Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIF7_LEIBR

TriTrypDb:

LbrM.30.2200 , LBRM2903_300028200

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HIF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.549
CLV_NRD_NRD_1	199	201	PF00675	0.253
CLV_NRD_NRD_1	32	34	PF00675	0.541
CLV_NRD_NRD_1	91	93	PF00675	0.521
CLV_PCSK_KEX2_1	122	124	PF00082	0.549
CLV_PCSK_KEX2_1	279	281	PF00082	0.547
CLV_PCSK_KEX2_1	284	286	PF00082	0.554
CLV_PCSK_KEX2_1	303	305	PF00082	0.371
CLV_PCSK_KEX2_1	31	33	PF00082	0.492
CLV_PCSK_KEX2_1	338	340	PF00082	0.586
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.606
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.607
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.344
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.590
CLV_PCSK_PC7_1	280	286	PF00082	0.571
CLV_PCSK_SKI1_1	156	160	PF00082	0.315
CLV_PCSK_SKI1_1	191	195	PF00082	0.235
CLV_PCSK_SKI1_1	215	219	PF00082	0.342
CLV_PCSK_SKI1_1	234	238	PF00082	0.249
CLV_PCSK_SKI1_1	279	283	PF00082	0.600
CLV_PCSK_SKI1_1	320	324	PF00082	0.444
CLV_PCSK_SKI1_1	96	100	PF00082	0.371
DOC_ANK_TNKS_1	30	37	PF00023	0.468
DOC_MAPK_gen_1	137	145	PF00069	0.484
DOC_MAPK_gen_1	200	208	PF00069	0.451
DOC_MAPK_MEF2A_6	137	145	PF00069	0.543
DOC_MAPK_MEF2A_6	344	353	PF00069	0.543
DOC_MAPK_NFAT4_5	344	352	PF00069	0.626
DOC_PP4_FxxP_1	180	183	PF00568	0.453
DOC_USP7_MATH_1	126	130	PF00917	0.653
DOC_USP7_MATH_1	337	341	PF00917	0.585
DOC_USP7_UBL2_3	138	142	PF12436	0.624
DOC_USP7_UBL2_3	274	278	PF12436	0.688
DOC_USP7_UBL2_3	357	361	PF12436	0.510
DOC_WW_Pin1_4	235	240	PF00397	0.539
DOC_WW_Pin1_4	59	64	PF00397	0.603
LIG_14-3-3_CanoR_1	215	221	PF00244	0.513
LIG_14-3-3_CanoR_1	38	47	PF00244	0.512
LIG_14-3-3_CanoR_1	75	81	PF00244	0.441
LIG_14-3-3_CanoR_1	85	91	PF00244	0.457
LIG_BIR_II_1	1	5	PF00653	0.353
LIG_FHA_1	150	156	PF00498	0.456
LIG_FHA_1	179	185	PF00498	0.459
LIG_FHA_1	200	206	PF00498	0.383
LIG_FHA_1	312	318	PF00498	0.588
LIG_FHA_1	353	359	PF00498	0.641
LIG_FHA_1	4	10	PF00498	0.514
LIG_FHA_1	85	91	PF00498	0.447
LIG_FHA_2	228	234	PF00498	0.567
LIG_FHA_2	46	52	PF00498	0.434
LIG_FHA_2	53	59	PF00498	0.473
LIG_Integrin_RGD_1	133	135	PF01839	0.750
LIG_Integrin_RGD_1	264	266	PF01839	0.661
LIG_LIR_Gen_1	238	249	PF02991	0.457
LIG_LIR_Nem_3	214	220	PF02991	0.454
LIG_LIR_Nem_3	238	244	PF02991	0.457
LIG_LIR_Nem_3	73	77	PF02991	0.454
LIG_PTB_Apo_2	68	75	PF02174	0.378
LIG_SH2_STAP1	21	25	PF00017	0.392
LIG_SH2_STAP1	245	249	PF00017	0.475
LIG_SH2_STAP1	65	69	PF00017	0.514
LIG_SH2_STAT5	197	200	PF00017	0.453
LIG_TRAF2_1	12	15	PF00917	0.378
