LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HIH5_LEIBR
TriTrypDb:
LbrM.30.2390 , LBRM2903_300030500 *
Length:
780

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH5

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 10
GO:0009987 cellular process 1 10
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0030544 Hsp70 protein binding 4 10
GO:0031072 heat shock protein binding 3 10
GO:0051879 Hsp90 protein binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 688 692 PF00656 0.600
CLV_NRD_NRD_1 278 280 PF00675 0.436
CLV_NRD_NRD_1 356 358 PF00675 0.609
CLV_NRD_NRD_1 512 514 PF00675 0.392
CLV_NRD_NRD_1 518 520 PF00675 0.395
CLV_NRD_NRD_1 525 527 PF00675 0.409
CLV_NRD_NRD_1 573 575 PF00675 0.419
CLV_NRD_NRD_1 676 678 PF00675 0.584
CLV_NRD_NRD_1 763 765 PF00675 0.506
CLV_PCSK_FUR_1 674 678 PF00082 0.517
CLV_PCSK_KEX2_1 278 280 PF00082 0.436
CLV_PCSK_KEX2_1 358 360 PF00082 0.574
CLV_PCSK_KEX2_1 512 514 PF00082 0.391
CLV_PCSK_KEX2_1 517 519 PF00082 0.397
CLV_PCSK_KEX2_1 525 527 PF00082 0.410
CLV_PCSK_KEX2_1 573 575 PF00082 0.419
CLV_PCSK_KEX2_1 674 676 PF00082 0.574
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.574
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.423
CLV_PCSK_PC7_1 513 519 PF00082 0.400
CLV_PCSK_SKI1_1 358 362 PF00082 0.509
CLV_PCSK_SKI1_1 502 506 PF00082 0.314
CLV_Separin_Metazoa 97 101 PF03568 0.360
DEG_APCC_DBOX_1 470 478 PF00400 0.440
DEG_APCC_DBOX_1 501 509 PF00400 0.417
DEG_Nend_Nbox_1 1 3 PF02207 0.465
DEG_SPOP_SBC_1 226 230 PF00917 0.403
DEG_SPOP_SBC_1 401 405 PF00917 0.356
DEG_SPOP_SBC_1 432 436 PF00917 0.388
DEG_SPOP_SBC_1 704 708 PF00917 0.741
DOC_CKS1_1 362 367 PF01111 0.301
DOC_CKS1_1 425 430 PF01111 0.534
DOC_CKS1_1 627 632 PF01111 0.653
DOC_CYCLIN_RxL_1 259 268 PF00134 0.230
DOC_CYCLIN_RxL_1 355 364 PF00134 0.361
DOC_MAPK_gen_1 260 267 PF00069 0.296
DOC_MAPK_gen_1 342 352 PF00069 0.475
DOC_MAPK_gen_1 762 771 PF00069 0.698
DOC_MAPK_MEF2A_6 260 267 PF00069 0.352
DOC_MAPK_MEF2A_6 484 491 PF00069 0.462
DOC_MAPK_MEF2A_6 502 510 PF00069 0.335
DOC_MAPK_MEF2A_6 764 773 PF00069 0.697
DOC_MAPK_NFAT4_5 484 492 PF00069 0.316
DOC_MAPK_RevD_3 503 518 PF00069 0.441
DOC_PP1_RVXF_1 260 267 PF00149 0.227
DOC_PP2B_LxvP_1 121 124 PF13499 0.302
DOC_PP2B_LxvP_1 34 37 PF13499 0.417
DOC_PP4_FxxP_1 652 655 PF00568 0.600
DOC_USP7_MATH_1 135 139 PF00917 0.427
DOC_USP7_MATH_1 140 144 PF00917 0.454
