77	81	PF00533	0.447
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.611
LIG_FHA_1	115	121	PF00498	0.272
LIG_FHA_1	142	148	PF00498	0.677
LIG_FHA_2	12	18	PF00498	0.558
LIG_LIR_Gen_1	151	160	PF02991	0.663
LIG_LIR_Gen_1	79	90	PF02991	0.287
LIG_LIR_Nem_3	107	112	PF02991	0.406
LIG_LIR_Nem_3	151	155	PF02991	0.633
LIG_LIR_Nem_3	157	163	PF02991	0.474
LIG_LIR_Nem_3	24	30	PF02991	0.429
LIG_LIR_Nem_3	78	83	PF02991	0.459
LIG_LYPXL_S_1	132	136	PF13949	0.274
LIG_LYPXL_yS_3	133	136	PF13949	0.274
LIG_MLH1_MIPbox_1	77	81	PF16413	0.447
LIG_MYND_1	111	115	PF01753	0.386
LIG_Pex14_2	81	85	PF04695	0.276
LIG_SH2_CRK	187	191	PF00017	0.412
LIG_SH2_CRK	33	37	PF00017	0.452
LIG_SH2_GRB2like	82	85	PF00017	0.298
LIG_SH2_STAT5	112	115	PF00017	0.412
LIG_SH2_STAT5	3	6	PF00017	0.422
LIG_SH2_STAT5	82	85	PF00017	0.298
LIG_SH3_3	137	143	PF00018	0.547
LIG_SH3_3	52	58	PF00018	0.312
LIG_SH3_3	95	101	PF00018	0.482
LIG_TYR_ITIM	131	136	PF00017	0.394
MOD_CDK_SPxxK_3	54	61	PF00069	0.274
MOD_CK1_1	8	14	PF00069	0.444
MOD_CK2_1	11	17	PF00069	0.410
MOD_GlcNHglycan	14	17	PF01048	0.628
MOD_GlcNHglycan	7	10	PF01048	0.615
MOD_GlcNHglycan	87	90	PF01048	0.300
MOD_GSK3_1	8	15	PF00069	0.447
MOD_NEK2_1	126	131	PF00069	0.310
MOD_NEK2_1	60	65	PF00069	0.668
MOD_NEK2_1	85	90	PF00069	0.306
MOD_PIKK_1	189	195	PF00454	0.383
MOD_PIKK_1	60	66	PF00454	0.626
MOD_Plk_4	178	184	PF00069	0.305
MOD_Plk_4	68	74	PF00069	0.620
MOD_ProDKin_1	45	51	PF00069	0.311
MOD_ProDKin_1	54	60	PF00069	0.247
MOD_SUMO_rev_2	63	71	PF00179	0.650
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.307
TRG_ENDOCYTIC_2	133	136	PF00928	0.278
TRG_ENDOCYTIC_2	187	190	PF00928	0.410
TRG_ENDOCYTIC_2	33	36	PF00928	0.424
TRG_ENDOCYTIC_2	82	85	PF00928	0.287
TRG_ENDOCYTIC_2	92	95	PF00928	0.257
TRG_ER_diArg_1	147	149	PF00400	0.676
TRG_ER_diArg_1	33	35	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT69	Leptomonas seymouri	70%	96%
A0A0S4KH82	Bodo saltans	47%	98%
A0A1X0P1K1	Trypanosomatidae	54%	100%
A0A3S7X3P8	Leishmania donovani	86%	98%
A4I5S7	Leishmania infantum	86%	98%
C9ZR46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	95%
E9B123	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4Q742	Leishmania major	83%	100%