SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIG3_LEIBR

TriTrypDb:

LbrM.30.2260 , LBRM2903_300029000

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.476
CLV_C14_Caspase3-7	224	228	PF00656	0.264
CLV_NRD_NRD_1	119	121	PF00675	0.461
CLV_NRD_NRD_1	175	177	PF00675	0.461
CLV_NRD_NRD_1	237	239	PF00675	0.339
CLV_NRD_NRD_1	240	242	PF00675	0.355
CLV_NRD_NRD_1	36	38	PF00675	0.629
CLV_NRD_NRD_1	372	374	PF00675	0.533
CLV_NRD_NRD_1	392	394	PF00675	0.500
CLV_NRD_NRD_1	67	69	PF00675	0.461
CLV_PCSK_FUR_1	117	121	PF00082	0.497
CLV_PCSK_FUR_1	238	242	PF00082	0.484
CLV_PCSK_FUR_1	248	252	PF00082	0.326
CLV_PCSK_KEX2_1	117	119	PF00082	0.396
CLV_PCSK_KEX2_1	175	177	PF00082	0.461
CLV_PCSK_KEX2_1	237	239	PF00082	0.339
CLV_PCSK_KEX2_1	240	242	PF00082	0.355
CLV_PCSK_KEX2_1	250	252	PF00082	0.365
CLV_PCSK_KEX2_1	35	37	PF00082	0.582
CLV_PCSK_KEX2_1	372	374	PF00082	0.507
CLV_PCSK_KEX2_1	392	394	PF00082	0.278
CLV_PCSK_KEX2_1	55	57	PF00082	0.346
CLV_PCSK_KEX2_1	67	69	PF00082	0.478
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.365
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.408
CLV_PCSK_PC7_1	31	37	PF00082	0.501
CLV_PCSK_SKI1_1	250	254	PF00082	0.335
CLV_PCSK_SKI1_1	271	275	PF00082	0.393
CLV_PCSK_SKI1_1	31	35	PF00082	0.435
CLV_PCSK_SKI1_1	373	377	PF00082	0.515
CLV_PCSK_SKI1_1	400	404	PF00082	0.514
CLV_Separin_Metazoa	338	342	PF03568	0.386
DEG_APCC_DBOX_1	391	399	PF00400	0.375
DOC_CKS1_1	183	188	PF01111	0.350
DOC_CKS1_1	196	201	PF01111	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	37	45	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	165	168	PF00134	0.320
DOC_MAPK_DCC_7	164	172	PF00069	0.331
DOC_MAPK_gen_1	175	183	PF00069	0.555
DOC_MAPK_gen_1	248	255	PF00069	0.391
DOC_MAPK_gen_1	35	43	PF00069	0.522
DOC_MAPK_gen_1	67	74	PF00069	0.356
DOC_MAPK_HePTP_8	64	76	PF00069	0.256
DOC_MAPK_MEF2A_6	164	172	PF00069	0.449
DOC_MAPK_MEF2A_6	36	45	PF00069	0.453
DOC_MAPK_MEF2A_6	67	76	PF00069	0.319
DOC_MAPK_RevD_3	21	36	PF00069	0.539
DOC_PP1_RVXF_1	407	413	PF00149	0.428
DOC_PP2B_LxvP_1	165	168	PF13499	0.320
DOC_PP4_FxxP_1	78	81	PF00568	0.321
DOC_USP7_MATH_1	192	196	PF00917	0.412
DOC_USP7_MATH_1	452	456	PF00917	0.518
DOC_WW_Pin1_4	182	187	PF00397	0.348
DOC_WW_Pin1_4	195	200	PF00397	0.408
DOC_WW_Pin1_4	448	453	PF00397	0.444
DOC_WW_Pin1_4	89	94	PF00397	0.349
LIG_14-3-3_CanoR_1	193	197	PF00244	0.483
LIG_14-3-3_CanoR_1	222	232	PF00244	0.423
LIG_14-3-3_CanoR_1	414	419	PF00244	0.480
LIG_AP2alpha_1	144	148	PF02296	0.425
LIG_APCC_ABBA_1	145	150	PF00400	0.440
LIG_BRCT_BRCA1_1	148	152	PF00533	0.317
LIG_BRCT_BRCA1_1	429	433	PF00533	0.346
LIG_BRCT_BRCA1_1	49	53	PF00533	0.433
LIG_BRCT_BRCA1_2	49	55	PF00533	0.356
LIG_DLG_GKlike_1	68	76	PF00625	0.265
LIG_FHA_1	127	133	PF00498	0.358
LIG_FHA_1	183	189	PF00498	0.366
LIG_FHA_1	196	202	PF00498	0.565
LIG_FHA_1	224	230	PF00498	0.432
LIG_FHA_1	351	357	PF00498	0.527
LIG_FHA_1	455	461	PF00498	0.459
LIG_FHA_1	90	96	PF00498	0.575
LIG_FHA_2	185	191	PF00498	0.486
LIG_FHA_2	252	258	PF00498	0.399
LIG_FHA_2	99	105	PF00498	0.321
LIG_GBD_Chelix_1	395	403	PF00786	0.416
LIG_KLC1_Yacidic_2	319	324	PF13176	0.328
LIG_LIR_Apic_2	213	219	PF02991	0.514
LIG_LIR_Apic_2	417	423	PF02991	0.258
LIG_LIR_Gen_1	142	152	PF02991	0.303
LIG_LIR_Gen_1	333	344	PF02991	0.423
LIG_LIR_Gen_1	430	439	PF02991	0.341
LIG_LIR_Nem_3	127	133	PF02991	0.349
LIG_LIR_Nem_3	142	147	PF02991	0.270
