Pre-mRNA cleavage complex II Clp1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA cleavage complex II Clp1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIH2_LEIBR

TriTrypDb:

LbrM.30.2360 , LBRM2903_300030100

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HIH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	2
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031124	mRNA 3'-end processing	8	2
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	1
GO:0051733	polydeoxyribonucleotide kinase activity	6	1
GO:0051734	polynucleotide kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.619
CLV_NRD_NRD_1	106	108	PF00675	0.326
CLV_NRD_NRD_1	208	210	PF00675	0.312
CLV_NRD_NRD_1	311	313	PF00675	0.392
CLV_PCSK_KEX2_1	106	108	PF00082	0.446
CLV_PCSK_KEX2_1	210	212	PF00082	0.323
CLV_PCSK_KEX2_1	309	311	PF00082	0.385
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.323
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.308
CLV_PCSK_SKI1_1	108	112	PF00082	0.524
CLV_PCSK_SKI1_1	141	145	PF00082	0.428
CLV_PCSK_SKI1_1	317	321	PF00082	0.418
CLV_PCSK_SKI1_1	403	407	PF00082	0.468
CLV_PCSK_SKI1_1	49	53	PF00082	0.504
DEG_APCC_DBOX_1	323	331	PF00400	0.531
DEG_Nend_UBRbox_3	1	3	PF02207	0.723
DEG_ODPH_VHL_1	394	407	PF01847	0.514
DOC_CDC14_PxL_1	290	298	PF14671	0.454
DOC_CKS1_1	77	82	PF01111	0.523
DOC_CYCLIN_RxL_1	106	116	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.549
DOC_MAPK_DCC_7	416	424	PF00069	0.600
DOC_MAPK_gen_1	209	215	PF00069	0.322
DOC_MAPK_MEF2A_6	141	148	PF00069	0.428
DOC_MAPK_MEF2A_6	353	360	PF00069	0.514
DOC_MAPK_MEF2A_6	416	424	PF00069	0.600
DOC_MAPK_NFAT4_5	141	149	PF00069	0.428
DOC_PP1_RVXF_1	284	291	PF00149	0.372
DOC_PP2B_LxvP_1	412	415	PF13499	0.422
DOC_PP2B_LxvP_1	418	421	PF13499	0.465
DOC_PP4_FxxP_1	393	396	PF00568	0.363
DOC_PP4_FxxP_1	40	43	PF00568	0.291
DOC_USP7_MATH_1	222	226	PF00917	0.350
DOC_USP7_MATH_1	302	306	PF00917	0.201
DOC_WW_Pin1_4	149	154	PF00397	0.428
DOC_WW_Pin1_4	241	246	PF00397	0.416
DOC_WW_Pin1_4	39	44	PF00397	0.243
DOC_WW_Pin1_4	406	411	PF00397	0.400
DOC_WW_Pin1_4	76	81	PF00397	0.502
LIG_14-3-3_CanoR_1	324	328	PF00244	0.552
LIG_14-3-3_CanoR_1	335	342	PF00244	0.475
LIG_APCC_ABBA_1	340	345	PF00400	0.496
LIG_BRCT_BRCA1_1	174	178	PF00533	0.428
LIG_BRCT_BRCA1_1	224	228	PF00533	0.428
LIG_BRCT_BRCA1_1	343	347	PF00533	0.258
LIG_FHA_1	262	268	PF00498	0.357
LIG_FHA_1	43	49	PF00498	0.530
LIG_FHA_1	54	60	PF00498	0.488
LIG_FHA_1	92	98	PF00498	0.520
LIG_FHA_2	182	188	PF00498	0.442
LIG_FHA_2	267	273	PF00498	0.449
LIG_LIR_Apic_2	119	124	PF02991	0.531
LIG_LIR_Apic_2	38	43	PF02991	0.252
LIG_LIR_Apic_2	392	396	PF02991	0.365
LIG_LIR_Gen_1	287	297	PF02991	0.432
