Putative tyrosine/dopa decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine/dopa decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HII2_LEIBR

TriTrypDb:

LbrM.30.2460 , LBRM2903_300031000

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HII2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006520	amino acid metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004837	tyrosine decarboxylase activity	5	2
GO:0005488	binding	1	3
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0019842	vitamin binding	3	3
GO:0030170	pyridoxal phosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0070279	vitamin B6 binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.478
CLV_NRD_NRD_1	221	223	PF00675	0.365
CLV_NRD_NRD_1	226	228	PF00675	0.367
CLV_NRD_NRD_1	337	339	PF00675	0.320
CLV_NRD_NRD_1	398	400	PF00675	0.361
CLV_NRD_NRD_1	455	457	PF00675	0.423
CLV_NRD_NRD_1	54	56	PF00675	0.641
CLV_PCSK_KEX2_1	221	223	PF00082	0.383
CLV_PCSK_KEX2_1	226	228	PF00082	0.338
CLV_PCSK_KEX2_1	398	400	PF00082	0.361
CLV_PCSK_KEX2_1	442	444	PF00082	0.416
CLV_PCSK_KEX2_1	455	457	PF00082	0.423
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.416
CLV_PCSK_PC7_1	222	228	PF00082	0.478
CLV_PCSK_SKI1_1	222	226	PF00082	0.365
CLV_PCSK_SKI1_1	36	40	PF00082	0.452
CLV_PCSK_SKI1_1	377	381	PF00082	0.328
CLV_PCSK_SKI1_1	471	475	PF00082	0.376
DEG_Nend_UBRbox_3	1	3	PF02207	0.615
DEG_ODPH_VHL_1	306	318	PF01847	0.478
DEG_SPOP_SBC_1	64	68	PF00917	0.478
DOC_MAPK_gen_1	374	383	PF00069	0.478
DOC_MAPK_gen_1	442	450	PF00069	0.541
DOC_MAPK_MEF2A_6	374	383	PF00069	0.446
DOC_MIT_MIM_1	409	418	PF04212	0.478
DOC_PP1_RVXF_1	24	31	PF00149	0.444
DOC_PP1_RVXF_1	359	366	PF00149	0.478
DOC_PP4_FxxP_1	116	119	PF00568	0.361
DOC_PP4_FxxP_1	144	147	PF00568	0.361
DOC_PP4_FxxP_1	372	375	PF00568	0.478
DOC_USP7_MATH_1	64	68	PF00917	0.478
DOC_WW_Pin1_4	100	105	PF00397	0.361
DOC_WW_Pin1_4	123	128	PF00397	0.361
DOC_WW_Pin1_4	250	255	PF00397	0.478
DOC_WW_Pin1_4	43	48	PF00397	0.491
LIG_14-3-3_CanoR_1	213	218	PF00244	0.361
LIG_ActinCP_TwfCPI_2	372	380	PF01115	0.478
LIG_BRCT_BRCA1_1	67	71	PF00533	0.478
LIG_CSL_BTD_1	96	99	PF09270	0.361
LIG_deltaCOP1_diTrp_1	138	144	PF00928	0.478
LIG_deltaCOP1_diTrp_1	16	20	PF00928	0.495
LIG_EVH1_1	8	12	PF00568	0.503
LIG_FHA_1	210	216	PF00498	0.361
LIG_FHA_1	261	267	PF00498	0.361
LIG_FHA_1	357	363	PF00498	0.414
LIG_FHA_2	128	134	PF00498	0.478
LIG_FHA_2	161	167	PF00498	0.361
LIG_FHA_2	182	188	PF00498	0.328
LIG_FHA_2	223	229	PF00498	0.361
LIG_FHA_2	449	455	PF00498	0.555
LIG_LIR_Apic_2	87	92	PF02991	0.361
LIG_LIR_Gen_1	14	22	PF02991	0.504
LIG_LIR_Gen_1	283	293	PF02991	0.478
LIG_LIR_Gen_1	321	328	PF02991	0.361
LIG_LIR_Gen_1	68	78	PF02991	0.478
LIG_LIR_Gen_1	93	102	PF02991	0.361
