Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HII3_LEIBR

TriTrypDb:

LbrM.30.2470 , LBRM2903_300031100

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HII3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.438
CLV_NRD_NRD_1	157	159	PF00675	0.513
CLV_PCSK_KEX2_1	157	159	PF00082	0.551
CLV_PCSK_KEX2_1	299	301	PF00082	0.532
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.414
CLV_PCSK_SKI1_1	160	164	PF00082	0.545
CLV_PCSK_SKI1_1	236	240	PF00082	0.377
CLV_PCSK_SKI1_1	278	282	PF00082	0.521
CLV_PCSK_SKI1_1	321	325	PF00082	0.458
DEG_APCC_DBOX_1	1	9	PF00400	0.447
DEG_COP1_1	326	333	PF00400	0.551
DEG_Nend_UBRbox_1	1	4	PF02207	0.442
DEG_SPOP_SBC_1	145	149	PF00917	0.366
DOC_CKS1_1	166	171	PF01111	0.536
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.430
DOC_MAPK_gen_1	2	11	PF00069	0.445
DOC_MAPK_MEF2A_6	18	25	PF00069	0.422
DOC_MAPK_MEF2A_6	2	9	PF00069	0.446
DOC_MAPK_MEF2A_6	202	209	PF00069	0.425
DOC_MAPK_NFAT4_5	2	10	PF00069	0.445
DOC_PP2B_LxvP_1	17	20	PF13499	0.434
DOC_PP2B_LxvP_1	252	255	PF13499	0.432
DOC_PP2B_LxvP_1	343	346	PF13499	0.544
DOC_USP7_MATH_1	111	115	PF00917	0.377
DOC_USP7_MATH_1	144	148	PF00917	0.315
DOC_USP7_MATH_1	161	165	PF00917	0.448
DOC_USP7_MATH_1	181	185	PF00917	0.240
DOC_USP7_MATH_1	205	209	PF00917	0.340
DOC_USP7_MATH_1	265	269	PF00917	0.455
DOC_USP7_MATH_1	383	387	PF00917	0.432
DOC_WW_Pin1_4	165	170	PF00397	0.503
DOC_WW_Pin1_4	244	249	PF00397	0.540
DOC_WW_Pin1_4	261	266	PF00397	0.304
DOC_WW_Pin1_4	298	303	PF00397	0.489
DOC_WW_Pin1_4	39	44	PF00397	0.424
LIG_14-3-3_CanoR_1	160	169	PF00244	0.456
LIG_14-3-3_CanoR_1	206	210	PF00244	0.467
LIG_14-3-3_CanoR_1	225	229	PF00244	0.388
LIG_14-3-3_CanoR_1	243	248	PF00244	0.545
LIG_14-3-3_CanoR_1	278	283	PF00244	0.470
LIG_14-3-3_CanoR_1	48	58	PF00244	0.552
LIG_Actin_WH2_2	268	285	PF00022	0.497
LIG_BRCT_BRCA1_1	133	137	PF00533	0.345
LIG_BRCT_BRCA1_1	43	47	PF00533	0.397
LIG_eIF4E_1	233	239	PF01652	0.493
LIG_FHA_1	225	231	PF00498	0.420
LIG_FHA_1	265	271	PF00498	0.462
LIG_FHA_1	325	331	PF00498	0.537
LIG_FHA_2	123	129	PF00498	0.600
LIG_FHA_2	367	373	PF00498	0.450
LIG_FHA_2	51	57	PF00498	0.566
LIG_HP1_1	205	209	PF01393	0.340
LIG_LIR_Apic_2	163	169	PF02991	0.532
LIG_LIR_Apic_2	55	61	PF02991	0.592
LIG_LIR_Gen_1	120	131	PF02991	0.535
LIG_LIR_Gen_1	3	13	PF02991	0.445
LIG_LIR_Gen_1	76	87	PF02991	0.267
LIG_LIR_Nem_3	382	387	PF02991	0.369
LIG_LIR_Nem_3	44	49	PF02991	0.396
LIG_LIR_Nem_3	76	82	PF02991	0.275
LIG_MLH1_MIPbox_1	133	137	PF16413	0.459
LIG_MLH1_MIPbox_1	43	47	PF16413	0.397
LIG_PDZ_Class_2	397	402	PF00595	0.417
LIG_Pex14_2	31	35	PF04695	0.413
LIG_Rb_LxCxE_1	183	203	PF01857	0.287
LIG_Rb_LxCxE_1	281	297	PF01857	0.552
LIG_REV1ctd_RIR_1	44	52	PF16727	0.397
LIG_SH2_CRK	33	37	PF00017	0.422
LIG_SH2_CRK	79	83	PF00017	0.289
LIG_SH2_NCK_1	166	170	PF00017	0.533
LIG_SH2_NCK_1	58	62	PF00017	0.700
LIG_SH2_NCK_1	79	83	PF00017	0.486
LIG_SH2_SRC	58	61	PF00017	0.710
LIG_SH2_STAP1	240	244	PF00017	0.565
LIG_SH2_STAT5	6	9	PF00017	0.448
