Putative heat shock 70-related protein 1,mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HII1_LEIBR

TriTrypDb:

LbrM.30.2450 , LBRM2903_300031400

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HII1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HII1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0044183	protein folding chaperone	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140657	ATP-dependent activity	1	6
GO:0140662	ATP-dependent protein folding chaperone	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.528
CLV_NRD_NRD_1	99	101	PF00675	0.320
CLV_PCSK_KEX2_1	4	6	PF00082	0.528
CLV_PCSK_KEX2_1	79	81	PF00082	0.339
CLV_PCSK_KEX2_1	94	96	PF00082	0.299
CLV_PCSK_KEX2_1	99	101	PF00082	0.321
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.339
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.299
CLV_PCSK_PC7_1	95	101	PF00082	0.297
CLV_PCSK_SKI1_1	108	112	PF00082	0.326
CLV_PCSK_SKI1_1	176	180	PF00082	0.299
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DOC_USP7_MATH_1	10	14	PF00917	0.546
DOC_USP7_UBL2_3	68	72	PF12436	0.364
DOC_WW_Pin1_4	133	138	PF00397	0.378
DOC_WW_Pin1_4	58	63	PF00397	0.336
LIG_BRCT_BRCA1_1	54	58	PF00533	0.363
LIG_EH1_1	90	98	PF00400	0.350
LIG_eIF4E_1	91	97	PF01652	0.326
LIG_FHA_1	24	30	PF00498	0.515
LIG_FHA_1	59	65	PF00498	0.350
LIG_LIR_Gen_1	36	44	PF02991	0.378
LIG_LIR_Nem_3	36	41	PF02991	0.392
LIG_LIR_Nem_3	88	93	PF02991	0.350
LIG_LRP6_Inhibitor_1	186	192	PF00058	0.350
LIG_PTB_Apo_2	109	116	PF02174	0.350
LIG_PTB_Phospho_1	109	115	PF10480	0.350
LIG_SH2_CRK	115	119	PF00017	0.350
LIG_SH2_CRK	38	42	PF00017	0.378
LIG_SH2_GRB2like	170	173	PF00017	0.378
LIG_SH2_NCK_1	38	42	PF00017	0.378
LIG_SH2_STAP1	38	42	PF00017	0.350
LIG_SH2_STAT5	170	173	PF00017	0.303
LIG_SH3_3	162	168	PF00018	0.321
LIG_SH3_3	191	197	PF00018	0.416
LIG_TYR_ITIM	113	118	PF00017	0.350
LIG_TYR_ITSM	34	41	PF00017	0.378
MOD_Cter_Amidation	97	100	PF01082	0.331
MOD_GlcNHglycan	12	15	PF01048	0.526
MOD_GSK3_1	19	26	PF00069	0.524
MOD_GSK3_1	36	43	PF00069	0.326
MOD_GSK3_1	81	88	PF00069	0.302
MOD_NEK2_1	148	153	PF00069	0.483
MOD_NEK2_1	156	161	PF00069	0.277
MOD_NEK2_1	34	39	PF00069	0.324
MOD_NEK2_2	86	91	PF00069	0.338
MOD_PIKK_1	135	141	PF00454	0.388
MOD_PIKK_1	19	25	PF00454	0.539
MOD_Plk_4	60	66	PF00069	0.331
MOD_Plk_4	86	92	PF00069	0.378
MOD_ProDKin_1	133	139	PF00069	0.378
MOD_ProDKin_1	58	64	PF00069	0.336
MOD_SUMO_rev_2	103	113	PF00179	0.350
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.321
TRG_ENDOCYTIC_2	115	118	PF00928	0.350
TRG_ENDOCYTIC_2	38	41	PF00928	0.378
TRG_ER_diArg_1	4	6	PF00400	0.581
TRG_ER_diArg_1	99	101	PF00400	0.297
TRG_ER_diLys_1	208	212	PF00400	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KFF1	Bodo saltans	33%	90%
A4HGY0	Leishmania braziliensis	54%	100%
A4HII6	Leishmania braziliensis	100%	100%
C9ZR49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	95%