Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIG0_LEIBR

TriTrypDb:

LbrM.30.2230 , LBRM2903_300028700

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HIG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIG0

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	20
GO:0008152	metabolic process	1	20
GO:0019538	protein metabolic process	3	20
GO:0036211	protein modification process	4	20
GO:0043170	macromolecule metabolic process	3	20
GO:0043412	macromolecule modification	4	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20
GO:1901564	organonitrogen compound metabolic process	3	20
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0018095	protein polyglutamylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018200	peptidyl-glutamic acid modification	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	7
GO:0016874	ligase activity	2	17
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	4
GO:0016881	acid-amino acid ligase activity	4	4
GO:0070739	protein-glutamic acid ligase activity	3	2
GO:0070740	tubulin-glutamic acid ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	4
GO:0004835	tubulin-tyrosine ligase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.436
CLV_C14_Caspase3-7	460	464	PF00656	0.428
CLV_C14_Caspase3-7	609	613	PF00656	0.533
CLV_C14_Caspase3-7	703	707	PF00656	0.405
CLV_NRD_NRD_1	110	112	PF00675	0.378
CLV_NRD_NRD_1	191	193	PF00675	0.285
CLV_NRD_NRD_1	286	288	PF00675	0.292
CLV_NRD_NRD_1	306	308	PF00675	0.242
CLV_NRD_NRD_1	413	415	PF00675	0.412
CLV_NRD_NRD_1	481	483	PF00675	0.472
CLV_NRD_NRD_1	511	513	PF00675	0.345
CLV_NRD_NRD_1	56	58	PF00675	0.394
CLV_PCSK_KEX2_1	110	112	PF00082	0.350
CLV_PCSK_KEX2_1	183	185	PF00082	0.283
CLV_PCSK_KEX2_1	191	193	PF00082	0.279
CLV_PCSK_KEX2_1	286	288	PF00082	0.340
CLV_PCSK_KEX2_1	382	384	PF00082	0.453
CLV_PCSK_KEX2_1	413	415	PF00082	0.436
CLV_PCSK_KEX2_1	481	483	PF00082	0.454
CLV_PCSK_KEX2_1	511	513	PF00082	0.371
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.279
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.453
CLV_PCSK_PC7_1	477	483	PF00082	0.386
CLV_PCSK_SKI1_1	191	195	PF00082	0.353
CLV_PCSK_SKI1_1	254	258	PF00082	0.262
CLV_PCSK_SKI1_1	286	290	PF00082	0.244
CLV_PCSK_SKI1_1	388	392	PF00082	0.598
CLV_PCSK_SKI1_1	404	408	PF00082	0.307
CLV_PCSK_SKI1_1	423	427	PF00082	0.679
CLV_PCSK_SKI1_1	575	579	PF00082	0.586
CLV_PCSK_SKI1_1	595	599	PF00082	0.527
CLV_PCSK_SKI1_1	602	606	PF00082	0.443
CLV_Separin_Metazoa	133	137	PF03568	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SCF_FBW7_1	577	582	PF00400	0.361
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.280
DOC_CYCLIN_yCln2_LP_2	593	599	PF00134	0.507
DOC_MAPK_DCC_7	136	146	PF00069	0.391
DOC_MAPK_FxFP_2	61	64	PF00069	0.433
DOC_MAPK_gen_1	136	143	PF00069	0.395
DOC_MAPK_gen_1	307	315	PF00069	0.472
DOC_MAPK_gen_1	623	630	PF00069	0.389
DOC_MAPK_MEF2A_6	138	146	PF00069	0.395
