LeishMANIAdb
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Phospholipid-transporting ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phospholipid-transporting ATPase
Gene product:
phospholipid-translocating P-type ATPase (flippase), putative
Species:
Leishmania braziliensis
UniProt:
A4HIF8_LEIBR
TriTrypDb:
LbrM.30.2210 , LBRM2903_300028300 * , LBRM2903_300028400 *
Length:
1244

Annotations

LeishMANIAdb annotations

Eukaryotic P-ATPase protein, its closest animal relatives (ATP11A) are involved in phospholipid transport.. Localization: Endosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4HIF8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 13
GO:0006869 lipid transport 5 13
GO:0015748 organophosphate ester transport 5 13
GO:0015914 phospholipid transport 6 13
GO:0051179 localization 1 13
GO:0051234 establishment of localization 2 13
GO:0071702 organic substance transport 4 13
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0034204 lipid translocation 4 1
GO:0045332 phospholipid translocation 5 1
GO:0061024 membrane organization 4 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097035 regulation of membrane lipid distribution 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0000287 magnesium ion binding 5 13
GO:0003824 catalytic activity 1 15
GO:0005215 transporter activity 1 15
GO:0005319 lipid transporter activity 2 15
GO:0005488 binding 1 16
GO:0005524 ATP binding 5 15
GO:0016462 pyrophosphatase activity 5 15
GO:0016787 hydrolase activity 2 15
GO:0016817 hydrolase activity, acting on acid anhydrides 3 15
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 15
GO:0016887 ATP hydrolysis activity 7 15
GO:0017076 purine nucleotide binding 4 15
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 15
GO:0030554 adenyl nucleotide binding 5 15
GO:0032553 ribonucleotide binding 3 15
GO:0032555 purine ribonucleotide binding 4 15
GO:0032559 adenyl ribonucleotide binding 5 15
GO:0035639 purine ribonucleoside triphosphate binding 4 15
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 15
GO:0043168 anion binding 3 15
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 15
GO:0140303 intramembrane lipid transporter activity 3 15
GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2 15
GO:0140657 ATP-dependent activity 1 15
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16
GO:0004518 nuclease activity 4 1
GO:0004519 endonuclease activity 5 1