LIG_SH3_3	327	333	PF00018	0.558
LIG_SH3_3	395	401	PF00018	0.454
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.414
LIG_SUMO_SIM_par_1	196	201	PF11976	0.442
LIG_SUMO_SIM_par_1	249	256	PF11976	0.437
LIG_TYR_ITIM	77	82	PF00017	0.280
MOD_CDC14_SPxK_1	301	304	PF00782	0.452
MOD_CDK_SPxK_1	298	304	PF00069	0.488
MOD_CK1_1	114	120	PF00069	0.433
MOD_CK1_1	148	154	PF00069	0.429
MOD_CK1_1	156	162	PF00069	0.479
MOD_CK1_1	246	252	PF00069	0.525
MOD_CK1_1	264	270	PF00069	0.279
MOD_CK1_1	338	344	PF00069	0.479
MOD_CK1_1	386	392	PF00069	0.505
MOD_CK1_1	50	56	PF00069	0.420
MOD_CK2_1	113	119	PF00069	0.511
MOD_CK2_1	122	128	PF00069	0.517
MOD_CK2_1	366	372	PF00069	0.600
MOD_GlcNHglycan	113	116	PF01048	0.564
MOD_GlcNHglycan	148	151	PF01048	0.331
MOD_GlcNHglycan	337	340	PF01048	0.468
MOD_GlcNHglycan	362	365	PF01048	0.523
MOD_GlcNHglycan	49	52	PF01048	0.596
MOD_GSK3_1	113	120	PF00069	0.500
MOD_GSK3_1	144	151	PF00069	0.409
MOD_GSK3_1	156	163	PF00069	0.494
MOD_GSK3_1	175	182	PF00069	0.261
MOD_GSK3_1	239	246	PF00069	0.546
MOD_GSK3_1	261	268	PF00069	0.346
MOD_GSK3_1	294	301	PF00069	0.601
MOD_GSK3_1	331	338	PF00069	0.447
MOD_GSK3_1	379	386	PF00069	0.447
MOD_GSK3_1	82	89	PF00069	0.457
MOD_N-GLC_1	92	97	PF02516	0.352
MOD_NEK2_1	100	105	PF00069	0.463
MOD_NEK2_1	131	136	PF00069	0.464
MOD_NEK2_1	239	244	PF00069	0.524
MOD_NEK2_1	294	299	PF00069	0.549
MOD_NEK2_1	387	392	PF00069	0.426
MOD_NEK2_1	47	52	PF00069	0.394
MOD_NEK2_1	87	92	PF00069	0.326
MOD_NEK2_2	161	166	PF00069	0.475
MOD_OFUCOSY	81	86	PF10250	0.436
MOD_PIKK_1	200	206	PF00454	0.570
MOD_PIKK_1	392	398	PF00454	0.501
MOD_PK_1	73	79	PF00069	0.381
MOD_PKA_2	156	162	PF00069	0.434
MOD_PKA_2	205	211	PF00069	0.466
MOD_PKA_2	224	230	PF00069	0.409
MOD_PKA_2	47	53	PF00069	0.399
MOD_PKB_1	158	166	PF00069	0.545
MOD_Plk_1	100	106	PF00069	0.587
MOD_Plk_4	100	106	PF00069	0.455
MOD_Plk_4	150	156	PF00069	0.526
MOD_Plk_4	224	230	PF00069	0.461
MOD_Plk_4	247	253	PF00069	0.450
MOD_Plk_4	331	337	PF00069	0.464
MOD_Plk_4	338	344	PF00069	0.393
MOD_Plk_4	87	93	PF00069	0.359
MOD_ProDKin_1	165	171	PF00069	0.505
MOD_ProDKin_1	244	250	PF00069	0.538
MOD_ProDKin_1	261	267	PF00069	0.308
MOD_ProDKin_1	298	304	PF00069	0.488
MOD_ProDKin_1	39	45	PF00069	0.425
TRG_DiLeu_BaEn_1	183	188	PF01217	0.288
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.432
TRG_ENDOCYTIC_2	123	126	PF00928	0.549
TRG_ENDOCYTIC_2	33	36	PF00928	0.421
TRG_ENDOCYTIC_2	6	9	PF00928	0.448
TRG_ENDOCYTIC_2	79	82	PF00928	0.289
TRG_ER_diArg_1	157	160	PF00400	0.554
TRG_ER_diArg_1	310	313	PF00400	0.367
TRG_NLS_MonoExtC_3	297	302	PF00514	0.351
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP9	Leptomonas seymouri	76%	100%
A0A1X0P1L9	Trypanosomatidae	41%	100%
A0A3Q8IF23	Leishmania donovani	85%	100%
A0A3R7LJF8	Trypanosoma rangeli	43%	100%
A4I5S6	Leishmania infantum	85%	100%
C9ZR45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B122	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q743	Leishmania major	85%	100%
V5CKN5	Trypanosoma cruzi	46%	100%