Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIG9_LEIBR

TriTrypDb:

LbrM.30.2330 , LBRM2903_300029700

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.469
CLV_NRD_NRD_1	124	126	PF00675	0.587
CLV_NRD_NRD_1	22	24	PF00675	0.490
CLV_NRD_NRD_1	296	298	PF00675	0.653
CLV_NRD_NRD_1	85	87	PF00675	0.539
CLV_PCSK_FUR_1	20	24	PF00082	0.531
CLV_PCSK_KEX2_1	124	126	PF00082	0.587
CLV_PCSK_KEX2_1	22	24	PF00082	0.494
CLV_PCSK_KEX2_1	231	233	PF00082	0.624
CLV_PCSK_KEX2_1	296	298	PF00082	0.653
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.624
CLV_PCSK_SKI1_1	22	26	PF00082	0.534
DOC_CYCLIN_RxL_1	19	28	PF00134	0.365
DOC_PP1_RVXF_1	33	39	PF00149	0.471
DOC_USP7_MATH_1	3	7	PF00917	0.653
LIG_14-3-3_CanoR_1	124	128	PF00244	0.599
LIG_14-3-3_CanoR_1	199	205	PF00244	0.704
LIG_14-3-3_CanoR_1	22	28	PF00244	0.511
LIG_14-3-3_CanoR_1	261	269	PF00244	0.441
LIG_14-3-3_CanoR_1	84	94	PF00244	0.477
LIG_14-3-3_CterR_2	296	300	PF00244	0.536
LIG_Actin_WH2_2	194	212	PF00022	0.442
LIG_Actin_WH2_2	72	88	PF00022	0.540
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_Clathr_ClatBox_1	149	153	PF01394	0.367
LIG_FHA_1	144	150	PF00498	0.350
LIG_FHA_1	163	169	PF00498	0.323
LIG_FHA_1	94	100	PF00498	0.487
LIG_FHA_2	153	159	PF00498	0.613
LIG_FHA_2	50	56	PF00498	0.456
LIG_FHA_2	86	92	PF00498	0.538
LIG_FHA_2	95	101	PF00498	0.533
LIG_LIR_Gen_1	275	283	PF02991	0.434
LIG_LIR_Nem_3	275	279	PF02991	0.432
LIG_SUMO_SIM_anti_2	143	151	PF11976	0.504
LIG_SUMO_SIM_anti_2	5	13	PF11976	0.601
LIG_SUMO_SIM_anti_2	62	70	PF11976	0.607
LIG_TRAF2_1	126	129	PF00917	0.632
LIG_TRAF2_1	225	228	PF00917	0.606
LIG_TRAF2_1	88	91	PF00917	0.369
MOD_CK2_1	123	129	PF00069	0.564
MOD_CK2_1	152	158	PF00069	0.523
MOD_CK2_1	25	31	PF00069	0.573
MOD_CK2_1	85	91	PF00069	0.495
MOD_CK2_1	94	100	PF00069	0.495
MOD_GlcNHglycan	1	4	PF01048	0.711
MOD_GlcNHglycan	133	136	PF01048	0.633
MOD_GlcNHglycan	206	209	PF01048	0.652
MOD_GlcNHglycan	213	216	PF01048	0.633
MOD_GlcNHglycan	291	294	PF01048	0.398
MOD_GlcNHglycan	5	9	PF01048	0.593
MOD_GSK3_1	119	126	PF00069	0.608
MOD_GSK3_1	200	207	PF00069	0.597
MOD_GSK3_1	256	263	PF00069	0.496
MOD_GSK3_1	268	275	PF00069	0.525
MOD_NEK2_1	197	202	PF00069	0.584
MOD_NEK2_1	204	209	PF00069	0.657
MOD_NEK2_1	25	30	PF00069	0.608
MOD_NEK2_1	268	273	PF00069	0.454
MOD_NEK2_1	94	99	PF00069	0.578
MOD_PIKK_1	235	241	PF00454	0.424
MOD_PIKK_1	25	31	PF00454	0.602
MOD_PIKK_1	85	91	PF00454	0.621
MOD_PKA_2	104	110	PF00069	0.455
MOD_PKA_2	123	129	PF00069	0.587
MOD_PKA_2	204	210	PF00069	0.474
MOD_PKA_2	260	266	PF00069	0.388
MOD_PKA_2	85	91	PF00069	0.473
MOD_Plk_1	152	158	PF00069	0.612
MOD_Plk_1	4	10	PF00069	0.518
MOD_Plk_2-3	153	159	PF00069	0.360
MOD_SUMO_for_1	150	153	PF00179	0.552
MOD_SUMO_rev_2	227	233	PF00179	0.629
MOD_SUMO_rev_2	28	37	PF00179	0.583
TRG_DiLeu_BaEn_1	145	150	PF01217	0.533
TRG_DiLeu_BaEn_1	42	47	PF01217	0.579
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.377
TRG_ER_diArg_1	123	125	PF00400	0.589
TRG_ER_diArg_1	20	23	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE9	Leptomonas seymouri	45%	96%
A0A1X0P1M8	Trypanosomatidae	29%	100%
A0A3S7X3N1	Leishmania donovani	78%	100%
A0A422NW57	Trypanosoma rangeli	28%	100%
A4I5R6	Leishmania infantum	78%	100%
C9ZR34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B111	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q755	Leishmania major	77%	100%
V5BGW1	Trypanosoma cruzi	32%	100%