GO:0004521 RNA endonuclease activity 5 1
GO:0004526 ribonuclease P activity 6 1
GO:0004540 RNA nuclease activity 4 1
GO:0004549 tRNA-specific ribonuclease activity 5 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 151 155 PF00656 0.496
CLV_C14_Caspase3-7 231 235 PF00656 0.533
CLV_C14_Caspase3-7 585 589 PF00656 0.499
CLV_C14_Caspase3-7 613 617 PF00656 0.571
CLV_C14_Caspase3-7 906 910 PF00656 0.563
CLV_NRD_NRD_1 1147 1149 PF00675 0.524
CLV_NRD_NRD_1 1189 1191 PF00675 0.367
CLV_NRD_NRD_1 1194 1196 PF00675 0.375
CLV_NRD_NRD_1 1202 1204 PF00675 0.383
CLV_NRD_NRD_1 1228 1230 PF00675 0.407
CLV_NRD_NRD_1 177 179 PF00675 0.506
CLV_NRD_NRD_1 40 42 PF00675 0.157
CLV_NRD_NRD_1 518 520 PF00675 0.299
CLV_PCSK_KEX2_1 1189 1191 PF00082 0.352
CLV_PCSK_KEX2_1 1194 1196 PF00082 0.357
CLV_PCSK_KEX2_1 1201 1203 PF00082 0.387
CLV_PCSK_KEX2_1 1206 1208 PF00082 0.356
CLV_PCSK_KEX2_1 1228 1230 PF00082 0.407
CLV_PCSK_KEX2_1 177 179 PF00082 0.504
CLV_PCSK_KEX2_1 40 42 PF00082 0.166
CLV_PCSK_KEX2_1 88 90 PF00082 0.321
CLV_PCSK_PC1ET2_1 1201 1203 PF00082 0.451
CLV_PCSK_PC1ET2_1 1206 1208 PF00082 0.445
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.321
CLV_PCSK_PC7_1 1185 1191 PF00082 0.382
CLV_PCSK_PC7_1 1197 1203 PF00082 0.444
CLV_PCSK_SKI1_1 101 105 PF00082 0.296
CLV_PCSK_SKI1_1 1025 1029 PF00082 0.241
CLV_PCSK_SKI1_1 1047 1051 PF00082 0.237
CLV_PCSK_SKI1_1 1056 1060 PF00082 0.327
CLV_PCSK_SKI1_1 1148 1152 PF00082 0.480
CLV_PCSK_SKI1_1 1185 1189 PF00082 0.341
CLV_PCSK_SKI1_1 1197 1201 PF00082 0.366
CLV_PCSK_SKI1_1 346 350 PF00082 0.279
CLV_PCSK_SKI1_1 532 536 PF00082 0.253
CLV_PCSK_SKI1_1 642 646 PF00082 0.282
CLV_PCSK_SKI1_1 649 653 PF00082 0.278
CLV_PCSK_SKI1_1 890 894 PF00082 0.251
CLV_PCSK_SKI1_1 949 953 PF00082 0.232
CLV_PCSK_SKI1_1 973 977 PF00082 0.303
CLV_Separin_Metazoa 813 817 PF03568 0.600
DEG_APCC_DBOX_1 1055 1063 PF00400 0.411
DEG_Nend_UBRbox_1 1 4 PF02207 0.530
DEG_ODPH_VHL_1 59 71 PF01847 0.305
DEG_SPOP_SBC_1 610 614 PF00917 0.664
DEG_SPOP_SBC_1 618 622 PF00917 0.737
DOC_CYCLIN_RxL_1 1145 1154 PF00134 0.315
DOC_CYCLIN_RxL_1 1194 1204 PF00134 0.639
DOC_CYCLIN_yCln2_LP_2 341 347 PF00134 0.235
DOC_MAPK_gen_1 1036 1044 PF00069 0.451
DOC_MAPK_gen_1 1194 1200 PF00069 0.567
DOC_MAPK_gen_1 519 525 PF00069 0.450
DOC_MAPK_gen_1 577 584 PF00069 0.449
DOC_MAPK_gen_1 895 905 PF00069 0.488
DOC_MAPK_HePTP_8 525 537 PF00069 0.338
DOC_MAPK_MEF2A_6 1021 1028 PF00069 0.445
DOC_MAPK_MEF2A_6 295 302 PF00069 0.368
DOC_MAPK_MEF2A_6 528 537 PF00069 0.398
DOC_MAPK_MEF2A_6 577 584 PF00069 0.437
DOC_MAPK_MEF2A_6 653 660 PF00069 0.612
DOC_MAPK_MEF2A_6 740 748 PF00069 0.540
DOC_MAPK_MEF2A_6 898 907 PF00069 0.465
DOC_MIT_MIM_1 863 873 PF04212 0.475
DOC_PP1_RVXF_1 39 46 PF00149 0.357
DOC_PP1_RVXF_1 589 595 PF00149 0.524
DOC_PP1_RVXF_1 796 803 PF00149 0.654
DOC_PP1_RVXF_1 947 954 PF00149 0.438
DOC_PP2B_LxvP_1 1166 1169 PF13499 0.324
DOC_PP2B_LxvP_1 329 332 PF13499 0.355
DOC_PP4_FxxP_1 1179 1182 PF00568 0.468
DOC_PP4_FxxP_1 39 42 PF00568 0.419
DOC_USP7_MATH_1 106 110 PF00917 0.521
DOC_USP7_MATH_1 1220 1224 PF00917 0.638
DOC_USP7_MATH_1 199 203 PF00917 0.544
DOC_USP7_MATH_1 318 322 PF00917 0.316
DOC_USP7_MATH_1 336 340 PF00917 0.343
DOC_USP7_MATH_1 393 397 PF00917 0.669
DOC_USP7_MATH_1 403 407 PF00917 0.502
DOC_USP7_MATH_1 489 493 PF00917 0.529
DOC_USP7_MATH_1 609 613 PF00917 0.640
DOC_USP7_MATH_1 756 760 PF00917 0.635
DOC_USP7_MATH_1 774 778 PF00917 0.645
DOC_USP7_MATH_1 781 785 PF00917 0.651
DOC_USP7_MATH_1 843 847 PF00917 0.644
DOC_WW_Pin1_4 1111 1116 PF00397 0.524
DOC_WW_Pin1_4 1216 1221 PF00397 0.576
DOC_WW_Pin1_4 505 510 PF00397 0.416
DOC_WW_Pin1_4 605 610 PF00397 0.564
DOC_WW_Pin1_4 620 625 PF00397 0.646
DOC_WW_Pin1_4 883 888 PF00397 0.488
LIG_14-3-3_CanoR_1 177 181 PF00244 0.608
LIG_14-3-3_CanoR_1 295 299 PF00244 0.524
LIG_14-3-3_CanoR_1 639 645 PF00244 0.520
LIG_14-3-3_CanoR_1 740 748 PF00244 0.540
LIG_14-3-3_CanoR_1 798 803 PF00244 0.629
LIG_14-3-3_CanoR_1 876 881 PF00244 0.454
LIG_Actin_WH2_2 1173 1191 PF00022 0.240
LIG_AP2alpha_1 996 1000 PF02296 0.180
LIG_APCC_ABBA_1 1234 1239 PF00400 0.510
LIG_BRCT_BRCA1_1 1051 1055 PF00533 0.253
LIG_BRCT_BRCA1_1 357 361 PF00533 0.295
LIG_CtBP_PxDLS_1 522 528 PF00389 0.524
LIG_deltaCOP1_diTrp_1 560 571 PF00928 0.387
LIG_eIF4E_1 1237 1243 PF01652 0.512
LIG_FHA_1 1088 1094 PF00498 0.308
LIG_FHA_1 1151 1157 PF00498 0.257
LIG_FHA_1 141 147 PF00498 0.478
LIG_FHA_1 148 154 PF00498 0.446
LIG_FHA_1 15 21 PF00498 0.519
LIG_FHA_1 177 183 PF00498 0.598
LIG_FHA_1 235 241 PF00498 0.537
LIG_FHA_1 350 356 PF00498 0.290
LIG_FHA_1 421 427 PF00498 0.459
LIG_FHA_1 481 487 PF00498 0.440
LIG_FHA_1 562 568 PF00498 0.467
LIG_FHA_1 577 583 PF00498 0.378
LIG_FHA_1 641 647 PF00498 0.467
LIG_FHA_1 655 661 PF00498 0.490
LIG_FHA_1 892 898 PF00498 0.462
LIG_FHA_1 902 908 PF00498 0.465
LIG_FHA_1 961 967 PF00498 0.396
LIG_FHA_2 1217 1223 PF00498 0.576
LIG_FHA_2 229 235 PF00498 0.605
LIG_FHA_2 267 273 PF00498 0.440
LIG_FHA_2 453 459 PF00498 0.684
LIG_FHA_2 650 656 PF00498 0.528
LIG_FHA_2 692 698 PF00498 0.459
LIG_FHA_2 705 711 PF00498 0.453
LIG_FHA_2 853 859 PF00498 0.475
LIG_FHA_2 993 999 PF00498 0.245
LIG_GBD_Chelix_1 712 720 PF00786 0.226
LIG_HCF-1_HBM_1 93 96 PF13415 0.556
LIG_HP1_1 1024 1028 PF01393 0.445
LIG_IBAR_NPY_1 1031 1033 PF08397 0.468
LIG_Integrin_RGD_1 1229 1231 PF01839 0.295
LIG_IRF3_LxIS_1 1156 1163 PF10401 0.150
LIG_LIR_Apic_2 324 330 PF02991 0.395
LIG_LIR_Apic_2 37 42 PF02991 0.419
LIG_LIR_Gen_1 1092 1103 PF02991 0.277
LIG_LIR_Gen_1 297 306 PF02991 0.167
LIG_LIR_Gen_1 450 460 PF02991 0.479
LIG_LIR_Gen_1 899 907 PF02991 0.399
LIG_LIR_Gen_1 943 953 PF02991 0.468
LIG_LIR_Gen_1 978 987 PF02991 0.343
LIG_LIR_Gen_1 995 1004 PF02991 0.211
LIG_LIR_LC3C_4 1163 1168 PF02991 0.393
LIG_LIR_LC3C_4 17 21 PF02991 0.448
LIG_LIR_Nem_3 1003 1008 PF02991 0.282
LIG_LIR_Nem_3 1052 1058 PF02991 0.291
LIG_LIR_Nem_3 1092 1098 PF02991 0.277
LIG_LIR_Nem_3 1140 1146 PF02991 0.246
LIG_LIR_Nem_3 1170 1176 PF02991 0.362
LIG_LIR_Nem_3 294 299 PF02991 0.345
LIG_LIR_Nem_3 325 331 PF02991 0.261
LIG_LIR_Nem_3 358 362 PF02991 0.322
LIG_LIR_Nem_3 450 456 PF02991 0.473
LIG_LIR_Nem_3 529 534 PF02991 0.417
LIG_LIR_Nem_3 82 87 PF02991 0.543
LIG_LIR_Nem_3 899 905 PF02991 0.406
LIG_LIR_Nem_3 943 948 PF02991 0.466
LIG_LIR_Nem_3 978 982 PF02991 0.306
LIG_LIR_Nem_3 995 1000 PF02991 0.189
LIG_NRBOX 640 646 PF00104 0.409
LIG_NRBOX 947 953 PF00104 0.429
LIG_PCNA_yPIPBox_3 307 320 PF02747 0.411
LIG_PCNA_yPIPBox_3 699 712 PF02747 0.473
LIG_PDZ_Class_2 1239 1244 PF00595 0.515
LIG_Pex14_1 1005 1009 PF04695 0.296
LIG_Pex14_1 1212 1216 PF04695 0.642
LIG_Pex14_2 1049 1053 PF04695 0.346
LIG_Pex14_2 1211 1215 PF04695 0.456
LIG_Pex14_2 996 1000 PF04695 0.223
LIG_PTB_Apo_2 1003 1010 PF02174 0.264
LIG_PTB_Apo_2 19 26 PF02174 0.437
LIG_PTB_Phospho_1 1003 1009 PF10480 0.305
LIG_PTB_Phospho_1 19 25 PF10480 0.437
LIG_REV1ctd_RIR_1 215 224 PF16727 0.544
LIG_SH2_CRK 1009 1013 PF00017 0.305
LIG_SH2_CRK 1095 1099 PF00017 0.275
LIG_SH2_CRK 531 535 PF00017 0.338
LIG_SH2_CRK 984 988 PF00017 0.341
LIG_SH2_NCK_1 1009 1013 PF00017 0.308
LIG_SH2_NCK_1 1091 1095 PF00017 0.299
LIG_SH2_NCK_1 984 988 PF00017 0.375
LIG_SH2_PTP2 299 302 PF00017 0.318
LIG_SH2_SRC 1128 1131 PF00017 0.411
LIG_SH2_SRC 546 549 PF00017 0.338
LIG_SH2_SRC 84 87 PF00017 0.500
LIG_SH2_STAP1 1091 1095 PF00017 0.276
LIG_SH2_STAP1 1104 1108 PF00017 0.273
LIG_SH2_STAP1 1130 1134 PF00017 0.415
LIG_SH2_STAP1 296 300 PF00017 0.289
LIG_SH2_STAT3 25 28 PF00017 0.524
LIG_SH2_STAT3 548 551 PF00017 0.338
LIG_SH2_STAT5 1009 1012 PF00017 0.296
LIG_SH2_STAT5 1017 1020 PF00017 0.276
LIG_SH2_STAT5 1033 1036 PF00017 0.515
LIG_SH2_STAT5 1095 1098 PF00017 0.356
LIG_SH2_STAT5 1104 1107 PF00017 0.371
LIG_SH2_STAT5 1128 1131 PF00017 0.292
LIG_SH2_STAT5 1143 1146 PF00017 0.315
LIG_SH2_STAT5 1173 1176 PF00017 0.378
LIG_SH2_STAT5 147 150 PF00017 0.477
LIG_SH2_STAT5 15 18 PF00017 0.445
LIG_SH2_STAT5 25 28 PF00017 0.387
LIG_SH2_STAT5 268 271 PF00017 0.474
LIG_SH2_STAT5 299 302 PF00017 0.199
LIG_SH2_STAT5 328 331 PF00017 0.344
LIG_SH2_STAT5 417 420 PF00017 0.431
LIG_SH2_STAT5 46 49 PF00017 0.245
LIG_SH2_STAT5 902 905 PF00017 0.374
LIG_SH2_STAT5 960 963 PF00017 0.472
LIG_SH2_STAT5 965 968 PF00017 0.450
LIG_SH3_3 1119 1125 PF00018 0.150
LIG_SH3_3 204 210 PF00018 0.424
LIG_SH3_3 222 228 PF00018 0.483
LIG_SH3_3 237 243 PF00018 0.564
LIG_SH3_3 350 356 PF00018 0.198
LIG_SH3_3 483 489 PF00018 0.534
LIG_SH3_3 55 61 PF00018 0.269
LIG_SH3_3 581 587 PF00018 0.483
LIG_SH3_3 621 627 PF00018 0.664
LIG_SH3_3 780 786 PF00018 0.656
LIG_SUMO_SIM_anti_2 1163 1168 PF11976 0.361
LIG_SUMO_SIM_anti_2 123 129 PF11976 0.463
LIG_SUMO_SIM_anti_2 136 141 PF11976 0.401
LIG_SUMO_SIM_anti_2 483 488 PF11976 0.508
LIG_SUMO_SIM_anti_2 685 692 PF11976 0.539
LIG_SUMO_SIM_anti_2 846 852 PF11976 0.492
LIG_SUMO_SIM_par_1 123 129 PF11976 0.482
LIG_SUMO_SIM_par_1 903 909 PF11976 0.438
LIG_TRAF2_1 1219 1222 PF00917 0.554
LIG_TYR_ITIM 1093 1098 PF00017 0.305
LIG_TYR_ITIM 1141 1146 PF00017 0.367
LIG_TYR_ITIM 1171 1176 PF00017 0.388
LIG_TYR_ITIM 982 987 PF00017 0.375
LIG_WRC_WIRS_1 1050 1055 PF05994 0.373
LIG_WRC_WIRS_1 799 804 PF05994 0.337
LIG_WRC_WIRS_1 976 981 PF05994 0.312
MOD_CDK_SPxxK_3 883 890 PF00069 0.340
MOD_CK1_1 176 182 PF00069 0.559
MOD_CK1_1 23 29 PF00069 0.254
MOD_CK1_1 294 300 PF00069 0.338
MOD_CK1_1 420 426 PF00069 0.320
MOD_CK1_1 447 453 PF00069 0.484
MOD_CK1_1 614 620 PF00069 0.662
MOD_CK1_1 686 692 PF00069 0.418
MOD_CK1_1 784 790 PF00069 0.549
MOD_CK1_1 805 811 PF00069 0.591
MOD_CK1_1 992 998 PF00069 0.264
MOD_CK2_1 1216 1222 PF00069 0.452
MOD_CK2_1 184 190 PF00069 0.539
MOD_CK2_1 318 324 PF00069 0.304
MOD_CK2_1 452 458 PF00069 0.646
MOD_CK2_1 489 495 PF00069 0.193
MOD_CK2_1 505 511 PF00069 0.259
MOD_CK2_1 649 655 PF00069 0.244
MOD_CK2_1 691 697 PF00069 0.322
MOD_CK2_1 924 930 PF00069 0.316
MOD_CMANNOS 1212 1215 PF00535 0.576
MOD_GlcNHglycan 108 111 PF01048 0.355
MOD_GlcNHglycan 1157 1160 PF01048 0.433
MOD_GlcNHglycan 143 146 PF01048 0.434
MOD_GlcNHglycan 320 323 PF01048 0.397
MOD_GlcNHglycan 335 339 PF01048 0.461
MOD_GlcNHglycan 394 398 PF01048 0.536
MOD_GlcNHglycan 449 452 PF01048 0.432
MOD_GlcNHglycan 491 494 PF01048 0.300
MOD_GlcNHglycan 495 498 PF01048 0.308
MOD_GlcNHglycan 588 591 PF01048 0.328
MOD_GlcNHglycan 685 688 PF01048 0.518
MOD_GlcNHglycan 776 779 PF01048 0.588
MOD_GlcNHglycan 839 842 PF01048 0.609
MOD_GlcNHglycan 844 848 PF01048 0.451
MOD_GlcNHglycan 926 929 PF01048 0.449
MOD_GlcNHglycan 991 994 PF01048 0.264
MOD_GSK3_1 1007 1014 PF00069 0.282
MOD_GSK3_1 106 113 PF00069 0.256
MOD_GSK3_1 1083 1090 PF00069 0.334
MOD_GSK3_1 1098 1105 PF00069 0.198
MOD_GSK3_1 1107 1114 PF00069 0.217
MOD_GSK3_1 1129 1136 PF00069 0.317
MOD_GSK3_1 1151 1158 PF00069 0.321
MOD_GSK3_1 1216 1223 PF00069 0.438
MOD_GSK3_1 230 237 PF00069 0.582
MOD_GSK3_1 266 273 PF00069 0.294
MOD_GSK3_1 318 325 PF00069 0.305
MOD_GSK3_1 420 427 PF00069 0.306
MOD_GSK3_1 447 454 PF00069 0.481
MOD_GSK3_1 489 496 PF00069 0.186
MOD_GSK3_1 572 579 PF00069 0.268
MOD_GSK3_1 605 612 PF00069 0.502
MOD_GSK3_1 614 621 PF00069 0.515
MOD_GSK3_1 798 805 PF00069 0.578
MOD_GSK3_1 826 833 PF00069 0.485
MOD_GSK3_1 852 859 PF00069 0.525
MOD_GSK3_1 872 879 PF00069 0.428
MOD_GSK3_1 92 99 PF00069 0.338
MOD_GSK3_1 943 950 PF00069 0.303
MOD_GSK3_1 967 974 PF00069 0.266
MOD_GSK3_1 992 999 PF00069 0.292
MOD_N-GLC_1 318 323 PF02516 0.501
MOD_N-GLC_1 447 452 PF02516 0.529
MOD_N-GLC_1 756 761 PF02516 0.632
MOD_N-GLC_1 802 807 PF02516 0.432
MOD_N-GLC_1 96 101 PF02516 0.509
MOD_NEK2_1 1049 1054 PF00069 0.355
MOD_NEK2_1 1065 1070 PF00069 0.201
MOD_NEK2_1 1098 1103 PF00069 0.264
MOD_NEK2_1 1150 1155 PF00069 0.386
MOD_NEK2_1 1160 1165 PF00069 0.374
MOD_NEK2_1 140 145 PF00069 0.418
MOD_NEK2_1 348 353 PF00069 0.281
MOD_NEK2_1 381 386 PF00069 0.485
MOD_NEK2_1 444 449 PF00069 0.319
MOD_NEK2_1 521 526 PF00069 0.353
MOD_NEK2_1 541 546 PF00069 0.108
MOD_NEK2_1 73 78 PF00069 0.253
MOD_NEK2_1 818 823 PF00069 0.551
MOD_NEK2_1 903 908 PF00069 0.397
MOD_NEK2_1 940 945 PF00069 0.316
MOD_NEK2_1 971 976 PF00069 0.274
MOD_NEK2_1 996 1001 PF00069 0.296
MOD_NEK2_2 654 659 PF00069 0.525
MOD_PIKK_1 1098 1104 PF00454 0.337
MOD_PIKK_1 184 190 PF00454 0.355
MOD_PIKK_1 424 430 PF00454 0.361
MOD_PIKK_1 805 811 PF00454 0.605
MOD_PIKK_1 885 891 PF00454 0.400
MOD_PIKK_1 940 946 PF00454 0.415
MOD_PK_1 876 882 PF00069 0.453
MOD_PKA_2 176 182 PF00069 0.564
MOD_PKA_2 23 29 PF00069 0.279
MOD_PKA_2 294 300 PF00069 0.375
MOD_PKA_2 739 745 PF00069 0.527
MOD_PKA_2 750 756 PF00069 0.620
MOD_PKB_1 869 877 PF00069 0.407
MOD_Plk_1 1087 1093 PF00069 0.331
MOD_Plk_1 1220 1226 PF00069 0.521
MOD_Plk_1 291 297 PF00069 0.371
MOD_Plk_1 561 567 PF00069 0.407
MOD_Plk_1 654 660 PF00069 0.455
MOD_Plk_1 805 811 PF00069 0.649
MOD_Plk_1 843 849 PF00069 0.432
MOD_Plk_1 92 98 PF00069 0.416
MOD_Plk_1 938 944 PF00069 0.264
MOD_Plk_2-3 495 501 PF00069 0.379
MOD_Plk_2-3 852 858 PF00069 0.441
MOD_Plk_4 1000 1006 PF00069 0.275
MOD_Plk_4 1011 1017 PF00069 0.305
MOD_Plk_4 1049 1055 PF00069 0.302
MOD_Plk_4 1102 1108 PF00069 0.334
MOD_Plk_4 1129 1135 PF00069 0.314
MOD_Plk_4 1167 1173 PF00069 0.383
MOD_Plk_4 1221 1227 PF00069 0.441
MOD_Plk_4 193 199 PF00069 0.304
MOD_Plk_4 210 216 PF00069 0.233
MOD_Plk_4 294 300 PF00069 0.213
MOD_Plk_4 349 355 PF00069 0.297
MOD_Plk_4 521 527 PF00069 0.348
MOD_Plk_4 631 637 PF00069 0.516
MOD_Plk_4 64 70 PF00069 0.208
MOD_Plk_4 654 660 PF00069 0.437
MOD_Plk_4 686 692 PF00069 0.467
MOD_Plk_4 852 858 PF00069 0.439
MOD_Plk_4 967 973 PF00069 0.278
MOD_Plk_4 992 998 PF00069 0.270
MOD_ProDKin_1 1111 1117 PF00069 0.411
MOD_ProDKin_1 1216 1222 PF00069 0.490
MOD_ProDKin_1 505 511 PF00069 0.259
MOD_ProDKin_1 605 611 PF00069 0.480
MOD_ProDKin_1 620 626 PF00069 0.570
MOD_ProDKin_1 883 889 PF00069 0.354
MOD_SUMO_rev_2 154 161 PF00179 0.446
MOD_SUMO_rev_2 574 580 PF00179 0.172
TRG_DiLeu_BaEn_1 665 670 PF01217 0.360
TRG_DiLeu_BaEn_1 813 818 PF01217 0.605
TRG_DiLeu_BaEn_2 654 660 PF01217 0.328
TRG_DiLeu_BaEn_4 1221 1227 PF01217 0.322
TRG_DiLeu_BaLyEn_6 1194 1199 PF01217 0.472
TRG_DiLeu_BaLyEn_6 67 72 PF01217 0.324
TRG_ENDOCYTIC_2 1095 1098 PF00928 0.275
TRG_ENDOCYTIC_2 1130 1133 PF00928 0.252
TRG_ENDOCYTIC_2 1143 1146 PF00928 0.345
TRG_ENDOCYTIC_2 1173 1176 PF00928 0.341
TRG_ENDOCYTIC_2 1205 1208 PF00928 0.504
TRG_ENDOCYTIC_2 299 302 PF00928 0.166
TRG_ENDOCYTIC_2 328 331 PF00928 0.441
TRG_ENDOCYTIC_2 36 39 PF00928 0.305
TRG_ENDOCYTIC_2 46 49 PF00928 0.220
TRG_ENDOCYTIC_2 531 534 PF00928 0.398
TRG_ENDOCYTIC_2 84 87 PF00928 0.413
TRG_ENDOCYTIC_2 902 905 PF00928 0.200
TRG_ENDOCYTIC_2 972 975 PF00928 0.284
TRG_ENDOCYTIC_2 984 987 PF00928 0.235
TRG_ER_diArg_1 1188 1190 PF00400 0.439
TRG_ER_diArg_1 1194 1197 PF00400 0.466
TRG_ER_diArg_1 39 41 PF00400 0.189
TRG_ER_diArg_1 864 867 PF00400 0.503
