Putative heat shock 70-related protein 1,mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HIH7_LEIBR

TriTrypDb:

LbrM.30.2410 , LBRM2903_300031400

Length:

318

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HIH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0044183	protein folding chaperone	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140662	ATP-dependent protein folding chaperone	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.408
CLV_NRD_NRD_1	274	276	PF00675	0.536
CLV_PCSK_FUR_1	230	234	PF00082	0.536
CLV_PCSK_KEX2_1	124	126	PF00082	0.544
CLV_PCSK_KEX2_1	232	234	PF00082	0.536
CLV_PCSK_KEX2_1	57	59	PF00082	0.557
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.544
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.536
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.557
CLV_PCSK_SKI1_1	57	61	PF00082	0.517
DEG_APCC_KENBOX_2	263	267	PF00400	0.536
DOC_MAPK_gen_1	198	204	PF00069	0.446
DOC_MAPK_MEF2A_6	170	179	PF00069	0.449
DOC_MAPK_RevD_3	110	125	PF00069	0.408
DOC_USP7_MATH_1	312	316	PF00917	0.756
DOC_USP7_UBL2_3	24	28	PF12436	0.472
DOC_USP7_UBL2_3	264	268	PF12436	0.553
DOC_WW_Pin1_4	95	100	PF00397	0.483
LIG_14-3-3_CanoR_1	125	130	PF00244	0.512
LIG_BIR_III_4	182	186	PF00653	0.530
LIG_BRCT_BRCA1_1	125	129	PF00533	0.449
LIG_Clathr_ClatBox_1	92	96	PF01394	0.483
LIG_CtBP_PxDLS_1	99	103	PF00389	0.466
LIG_FHA_1	10	16	PF00498	0.472
LIG_FHA_1	102	108	PF00498	0.503
LIG_FHA_1	176	182	PF00498	0.512
LIG_FHA_1	290	296	PF00498	0.541
LIG_FHA_2	128	134	PF00498	0.444
LIG_FHA_2	188	194	PF00498	0.536
LIG_FHA_2	245	251	PF00498	0.500
LIG_LIR_Gen_1	126	134	PF02991	0.543
LIG_LIR_Nem_3	109	114	PF02991	0.408
LIG_LIR_Nem_3	126	132	PF02991	0.410
LIG_LIR_Nem_3	255	259	PF02991	0.536
LIG_LIR_Nem_3	6	11	PF02991	0.472
LIG_LIR_Nem_3	63	68	PF02991	0.541
LIG_REV1ctd_RIR_1	57	63	PF16727	0.483
LIG_SH2_STAT5	258	261	PF00017	0.566
LIG_SH3_3	110	116	PF00018	0.441
LIG_SH3_3	160	166	PF00018	0.493
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.443
LIG_SUMO_SIM_par_1	91	96	PF11976	0.454
LIG_SUMO_SIM_par_1	98	105	PF11976	0.456
LIG_SxIP_EBH_1	114	125	PF03271	0.496
LIG_UBA3_1	110	117	PF00899	0.408
MOD_CK1_1	101	107	PF00069	0.530
MOD_CK2_1	127	133	PF00069	0.507
MOD_CK2_1	244	250	PF00069	0.489
MOD_CK2_1	257	263	PF00069	0.388
MOD_CK2_1	3	9	PF00069	0.547
MOD_GlcNHglycan	206	209	PF01048	0.533
MOD_GlcNHglycan	314	317	PF01048	0.798
MOD_GSK3_1	123	130	PF00069	0.458
MOD_GSK3_1	204	211	PF00069	0.535
MOD_GSK3_1	241	248	PF00069	0.497
MOD_GSK3_1	98	105	PF00069	0.568
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	102	107	PF00069	0.408
MOD_PIKK_1	241	247	PF00454	0.531
MOD_Plk_1	16	22	PF00069	0.472
MOD_Plk_1	175	181	PF00069	0.483
MOD_Plk_4	102	108	PF00069	0.457
MOD_ProDKin_1	95	101	PF00069	0.483
MOD_SUMO_for_1	139	142	PF00179	0.408
MOD_SUMO_for_1	231	234	PF00179	0.550
MOD_SUMO_rev_2	250	259	PF00179	0.570
MOD_SUMO_rev_2	29	37	PF00179	0.419
MOD_SUMO_rev_2	54	59	PF00179	0.536
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.472
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYN5	Trypanosomatidae	43%	81%
A4HIH9	Leishmania braziliensis	99%	89%
E9B0A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
V5B942	Trypanosoma cruzi	41%	69%
V5BZ53	Trypanosoma cruzi	41%	66%