LIG_LIR_Nem_3	149	155	PF02991	0.309
LIG_LIR_Nem_3	333	339	PF02991	0.433
LIG_LIR_Nem_3	419	425	PF02991	0.321
LIG_LIR_Nem_3	430	436	PF02991	0.342
LIG_LYPXL_yS_3	422	425	PF13949	0.285
LIG_PDZ_Class_1	459	464	PF00595	0.474
LIG_Pex14_2	144	148	PF04695	0.425
LIG_Pex14_2	412	416	PF04695	0.474
LIG_SH2_CRK	130	134	PF00017	0.320
LIG_SH2_SRC	136	139	PF00017	0.410
LIG_SH2_SRC	207	210	PF00017	0.453
LIG_SH2_SRC	79	82	PF00017	0.450
LIG_SH2_STAP1	136	140	PF00017	0.399
LIG_SH2_STAT5	207	210	PF00017	0.400
LIG_SH2_STAT5	322	325	PF00017	0.362
LIG_SH2_STAT5	437	440	PF00017	0.479
LIG_SH3_3	193	199	PF00018	0.355
LIG_SH3_3	2	8	PF00018	0.463
LIG_SH3_3	420	426	PF00018	0.383
LIG_SH3_3	436	442	PF00018	0.332
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.317
LIG_SUMO_SIM_par_1	251	257	PF11976	0.404
LIG_TRAF2_1	358	361	PF00917	0.446
LIG_TRFH_1	422	426	PF08558	0.284
MOD_CK1_1	139	145	PF00069	0.452
MOD_CK1_1	195	201	PF00069	0.565
MOD_CK1_1	210	216	PF00069	0.461
MOD_CK1_1	94	100	PF00069	0.375
MOD_CK2_1	452	458	PF00069	0.460
MOD_CK2_1	98	104	PF00069	0.425
MOD_Cter_Amidation	248	251	PF01082	0.421
MOD_GlcNHglycan	209	212	PF01048	0.424
MOD_GlcNHglycan	257	261	PF01048	0.361
MOD_GlcNHglycan	294	297	PF01048	0.507
MOD_GlcNHglycan	429	432	PF01048	0.433
MOD_GSK3_1	122	129	PF00069	0.521
MOD_GSK3_1	294	301	PF00069	0.360
MOD_GSK3_1	427	434	PF00069	0.422
MOD_GSK3_1	448	455	PF00069	0.500
MOD_GSK3_1	94	101	PF00069	0.512
MOD_LATS_1	326	332	PF00433	0.403
MOD_N-GLC_1	292	297	PF02516	0.398
MOD_NEK2_1	221	226	PF00069	0.317
MOD_NEK2_1	329	334	PF00069	0.501
MOD_NEK2_1	339	344	PF00069	0.400
MOD_NEK2_1	9	14	PF00069	0.422
MOD_PIKK_1	122	128	PF00454	0.536
MOD_PIKK_1	25	31	PF00454	0.568
MOD_PIKK_1	431	437	PF00454	0.329
MOD_PK_1	414	420	PF00069	0.476
MOD_PK_1	456	462	PF00069	0.463
MOD_PKA_2	192	198	PF00069	0.516
MOD_PKA_2	221	227	PF00069	0.479
MOD_Plk_1	103	109	PF00069	0.263
MOD_Plk_1	279	285	PF00069	0.421
MOD_Plk_1	68	74	PF00069	0.426
MOD_Plk_2-3	184	190	PF00069	0.493
MOD_Plk_4	103	109	PF00069	0.502
MOD_Plk_4	139	145	PF00069	0.340
MOD_Plk_4	192	198	PF00069	0.398
MOD_Plk_4	251	257	PF00069	0.442
MOD_Plk_4	294	300	PF00069	0.411
MOD_Plk_4	350	356	PF00069	0.348
MOD_Plk_4	68	74	PF00069	0.456
MOD_Plk_4	94	100	PF00069	0.477
MOD_ProDKin_1	182	188	PF00069	0.349
MOD_ProDKin_1	195	201	PF00069	0.412
MOD_ProDKin_1	448	454	PF00069	0.445
MOD_ProDKin_1	89	95	PF00069	0.364
MOD_SUMO_for_1	217	220	PF00179	0.306
MOD_SUMO_for_1	54	57	PF00179	0.477
MOD_SUMO_rev_2	378	384	PF00179	0.493
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.383
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.527
TRG_ENDOCYTIC_2	130	133	PF00928	0.327
TRG_ENDOCYTIC_2	422	425	PF00928	0.285
TRG_ER_diArg_1	117	120	PF00400	0.436
TRG_ER_diArg_1	237	240	PF00400	0.335
TRG_ER_diArg_1	312	315	PF00400	0.503
TRG_ER_diArg_1	35	37	PF00400	0.523
TRG_ER_diArg_1	371	373	PF00400	0.539
TRG_ER_diArg_1	392	394	PF00400	0.483
TRG_ER_diArg_1	66	68	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P922	Leptomonas seymouri	73%	100%
A0A1X0P2C1	Trypanosomatidae	47%	100%
A0A3S7X3J4	Leishmania donovani	87%	100%
A0A422NW63	Trypanosoma rangeli	48%	100%
A4I5Q9	Leishmania infantum	87%	100%
C9ZR28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B104	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q762	Leishmania major	88%	100%
V5BGV8	Trypanosoma cruzi	46%	100%