Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase PTH2, putative

Species:

Leishmania braziliensis

UniProt:

A4HIH3_LEIBR

TriTrypDb:

LbrM.30.2370 , LBRM2903_300030200

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HIH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004045	aminoacyl-tRNA hydrolase activity	5	19
GO:0016787	hydrolase activity	2	19
GO:0016788	hydrolase activity, acting on ester bonds	3	19
GO:0052689	carboxylic ester hydrolase activity	4	19
GO:0140098	catalytic activity, acting on RNA	3	19
GO:0140101	catalytic activity, acting on a tRNA	4	19
GO:0140640	catalytic activity, acting on a nucleic acid	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.507
CLV_PCSK_SKI1_1	41	45	PF00082	0.287
DEG_Nend_UBRbox_2	1	3	PF02207	0.448
DEG_SPOP_SBC_1	156	160	PF00917	0.518
DEG_SPOP_SBC_1	83	87	PF00917	0.473
DOC_MAPK_DCC_7	137	145	PF00069	0.378
DOC_MAPK_gen_1	137	145	PF00069	0.473
DOC_MAPK_MEF2A_6	137	145	PF00069	0.473
DOC_MAPK_MEF2A_6	163	172	PF00069	0.457
DOC_MAPK_MEF2A_6	47	54	PF00069	0.440
DOC_USP7_MATH_1	162	166	PF00917	0.498
DOC_USP7_MATH_1	174	178	PF00917	0.426
DOC_USP7_MATH_1	82	86	PF00917	0.546
DOC_USP7_UBL2_3	117	121	PF12436	0.451
LIG_14-3-3_CanoR_1	130	140	PF00244	0.436
LIG_14-3-3_CanoR_1	146	153	PF00244	0.508
LIG_deltaCOP1_diTrp_1	7	13	PF00928	0.432
LIG_FHA_1	156	162	PF00498	0.378
LIG_FHA_1	182	188	PF00498	0.499
LIG_FHA_2	16	22	PF00498	0.494
LIG_FHA_2	53	59	PF00498	0.545
LIG_LIR_Gen_1	29	40	PF02991	0.408
LIG_LIR_Nem_3	8	14	PF02991	0.435
LIG_NRBOX	69	75	PF00104	0.457
LIG_Pex14_1	103	107	PF04695	0.483
LIG_SH2_STAT5	107	110	PF00017	0.474
LIG_SH3_3	176	182	PF00018	0.551
LIG_SUMO_SIM_anti_2	164	171	PF11976	0.437
LIG_TRAF2_1	55	58	PF00917	0.551
MOD_CK1_1	16	22	PF00069	0.559
MOD_CK2_1	15	21	PF00069	0.513
MOD_CK2_1	27	33	PF00069	0.459
MOD_CK2_1	45	51	PF00069	0.462
MOD_CK2_1	52	58	PF00069	0.509
MOD_CMANNOS	103	106	PF00535	0.283
MOD_GlcNHglycan	64	67	PF01048	0.286
MOD_GlcNHglycan	80	83	PF01048	0.368
MOD_GlcNHglycan	86	89	PF01048	0.385
MOD_GSK3_1	12	19	PF00069	0.500
MOD_GSK3_1	157	164	PF00069	0.447
MOD_GSK3_1	78	85	PF00069	0.545
MOD_N-GLC_1	52	57	PF02516	0.178
MOD_N-GLC_1	78	83	PF02516	0.296
MOD_NEK2_1	52	57	PF00069	0.546
MOD_NEK2_1	62	67	PF00069	0.454
MOD_NEK2_2	116	121	PF00069	0.474
MOD_PKA_2	145	151	PF00069	0.457
MOD_Plk_1	7	13	PF00069	0.657
MOD_Plk_2-3	27	33	PF00069	0.525
MOD_Plk_2-3	7	13	PF00069	0.468
TRG_ENDOCYTIC_2	32	35	PF00928	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P574	Leptomonas seymouri	31%	88%
A0A0N1IHT0	Leptomonas seymouri	49%	79%
A0A0S4IQJ1	Bodo saltans	32%	68%
A0A1X0P1N6	Trypanosomatidae	38%	73%
A0A3Q8IED2	Leishmania donovani	76%	100%
A0A3S7WPI5	Leishmania donovani	28%	100%
A0A422NW74	Trypanosoma rangeli	37%	79%
A4H4Q4	Leishmania braziliensis	29%	100%
A4HSY3	Leishmania infantum	28%	88%
A4I5S0	Leishmania infantum	76%	100%
C9ZR39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	75%
C9ZTL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	93%
E9AKW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q751	Leishmania major	73%	100%
Q4QIY6	Leishmania major	30%	100%
V5BGW4	Trypanosoma cruzi	33%	78%