DOC_USP7_MATH_1 166 170 PF00917 0.439
DOC_USP7_MATH_1 211 215 PF00917 0.441
DOC_USP7_MATH_1 226 230 PF00917 0.509
DOC_USP7_MATH_1 233 237 PF00917 0.550
DOC_USP7_MATH_1 381 385 PF00917 0.406
DOC_USP7_MATH_1 408 412 PF00917 0.534
DOC_USP7_MATH_1 413 417 PF00917 0.546
DOC_USP7_MATH_1 465 469 PF00917 0.335
DOC_USP7_MATH_1 533 537 PF00917 0.749
DOC_USP7_MATH_1 548 552 PF00917 0.771
DOC_USP7_MATH_1 584 588 PF00917 0.548
DOC_USP7_MATH_1 622 626 PF00917 0.669
DOC_USP7_MATH_1 698 702 PF00917 0.709
DOC_USP7_MATH_1 704 708 PF00917 0.707
DOC_USP7_MATH_1 774 778 PF00917 0.714
DOC_USP7_MATH_2 630 636 PF00917 0.533
DOC_WW_Pin1_4 222 227 PF00397 0.464
DOC_WW_Pin1_4 361 366 PF00397 0.291
DOC_WW_Pin1_4 374 379 PF00397 0.481
DOC_WW_Pin1_4 424 429 PF00397 0.536
DOC_WW_Pin1_4 436 441 PF00397 0.504
DOC_WW_Pin1_4 558 563 PF00397 0.735
DOC_WW_Pin1_4 626 631 PF00397 0.646
DOC_WW_Pin1_4 638 643 PF00397 0.741
DOC_WW_Pin1_4 711 716 PF00397 0.668
DOC_WW_Pin1_4 717 722 PF00397 0.650
LIG_14-3-3_CanoR_1 192 197 PF00244 0.407
LIG_14-3-3_CanoR_1 289 295 PF00244 0.392
LIG_14-3-3_CanoR_1 400 408 PF00244 0.484
LIG_14-3-3_CanoR_1 459 463 PF00244 0.364
LIG_14-3-3_CanoR_1 512 520 PF00244 0.603
LIG_14-3-3_CanoR_1 609 615 PF00244 0.606
LIG_14-3-3_CanoR_1 665 670 PF00244 0.677
LIG_Actin_WH2_2 751 769 PF00022 0.652
LIG_APCC_ABBA_1 263 268 PF00400 0.395
LIG_APCC_ABBAyCdc20_2 262 268 PF00400 0.395
LIG_BIR_III_4 547 551 PF00653 0.582
LIG_BRCT_BRCA1_1 21 25 PF00533 0.376
LIG_BRCT_BRCA1_1 624 628 PF00533 0.660
LIG_Clathr_ClatBox_1 264 268 PF01394 0.238
LIG_CtBP_PxDLS_1 493 497 PF00389 0.262
LIG_eIF4E_1 355 361 PF01652 0.358
LIG_FHA_1 123 129 PF00498 0.344
LIG_FHA_1 375 381 PF00498 0.488
LIG_FHA_1 420 426 PF00498 0.585
LIG_FHA_1 428 434 PF00498 0.563
LIG_FHA_1 486 492 PF00498 0.471
LIG_FHA_1 498 504 PF00498 0.320
LIG_FHA_1 580 586 PF00498 0.616
LIG_FHA_1 63 69 PF00498 0.361
LIG_FHA_1 661 667 PF00498 0.721
LIG_FHA_1 770 776 PF00498 0.758
LIG_FHA_1 82 88 PF00498 0.418
LIG_FHA_2 159 165 PF00498 0.533
LIG_FHA_2 192 198 PF00498 0.454
LIG_FHA_2 4 10 PF00498 0.493
LIG_FHA_2 441 447 PF00498 0.525
LIG_FHA_2 54 60 PF00498 0.428
LIG_FHA_2 540 546 PF00498 0.690
LIG_FHA_2 627 633 PF00498 0.664
LIG_Integrin_isoDGR_2 91 93 PF01839 0.502
LIG_LIR_Apic_2 625 630 PF02991 0.696
LIG_LIR_Apic_2 650 655 PF02991 0.599
LIG_LIR_Gen_1 134 140 PF02991 0.433
LIG_LIR_Gen_1 187 196 PF02991 0.467
