Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIG5_LEIBR

TriTrypDb:

LbrM.30.2280 , LBRM2903_300029200

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.418
CLV_C14_Caspase3-7	96	100	PF00656	0.528
CLV_NRD_NRD_1	254	256	PF00675	0.584
CLV_NRD_NRD_1	82	84	PF00675	0.388
CLV_PCSK_SKI1_1	109	113	PF00082	0.501
CLV_PCSK_SKI1_1	117	121	PF00082	0.412
CLV_PCSK_SKI1_1	132	136	PF00082	0.428
DEG_SPOP_SBC_1	35	39	PF00917	0.606
DOC_MAPK_gen_1	115	124	PF00069	0.434
DOC_MAPK_MEF2A_6	115	124	PF00069	0.332
DOC_MAPK_NFAT4_5	117	125	PF00069	0.336
DOC_PP1_RVXF_1	107	114	PF00149	0.476
DOC_PP1_RVXF_1	130	137	PF00149	0.421
DOC_PP1_RVXF_1	213	220	PF00149	0.432
DOC_USP7_MATH_1	188	192	PF00917	0.441
DOC_USP7_MATH_1	86	90	PF00917	0.559
DOC_USP7_UBL2_3	84	88	PF12436	0.390
DOC_WW_Pin1_4	154	159	PF00397	0.587
DOC_WW_Pin1_4	27	32	PF00397	0.512
DOC_WW_Pin1_4	65	70	PF00397	0.534
LIG_14-3-3_CanoR_1	115	120	PF00244	0.380
LIG_14-3-3_CanoR_1	132	137	PF00244	0.422
LIG_14-3-3_CanoR_1	20	28	PF00244	0.609
LIG_APCC_ABBA_1	59	64	PF00400	0.469
LIG_BRCT_BRCA1_1	109	113	PF00533	0.568
LIG_deltaCOP1_diTrp_1	295	303	PF00928	0.572
LIG_DLG_GKlike_1	115	122	PF00625	0.327
LIG_FHA_1	124	130	PF00498	0.409
LIG_FHA_1	170	176	PF00498	0.426
LIG_FHA_1	35	41	PF00498	0.715
LIG_FHA_2	200	206	PF00498	0.479
LIG_FHA_2	239	245	PF00498	0.406
LIG_IBAR_NPY_1	345	347	PF08397	0.444
LIG_LIR_Gen_1	103	113	PF02991	0.502
LIG_LIR_Gen_1	118	124	PF02991	0.426
LIG_LIR_Gen_1	226	234	PF02991	0.522
LIG_LIR_Gen_1	302	311	PF02991	0.577
LIG_LIR_Nem_3	103	108	PF02991	0.463
LIG_LIR_Nem_3	110	116	PF02991	0.472
LIG_LIR_Nem_3	118	122	PF02991	0.418
LIG_LIR_Nem_3	226	232	PF02991	0.538
LIG_LIR_Nem_3	302	306	PF02991	0.506
LIG_MLH1_MIPbox_1	109	113	PF16413	0.568
LIG_NRBOX	202	208	PF00104	0.421
LIG_REV1ctd_RIR_1	110	119	PF16727	0.524
LIG_SH2_STAT5	174	177	PF00017	0.422
LIG_SH2_STAT5	347	350	PF00017	0.607
LIG_SH2_STAT5	62	65	PF00017	0.463
LIG_SH2_STAT5	74	77	PF00017	0.445
LIG_SH3_3	131	137	PF00018	0.435
LIG_SH3_3	28	34	PF00018	0.563
LIG_SH3_3	336	342	PF00018	0.454
LIG_SUMO_SIM_par_1	120	126	PF11976	0.363
LIG_TRAF2_1	100	103	PF00917	0.368
LIG_TRAF2_1	69	72	PF00917	0.408
LIG_TRAF2_2	137	142	PF00917	0.528
LIG_WRC_WIRS_1	116	121	PF05994	0.475
MOD_CDC14_SPxK_1	157	160	PF00782	0.454
MOD_CDC14_SPxK_1	30	33	PF00782	0.566
MOD_CDK_SPxK_1	154	160	PF00069	0.462
MOD_CDK_SPxK_1	27	33	PF00069	0.551
MOD_CK1_1	123	129	PF00069	0.500
MOD_CK1_1	169	175	PF00069	0.355
MOD_CK1_1	178	184	PF00069	0.324
MOD_CK2_1	199	205	PF00069	0.481
MOD_CK2_1	49	55	PF00069	0.470
MOD_GlcNHglycan	180	183	PF01048	0.421
MOD_GlcNHglycan	190	193	PF01048	0.497
MOD_GlcNHglycan	285	288	PF01048	0.629
MOD_GlcNHglycan	7	10	PF01048	0.428
MOD_GSK3_1	103	110	PF00069	0.451
MOD_GSK3_1	16	23	PF00069	0.626
MOD_GSK3_1	243	250	PF00069	0.551
MOD_NEK2_1	166	171	PF00069	0.376
MOD_NEK2_1	318	323	PF00069	0.594
MOD_NEK2_2	62	67	PF00069	0.454
MOD_PIKK_1	175	181	PF00454	0.457
MOD_PIKK_1	49	55	PF00454	0.354
MOD_Plk_1	103	109	PF00069	0.368
MOD_Plk_1	243	249	PF00069	0.542
MOD_Plk_1	334	340	PF00069	0.471
MOD_Plk_1	35	41	PF00069	0.594
MOD_Plk_2-3	199	205	PF00069	0.481
MOD_Plk_4	107	113	PF00069	0.607
MOD_Plk_4	169	175	PF00069	0.437
MOD_Plk_4	334	340	PF00069	0.471
MOD_Plk_4	36	42	PF00069	0.701
MOD_ProDKin_1	154	160	PF00069	0.583
MOD_ProDKin_1	27	33	PF00069	0.512
MOD_ProDKin_1	65	71	PF00069	0.528
MOD_SUMO_for_1	278	281	PF00179	0.558
MOD_SUMO_rev_2	271	278	PF00179	0.594
MOD_SUMO_rev_2	286	294	PF00179	0.448
MOD_SUMO_rev_2	52	61	PF00179	0.370
MOD_SUMO_rev_2	8	17	PF00179	0.535
TRG_DiLeu_BaEn_4	103	109	PF01217	0.368
TRG_ER_diArg_1	114	117	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P9	Leptomonas seymouri	48%	100%
A0A3Q8II20	Leishmania donovani	68%	100%
A4I5R1	Leishmania infantum	68%	100%
E9B106	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q760	Leishmania major	62%	98%