DnaJ domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIH6_LEIBR

TriTrypDb:

LbrM.30.2400 , LBRM2903_300030600

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HIH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH6

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.451
CLV_C14_Caspase3-7	47	51	PF00656	0.292
CLV_NRD_NRD_1	151	153	PF00675	0.672
CLV_NRD_NRD_1	198	200	PF00675	0.595
CLV_NRD_NRD_1	84	86	PF00675	0.678
CLV_NRD_NRD_1	97	99	PF00675	0.717
CLV_PCSK_KEX2_1	151	153	PF00082	0.672
CLV_PCSK_KEX2_1	197	199	PF00082	0.595
CLV_PCSK_KEX2_1	250	252	PF00082	0.427
CLV_PCSK_KEX2_1	261	263	PF00082	0.394
CLV_PCSK_KEX2_1	84	86	PF00082	0.680
CLV_PCSK_KEX2_1	97	99	PF00082	0.729
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.427
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.394
CLV_PCSK_SKI1_1	173	177	PF00082	0.676
CLV_PCSK_SKI1_1	199	203	PF00082	0.649
CLV_PCSK_SKI1_1	24	28	PF00082	0.534
CLV_PCSK_SKI1_1	62	66	PF00082	0.562
CLV_PCSK_SKI1_1	8	12	PF00082	0.740
DEG_APCC_DBOX_1	97	105	PF00400	0.436
DEG_COP1_1	306	315	PF00400	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DEG_SPOP_SBC_1	127	131	PF00917	0.535
DOC_ANK_TNKS_1	150	157	PF00023	0.451
DOC_CYCLIN_RxL_1	5	15	PF00134	0.523
DOC_CYCLIN_RxL_1	59	67	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.540
DOC_MAPK_gen_1	282	289	PF00069	0.658
DOC_MAPK_MEF2A_6	235	244	PF00069	0.419
DOC_MAPK_RevD_3	238	251	PF00069	0.451
DOC_PP2B_LxvP_1	73	76	PF13499	0.494
DOC_PP2B_LxvP_1	9	12	PF13499	0.556
DOC_USP7_MATH_1	119	123	PF00917	0.588
DOC_USP7_MATH_1	48	52	PF00917	0.205
DOC_USP7_UBL2_3	28	32	PF12436	0.296
DOC_USP7_UBL2_3	62	66	PF12436	0.362
DOC_WW_Pin1_4	128	133	PF00397	0.521
DOC_WW_Pin1_4	150	155	PF00397	0.402
DOC_WW_Pin1_4	311	316	PF00397	0.686
LIG_14-3-3_CanoR_1	182	187	PF00244	0.359
LIG_14-3-3_CanoR_1	212	220	PF00244	0.457
LIG_Actin_WH2_2	50	68	PF00022	0.296
LIG_AP2alpha_2	15	17	PF02296	0.313
LIG_EVH1_2	315	319	PF00568	0.731
LIG_FHA_1	191	197	PF00498	0.386
LIG_FHA_1	5	11	PF00498	0.372
LIG_FHA_2	133	139	PF00498	0.484
LIG_FHA_2	25	31	PF00498	0.334
LIG_FHA_2	276	282	PF00498	0.599
LIG_FHA_2	304	310	PF00498	0.618
LIG_IBAR_NPY_1	230	232	PF08397	0.292
LIG_LIR_Gen_1	165	176	PF02991	0.381
LIG_LIR_Gen_1	181	190	PF02991	0.418
LIG_LIR_Gen_1	263	270	PF02991	0.511
LIG_LIR_Gen_1	328	334	PF02991	0.674
LIG_LIR_Gen_1	67	78	PF02991	0.396
LIG_LIR_Nem_3	15	20	PF02991	0.320
LIG_LIR_Nem_3	165	171	PF02991	0.374
LIG_LIR_Nem_3	181	186	PF02991	0.437
LIG_LIR_Nem_3	263	269	PF02991	0.533
LIG_LIR_Nem_3	317	323	PF02991	0.651
LIG_LIR_Nem_3	328	333	PF02991	0.604
LIG_LIR_Nem_3	67	73	PF02991	0.388
LIG_OCRL_FandH_1	1	13	PF00620	0.370
LIG_SH2_CRK	237	241	PF00017	0.480
LIG_SH2_CRK	320	324	PF00017	0.723
LIG_SH2_CRK	330	334	PF00017	0.722
LIG_SH2_CRK	61	65	PF00017	0.296
LIG_SH2_CRK	87	91	PF00017	0.567
LIG_SH2_GRB2like	160	163	PF00017	0.308
LIG_SH2_NCK_1	330	334	PF00017	0.746
LIG_SH2_NCK_1	87	91	PF00017	0.567
LIG_SH2_SRC	87	90	PF00017	0.393