TRG_NLS_MonoExtC_3 87 93 PF00514 0.416
TRG_Pf-PMV_PEXEL_1 1148 1152 PF00026 0.150
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.346
TRG_Pf-PMV_PEXEL_1 390 394 PF00026 0.400
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF54 Leptomonas seymouri 62% 96%
A0A0S4ITW3 Bodo saltans 43% 90%
A0A0S4J0T6 Bodo saltans 30% 96%
A0A0S4JP22 Bodo saltans 29% 100%
A0A1X0P1Z0 Trypanosomatidae 50% 100%
A0A3Q8IFQ5 Leishmania donovani 74% 97%
A0A3Q8INM6 Leishmania donovani 27% 100%
A0A3R7NV92 Trypanosoma rangeli 29% 100%
A0A3S5IS27 Trypanosoma rangeli 50% 100%
A0A422NNI9 Trypanosoma rangeli 26% 100%
A3FIN4 Mus musculus 28% 100%
A4H7E2 Leishmania braziliensis 28% 100%
A4H7E4 Leishmania braziliensis 28% 100%
A4HAY0 Leishmania braziliensis 29% 82%
A4HVT2 Leishmania infantum 28% 100%
A4I5Q4 Leishmania infantum 75% 97%
A4IA89 Leishmania infantum 27% 100%
C9ZR23 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
D4AA47 Rattus norvegicus 28% 99%
E9B0Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 97%
E9B5B1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
G5EBH1 Caenorhabditis elegans 25% 100%
O36028 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 91%
O43520 Homo sapiens 29% 99%
O60423 Homo sapiens 28% 96%
O94296 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 99%
P32660 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 79%
P39524 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 92%
P57792 Arabidopsis thaliana 29% 100%
P98196 Homo sapiens 28% 100%
P98197 Mus musculus 27% 100%
P98198 Homo sapiens 26% 100%
P98199 Mus musculus 26% 100%
P98204 Arabidopsis thaliana 27% 100%
Q09891 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 89%
Q12675 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 77%
Q148W0 Mus musculus 28% 99%
Q4Q2M2 Leishmania major 26% 100%
Q4Q2T2 Leishmania major 28% 100%
Q4Q767 Leishmania major 75% 100%
Q4QG01 Leishmania major 28% 100%
Q6UQ17 Mus musculus 27% 93%
Q6VXY9 Leishmania donovani 28% 100%
Q8TF62 Homo sapiens 26% 100%
Q9LI83 Arabidopsis thaliana 27% 100%
Q9LK90 Arabidopsis thaliana 29% 100%
Q9LNQ4 Arabidopsis thaliana 25% 100%
Q9LVK9 Arabidopsis thaliana 26% 100%
Q9QZW0 Mus musculus 27% 100%
Q9SAF5 Arabidopsis thaliana 27% 100%
Q9SGG3 Arabidopsis thaliana 25% 100%
Q9SX33 Arabidopsis thaliana 27% 100%
Q9XIE6 Arabidopsis thaliana 28% 100%
V5BQC7 Trypanosoma cruzi 30% 100%
V5DCY9 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS