DUF155 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YagE family COG1723, putative

Species:

Leishmania braziliensis

UniProt:

A4HIF4_LEIBR

TriTrypDb:

LbrM.30.2170 , LBRM2903_300027900

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0016020	membrane	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HIF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.552
CLV_NRD_NRD_1	24	26	PF00675	0.543
CLV_NRD_NRD_1	268	270	PF00675	0.447
CLV_NRD_NRD_1	300	302	PF00675	0.449
CLV_NRD_NRD_1	316	318	PF00675	0.492
CLV_NRD_NRD_1	356	358	PF00675	0.392
CLV_NRD_NRD_1	392	394	PF00675	0.293
CLV_NRD_NRD_1	529	531	PF00675	0.320
CLV_NRD_NRD_1	55	57	PF00675	0.533
CLV_NRD_NRD_1	598	600	PF00675	0.361
CLV_PCSK_FUR_1	266	270	PF00082	0.508
CLV_PCSK_FUR_1	53	57	PF00082	0.558
CLV_PCSK_KEX2_1	121	123	PF00082	0.552
CLV_PCSK_KEX2_1	23	25	PF00082	0.550
CLV_PCSK_KEX2_1	268	270	PF00082	0.460
CLV_PCSK_KEX2_1	300	302	PF00082	0.449
CLV_PCSK_KEX2_1	316	318	PF00082	0.495
CLV_PCSK_KEX2_1	356	358	PF00082	0.399
CLV_PCSK_KEX2_1	528	530	PF00082	0.336
CLV_PCSK_KEX2_1	53	55	PF00082	0.539
CLV_PCSK_KEX2_1	598	600	PF00082	0.361
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.378
CLV_PCSK_PC7_1	264	270	PF00082	0.433
CLV_PCSK_PC7_1	50	56	PF00082	0.456
CLV_PCSK_SKI1_1	18	22	PF00082	0.449
CLV_PCSK_SKI1_1	268	272	PF00082	0.477
CLV_PCSK_SKI1_1	461	465	PF00082	0.331
CLV_PCSK_SKI1_1	509	513	PF00082	0.284
DEG_APCC_DBOX_1	207	215	PF00400	0.675
DEG_APCC_DBOX_1	263	271	PF00400	0.697
DEG_APCC_DBOX_1	343	351	PF00400	0.633
DEG_APCC_DBOX_1	598	606	PF00400	0.465
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DEG_SPOP_SBC_1	43	47	PF00917	0.640
DOC_CKS1_1	1	6	PF01111	0.629
DOC_CKS1_1	512	517	PF01111	0.578
DOC_CYCLIN_RxL_1	207	217	PF00134	0.687
DOC_CYCLIN_RxL_1	264	275	PF00134	0.714
DOC_CYCLIN_RxL_1	461	469	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.562
DOC_MAPK_gen_1	208	216	PF00069	0.688
DOC_MAPK_gen_1	528	540	PF00069	0.563
DOC_MAPK_MEF2A_6	208	216	PF00069	0.626
DOC_MAPK_MEF2A_6	480	487	PF00069	0.465
DOC_MAPK_RevD_3	255	269	PF00069	0.607
DOC_PP1_RVXF_1	462	469	PF00149	0.530
DOC_PP1_RVXF_1	575	581	PF00149	0.562
DOC_PP2B_LxvP_1	194	197	PF13499	0.639
DOC_PP2B_LxvP_1	70	73	PF13499	0.626
DOC_PP4_FxxP_1	115	118	PF00568	0.598
DOC_USP7_MATH_1	43	47	PF00917	0.759
DOC_USP7_MATH_1	478	482	PF00917	0.516
DOC_USP7_MATH_1	49	53	PF00917	0.779
DOC_USP7_MATH_1	544	548	PF00917	0.540
DOC_USP7_MATH_1	73	77	PF00917	0.680
