Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 31

Species:

Leishmania braziliensis

UniProt:

A4HIH1_LEIBR

TriTrypDb:

LbrM.30.2350 , LBRM2903_300030000

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HIH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.328
CLV_NRD_NRD_1	57	59	PF00675	0.292
CLV_PCSK_FUR_1	171	175	PF00082	0.333
CLV_PCSK_KEX2_1	161	163	PF00082	0.314
CLV_PCSK_KEX2_1	173	175	PF00082	0.237
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.262
CLV_PCSK_PC7_1	169	175	PF00082	0.408
CLV_PCSK_SKI1_1	173	177	PF00082	0.271
CLV_PCSK_SKI1_1	71	75	PF00082	0.331
CLV_PCSK_SKI1_1	99	103	PF00082	0.492
DEG_APCC_DBOX_1	98	106	PF00400	0.359
DEG_SPOP_SBC_1	9	13	PF00917	0.690
DEG_SPOP_SBC_1	93	97	PF00917	0.461
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.368
DOC_MAPK_gen_1	171	180	PF00069	0.439
DOC_MAPK_gen_1	58	64	PF00069	0.458
DOC_MAPK_RevD_3	149	163	PF00069	0.276
DOC_PP2B_LxvP_1	85	88	PF13499	0.417
DOC_USP7_MATH_1	131	135	PF00917	0.334
DOC_USP7_MATH_1	187	191	PF00917	0.393
DOC_USP7_MATH_1	246	250	PF00917	0.786
DOC_USP7_MATH_1	9	13	PF00917	0.674
DOC_WW_Pin1_4	251	256	PF00397	0.729
DOC_WW_Pin1_4	94	99	PF00397	0.289
LIG_14-3-3_CanoR_1	108	116	PF00244	0.416
LIG_14-3-3_CanoR_1	186	196	PF00244	0.368
LIG_14-3-3_CanoR_1	222	226	PF00244	0.495
LIG_14-3-3_CanoR_1	28	32	PF00244	0.563
LIG_14-3-3_CanoR_1	71	77	PF00244	0.493
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_deltaCOP1_diTrp_1	137	146	PF00928	0.361
LIG_FHA_1	12	18	PF00498	0.624
LIG_FHA_1	143	149	PF00498	0.399
LIG_FHA_1	170	176	PF00498	0.499
LIG_FHA_1	189	195	PF00498	0.344
LIG_FHA_1	215	221	PF00498	0.314
LIG_FHA_1	24	30	PF00498	0.493
LIG_FHA_1	59	65	PF00498	0.450
LIG_FHA_2	208	214	PF00498	0.334
LIG_LIR_Apic_2	12	18	PF02991	0.567
LIG_LIR_Apic_2	145	149	PF02991	0.368
LIG_LIR_Apic_2	224	228	PF02991	0.603
LIG_LIR_Gen_1	107	116	PF02991	0.364
LIG_LIR_Gen_1	138	149	PF02991	0.351
LIG_LIR_Gen_1	190	197	PF02991	0.335
LIG_LIR_Gen_1	22	31	PF02991	0.562
LIG_LIR_Nem_3	107	112	PF02991	0.388
LIG_LIR_Nem_3	122	127	PF02991	0.290
LIG_LIR_Nem_3	138	144	PF02991	0.394
LIG_LIR_Nem_3	22	27	PF02991	0.530
LIG_LIR_Nem_3	30	34	PF02991	0.472
LIG_Pex14_1	139	143	PF04695	0.334
LIG_RPA_C_Fungi	157	169	PF08784	0.523
LIG_SH2_STAP1	124	128	PF00017	0.348
LIG_SH2_STAT3	45	48	PF00017	0.417
LIG_SH2_STAT5	16	19	PF00017	0.594
LIG_SH2_STAT5	219	222	PF00017	0.326
LIG_SH2_STAT5	72	75	PF00017	0.306
LIG_SH2_STAT5	91	94	PF00017	0.171
LIG_SH3_3	191	197	PF00018	0.312
LIG_SH3_3	249	255	PF00018	0.608
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.409
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.193
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.417
LIG_SUMO_SIM_par_1	110	117	PF11976	0.440
LIG_UBA3_1	152	157	PF00899	0.358
LIG_WRC_WIRS_1	189	194	PF05994	0.334
MOD_CDK_SPK_2	94	99	PF00069	0.338
MOD_CK1_1	190	196	PF00069	0.360
MOD_CK1_1	237	243	PF00069	0.567
MOD_CK2_1	132	138	PF00069	0.472
MOD_CK2_1	19	25	PF00069	0.452
MOD_CK2_1	207	213	PF00069	0.337
MOD_Cter_Amidation	56	59	PF01082	0.427
MOD_GlcNHglycan	1	4	PF01048	0.687
MOD_GlcNHglycan	166	169	PF01048	0.507
MOD_GSK3_1	119	126	PF00069	0.496
MOD_GSK3_1	147	154	PF00069	0.274
MOD_GSK3_1	19	26	PF00069	0.437
MOD_GSK3_1	230	237	PF00069	0.543
MOD_GSK3_1	238	245	PF00069	0.561
MOD_N-GLC_1	238	243	PF02516	0.688
MOD_NEK2_1	164	169	PF00069	0.490
MOD_NEK2_1	207	212	PF00069	0.320
MOD_NEK2_1	215	220	PF00069	0.297
MOD_NEK2_1	238	243	PF00069	0.564
MOD_NEK2_1	39	44	PF00069	0.425
MOD_NEK2_1	92	97	PF00069	0.460
MOD_PKA_1	58	64	PF00069	0.357
MOD_PKA_2	107	113	PF00069	0.559
MOD_PKA_2	221	227	PF00069	0.374
MOD_PKA_2	27	33	PF00069	0.445
MOD_Plk_1	230	236	PF00069	0.541
MOD_Plk_4	11	17	PF00069	0.523
MOD_Plk_4	147	153	PF00069	0.350
MOD_Plk_4	207	213	PF00069	0.345
MOD_Plk_4	215	221	PF00069	0.342
MOD_Plk_4	39	45	PF00069	0.414
MOD_Plk_4	80	86	PF00069	0.317
MOD_ProDKin_1	94	100	PF00069	0.346
TRG_ENDOCYTIC_2	31	34	PF00928	0.427
TRG_ER_diArg_1	161	163	PF00400	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK1	Leptomonas seymouri	69%	97%
A0A0S4ILA8	Bodo saltans	42%	100%
A0A1X0P1K3	Trypanosomatidae	49%	100%
A0A3S7X3K3	Leishmania donovani	88%	94%
A0A422NWC9	Trypanosoma rangeli	55%	100%
A4I5R8	Leishmania infantum	88%	94%
C9ZR37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	80%
E9B113	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	94%
Q4Q753	Leishmania major	87%	100%
V5AWV4	Trypanosoma cruzi	52%	100%