LIG_LIR_Gen_1 347 356 PF02991 0.370
LIG_LIR_Gen_1 611 622 PF02991 0.571
LIG_LIR_Gen_1 83 94 PF02991 0.360
LIG_LIR_Nem_3 134 139 PF02991 0.524
LIG_LIR_Nem_3 150 156 PF02991 0.494
LIG_LIR_Nem_3 187 191 PF02991 0.489
LIG_LIR_Nem_3 347 352 PF02991 0.447
LIG_LIR_Nem_3 461 466 PF02991 0.433
LIG_LIR_Nem_3 540 546 PF02991 0.761
LIG_LIR_Nem_3 611 617 PF02991 0.557
LIG_LIR_Nem_3 618 624 PF02991 0.516
LIG_LIR_Nem_3 625 631 PF02991 0.526
LIG_LIR_Nem_3 83 89 PF02991 0.342
LIG_MLH1_MIPbox_1 624 628 PF16413 0.585
LIG_Pex14_1 287 291 PF04695 0.338
LIG_Pex14_2 204 208 PF04695 0.400
LIG_PTB_Apo_2 726 733 PF02174 0.591
LIG_Rb_LxCxE_1 369 384 PF01857 0.410
LIG_RPA_C_Fungi 507 519 PF08784 0.467
LIG_SH2_CRK 136 140 PF00017 0.638
LIG_SH2_CRK 153 157 PF00017 0.638
LIG_SH2_CRK 597 601 PF00017 0.371
LIG_SH2_CRK 621 625 PF00017 0.447
LIG_SH2_SRC 527 530 PF00017 0.415
LIG_SH2_SRC 621 624 PF00017 0.388
LIG_SH2_SRC 653 656 PF00017 0.556
LIG_SH2_STAP1 320 324 PF00017 0.571
LIG_SH2_STAT5 218 221 PF00017 0.484
LIG_SH2_STAT5 291 294 PF00017 0.406
LIG_SH2_STAT5 336 339 PF00017 0.558
LIG_SH2_STAT5 451 454 PF00017 0.483
LIG_SH2_STAT5 527 530 PF00017 0.697
LIG_SH2_STAT5 623 626 PF00017 0.403
LIG_SH2_STAT5 627 630 PF00017 0.447
LIG_SH2_STAT5 653 656 PF00017 0.481
LIG_SH2_STAT5 657 660 PF00017 0.473
LIG_SH2_STAT5 669 672 PF00017 0.572
LIG_SH2_STAT5 86 89 PF00017 0.424
LIG_SH3_2 562 567 PF14604 0.474
LIG_SH3_3 129 135 PF00018 0.438
LIG_SH3_3 220 226 PF00018 0.567
LIG_SH3_3 33 39 PF00018 0.588
LIG_SH3_3 359 365 PF00018 0.406
LIG_SH3_3 559 565 PF00018 0.658
LIG_SUMO_SIM_anti_2 238 246 PF11976 0.611
LIG_SUMO_SIM_anti_2 753 759 PF11976 0.578
LIG_SUMO_SIM_par_1 629 635 PF11976 0.552
LIG_SUMO_SIM_par_1 750 756 PF11976 0.630
LIG_SUMO_SIM_par_1 771 777 PF11976 0.630
LIG_TRAF2_1 473 476 PF00917 0.331
LIG_TYR_ITIM 595 600 PF00017 0.408
LIG_TYR_ITSM 82 89 PF00017 0.333
LIG_WRPW_2 399 402 PF00400 0.388
MOD_CDK_SPK_2 436 441 PF00069 0.501
MOD_CDK_SPxxK_3 560 567 PF00069 0.490
MOD_CK1_1 112 118 PF00069 0.622
MOD_CK1_1 126 132 PF00069 0.245
MOD_CK1_1 225 231 PF00069 0.701
MOD_CK1_1 238 244 PF00069 0.732
MOD_CK1_1 426 432 PF00069 0.648
MOD_CK1_1 436 442 PF00069 0.718
MOD_CK1_1 635 641 PF00069 0.537
MOD_CK1_1 668 674 PF00069 0.582
MOD_CK1_1 708 714 PF00069 0.747
MOD_CK1_1 716 722 PF00069 0.764
MOD_CK1_1 85 91 PF00069 0.508
MOD_CK2_1 158 164 PF00069 0.635