DOC_WW_Pin1_4	181	186	PF00397	0.724
DOC_WW_Pin1_4	256	261	PF00397	0.579
DOC_WW_Pin1_4	443	448	PF00397	0.517
DOC_WW_Pin1_4	511	516	PF00397	0.578
LIG_14-3-3_CanoR_1	171	181	PF00244	0.778
LIG_14-3-3_CanoR_1	2	8	PF00244	0.633
LIG_14-3-3_CanoR_1	237	243	PF00244	0.620
LIG_14-3-3_CanoR_1	288	293	PF00244	0.792
LIG_14-3-3_CanoR_1	357	367	PF00244	0.598
LIG_14-3-3_CanoR_1	509	515	PF00244	0.562
LIG_14-3-3_CanoR_1	54	64	PF00244	0.771
LIG_14-3-3_CanoR_1	577	581	PF00244	0.580
LIG_14-3-3_CanoR_1	67	71	PF00244	0.769
LIG_BRCT_BRCA1_1	606	610	PF00533	0.320
LIG_Clathr_ClatBox_1	452	456	PF01394	0.411
LIG_Clathr_ClatBox_1	614	618	PF01394	0.413
LIG_deltaCOP1_diTrp_1	553	560	PF00928	0.486
LIG_EH1_1	609	617	PF00400	0.327
LIG_FHA_1	137	143	PF00498	0.756
LIG_FHA_1	207	213	PF00498	0.697
LIG_FHA_1	218	224	PF00498	0.632
LIG_FHA_1	273	279	PF00498	0.759
LIG_FHA_1	517	523	PF00498	0.569
LIG_FHA_1	621	627	PF00498	0.493
LIG_FHA_2	222	228	PF00498	0.645
LIG_FHA_2	300	306	PF00498	0.774
LIG_FHA_2	512	518	PF00498	0.591
LIG_FHA_2	81	87	PF00498	0.639
LIG_GBD_Chelix_1	612	620	PF00786	0.373
LIG_HCF-1_HBM_1	415	418	PF13415	0.508
LIG_IRF3_LxIS_1	211	217	PF10401	0.628
LIG_LIR_Apic_2	113	118	PF02991	0.723
LIG_LIR_Apic_2	469	474	PF02991	0.475
LIG_LIR_Apic_2	553	559	PF02991	0.479
LIG_LIR_Gen_1	251	260	PF02991	0.636
LIG_LIR_Gen_1	335	345	PF02991	0.524
LIG_LIR_Gen_1	375	381	PF02991	0.499
LIG_LIR_Gen_1	607	617	PF02991	0.343
LIG_LIR_Nem_3	239	245	PF02991	0.639
LIG_LIR_Nem_3	251	255	PF02991	0.649
LIG_LIR_Nem_3	335	341	PF02991	0.518
LIG_LIR_Nem_3	375	379	PF02991	0.556
LIG_LIR_Nem_3	498	503	PF02991	0.536
LIG_LIR_Nem_3	517	521	PF02991	0.409
LIG_LIR_Nem_3	607	613	PF02991	0.343
LIG_LIR_Nem_3	628	634	PF02991	0.456
LIG_MYND_1	179	183	PF01753	0.803
LIG_NRBOX	610	616	PF00104	0.362
LIG_PCNA_PIPBox_1	420	429	PF02747	0.475
LIG_PCNA_yPIPBox_3	417	427	PF02747	0.457
LIG_Pex14_1	234	238	PF04695	0.587
LIG_Pex14_1	560	564	PF04695	0.469
LIG_SH2_CRK	242	246	PF00017	0.607
LIG_SH2_CRK	252	256	PF00017	0.585
LIG_SH2_CRK	338	342	PF00017	0.521
LIG_SH2_NCK_1	338	342	PF00017	0.584
LIG_SH2_NCK_1	39	43	PF00017	0.635
LIG_SH2_NCK_1	565	569	PF00017	0.562
LIG_SH2_STAP1	238	242	PF00017	0.678
LIG_SH2_STAP1	338	342	PF00017	0.535
LIG_SH2_STAT5	238	241	PF00017	0.608
LIG_SH2_STAT5	248	251	PF00017	0.561
LIG_SH2_STAT5	418	421	PF00017	0.474
LIG_SH2_STAT5	471	474	PF00017	0.475
LIG_SH2_STAT5	499	502	PF00017	0.536
LIG_SH2_STAT5	631	634	PF00017	0.311
