Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIF6_LEIBR

TriTrypDb:

LbrM.30.2190 , LBRM2903_300028100

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HIF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.672
CLV_NRD_NRD_1	173	175	PF00675	0.335
CLV_NRD_NRD_1	67	69	PF00675	0.336
CLV_PCSK_KEX2_1	127	129	PF00082	0.697
CLV_PCSK_KEX2_1	173	175	PF00082	0.335
CLV_PCSK_KEX2_1	67	69	PF00082	0.339
CLV_PCSK_SKI1_1	138	142	PF00082	0.597
CLV_PCSK_SKI1_1	143	147	PF00082	0.580
CLV_PCSK_SKI1_1	173	177	PF00082	0.259
CLV_PCSK_SKI1_1	18	22	PF00082	0.486
CLV_PCSK_SKI1_1	67	71	PF00082	0.373
CLV_PCSK_SKI1_1	97	101	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.705
DOC_CKS1_1	150	155	PF01111	0.394
DOC_MAPK_gen_1	127	136	PF00069	0.413
DOC_MAPK_gen_1	138	148	PF00069	0.371
DOC_MAPK_MEF2A_6	275	282	PF00069	0.314
DOC_PP1_RVXF_1	66	73	PF00149	0.439
DOC_PP2B_LxvP_1	293	296	PF13499	0.567
DOC_PP4_FxxP_1	78	81	PF00568	0.546
DOC_WW_Pin1_4	129	134	PF00397	0.489
DOC_WW_Pin1_4	149	154	PF00397	0.316
DOC_WW_Pin1_4	204	209	PF00397	0.610
DOC_WW_Pin1_4	23	28	PF00397	0.735
LIG_14-3-3_CanoR_1	173	182	PF00244	0.600
LIG_deltaCOP1_diTrp_1	217	222	PF00928	0.690
LIG_eIF4E_1	150	156	PF01652	0.296
LIG_FHA_1	150	156	PF00498	0.278
LIG_FHA_1	224	230	PF00498	0.595
LIG_FHA_1	99	105	PF00498	0.357
LIG_FHA_2	165	171	PF00498	0.355
LIG_FHA_2	27	33	PF00498	0.697
LIG_FHA_2	87	93	PF00498	0.545
LIG_LIR_Gen_1	164	172	PF02991	0.459
LIG_LIR_Nem_3	164	169	PF02991	0.351
LIG_MYND_1	292	296	PF01753	0.447
LIG_MYND_3	87	91	PF01753	0.672
LIG_PCNA_yPIPBox_3	138	149	PF02747	0.452
LIG_Pex14_2	162	166	PF04695	0.447
LIG_Pex14_2	74	78	PF04695	0.591
LIG_PTB_Apo_2	155	162	PF02174	0.335
LIG_PTB_Phospho_1	155	161	PF10480	0.335
LIG_SH2_CRK	150	154	PF00017	0.392
LIG_SH2_CRK	17	21	PF00017	0.641
LIG_SH2_CRK	79	83	PF00017	0.587
LIG_SH2_NCK_1	150	154	PF00017	0.392
LIG_SH2_STAP1	225	229	PF00017	0.587
LIG_SH2_STAT5	150	153	PF00017	0.398
LIG_SH2_STAT5	161	164	PF00017	0.310
LIG_SH2_STAT5	225	228	PF00017	0.589
LIG_SH2_STAT5	79	82	PF00017	0.531
LIG_SH3_3	112	118	PF00018	0.525
LIG_SH3_3	243	249	PF00018	0.414
LIG_SH3_3	46	52	PF00018	0.517
LIG_TRAF2_1	89	92	PF00917	0.538
LIG_UBA3_1	269	275	PF00899	0.285
LIG_WRC_WIRS_1	284	289	PF05994	0.441
LIG_WRC_WIRS_1	99	104	PF05994	0.335
MOD_CDK_SPK_2	204	209	PF00069	0.610
MOD_CDK_SPK_2	23	28	PF00069	0.735
MOD_CDK_SPxxK_3	204	211	PF00069	0.609
MOD_CK2_1	164	170	PF00069	0.339
MOD_CK2_1	86	92	PF00069	0.607
MOD_Cter_Amidation	65	68	PF01082	0.427
MOD_GlcNHglycan	12	15	PF01048	0.341
MOD_GlcNHglycan	187	190	PF01048	0.489
MOD_GlcNHglycan	250	253	PF01048	0.575
MOD_GlcNHglycan	262	265	PF01048	0.593
MOD_GlcNHglycan	287	290	PF01048	0.408
MOD_GlcNHglycan	37	40	PF01048	0.265
MOD_GSK3_1	113	120	PF00069	0.239
MOD_GSK3_1	185	192	PF00069	0.745
MOD_GSK3_1	238	245	PF00069	0.399
MOD_GSK3_1	93	100	PF00069	0.668
MOD_N-GLC_1	141	146	PF02516	0.666
MOD_N-GLC_1	185	190	PF02516	0.392
MOD_N-GLC_1	223	228	PF02516	0.404
MOD_NEK2_1	123	128	PF00069	0.406
MOD_NEK2_1	148	153	PF00069	0.437
MOD_NEK2_1	203	208	PF00069	0.609
MOD_NEK2_1	283	288	PF00069	0.335
MOD_NEK2_1	98	103	PF00069	0.534
MOD_NEK2_2	161	166	PF00069	0.454
MOD_PIKK_1	198	204	PF00454	0.602
MOD_PK_1	211	217	PF00069	0.583
MOD_PKA_1	173	179	PF00069	0.473
MOD_PKA_2	173	179	PF00069	0.473
MOD_PKB_1	209	217	PF00069	0.589
MOD_Plk_1	141	147	PF00069	0.486
MOD_Plk_4	141	147	PF00069	0.398
MOD_Plk_4	161	167	PF00069	0.150
MOD_Plk_4	189	195	PF00069	0.668
MOD_Plk_4	211	217	PF00069	0.710
MOD_Plk_4	255	261	PF00069	0.419
MOD_Plk_4	32	38	PF00069	0.624
MOD_Plk_4	98	104	PF00069	0.486
MOD_ProDKin_1	129	135	PF00069	0.487
MOD_ProDKin_1	149	155	PF00069	0.309
MOD_ProDKin_1	204	210	PF00069	0.609
MOD_ProDKin_1	23	29	PF00069	0.734
MOD_SUMO_for_1	20	23	PF00179	0.623
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.447
TRG_ENDOCYTIC_2	17	20	PF00928	0.705
TRG_ENDOCYTIC_2	79	82	PF00928	0.554
TRG_ER_diArg_1	127	129	PF00400	0.316
TRG_ER_diArg_1	172	174	PF00400	0.527
TRG_ER_diArg_1	208	211	PF00400	0.788
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P6	Leptomonas seymouri	71%	100%
A0A0S4IQI4	Bodo saltans	50%	100%
A0A1X0P365	Trypanosomatidae	51%	100%
A0A3Q8IC29	Leishmania donovani	82%	100%
A4I5Q2	Leishmania infantum	82%	100%
C9ZR21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B0Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q769	Leishmania major	82%	100%
V5BLB5	Trypanosoma cruzi	51%	100%