Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIG8_LEIBR

TriTrypDb:

LbrM.30.2310 , LBRM2903_300029500

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HIG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.408
CLV_C14_Caspase3-7	443	447	PF00656	0.391
CLV_NRD_NRD_1	136	138	PF00675	0.227
CLV_NRD_NRD_1	246	248	PF00675	0.424
CLV_PCSK_KEX2_1	119	121	PF00082	0.412
CLV_PCSK_KEX2_1	136	138	PF00082	0.243
CLV_PCSK_KEX2_1	246	248	PF00082	0.551
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.412
CLV_PCSK_PC7_1	115	121	PF00082	0.447
CLV_PCSK_PC7_1	132	138	PF00082	0.130
CLV_PCSK_SKI1_1	247	251	PF00082	0.444
CLV_PCSK_SKI1_1	4	8	PF00082	0.441
CLV_PCSK_SKI1_1	418	422	PF00082	0.577
DEG_APCC_DBOX_1	245	253	PF00400	0.433
DEG_SCF_TRCP1_1	254	259	PF00400	0.421
DOC_ANK_TNKS_1	119	126	PF00023	0.415
DOC_CYCLIN_yClb1_LxF_4	379	384	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.258
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.479
DOC_MAPK_gen_1	353	362	PF00069	0.648
DOC_MAPK_MEF2A_6	170	177	PF00069	0.308
DOC_PP1_RVXF_1	379	385	PF00149	0.407
DOC_PP2B_LxvP_1	376	379	PF13499	0.371
DOC_USP7_MATH_1	538	542	PF00917	0.411
DOC_USP7_UBL2_3	355	359	PF12436	0.445
LIG_14-3-3_CanoR_1	211	215	PF00244	0.441
LIG_14-3-3_CanoR_1	246	250	PF00244	0.494
LIG_14-3-3_CanoR_1	296	304	PF00244	0.535
LIG_14-3-3_CanoR_1	381	385	PF00244	0.371
LIG_14-3-3_CanoR_1	4	12	PF00244	0.302
LIG_14-3-3_CanoR_1	432	438	PF00244	0.446
LIG_14-3-3_CanoR_1	481	490	PF00244	0.437
LIG_Actin_WH2_2	368	383	PF00022	0.373
LIG_Actin_WH2_2	387	404	PF00022	0.398
LIG_Actin_WH2_2	494	512	PF00022	0.421
LIG_APCC_ABBA_1	166	171	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	130	134	PF00533	0.487
LIG_BRCT_BRCA1_1	444	448	PF00533	0.526
LIG_FHA_1	381	387	PF00498	0.431
LIG_FHA_1	481	487	PF00498	0.496
LIG_FHA_1	5	11	PF00498	0.258
LIG_FHA_1	91	97	PF00498	0.256
LIG_FHA_2	224	230	PF00498	0.477
LIG_FHA_2	287	293	PF00498	0.462
LIG_KLC1_Yacidic_2	70	74	PF13176	0.511
LIG_LIR_Apic_2	463	469	PF02991	0.391
LIG_LIR_Gen_1	217	227	PF02991	0.383
LIG_LIR_Gen_1	228	239	PF02991	0.386
LIG_LIR_Gen_1	70	80	PF02991	0.678
LIG_LIR_Nem_3	217	223	PF02991	0.397
LIG_LIR_Nem_3	228	234	PF02991	0.460
LIG_LIR_Nem_3	314	319	PF02991	0.568
LIG_LIR_Nem_3	419	424	PF02991	0.450
LIG_LIR_Nem_3	445	451	PF02991	0.469
LIG_PDZ_Class_2	541	546	PF00595	0.367
LIG_SH2_NCK_1	220	224	PF00017	0.389
LIG_SH2_SRC	64	67	PF00017	0.495
LIG_SH2_STAP1	216	220	PF00017	0.527
LIG_SH2_STAP1	482	486	PF00017	0.486
LIG_SH2_STAT3	162	165	PF00017	0.258
LIG_SH2_STAT5	105	108	PF00017	0.355
LIG_SH2_STAT5	162	165	PF00017	0.243
LIG_SH2_STAT5	216	219	PF00017	0.317
LIG_SH2_STAT5	267	270	PF00017	0.516
LIG_SH2_STAT5	482	485	PF00017	0.578
LIG_SH2_STAT5	72	75	PF00017	0.589
LIG_SH3_1	78	84	PF00018	0.355
LIG_SH3_3	449	455	PF00018	0.355
LIG_SH3_3	78	84	PF00018	0.355
LIG_SUMO_SIM_anti_2	539	546	PF11976	0.353
LIG_SUMO_SIM_par_1	17	22	PF11976	0.211
LIG_SUMO_SIM_par_1	317	323	PF11976	0.591
LIG_WRC_WIRS_1	231	236	PF05994	0.360
LIG_WRC_WIRS_1	368	373	PF05994	0.416
MOD_CK1_1	128	134	PF00069	0.574
MOD_CK1_1	358	364	PF00069	0.513
MOD_CK1_1	367	373	PF00069	0.482
MOD_CK1_1	39	45	PF00069	0.365
MOD_CK2_1	191	197	PF00069	0.489
MOD_CK2_1	223	229	PF00069	0.491
MOD_CK2_1	286	292	PF00069	0.371
MOD_CK2_1	49	55	PF00069	0.519
MOD_GlcNHglycan	1	4	PF01048	0.399
MOD_GlcNHglycan	116	119	PF01048	0.447
MOD_GlcNHglycan	254	257	PF01048	0.403
MOD_GlcNHglycan	313	316	PF01048	0.470
MOD_GlcNHglycan	350	353	PF01048	0.575
MOD_GlcNHglycan	363	366	PF01048	0.487
MOD_GlcNHglycan	38	41	PF01048	0.286
MOD_GSK3_1	210	217	PF00069	0.532
MOD_GSK3_1	252	259	PF00069	0.353
MOD_GSK3_1	440	447	PF00069	0.473
MOD_GSK3_1	51	58	PF00069	0.352
MOD_GSK3_1	536	543	PF00069	0.330
MOD_N-GLC_1	23	28	PF02516	0.317
MOD_N-GLC_1	274	279	PF02516	0.507
MOD_N-GLC_1	348	353	PF02516	0.652
MOD_NEK2_1	127	132	PF00069	0.570
MOD_NEK2_1	150	155	PF00069	0.337
MOD_NEK2_1	173	178	PF00069	0.439
MOD_NEK2_1	260	265	PF00069	0.453
MOD_NEK2_1	324	329	PF00069	0.490
MOD_NEK2_1	348	353	PF00069	0.679
MOD_NEK2_1	36	41	PF00069	0.300
MOD_NEK2_1	380	385	PF00069	0.383
MOD_NEK2_1	420	425	PF00069	0.477
MOD_NEK2_1	48	53	PF00069	0.445
MOD_PIKK_1	150	156	PF00454	0.382
MOD_PIKK_1	295	301	PF00454	0.471
MOD_PIKK_1	408	414	PF00454	0.473
MOD_PIKK_1	453	459	PF00454	0.534
MOD_PK_1	440	446	PF00069	0.454
MOD_PKA_2	114	120	PF00069	0.427
MOD_PKA_2	210	216	PF00069	0.438
MOD_PKA_2	245	251	PF00069	0.433
MOD_PKA_2	252	258	PF00069	0.386
MOD_PKA_2	295	301	PF00069	0.592
MOD_PKA_2	380	386	PF00069	0.377
MOD_PKA_2	453	459	PF00069	0.577
MOD_PKA_2	480	486	PF00069	0.426
MOD_Plk_1	107	113	PF00069	0.399
MOD_Plk_1	223	229	PF00069	0.306
MOD_Plk_1	23	29	PF00069	0.272
MOD_Plk_1	256	262	PF00069	0.459
MOD_Plk_1	274	280	PF00069	0.481
MOD_Plk_1	322	328	PF00069	0.546
MOD_Plk_1	390	396	PF00069	0.405
MOD_Plk_2-3	191	197	PF00069	0.525
MOD_Plk_2-3	334	340	PF00069	0.585
MOD_Plk_4	191	197	PF00069	0.465
MOD_Plk_4	210	216	PF00069	0.469
MOD_Plk_4	274	280	PF00069	0.511
MOD_Plk_4	364	370	PF00069	0.606
MOD_Plk_4	390	396	PF00069	0.475
MOD_Plk_4	444	450	PF00069	0.413
MOD_Plk_4	540	546	PF00069	0.358
TRG_ENDOCYTIC_2	220	223	PF00928	0.388
TRG_ENDOCYTIC_2	72	75	PF00928	0.663
TRG_ER_diArg_1	135	137	PF00400	0.272
TRG_ER_diArg_1	245	247	PF00400	0.536
TRG_ER_diArg_1	32	35	PF00400	0.308
TRG_ER_diArg_1	399	402	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9X5	Leptomonas seymouri	66%	99%
A0A0S4IQV6	Bodo saltans	43%	98%
A0A1X0P2R0	Trypanosomatidae	49%	95%
A0A3Q8IC39	Leishmania donovani	82%	100%
A0A3R7M632	Trypanosoma rangeli	50%	97%
A4I5R4	Leishmania infantum	82%	100%
C9ZR32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9B109	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q757	Leishmania major	80%	100%
Q9D2H5	Mus musculus	23%	76%
V5DCZ6	Trypanosoma cruzi	51%	97%