LIG_TRAF2_1	41	44	PF00917	0.412
LIG_UBA3_1	194	201	PF00899	0.449
MOD_CK1_1	106	112	PF00069	0.549
MOD_CK1_1	216	222	PF00069	0.479
MOD_CK1_1	76	82	PF00069	0.464
MOD_CK2_1	162	168	PF00069	0.435
MOD_CK2_1	227	233	PF00069	0.547
MOD_CK2_1	337	343	PF00069	0.355
MOD_CK2_1	38	44	PF00069	0.458
MOD_CK2_1	45	51	PF00069	0.529
MOD_Cter_Amidation	276	279	PF01082	0.687
MOD_GlcNHglycan	114	117	PF01048	0.545
MOD_GlcNHglycan	128	131	PF01048	0.586
MOD_GlcNHglycan	339	342	PF01048	0.573
MOD_GSK3_1	108	115	PF00069	0.540
MOD_GSK3_1	162	169	PF00069	0.544
MOD_GSK3_1	59	66	PF00069	0.597
MOD_GSK3_1	79	86	PF00069	0.322
MOD_GSK3_1	99	106	PF00069	0.482
MOD_N-GLC_1	178	183	PF02516	0.178
MOD_N-GLC_1	59	64	PF02516	0.558
MOD_N-GLC_1	70	75	PF02516	0.147
MOD_NEK2_1	107	112	PF00069	0.567
MOD_NEK2_1	162	167	PF00069	0.378
MOD_NEK2_1	227	232	PF00069	0.523
MOD_NEK2_1	25	30	PF00069	0.498
MOD_NEK2_1	325	330	PF00069	0.322
MOD_NEK2_2	70	75	PF00069	0.464
MOD_OFUCOSY	61	67	PF10250	0.332
MOD_PIKK_1	325	331	PF00454	0.540
MOD_PIKK_1	38	44	PF00454	0.539
MOD_PK_1	303	309	PF00069	0.359
MOD_PKA_1	303	309	PF00069	0.482
MOD_PKA_2	199	205	PF00069	0.388
MOD_PKA_2	227	233	PF00069	0.528
MOD_PKA_2	294	300	PF00069	0.638
MOD_PKA_2	303	309	PF00069	0.585
MOD_PKA_2	45	51	PF00069	0.559
MOD_PKA_2	84	90	PF00069	0.458
MOD_PKA_2	99	105	PF00069	0.379
MOD_Plk_1	178	184	PF00069	0.387
MOD_Plk_1	70	76	PF00069	0.378
MOD_Plk_4	103	109	PF00069	0.589
MOD_Plk_4	303	309	PF00069	0.359
MOD_Plk_4	52	58	PF00069	0.426
MOD_ProDKin_1	235	241	PF00069	0.539
MOD_ProDKin_1	59	65	PF00069	0.594
MOD_SUMO_for_1	12	15	PF00179	0.378
MOD_SUMO_for_1	283	286	PF00179	0.686
MOD_SUMO_rev_2	129	139	PF00179	0.644
TRG_DiLeu_BaEn_1	321	326	PF01217	0.525
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.539
TRG_ENDOCYTIC_2	241	244	PF00928	0.453
TRG_ER_diArg_1	290	293	PF00400	0.581
TRG_ER_diArg_1	30	33	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A3	Leptomonas seymouri	74%	99%
A0A0S4ILF0	Bodo saltans	46%	100%
A0A1X0P2R4	Trypanosomatidae	54%	100%
A0A3Q8IFW9	Leishmania donovani	82%	100%
A0A422NW52	Trypanosoma rangeli	53%	100%
A4I5Q3	Leishmania infantum	82%	100%
C9ZR22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B0Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
G0S920	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	69%
O59811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	80%
Q06709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	86%
Q4Q768	Leishmania major	82%	100%
Q8H1G5	Arabidopsis thaliana	25%	92%
Q9ZQ18	Arabidopsis thaliana	25%	94%
V5BC84	Trypanosoma cruzi	55%	100%