LIG_LIR_Nem_3	14	20	PF02991	0.511
LIG_LIR_Nem_3	269	275	PF02991	0.361
LIG_LIR_Nem_3	283	288	PF02991	0.361
LIG_LIR_Nem_3	321	326	PF02991	0.361
LIG_LIR_Nem_3	330	335	PF02991	0.361
LIG_LIR_Nem_3	364	368	PF02991	0.331
LIG_LIR_Nem_3	384	390	PF02991	0.328
LIG_LIR_Nem_3	424	430	PF02991	0.361
LIG_LIR_Nem_3	68	74	PF02991	0.365
LIG_LIR_Nem_3	93	98	PF02991	0.361
LIG_LYPXL_yS_3	476	479	PF13949	0.403
LIG_MYND_1	6	10	PF01753	0.508
LIG_PCNA_PIPBox_1	484	493	PF02747	0.405
LIG_PDZ_Class_2	499	504	PF00595	0.474
LIG_Pex14_2	372	376	PF04695	0.478
LIG_Pex14_2	94	98	PF04695	0.361
LIG_REV1ctd_RIR_1	330	340	PF16727	0.361
LIG_SH2_CRK	445	449	PF00017	0.548
LIG_SH2_PTP2	382	385	PF00017	0.478
LIG_SH2_SRC	463	466	PF00017	0.559
LIG_SH2_STAP1	282	286	PF00017	0.478
LIG_SH2_STAT5	199	202	PF00017	0.361
LIG_SH2_STAT5	340	343	PF00017	0.414
LIG_SH2_STAT5	351	354	PF00017	0.294
LIG_SH2_STAT5	356	359	PF00017	0.250
LIG_SH2_STAT5	382	385	PF00017	0.317
LIG_SH2_STAT5	406	409	PF00017	0.358
LIG_SH2_STAT5	463	466	PF00017	0.559
LIG_SH2_STAT5	490	493	PF00017	0.403
LIG_SH3_1	41	47	PF00018	0.580
LIG_SH3_3	156	162	PF00018	0.303
LIG_SH3_3	3	9	PF00018	0.517
LIG_SH3_3	302	308	PF00018	0.361
LIG_SH3_3	41	47	PF00018	0.580
LIG_SH3_3	416	422	PF00018	0.369
LIG_TRAF2_1	185	188	PF00917	0.361
LIG_TRAF2_1	451	454	PF00917	0.441
LIG_TYR_ITIM	385	390	PF00017	0.303
LIG_TYR_ITIM	474	479	PF00017	0.397
MOD_CK2_1	127	133	PF00069	0.478
MOD_CK2_1	160	166	PF00069	0.361
MOD_CK2_1	181	187	PF00069	0.328
MOD_CK2_1	222	228	PF00069	0.361
MOD_CK2_1	448	454	PF00069	0.551
MOD_GlcNHglycan	192	195	PF01048	0.325
MOD_GSK3_1	123	130	PF00069	0.439
MOD_GSK3_1	148	155	PF00069	0.361
MOD_GSK3_1	209	216	PF00069	0.361
MOD_GSK3_1	261	268	PF00069	0.470
MOD_GSK3_1	318	325	PF00069	0.347
MOD_GSK3_1	341	348	PF00069	0.312
MOD_GSK3_1	350	357	PF00069	0.289
MOD_N-GLC_1	318	323	PF02516	0.361
MOD_N-GLC_1	345	350	PF02516	0.361
MOD_NEK2_1	327	332	PF00069	0.358
MOD_NEK2_1	345	350	PF00069	0.180
MOD_PIKK_1	65	71	PF00454	0.478
MOD_Plk_1	280	286	PF00069	0.478
MOD_Plk_2-3	70	76	PF00069	0.478
MOD_Plk_4	131	137	PF00069	0.391
MOD_Plk_4	213	219	PF00069	0.361
MOD_Plk_4	280	286	PF00069	0.365
MOD_Plk_4	312	318	PF00069	0.365
MOD_Plk_4	322	328	PF00069	0.354
MOD_Plk_4	70	76	PF00069	0.397
MOD_ProDKin_1	100	106	PF00069	0.361
MOD_ProDKin_1	123	129	PF00069	0.361
MOD_ProDKin_1	250	256	PF00069	0.478
MOD_ProDKin_1	43	49	PF00069	0.493
MOD_SUMO_rev_2	420	427	PF00179	0.361
TRG_DiLeu_BaEn_3	453	459	PF01217	0.422
TRG_ENDOCYTIC_2	382	385	PF00928	0.317
TRG_ENDOCYTIC_2	387	390	PF00928	0.324
TRG_ENDOCYTIC_2	445	448	PF00928	0.539
TRG_ENDOCYTIC_2	476	479	PF00928	0.403
TRG_ENDOCYTIC_2	95	98	PF00928	0.361
TRG_ER_diArg_1	220	222	PF00400	0.478
TRG_ER_diArg_1	397	399	PF00400	0.361