MOD_CK2_1 191 197 PF00069 0.520
MOD_CK2_1 3 9 PF00069 0.515
MOD_CK2_1 400 406 PF00069 0.580
MOD_CK2_1 440 446 PF00069 0.557
MOD_CK2_1 53 59 PF00069 0.354
MOD_CK2_1 539 545 PF00069 0.513
MOD_CK2_1 626 632 PF00069 0.496
MOD_CK2_1 732 738 PF00069 0.471
MOD_GlcNHglycan 149 152 PF01048 0.642
MOD_GlcNHglycan 168 171 PF01048 0.698
MOD_GlcNHglycan 410 413 PF01048 0.729
MOD_GlcNHglycan 416 419 PF01048 0.585
MOD_GlcNHglycan 514 517 PF01048 0.560
MOD_GlcNHglycan 529 533 PF01048 0.574
MOD_GlcNHglycan 550 553 PF01048 0.627
MOD_GlcNHglycan 624 627 PF01048 0.526
MOD_GlcNHglycan 645 648 PF01048 0.612
MOD_GlcNHglycan 670 673 PF01048 0.737
MOD_GlcNHglycan 94 97 PF01048 0.433
MOD_GSK3_1 122 129 PF00069 0.417
MOD_GSK3_1 142 149 PF00069 0.560
MOD_GSK3_1 218 225 PF00069 0.556
MOD_GSK3_1 227 234 PF00069 0.691
MOD_GSK3_1 402 409 PF00069 0.573
MOD_GSK3_1 414 421 PF00069 0.662
MOD_GSK3_1 423 430 PF00069 0.739
MOD_GSK3_1 432 439 PF00069 0.789
MOD_GSK3_1 450 457 PF00069 0.570
MOD_GSK3_1 476 483 PF00069 0.507
MOD_GSK3_1 533 540 PF00069 0.671
MOD_GSK3_1 548 555 PF00069 0.640
MOD_GSK3_1 622 629 PF00069 0.617
MOD_GSK3_1 643 650 PF00069 0.591
MOD_GSK3_1 661 668 PF00069 0.674
MOD_GSK3_1 704 711 PF00069 0.680
MOD_GSK3_1 713 720 PF00069 0.786
MOD_GSK3_1 81 88 PF00069 0.572
MOD_GSK3_1 99 106 PF00069 0.390
MOD_N-GLC_1 238 243 PF02516 0.749
MOD_N-GLC_1 80 85 PF02516 0.495
MOD_N-GLC_2 313 315 PF02516 0.285
MOD_NEK2_1 1 6 PF00069 0.672
MOD_NEK2_1 117 122 PF00069 0.442
MOD_NEK2_1 41 46 PF00069 0.564
MOD_NEK2_1 480 485 PF00069 0.526
MOD_NEK2_1 506 511 PF00069 0.368
MOD_NEK2_1 520 525 PF00069 0.543
MOD_NEK2_1 528 533 PF00069 0.538
MOD_NEK2_1 568 573 PF00069 0.575
MOD_NEK2_1 62 67 PF00069 0.466
MOD_NEK2_1 689 694 PF00069 0.683
MOD_NEK2_1 709 714 PF00069 0.619
MOD_NEK2_1 732 737 PF00069 0.618
MOD_NEK2_1 82 87 PF00069 0.253
MOD_NEK2_2 158 163 PF00069 0.457
MOD_NEK2_2 381 386 PF00069 0.522
MOD_NEK2_2 497 502 PF00069 0.394
MOD_OFUCOSY 122 127 PF10250 0.480
MOD_PIKK_1 218 224 PF00454 0.546
MOD_PIKK_1 336 342 PF00454 0.496
MOD_PIKK_1 454 460 PF00454 0.554
MOD_PIKK_1 53 59 PF00454 0.529
MOD_PIKK_1 73 79 PF00454 0.269
MOD_PKA_1 512 518 PF00069 0.594
MOD_PKA_1 675 681 PF00069 0.771
MOD_PKA_2 158 164 PF00069 0.587
MOD_PKA_2 191 197 PF00069 0.588
MOD_PKA_2 406 412 PF00069 0.528
MOD_PKA_2 440 446 PF00069 0.712
MOD_PKA_2 458 464 PF00069 0.444
MOD_PKA_2 512 518 PF00069 0.542
MOD_PKA_2 608 614 PF00069 0.436
MOD_PKA_2 675 681 PF00069 0.741
MOD_PKA_2 696 702 PF00069 0.738
MOD_PKA_2 92 98 PF00069 0.377
MOD_PKA_2 99 105 PF00069 0.387
MOD_PKB_1 163 171 PF00069 0.473
MOD_Plk_1 20 26 PF00069 0.637
MOD_Plk_1 238 244 PF00069 0.759
MOD_Plk_1 41 47 PF00069 0.691
MOD_Plk_1 568 574 PF00069 0.587
MOD_Plk_1 661 667 PF00069 0.515
MOD_Plk_2-3 21 27 PF00069 0.521
MOD_Plk_2-3 598 604 PF00069 0.407
MOD_Plk_2-3 696 702 PF00069 0.714
MOD_Plk_4 103 109 PF00069 0.480
MOD_Plk_4 238 244 PF00069 0.600
MOD_Plk_4 283 289 PF00069 0.351
MOD_Plk_4 367 373 PF00069 0.599
MOD_Plk_4 381 387 PF00069 0.473
MOD_Plk_4 458 464 PF00069 0.459
MOD_Plk_4 62 68 PF00069 0.535
MOD_Plk_4 647 653 PF00069 0.586
MOD_Plk_4 753 759 PF00069 0.746
MOD_Plk_4 82 88 PF00069 0.408
MOD_ProDKin_1 222 228 PF00069 0.601
MOD_ProDKin_1 361 367 PF00069 0.356
MOD_ProDKin_1 374 380 PF00069 0.616
MOD_ProDKin_1 424 430 PF00069 0.691
MOD_ProDKin_1 436 442 PF00069 0.651
MOD_ProDKin_1 558 564 PF00069 0.685
MOD_ProDKin_1 626 632 PF00069 0.573
MOD_ProDKin_1 638 644 PF00069 0.698
MOD_ProDKin_1 711 717 PF00069 0.600
MOD_SUMO_for_1 604 607 PF00179 0.535
MOD_SUMO_for_1 727 730 PF00179 0.493
MOD_SUMO_rev_2 587 596 PF00179 0.486
MOD_SUMO_rev_2 598 606 PF00179 0.459
TRG_DiLeu_BaEn_1 476 481 PF01217 0.333
TRG_ENDOCYTIC_2 136 139 PF00928 0.414
TRG_ENDOCYTIC_2 153 156 PF00928 0.637
TRG_ENDOCYTIC_2 291 294 PF00928 0.423
TRG_ENDOCYTIC_2 463 466 PF00928 0.531
TRG_ENDOCYTIC_2 597 600 PF00928 0.374
TRG_ENDOCYTIC_2 614 617 PF00928 0.359
TRG_ENDOCYTIC_2 621 624 PF00928 0.385
TRG_ENDOCYTIC_2 86 89 PF00928 0.408
TRG_ER_diArg_1 259 262 PF00400 0.349
TRG_ER_diArg_1 356 359 PF00400 0.518
TRG_ER_diArg_1 512 514 PF00400 0.493
TRG_ER_diArg_1 518 520 PF00400 0.516
TRG_ER_diArg_1 525 527 PF00400 0.545
TRG_ER_diArg_1 572 574 PF00400 0.520
TRG_ER_diArg_1 674 677 PF00400 0.755
TRG_NES_CRM1_1 591 603 PF08389 0.283
TRG_Pf-PMV_PEXEL_1 518 522 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3V6 Leptomonas seymouri 53% 91%
A0A0S4IQF5 Bodo saltans 29% 100%
A0A1X0P352 Trypanosomatidae 32% 100%
A0A3Q8IJJ7 Leishmania donovani 77% 100%
A0A3R7NPX7 Trypanosoma rangeli 33% 100%
A4I5S2 Leishmania infantum 78% 100%
C9ZR41 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B117 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4Q749 Leishmania major 75% 100%
V5BC99 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS