SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIG4_LEIBR

TriTrypDb:

LbrM.30.2270 , LBRM2903_300029100

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.383
CLV_C14_Caspase3-7	261	265	PF00656	0.381
CLV_NRD_NRD_1	20	22	PF00675	0.405
CLV_NRD_NRD_1	77	79	PF00675	0.215
CLV_PCSK_KEX2_1	19	21	PF00082	0.393
CLV_PCSK_KEX2_1	77	79	PF00082	0.215
CLV_PCSK_PC7_1	16	22	PF00082	0.390
CLV_PCSK_SKI1_1	26	30	PF00082	0.292
CLV_PCSK_SKI1_1	303	307	PF00082	0.388
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.466
DOC_MAPK_gen_1	247	255	PF00069	0.467
DOC_MAPK_gen_1	77	85	PF00069	0.508
DOC_MAPK_MEF2A_6	36	45	PF00069	0.450
DOC_MAPK_NFAT4_5	36	44	PF00069	0.525
DOC_PP2B_LxvP_1	251	254	PF13499	0.532
DOC_PP2B_LxvP_1	41	44	PF13499	0.527
DOC_USP7_MATH_1	263	267	PF00917	0.502
DOC_USP7_MATH_1	288	292	PF00917	0.483
DOC_USP7_MATH_1	293	297	PF00917	0.435
DOC_WW_Pin1_4	129	134	PF00397	0.436
DOC_WW_Pin1_4	228	233	PF00397	0.381
DOC_WW_Pin1_4	280	285	PF00397	0.545
DOC_WW_Pin1_4	323	328	PF00397	0.663
DOC_WW_Pin1_4	52	57	PF00397	0.428
LIG_14-3-3_CanoR_1	61	70	PF00244	0.509
LIG_APCC_ABBA_1	83	88	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.429
LIG_BRCT_BRCA1_1	171	175	PF00533	0.482
LIG_BRCT_BRCA1_1	177	181	PF00533	0.442
LIG_deltaCOP1_diTrp_1	88	96	PF00928	0.531
LIG_FHA_1	100	106	PF00498	0.414
LIG_FHA_1	330	336	PF00498	0.661
LIG_FHA_2	219	225	PF00498	0.463
LIG_FHA_2	304	310	PF00498	0.447
LIG_Integrin_RGD_1	36	38	PF01839	0.235
LIG_LIR_Gen_1	65	73	PF02991	0.381
LIG_LIR_Gen_1	88	98	PF02991	0.531
LIG_LIR_Nem_3	178	184	PF02991	0.459
LIG_LIR_Nem_3	224	228	PF02991	0.471
LIG_LIR_Nem_3	65	70	PF02991	0.581
LIG_LIR_Nem_3	88	93	PF02991	0.531
LIG_PCNA_PIPBox_1	186	195	PF02747	0.446
LIG_Pex14_1	92	96	PF04695	0.531
LIG_Pex14_2	86	90	PF04695	0.482
LIG_SH2_CRK	47	51	PF00017	0.531
LIG_SH2_SRC	148	151	PF00017	0.482
LIG_SH2_STAP1	148	152	PF00017	0.482
LIG_SH2_STAT3	49	52	PF00017	0.381
LIG_SH2_STAT5	146	149	PF00017	0.436
LIG_SH2_STAT5	184	187	PF00017	0.467
LIG_SH2_STAT5	244	247	PF00017	0.436
LIG_SH2_STAT5	351	354	PF00017	0.449
LIG_SH2_STAT5	47	50	PF00017	0.449
LIG_SH3_3	266	272	PF00018	0.449
LIG_SH3_5	180	184	PF00018	0.466
LIG_Sin3_3	286	293	PF02671	0.396
LIG_TYR_ITIM	45	50	PF00017	0.531
MOD_CDK_SPK_2	323	328	PF00069	0.470
MOD_CK1_1	191	197	PF00069	0.502
MOD_CK1_1	257	263	PF00069	0.482
MOD_CK1_1	265	271	PF00069	0.563
MOD_CK1_1	62	68	PF00069	0.477
MOD_CK2_1	129	135	PF00069	0.436
MOD_CK2_1	194	200	PF00069	0.470
MOD_CK2_1	218	224	PF00069	0.549
MOD_CK2_1	303	309	PF00069	0.505
MOD_CK2_1	62	68	PF00069	0.509
MOD_GlcNHglycan	120	123	PF01048	0.271
MOD_GlcNHglycan	154	157	PF01048	0.339
MOD_GlcNHglycan	197	200	PF01048	0.331
MOD_GlcNHglycan	290	293	PF01048	0.363
MOD_GlcNHglycan	62	65	PF01048	0.365
MOD_GlcNHglycan	96	99	PF01048	0.336
MOD_GSK3_1	118	125	PF00069	0.436
MOD_GSK3_1	191	198	PF00069	0.556
MOD_GSK3_1	230	237	PF00069	0.525
MOD_GSK3_1	254	261	PF00069	0.459
MOD_GSK3_1	48	55	PF00069	0.446
MOD_GSK3_1	59	66	PF00069	0.446
MOD_GSK3_1	99	106	PF00069	0.438
MOD_N-GLC_2	278	280	PF02516	0.282
MOD_NEK2_1	107	112	PF00069	0.394
MOD_NEK2_1	127	132	PF00069	0.471
MOD_NEK2_1	152	157	PF00069	0.578
MOD_NEK2_1	175	180	PF00069	0.522
MOD_NEK2_1	234	239	PF00069	0.494
MOD_NEK2_1	245	250	PF00069	0.476
MOD_NEK2_1	255	260	PF00069	0.502
MOD_NEK2_1	39	44	PF00069	0.480
MOD_NEK2_1	59	64	PF00069	0.350
MOD_NEK2_2	188	193	PF00069	0.531
MOD_OFUCOSY	204	210	PF10250	0.181
MOD_PIKK_1	48	54	PF00454	0.482
MOD_PKA_2	315	321	PF00069	0.575
MOD_PKA_2	60	66	PF00069	0.557
MOD_PKA_2	94	100	PF00069	0.460
MOD_Plk_1	134	140	PF00069	0.429
MOD_Plk_1	309	315	PF00069	0.449
MOD_Plk_2-3	230	236	PF00069	0.511
MOD_Plk_2-3	309	315	PF00069	0.467
MOD_Plk_4	122	128	PF00069	0.502
MOD_Plk_4	188	194	PF00069	0.539
MOD_Plk_4	230	236	PF00069	0.507
MOD_Plk_4	239	245	PF00069	0.470
MOD_Plk_4	265	271	PF00069	0.507
MOD_Plk_4	331	337	PF00069	0.740
MOD_ProDKin_1	129	135	PF00069	0.436
MOD_ProDKin_1	228	234	PF00069	0.381
MOD_ProDKin_1	280	286	PF00069	0.545
MOD_ProDKin_1	323	329	PF00069	0.660
MOD_ProDKin_1	52	58	PF00069	0.428
TRG_DiLeu_BaEn_1	230	235	PF01217	0.381
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.457
TRG_ENDOCYTIC_2	47	50	PF00928	0.469
TRG_ER_diArg_1	19	21	PF00400	0.418
TRG_ER_diArg_1	246	249	PF00400	0.436
TRG_ER_diArg_1	76	78	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ4	Leptomonas seymouri	50%	98%
A0A1X0P1P8	Trypanosomatidae	40%	100%
A0A3Q8IEW5	Leishmania donovani	78%	100%
A0A3R7MQP1	Trypanosoma rangeli	41%	100%
A4I5R0	Leishmania infantum	78%	100%
C9ZR29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B105	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q761	Leishmania major	76%	100%
V5BLC5	Trypanosoma cruzi	37%	72%