LIG_SH2_STAP1	237	241	PF00017	0.480
LIG_SH2_STAP1	330	334	PF00017	0.716
LIG_SH2_STAT3	158	161	PF00017	0.358
LIG_SH2_STAT5	158	161	PF00017	0.427
LIG_SH2_STAT5	232	235	PF00017	0.280
LIG_SH2_STAT5	246	249	PF00017	0.349
LIG_SH2_STAT5	330	333	PF00017	0.691
LIG_SH3_3	307	313	PF00018	0.631
LIG_SH3_3	320	326	PF00018	0.664
LIG_Sin3_3	293	300	PF02671	0.606
LIG_TRAF2_1	100	103	PF00917	0.411
LIG_TRAF2_1	135	138	PF00917	0.485
LIG_TYR_ITSM	316	323	PF00017	0.566
LIG_WRC_WIRS_1	183	188	PF05994	0.429
MOD_CDK_SPxxK_3	150	157	PF00069	0.413
MOD_CK1_1	123	129	PF00069	0.579
MOD_CK2_1	132	138	PF00069	0.459
MOD_CK2_1	164	170	PF00069	0.434
MOD_CK2_1	24	30	PF00069	0.313
MOD_CK2_1	275	281	PF00069	0.535
MOD_CK2_1	311	317	PF00069	0.683
MOD_GlcNHglycan	124	128	PF01048	0.743
MOD_GlcNHglycan	142	145	PF01048	0.485
MOD_GlcNHglycan	24	27	PF01048	0.516
MOD_GlcNHglycan	50	53	PF01048	0.539
MOD_GSK3_1	103	110	PF00069	0.571
MOD_GSK3_1	119	126	PF00069	0.533
MOD_GSK3_1	128	135	PF00069	0.479
MOD_GSK3_1	146	153	PF00069	0.377
MOD_GSK3_1	171	178	PF00069	0.320
MOD_GSK3_1	20	27	PF00069	0.313
MOD_GSK3_1	249	256	PF00069	0.619
MOD_GSK3_1	311	318	PF00069	0.695
MOD_LATS_1	258	264	PF00433	0.565
MOD_N-GLC_1	127	132	PF02516	0.618
MOD_NEK2_1	171	176	PF00069	0.306
MOD_NEK2_1	20	25	PF00069	0.298
MOD_NEK2_1	253	258	PF00069	0.615
MOD_NEK2_1	319	324	PF00069	0.747
MOD_NEK2_1	4	9	PF00069	0.481
MOD_PIKK_1	175	181	PF00454	0.352
MOD_PIKK_1	260	266	PF00454	0.675
MOD_PKA_1	260	266	PF00069	0.624
MOD_PKA_2	254	260	PF00069	0.558
MOD_PKA_2	78	84	PF00069	0.380
MOD_Plk_1	164	170	PF00069	0.434
MOD_Plk_1	171	177	PF00069	0.443
MOD_Plk_1	208	214	PF00069	0.491
MOD_Plk_2-3	164	170	PF00069	0.434
MOD_Plk_2-3	303	309	PF00069	0.615
MOD_Plk_4	164	170	PF00069	0.403
MOD_Plk_4	315	321	PF00069	0.691
MOD_Plk_4	328	334	PF00069	0.735
MOD_ProDKin_1	128	134	PF00069	0.513
MOD_ProDKin_1	150	156	PF00069	0.402
MOD_ProDKin_1	311	317	PF00069	0.688
MOD_SUMO_for_1	52	55	PF00179	0.362
MOD_SUMO_rev_2	150	159	PF00179	0.437
MOD_SUMO_rev_2	25	33	PF00179	0.316
TRG_AP2beta_CARGO_1	15	24	PF09066	0.296
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.536
TRG_ENDOCYTIC_2	183	186	PF00928	0.443
TRG_ENDOCYTIC_2	237	240	PF00928	0.360
TRG_ENDOCYTIC_2	266	269	PF00928	0.592
TRG_ENDOCYTIC_2	320	323	PF00928	0.729
TRG_ENDOCYTIC_2	330	333	PF00928	0.720
TRG_ENDOCYTIC_2	35	38	PF00928	0.313
TRG_ENDOCYTIC_2	61	64	PF00928	0.284
TRG_ENDOCYTIC_2	70	73	PF00928	0.383
TRG_ER_diArg_1	196	199	PF00400	0.384
TRG_NLS_Bipartite_1	250	264	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.751

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM1	Leptomonas seymouri	70%	100%
A0A0S4IL99	Bodo saltans	41%	100%
A0A1X0P2Q0	Trypanosomatidae	49%	100%
A0A3S7X3P0	Leishmania donovani	82%	100%
A4I5S3	Leishmania infantum	82%	100%
C9ZR42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B118	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q748	Leishmania major	81%	100%
V5AWW0	Trypanosoma cruzi	44%	100%