TRG_ER_diArg_1	455	457	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0A2IDH4	Penicillium expansum	25%	100%
A0A0N1I150	Leptomonas seymouri	74%	100%
A0A0S4JDB2	Bodo saltans	33%	93%
A0A2H5AIY0	Narcissus pseudonarcissus	36%	98%
A0A2H5AIY2	Narcissus pseudonarcissus	35%	100%
A0A2I6B3P0	Rhodiola rosea	35%	100%
A0PA85	Canis lupus familiaris	22%	85%
A6QM00	Bos taurus	22%	97%
A7B1V0	Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)	24%	100%
E9FCP7	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	22%	100%
I1RV23	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	21%	97%
O82415	Papaver somniferum	33%	98%
O88533	Mus musculus	35%	100%
O96567	Drosophila simulans	35%	99%
O96569	Drosophila lebanonensis	36%	100%
O96571	Drosophila lebanonensis	33%	100%
P05031	Drosophila melanogaster	34%	99%
P14173	Rattus norvegicus	36%	100%
P14748	Felis catus	22%	85%
P16453	Rattus norvegicus	33%	77%
P17770	Catharanthus roseus	37%	100%
P18088	Rattus norvegicus	22%	85%
P18486	Drosophila melanogaster	35%	99%
P19113	Homo sapiens	34%	76%
P20228	Drosophila melanogaster	24%	99%
P20711	Homo sapiens	35%	100%
P22781	Cavia porcellus	35%	100%
P23738	Mus musculus	34%	76%
P27718	Bos taurus	37%	100%
P48318	Mus musculus	22%	85%
P48319	Sus scrofa	22%	85%
P48320	Mus musculus	23%	86%
P48321	Sus scrofa	23%	86%
P48861	Manduca sexta	32%	99%
P54768	Papaver somniferum	33%	97%
P54769	Papaver somniferum	35%	95%
P54770	Papaver somniferum	38%	95%
P54771	Papaver somniferum	33%	96%
P71362	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	99%
P80041	Sus scrofa	36%	100%
P93082	Camptotheca acuminata	36%	100%
P93083	Camptotheca acuminata	36%	100%
Q05329	Homo sapiens	23%	86%
Q05683	Rattus norvegicus	23%	86%
Q06085	Petroselinum crispum	37%	100%
Q06086	Petroselinum crispum	36%	98%
Q06087	Petroselinum crispum	36%	98%
Q06088	Petroselinum crispum	36%	99%
Q0VCA1	Bos taurus	22%	85%
Q0ZQX0	Petunia hybrida	33%	100%
Q0ZS27	Rosa hybrid cultivar	35%	99%
Q16S21	Aedes aegypti	32%	97%
Q28D99	Xenopus tropicalis	21%	99%
Q43908	Acinetobacter baumannii	23%	99%
Q4PRC2	Canis lupus familiaris	23%	86%
Q5E6F9	Aliivibrio fischeri (strain ATCC 700601 / ES114)	25%	92%
Q5EA83	Bos taurus	34%	77%
Q5IS68	Pan troglodytes	22%	85%
Q5R7S7	Pongo abelii	21%	85%
Q64611	Rattus norvegicus	24%	100%
Q6ZJK7	Oryza sativa subsp. japonica	34%	98%
Q6ZQY3	Homo sapiens	23%	97%
Q7XHL3	Oryza sativa subsp. japonica	34%	100%
Q80WP8	Mus musculus	24%	92%
Q8RY79	Arabidopsis thaliana	34%	100%
Q94EE9	Oryza sativa subsp. japonica	36%	95%
Q95ZS2	Caenorhabditis elegans	33%	71%
Q99259	Homo sapiens	22%	85%
Q9DBE0	Mus musculus	23%	100%
Q9M0G4	Arabidopsis thaliana	35%	92%
Q9Y600	Homo sapiens	23%	100%
Q9Z3R1	Rhizobium meliloti (strain 1021)	25%	100%