LIG_SH3_3	162	168	PF00018	0.664
LIG_SH3_3	177	183	PF00018	0.795
LIG_SH3_3	201	207	PF00018	0.668
LIG_SH3_3	254	260	PF00018	0.647
LIG_SH3_3	318	324	PF00018	0.754
LIG_SH3_3	438	444	PF00018	0.570
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.727
LIG_SUMO_SIM_anti_2	618	624	PF11976	0.238
LIG_SUMO_SIM_par_1	103	109	PF11976	0.633
LIG_SUMO_SIM_par_1	451	456	PF11976	0.578
LIG_SUMO_SIM_par_1	481	486	PF11976	0.491
LIG_SUMO_SIM_par_1	612	618	PF11976	0.343
LIG_TRAF2_1	13	16	PF00917	0.643
LIG_TRAF2_1	197	200	PF00917	0.638
LIG_TYR_ITIM	336	341	PF00017	0.514
LIG_UBA3_1	588	596	PF00899	0.560
LIG_WRC_WIRS_1	373	378	PF05994	0.547
LIG_WRC_WIRS_1	484	489	PF05994	0.562
MOD_CK1_1	184	190	PF00069	0.716
MOD_CK1_1	217	223	PF00069	0.620
MOD_CK1_1	251	257	PF00069	0.679
MOD_CK1_1	272	278	PF00069	0.725
MOD_CK1_1	322	328	PF00069	0.739
MOD_CK1_1	372	378	PF00069	0.514
MOD_CK1_1	576	582	PF00069	0.611
MOD_CK1_1	6	12	PF00069	0.662
MOD_CK2_1	221	227	PF00069	0.620
MOD_CK2_1	511	517	PF00069	0.591
MOD_CK2_1	80	86	PF00069	0.644
MOD_CK2_1	9	15	PF00069	0.644
MOD_Cter_Amidation	298	301	PF01082	0.499
MOD_Cter_Amidation	596	599	PF01082	0.440
MOD_GlcNHglycan	12	15	PF01048	0.483
MOD_GlcNHglycan	140	145	PF01048	0.609
MOD_GlcNHglycan	176	179	PF01048	0.539
MOD_GlcNHglycan	25	28	PF01048	0.501
MOD_GlcNHglycan	271	274	PF01048	0.394
MOD_GlcNHglycan	311	314	PF01048	0.589
MOD_GlcNHglycan	324	327	PF01048	0.491
MOD_GlcNHglycan	40	43	PF01048	0.446
MOD_GlcNHglycan	404	407	PF01048	0.318
MOD_GlcNHglycan	493	496	PF01048	0.342
MOD_GlcNHglycan	83	86	PF01048	0.573
MOD_GSK3_1	136	143	PF00069	0.722
MOD_GSK3_1	153	160	PF00069	0.761
MOD_GSK3_1	170	177	PF00069	0.723
MOD_GSK3_1	217	224	PF00069	0.613
MOD_GSK3_1	232	239	PF00069	0.606
MOD_GSK3_1	299	306	PF00069	0.810
MOD_GSK3_1	3	10	PF00069	0.690
MOD_GSK3_1	315	322	PF00069	0.742
MOD_GSK3_1	332	339	PF00069	0.440
MOD_GSK3_1	368	375	PF00069	0.504
MOD_GSK3_1	38	45	PF00069	0.674
MOD_GSK3_1	483	490	PF00069	0.500
MOD_GSK3_1	55	62	PF00069	0.687
MOD_GSK3_1	576	583	PF00069	0.620
MOD_GSK3_1	621	628	PF00069	0.326
MOD_N-GLC_1	217	222	PF02516	0.480
MOD_N-GLC_1	232	237	PF02516	0.353
MOD_N-GLC_1	571	576	PF02516	0.316
MOD_NEK2_1	172	177	PF00069	0.702
MOD_NEK2_1	214	219	PF00069	0.692
MOD_NEK2_1	232	237	PF00069	0.506
MOD_NEK2_1	286	291	PF00069	0.787
MOD_NEK2_1	368	373	PF00069	0.488
MOD_NEK2_1	379	384	PF00069	0.509
MOD_NEK2_1	404	409	PF00069	0.482
MOD_NEK2_1	44	49	PF00069	0.718
