Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIF5_LEIBR

TriTrypDb:

LbrM.30.2180 , LBRM2903_300028000

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.324
CLV_NRD_NRD_1	3	5	PF00675	0.564
CLV_NRD_NRD_1	44	46	PF00675	0.557
CLV_PCSK_KEX2_1	2	4	PF00082	0.599
CLV_PCSK_KEX2_1	44	46	PF00082	0.508
CLV_PCSK_SKI1_1	4	8	PF00082	0.664
DEG_APCC_KENBOX_2	31	35	PF00400	0.411
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DOC_CYCLIN_RxL_1	1	10	PF00134	0.644
DOC_MAPK_gen_1	2	8	PF00069	0.592
DOC_PP1_RVXF_1	10	17	PF00149	0.378
DOC_PP2B_LxvP_1	231	234	PF13499	0.524
DOC_USP7_MATH_1	159	163	PF00917	0.644
DOC_USP7_MATH_1	237	241	PF00917	0.362
DOC_WW_Pin1_4	105	110	PF00397	0.709
DOC_WW_Pin1_4	124	129	PF00397	0.476
LIG_14-3-3_CanoR_1	113	120	PF00244	0.492
LIG_14-3-3_CanoR_1	140	145	PF00244	0.544
LIG_14-3-3_CterR_2	246	250	PF00244	0.409
LIG_APCC_ABBA_1	36	41	PF00400	0.463
LIG_BIR_III_4	236	240	PF00653	0.324
LIG_BRCT_BRCA1_1	162	166	PF00533	0.617
LIG_BRCT_BRCA1_1	184	188	PF00533	0.437
LIG_BRCT_BRCA1_1	70	74	PF00533	0.465
LIG_eIF4E_1	30	36	PF01652	0.566
LIG_FHA_1	8	14	PF00498	0.549
LIG_FHA_2	127	133	PF00498	0.579
LIG_FHA_2	90	96	PF00498	0.753
LIG_LIR_Apic_2	169	173	PF02991	0.424
LIG_LIR_Gen_1	117	128	PF02991	0.598
LIG_LIR_Gen_1	139	150	PF02991	0.482
LIG_LIR_Gen_1	199	208	PF02991	0.622
LIG_LIR_Nem_3	117	123	PF02991	0.605
LIG_LIR_Nem_3	139	144	PF02991	0.499
LIG_LIR_Nem_3	199	203	PF02991	0.551
LIG_LIR_Nem_3	60	66	PF02991	0.472
LIG_LYPXL_S_1	224	228	PF13949	0.284
LIG_LYPXL_yS_3	225	228	PF13949	0.282
LIG_MLH1_MIPbox_1	163	167	PF16413	0.592
LIG_PCNA_TLS_4	149	156	PF02747	0.329
LIG_Pex14_2	166	170	PF04695	0.472
LIG_SH2_STAT3	67	70	PF00017	0.377
LIG_SH2_STAT5	155	158	PF00017	0.474
LIG_SH2_STAT5	64	67	PF00017	0.399
LIG_SH3_3	106	112	PF00018	0.702
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.285
LIG_WRC_WIRS_1	141	146	PF05994	0.517
LIG_WRC_WIRS_1	197	202	PF05994	0.594
LIG_WRC_WIRS_1	245	250	PF05994	0.589
LIG_WRC_WIRS_1	66	71	PF05994	0.407
MOD_CK1_1	127	133	PF00069	0.615
MOD_CK1_1	199	205	PF00069	0.530
MOD_CK2_1	126	132	PF00069	0.445
MOD_CK2_1	14	20	PF00069	0.428
MOD_CK2_1	155	161	PF00069	0.536
MOD_CK2_1	237	243	PF00069	0.460
MOD_GlcNHglycan	15	19	PF01048	0.359
MOD_GlcNHglycan	157	160	PF01048	0.553
MOD_GlcNHglycan	70	73	PF01048	0.399
MOD_GSK3_1	155	162	PF00069	0.560
MOD_GSK3_1	178	185	PF00069	0.416
MOD_GSK3_1	85	92	PF00069	0.641
MOD_GSK3_1	96	103	PF00069	0.692
MOD_N-GLC_1	118	123	PF02516	0.401
MOD_N-GLC_1	159	164	PF02516	0.562
MOD_NEK2_1	14	19	PF00069	0.544
MOD_NEK2_1	65	70	PF00069	0.398
MOD_NEK2_1	7	12	PF00069	0.632
MOD_PIKK_1	85	91	PF00454	0.631
MOD_PKA_2	182	188	PF00069	0.450
MOD_PKA_2	55	61	PF00069	0.386
MOD_PKB_1	138	146	PF00069	0.530
MOD_Plk_2-3	79	85	PF00069	0.539
MOD_Plk_4	183	189	PF00069	0.526
MOD_Plk_4	199	205	PF00069	0.536
MOD_Plk_4	34	40	PF00069	0.409
MOD_ProDKin_1	105	111	PF00069	0.707
MOD_ProDKin_1	124	130	PF00069	0.463
MOD_SUMO_for_1	114	117	PF00179	0.762
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.376
TRG_ENDOCYTIC_2	225	228	PF00928	0.282
TRG_ENDOCYTIC_2	63	66	PF00928	0.368
TRG_ER_diArg_1	1	4	PF00400	0.608
TRG_ER_diArg_1	149	152	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P919	Leptomonas seymouri	54%	100%
A0A0N1I9X1	Leptomonas seymouri	45%	100%
A0A3S7X3I9	Leishmania donovani	77%	100%
A4I5Q1	Leishmania infantum	76%	100%
E9B0Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q770	Leishmania major	77%	100%