DOC_MAPK_MEF2A_6	307	315	PF00069	0.464
DOC_MAPK_MEF2A_6	623	632	PF00069	0.452
DOC_MAPK_NFAT4_5	308	316	PF00069	0.472
DOC_PP2B_LxvP_1	100	103	PF13499	0.324
DOC_PP2B_LxvP_1	426	429	PF13499	0.505
DOC_PP2B_LxvP_1	43	46	PF13499	0.490
DOC_PP2B_LxvP_1	670	673	PF13499	0.573
DOC_PP4_FxxP_1	61	64	PF00568	0.433
DOC_USP7_MATH_1	147	151	PF00917	0.576
DOC_USP7_MATH_1	236	240	PF00917	0.495
DOC_USP7_MATH_1	248	252	PF00917	0.395
DOC_USP7_MATH_1	316	320	PF00917	0.452
DOC_USP7_MATH_1	336	340	PF00917	0.534
DOC_USP7_MATH_1	38	42	PF00917	0.642
DOC_USP7_MATH_1	608	612	PF00917	0.613
DOC_USP7_MATH_1	617	621	PF00917	0.492
DOC_USP7_MATH_1	661	665	PF00917	0.726
DOC_USP7_MATH_1	679	683	PF00917	0.531
DOC_USP7_MATH_2	224	230	PF00917	0.444
DOC_USP7_UBL2_3	279	283	PF12436	0.557
DOC_WW_Pin1_4	148	153	PF00397	0.459
DOC_WW_Pin1_4	200	205	PF00397	0.430
DOC_WW_Pin1_4	28	33	PF00397	0.747
DOC_WW_Pin1_4	343	348	PF00397	0.665
DOC_WW_Pin1_4	466	471	PF00397	0.487
DOC_WW_Pin1_4	475	480	PF00397	0.617
DOC_WW_Pin1_4	51	56	PF00397	0.451
DOC_WW_Pin1_4	575	580	PF00397	0.497
LIG_14-3-3_CanoR_1	136	142	PF00244	0.478
LIG_14-3-3_CanoR_1	286	294	PF00244	0.519
LIG_14-3-3_CanoR_1	3	9	PF00244	0.390
LIG_14-3-3_CanoR_1	388	396	PF00244	0.620
LIG_14-3-3_CanoR_1	423	429	PF00244	0.663
LIG_14-3-3_CanoR_1	57	62	PF00244	0.419
LIG_14-3-3_CanoR_1	595	604	PF00244	0.437
LIG_Actin_WH2_2	35	52	PF00022	0.592
LIG_BRCT_BRCA1_1	127	131	PF00533	0.536
LIG_BRCT_BRCA1_1	548	552	PF00533	0.511
LIG_BRCT_BRCA1_1	59	63	PF00533	0.380
LIG_BRCT_BRCA1_1	663	667	PF00533	0.736
LIG_Clathr_ClatBox_1	567	571	PF01394	0.351
LIG_deltaCOP1_diTrp_1	450	459	PF00928	0.345
LIG_EH_1	533	537	PF12763	0.444
LIG_eIF4E_1	297	303	PF01652	0.431
LIG_eIF4E_1	696	702	PF01652	0.384
LIG_FHA_1	283	289	PF00498	0.568
LIG_FHA_1	34	40	PF00498	0.506
LIG_FHA_1	494	500	PF00498	0.523
LIG_FHA_1	559	565	PF00498	0.465
LIG_FHA_2	316	322	PF00498	0.441
LIG_FHA_2	438	444	PF00498	0.429
LIG_FHA_2	596	602	PF00498	0.481
LIG_FHA_2	622	628	PF00498	0.526
LIG_FHA_2	701	707	PF00498	0.298
LIG_FXI_DFP_1	143	147	PF00024	0.443
LIG_GBD_Chelix_1	491	499	PF00786	0.252
LIG_LIR_Apic_2	220	224	PF02991	0.463
LIG_LIR_Apic_2	60	64	PF02991	0.444
LIG_LIR_Gen_1	128	135	PF02991	0.544
LIG_LIR_Gen_1	212	222	PF02991	0.467
LIG_LIR_Gen_1	268	276	PF02991	0.533
LIG_LIR_Gen_1	338	347	PF02991	0.465
LIG_LIR_Nem_3	159	164	PF02991	0.515
LIG_LIR_Nem_3	268	272	PF02991	0.463
LIG_LIR_Nem_3	318	323	PF02991	0.450
LIG_LIR_Nem_3	338	343	PF02991	0.465
LIG_LIR_Nem_3	401	406	PF02991	0.364
LIG_LIR_Nem_3	518	523	PF02991	0.502
LIG_LIR_Nem_3	664	670	PF02991	0.676
LIG_LIR_Nem_3	706	711	PF02991	0.401
LIG_LIR_Nem_3	94	100	PF02991	0.350
LIG_MLH1_MIPbox_1	59	63	PF16413	0.474
LIG_MYND_3	543	547	PF01753	0.504
LIG_Pex14_2	642	646	PF04695	0.338
LIG_SH2_CRK	320	324	PF00017	0.484
LIG_SH2_PTP2	314	317	PF00017	0.443
LIG_SH2_SRC	461	464	PF00017	0.453
LIG_SH2_STAP1	98	102	PF00017	0.335
LIG_SH2_STAT3	216	219	PF00017	0.351
LIG_SH2_STAT3	292	295	PF00017	0.481
LIG_SH2_STAT3	696	699	PF00017	0.384
LIG_SH2_STAT3	74	77	PF00017	0.522
LIG_SH2_STAT5	157	160	PF00017	0.409
LIG_SH2_STAT5	292	295	PF00017	0.456
LIG_SH2_STAT5	297	300	PF00017	0.442
LIG_SH2_STAT5	314	317	PF00017	0.482
LIG_SH2_STAT5	340	343	PF00017	0.435
LIG_SH2_STAT5	415	418	PF00017	0.491
LIG_SH2_STAT5	461	464	PF00017	0.470
LIG_SH2_STAT5	48	51	PF00017	0.424
LIG_SH2_STAT5	519	522	PF00017	0.504
LIG_SH2_STAT5	62	65	PF00017	0.383
LIG_SH2_STAT5	689	692	PF00017	0.516
LIG_SH3_1	644	650	PF00018	0.341
LIG_SH3_3	510	516	PF00018	0.507
LIG_SH3_3	644	650	PF00018	0.296
LIG_SUMO_SIM_par_1	424	433	PF11976	0.503
LIG_SUMO_SIM_par_1	536	542	PF11976	0.484
LIG_SUMO_SIM_par_1	566	571	PF11976	0.351
LIG_TRAF2_1	358	361	PF00917	0.672
LIG_UBA3_1	272	279	PF00899	0.533
LIG_WW_1	71	74	PF00397	0.468
MOD_CDC14_SPxK_1	54	57	PF00782	0.487
MOD_CDK_SPxK_1	475	481	PF00069	0.447
MOD_CDK_SPxK_1	51	57	PF00069	0.515
MOD_CDK_SPxxK_3	200	207	PF00069	0.430
MOD_CDK_SPxxK_3	343	350	PF00069	0.561
MOD_CDK_SPxxK_3	475	482	PF00069	0.434
MOD_CDK_SPxxK_3	51	58	PF00069	0.517
MOD_CK1_1	148	154	PF00069	0.541
MOD_CK1_1	282	288	PF00069	0.529
MOD_CK1_1	31	37	PF00069	0.649
MOD_CK1_1	345	351	PF00069	0.659
MOD_CK1_1	466	472	PF00069	0.655
MOD_CK1_1	545	551	PF00069	0.453
MOD_CK1_1	652	658	PF00069	0.619
MOD_CK1_1	663	669	PF00069	0.664
MOD_CK1_1	671	677	PF00069	0.676
MOD_CK1_1	80	86	PF00069	0.453
MOD_CK1_1	89	95	PF00069	0.468
MOD_CK2_1	147	153	PF00069	0.435
MOD_CK2_1	424	430	PF00069	0.554
MOD_CK2_1	437	443	PF00069	0.547
MOD_CK2_1	515	521	PF00069	0.481
MOD_CK2_1	595	601	PF00069	0.348
MOD_CK2_1	651	657	PF00069	0.604
MOD_CK2_1	90	96	PF00069	0.399
MOD_Cter_Amidation	305	308	PF01082	0.288
MOD_Cter_Amidation	411	414	PF01082	0.385
MOD_GlcNHglycan	147	150	PF01048	0.511
MOD_GlcNHglycan	352	356	PF01048	0.652
MOD_GlcNHglycan	370	373	PF01048	0.684
MOD_GlcNHglycan	385	388	PF01048	0.679
MOD_GlcNHglycan	430	435	PF01048	0.442
MOD_GlcNHglycan	549	552	PF01048	0.303
MOD_GlcNHglycan	619	622	PF01048	0.661
MOD_GlcNHglycan	651	654	PF01048	0.677
MOD_GlcNHglycan	663	666	PF01048	0.733
MOD_GlcNHglycan	667	670	PF01048	0.736
MOD_GSK3_1	26	33	PF00069	0.627
MOD_GSK3_1	338	345	PF00069	0.549
MOD_GSK3_1	364	371	PF00069	0.649
MOD_GSK3_1	465	472	PF00069	0.507
MOD_GSK3_1	477	484	PF00069	0.414
MOD_GSK3_1	542	549	PF00069	0.479
MOD_GSK3_1	575	582	PF00069	0.566
MOD_GSK3_1	613	620	PF00069	0.476
MOD_GSK3_1	649	656	PF00069	0.547
MOD_GSK3_1	661	668	PF00069	0.646
MOD_GSK3_1	700	707	PF00069	0.463
MOD_GSK3_1	76	83	PF00069	0.516
MOD_GSK3_1	86	93	PF00069	0.446
MOD_N-GLC_1	383	388	PF02516	0.477
MOD_N-GLC_1	407	412	PF02516	0.378
MOD_N-GLC_1	558	563	PF02516	0.151
MOD_N-GLC_1	575	580	PF02516	0.602
MOD_NEK2_1	163	168	PF00069	0.562
MOD_NEK2_1	23	28	PF00069	0.498
MOD_NEK2_1	288	293	PF00069	0.498
MOD_NEK2_1	368	373	PF00069	0.639
MOD_NEK2_1	451	456	PF00069	0.373
MOD_NEK2_1	546	551	PF00069	0.441
MOD_NEK2_1	583	588	PF00069	0.556
MOD_NEK2_1	651	656	PF00069	0.632
MOD_NEK2_1	88	93	PF00069	0.401
MOD_OFUCOSY	374	380	PF10250	0.451
MOD_PIKK_1	256	262	PF00454	0.566
MOD_PIKK_1	584	590	PF00454	0.453
MOD_PKA_1	481	487	PF00069	0.347
MOD_PKA_1	57	63	PF00069	0.353
MOD_PKA_2	137	143	PF00069	0.536
MOD_PKA_2	226	232	PF00069	0.568
MOD_PKA_2	248	254	PF00069	0.449
MOD_PKA_2	4	10	PF00069	0.384
MOD_PKA_2	481	487	PF00069	0.324
MOD_PKB_1	402	410	PF00069	0.496
MOD_Plk_1	359	365	PF00069	0.447
MOD_Plk_1	407	413	PF00069	0.401
MOD_Plk_1	430	436	PF00069	0.589
MOD_Plk_1	437	443	PF00069	0.634
MOD_Plk_4	217	223	PF00069	0.482
MOD_Plk_4	226	232	PF00069	0.562
MOD_Plk_4	288	294	PF00069	0.534
MOD_Plk_4	321	327	PF00069	0.452
MOD_Plk_4	359	365	PF00069	0.447
MOD_Plk_4	38	44	PF00069	0.689
MOD_Plk_4	515	521	PF00069	0.533
MOD_Plk_4	57	63	PF00069	0.382
MOD_Plk_4	579	585	PF00069	0.601
MOD_Plk_4	685	691	PF00069	0.564
MOD_ProDKin_1	148	154	PF00069	0.450
MOD_ProDKin_1	200	206	PF00069	0.430
MOD_ProDKin_1	28	34	PF00069	0.745
MOD_ProDKin_1	343	349	PF00069	0.663
MOD_ProDKin_1	466	472	PF00069	0.495
MOD_ProDKin_1	475	481	PF00069	0.605
MOD_ProDKin_1	51	57	PF00069	0.449
MOD_ProDKin_1	575	581	PF00069	0.499
MOD_SUMO_for_1	632	635	PF00179	0.251
MOD_SUMO_rev_2	275	281	PF00179	0.468
TRG_DiLeu_BaEn_1	159	164	PF01217	0.323
TRG_DiLeu_BaEn_1	226	231	PF01217	0.483
TRG_DiLeu_BaEn_1	299	304	PF01217	0.465
TRG_DiLeu_BaEn_1	490	495	PF01217	0.550
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.328
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.549
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.431
TRG_DiLeu_LyEn_5	159	164	PF01217	0.323
TRG_ENDOCYTIC_2	214	217	PF00928	0.465
TRG_ENDOCYTIC_2	314	317	PF00928	0.449
TRG_ENDOCYTIC_2	320	323	PF00928	0.465
TRG_ENDOCYTIC_2	340	343	PF00928	0.419
TRG_ENDOCYTIC_2	415	418	PF00928	0.495
TRG_ENDOCYTIC_2	519	522	PF00928	0.504
TRG_ENDOCYTIC_2	97	100	PF00928	0.333
TRG_ER_diArg_1	109	111	PF00400	0.395
TRG_ER_diArg_1	135	138	PF00400	0.657
TRG_ER_diArg_1	190	192	PF00400	0.507
TRG_ER_diArg_1	2	5	PF00400	0.482
TRG_ER_diArg_1	286	288	PF00400	0.540
TRG_ER_diArg_1	413	415	PF00400	0.478
TRG_ER_diArg_1	481	483	PF00400	0.442
TRG_ER_diArg_1	510	512	PF00400	0.449
TRG_ER_diArg_1	64	67	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q6	Leptomonas seymouri	58%	99%
A0A0S4ISF0	Bodo saltans	37%	100%
A0A0S4KQK8	Bodo saltans	30%	100%
A0A1X0P1M0	Trypanosomatidae	41%	100%
A0A3Q8IDL7	Leishmania donovani	27%	98%
A0A3Q8IEC1	Leishmania donovani	76%	100%
A0A3S5IS28	Trypanosoma rangeli	44%	100%
A4HYN9	Leishmania infantum	27%	98%
A4I5Q6	Leishmania infantum	76%	100%
A8CVX7	Danio rerio	24%	92%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AID0	Leishmania braziliensis	25%	95%
E9B101	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q765	Leishmania major	76%	99%
Q4QCW7	Leishmania major	27%	100%
V5B4U2	Trypanosoma cruzi	25%	100%
V5BLC0	Trypanosoma cruzi	42%	100%