MOD_NEK2_1	485	490	PF00069	0.475
MOD_NEK2_1	491	496	PF00069	0.475
MOD_NEK2_1	5	10	PF00069	0.746
MOD_NEK2_1	620	625	PF00069	0.456
MOD_NEK2_2	349	354	PF00069	0.613
MOD_NEK2_2	544	549	PF00069	0.508
MOD_PIKK_1	157	163	PF00454	0.618
MOD_PIKK_1	307	313	PF00454	0.812
MOD_PKA_1	121	127	PF00069	0.605
MOD_PKA_1	23	29	PF00069	0.643
MOD_PKA_1	55	61	PF00069	0.720
MOD_PKA_2	121	127	PF00069	0.727
MOD_PKA_2	170	176	PF00069	0.753
MOD_PKA_2	23	29	PF00069	0.820
MOD_PKA_2	236	242	PF00069	0.627
MOD_PKA_2	287	293	PF00069	0.764
MOD_PKA_2	299	305	PF00069	0.705
MOD_PKA_2	315	321	PF00069	0.765
MOD_PKA_2	49	55	PF00069	0.787
MOD_PKA_2	576	582	PF00069	0.610
MOD_PKA_2	66	72	PF00069	0.710
MOD_PKB_1	53	61	PF00069	0.653
MOD_Plk_1	153	159	PF00069	0.782
MOD_Plk_1	16	22	PF00069	0.647
MOD_Plk_2-3	136	142	PF00069	0.675
MOD_Plk_4	251	257	PF00069	0.603
MOD_Plk_4	349	355	PF00069	0.562
MOD_Plk_4	576	582	PF00069	0.593
MOD_Plk_4	625	631	PF00069	0.388
MOD_Plk_4	66	72	PF00069	0.694
MOD_ProDKin_1	181	187	PF00069	0.724
MOD_ProDKin_1	256	262	PF00069	0.580
MOD_ProDKin_1	443	449	PF00069	0.517
MOD_ProDKin_1	511	517	PF00069	0.578
TRG_DiLeu_BaEn_1	517	522	PF01217	0.559
TRG_DiLeu_BaEn_1	66	71	PF01217	0.637
TRG_DiLeu_BaEn_4	16	22	PF01217	0.647
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.767
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.800
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.685
TRG_ENDOCYTIC_2	242	245	PF00928	0.611
TRG_ENDOCYTIC_2	252	255	PF00928	0.597
TRG_ENDOCYTIC_2	338	341	PF00928	0.515
TRG_ENDOCYTIC_2	600	603	PF00928	0.536
TRG_ENDOCYTIC_2	631	634	PF00928	0.331
TRG_ER_diArg_1	120	122	PF00400	0.742
TRG_ER_diArg_1	207	210	PF00400	0.665
TRG_ER_diArg_1	23	25	PF00400	0.745
TRG_ER_diArg_1	264	267	PF00400	0.619
TRG_ER_diArg_1	268	270	PF00400	0.652
TRG_ER_diArg_1	294	297	PF00400	0.744
TRG_ER_diArg_1	529	531	PF00400	0.564
TRG_ER_diArg_1	53	56	PF00400	0.741
TRG_ER_diArg_1	598	600	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.211

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P4	Leptomonas seymouri	60%	94%
A0A0S4IQM3	Bodo saltans	37%	100%
A0A1X0P1X6	Trypanosomatidae	46%	98%
A0A3Q8IS20	Leishmania donovani	81%	100%
A0A422NW98	Trypanosoma rangeli	42%	100%
A4I5Q0	Leishmania infantum	81%	100%
C9ZR20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9B0Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q771	Leishmania major	79%	100%
V5BGV1	Trypanosoma cruzi	43%	100%