Putative heat shock 70-related protein 1,mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HIH9_LEIBR

TriTrypDb:

LbrM.30.2430 , LBRM2903_300030900

Length:

356

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HIH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0044183	protein folding chaperone	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0140662	ATP-dependent protein folding chaperone	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	218	220	PF00675	0.262
CLV_NRD_NRD_1	295	297	PF00675	0.480
CLV_PCSK_FUR_1	251	255	PF00082	0.495
CLV_PCSK_KEX2_1	145	147	PF00082	0.373
CLV_PCSK_KEX2_1	253	255	PF00082	0.495
CLV_PCSK_KEX2_1	78	80	PF00082	0.293
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.373
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.495
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.293
CLV_PCSK_SKI1_1	78	82	PF00082	0.464
DEG_APCC_KENBOX_2	284	288	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.223
DOC_MAPK_gen_1	219	225	PF00069	0.307
DOC_MAPK_MEF2A_6	191	200	PF00069	0.357
DOC_MAPK_RevD_3	131	146	PF00069	0.239
DOC_USP7_MATH_1	333	337	PF00917	0.705
DOC_USP7_UBL2_3	285	289	PF12436	0.493
DOC_USP7_UBL2_3	45	49	PF12436	0.472
DOC_WW_Pin1_4	116	121	PF00397	0.384
LIG_14-3-3_CanoR_1	146	151	PF00244	0.287
LIG_BIR_III_4	203	207	PF00653	0.464
LIG_BRCT_BRCA1_1	146	150	PF00533	0.359
LIG_Clathr_ClatBox_1	113	117	PF01394	0.384
LIG_CtBP_PxDLS_1	120	124	PF00389	0.380
LIG_FHA_1	123	129	PF00498	0.420
LIG_FHA_1	197	203	PF00498	0.453
LIG_FHA_1	31	37	PF00498	0.480
LIG_FHA_1	311	317	PF00498	0.484
LIG_FHA_2	149	155	PF00498	0.360
LIG_FHA_2	209	215	PF00498	0.463
LIG_FHA_2	266	272	PF00498	0.403
LIG_LIR_Gen_1	147	155	PF02991	0.264
LIG_LIR_Nem_3	130	135	PF02991	0.451
LIG_LIR_Nem_3	147	153	PF02991	0.260
LIG_LIR_Nem_3	27	32	PF02991	0.496
LIG_LIR_Nem_3	276	280	PF02991	0.479
LIG_LIR_Nem_3	84	89	PF02991	0.495
LIG_REV1ctd_RIR_1	78	84	PF16727	0.384
LIG_SH2_STAT5	279	282	PF00017	0.481
LIG_SH3_3	131	137	PF00018	0.287
LIG_SH3_3	181	187	PF00018	0.390
LIG_SH3_3	2	8	PF00018	0.464
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.359
LIG_SUMO_SIM_par_1	112	117	PF11976	0.362
LIG_SUMO_SIM_par_1	119	126	PF11976	0.365
LIG_SxIP_EBH_1	135	146	PF03271	0.421
LIG_UBA3_1	131	138	PF00899	0.231
MOD_CK1_1	122	128	PF00069	0.387
MOD_CK1_1	336	342	PF00069	0.693
MOD_CK2_1	148	154	PF00069	0.231
MOD_CK2_1	24	30	PF00069	0.532
MOD_CK2_1	265	271	PF00069	0.432
MOD_CK2_1	278	284	PF00069	0.331
MOD_GlcNHglycan	227	230	PF01048	0.386
MOD_GlcNHglycan	335	338	PF01048	0.736
MOD_GlcNHglycan	341	344	PF01048	0.590
MOD_GSK3_1	119	126	PF00069	0.483
MOD_GSK3_1	144	151	PF00069	0.350
MOD_GSK3_1	225	232	PF00069	0.430
MOD_GSK3_1	262	269	PF00069	0.396
MOD_GSK3_1	333	340	PF00069	0.667
MOD_NEK2_1	123	128	PF00069	0.278
MOD_NEK2_1	22	27	PF00069	0.451
MOD_PIKK_1	262	268	PF00454	0.472
MOD_Plk_1	196	202	PF00069	0.416
MOD_Plk_1	37	43	PF00069	0.522
MOD_Plk_4	123	129	PF00069	0.304
MOD_Plk_4	137	143	PF00069	0.237
MOD_ProDKin_1	116	122	PF00069	0.384
MOD_SUMO_for_1	160	163	PF00179	0.231
MOD_SUMO_for_1	252	255	PF00179	0.491
MOD_SUMO_rev_2	271	280	PF00179	0.513
MOD_SUMO_rev_2	50	58	PF00179	0.380
MOD_SUMO_rev_2	75	80	PF00179	0.495
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.480
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYN5	Trypanosomatidae	42%	91%
A4HIH7	Leishmania braziliensis	99%	100%
C9ZRV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	69%
E9B0A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
V5B942	Trypanosoma cruzi	41%	77%
V5BZ53	Trypanosoma cruzi	41%	74%