LIG_LIR_Nem_3	287	293	PF02991	0.461
LIG_LIR_Nem_3	344	350	PF02991	0.466
LIG_LIR_Nem_3	351	355	PF02991	0.375
LIG_NRBOX	253	259	PF00104	0.277
LIG_PTB_Apo_2	227	234	PF02174	0.428
LIG_PTB_Apo_2	274	281	PF02174	0.201
LIG_PTB_Phospho_1	274	280	PF10480	0.201
LIG_RPA_C_Fungi	91	103	PF08784	0.458
LIG_SH2_CRK	280	284	PF00017	0.338
LIG_SH2_PTP2	158	161	PF00017	0.454
LIG_SH2_PTP2	50	53	PF00017	0.259
LIG_SH2_SRC	158	161	PF00017	0.357
LIG_SH2_STAT5	158	161	PF00017	0.434
LIG_SH2_STAT5	212	215	PF00017	0.307
LIG_SH2_STAT5	318	321	PF00017	0.307
LIG_SH2_STAT5	50	53	PF00017	0.422
LIG_SH3_3	160	166	PF00018	0.418
LIG_SH3_3	176	182	PF00018	0.311
LIG_SH3_3	288	294	PF00018	0.371
LIG_SH3_3	296	302	PF00018	0.300
LIG_SH3_3	404	410	PF00018	0.503
LIG_SH3_3	74	80	PF00018	0.557
LIG_SUMO_SIM_anti_2	337	346	PF11976	0.411
LIG_SUMO_SIM_par_1	125	131	PF11976	0.395
LIG_SUMO_SIM_par_1	255	262	PF11976	0.225
LIG_SUMO_SIM_par_1	29	34	PF11976	0.367
LIG_SUMO_SIM_par_1	337	346	PF11976	0.337
LIG_SUMO_SIM_par_1	98	105	PF11976	0.539
LIG_TRAF2_1	113	116	PF00917	0.636
LIG_TRAF2_1	23	26	PF00917	0.531
LIG_UBA3_1	100	108	PF00899	0.555
LIG_WRC_WIRS_1	390	395	PF05994	0.365
MOD_CDK_SPxxK_3	39	46	PF00069	0.257
MOD_CK1_1	203	209	PF00069	0.395
MOD_CK1_1	244	250	PF00069	0.395
MOD_CK1_1	259	265	PF00069	0.222
MOD_CK1_1	3	9	PF00069	0.513
MOD_CK1_1	42	48	PF00069	0.526
MOD_CK2_1	110	116	PF00069	0.549
MOD_CK2_1	181	187	PF00069	0.442
MOD_CK2_1	228	234	PF00069	0.463
MOD_CK2_1	302	308	PF00069	0.275
MOD_CK2_1	348	354	PF00069	0.451
MOD_CK2_1	368	374	PF00069	0.202
MOD_CK2_1	394	400	PF00069	0.505
MOD_GlcNHglycan	174	177	PF01048	0.428
MOD_GlcNHglycan	21	24	PF01048	0.412
MOD_GlcNHglycan	304	307	PF01048	0.458
MOD_GlcNHglycan	33	36	PF01048	0.442
MOD_GlcNHglycan	370	373	PF01048	0.466
MOD_GlcNHglycan	396	399	PF01048	0.467
MOD_GlcNHglycan	81	84	PF01048	0.473
MOD_GSK3_1	15	22	PF00069	0.417
MOD_GSK3_1	239	246	PF00069	0.444
MOD_GSK3_1	252	259	PF00069	0.309
MOD_GSK3_1	319	326	PF00069	0.366
MOD_GSK3_1	6	13	PF00069	0.507
MOD_GSK3_1	72	79	PF00069	0.402
MOD_NEK2_1	117	122	PF00069	0.570
MOD_NEK2_1	228	233	PF00069	0.392
MOD_NEK2_1	239	244	PF00069	0.305
MOD_NEK2_1	261	266	PF00069	0.383
MOD_NEK2_1	284	289	PF00069	0.372
MOD_NEK2_1	31	36	PF00069	0.462
MOD_NEK2_1	319	324	PF00069	0.334
MOD_NEK2_1	91	96	PF00069	0.431
MOD_PIKK_1	10	16	PF00454	0.396
MOD_PKA_2	117	123	PF00069	0.473
MOD_PKA_2	323	329	PF00069	0.540
MOD_PKA_2	334	340	PF00069	0.484
MOD_Plk_1	72	78	PF00069	0.332
MOD_Plk_2-3	348	354	PF00069	0.414
MOD_Plk_4	193	199	PF00069	0.320
MOD_Plk_4	256	262	PF00069	0.326
MOD_Plk_4	323	329	PF00069	0.357
MOD_Plk_4	389	395	PF00069	0.422
MOD_ProDKin_1	149	155	PF00069	0.428
MOD_ProDKin_1	241	247	PF00069	0.416
MOD_ProDKin_1	39	45	PF00069	0.250
MOD_ProDKin_1	406	412	PF00069	0.396
MOD_ProDKin_1	76	82	PF00069	0.506
TRG_DiLeu_BaEn_1	87	92	PF01217	0.491
TRG_DiLeu_BaEn_2	233	239	PF01217	0.454
TRG_DiLeu_BaEn_2	273	279	PF01217	0.458
TRG_ENDOCYTIC_2	158	161	PF00928	0.454
TRG_ENDOCYTIC_2	212	215	PF00928	0.307
TRG_ENDOCYTIC_2	280	283	PF00928	0.338
TRG_ER_diArg_1	209	212	PF00400	0.296
TRG_ER_diArg_1	310	312	PF00400	0.449
TRG_NLS_MonoExtC_3	208	214	PF00514	0.312
TRG_NLS_MonoExtN_4	106	111	PF00514	0.359
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT73	Leptomonas seymouri	69%	99%
A0A0S4IVZ6	Bodo saltans	32%	98%
A0A1X0P2B1	Trypanosomatidae	41%	100%
A0A3R7KU37	Trypanosoma rangeli	37%	100%
A0A3S5H7N4	Leishmania donovani	88%	100%
A2RAW3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	89%
A2VE01	Bos taurus	26%	100%
A4I5R9	Leishmania infantum	87%	100%
A4QQE0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	93%
A6S936	Botryotinia fuckeliana (strain B05.10)	25%	92%
A7RG82	Nematostella vectensis	27%	99%
A8PB32	Brugia malayi	27%	98%
A8X9U4	Caenorhabditis briggsae	27%	99%
B0CS49	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	22%	87%
B0VZR4	Culex quinquefasciatus	26%	100%
B3MGZ0	Drosophila ananassae	24%	100%
B3NRK6	Drosophila erecta	24%	100%
B4GGT6	Drosophila persimilis	23%	100%
B4HQJ2	Drosophila sechellia	24%	100%
B4JVN0	Drosophila grimshawi	24%	100%
B4KML2	Drosophila mojavensis	24%	100%
B4MCL6	Drosophila virilis	24%	100%
B4MRZ9	Drosophila willistoni	23%	100%
B4P4H2	Drosophila yakuba	24%	100%
B4QEE3	Drosophila simulans	24%	100%
C9ZKC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	96%
C9ZR38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E7F3I6	Danio rerio	29%	96%
E9B114	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P52874	Caenorhabditis elegans	26%	99%
Q0U2G5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	91%
Q10299	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	93%
Q16WA6	Aedes aegypti	25%	100%
Q1DKL9	Coccidioides immitis (strain RS)	22%	76%
Q28ZT4	Drosophila pseudoobscura pseudoobscura	23%	100%
Q4Q752	Leishmania major	87%	100%
Q4R7R3	Macaca fascicularis	26%	100%
Q54N48	Dictyostelium discoideum	23%	93%
Q5BH19	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	78%
Q5PQL4	Rattus norvegicus	26%	100%
Q5ZJL4	Gallus gallus	25%	100%
Q66JK4	Xenopus tropicalis	26%	97%
Q6NS21	Xenopus laevis	27%	97%
Q7K284	Drosophila melanogaster	24%	100%
Q7QJW7	Anopheles gambiae	28%	100%
Q92989	Homo sapiens	26%	100%
Q99LI9	Mus musculus	26%	100%
Q9FLE2	Arabidopsis thaliana	23%	100%
Q9SR06	Arabidopsis thaliana	26%	96%
V5DD01	Trypanosoma cruzi	40%	92%