C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania braziliensis

UniProt:

A4HIF2_LEIBR

TriTrypDb:

LbrM.30.2150 , LBRM2903_300027700

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	151	153	PF00082	0.508
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.568
CLV_PCSK_SKI1_1	113	117	PF00082	0.594
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DOC_CKS1_1	143	148	PF01111	0.576
DOC_MAPK_gen_1	42	51	PF00069	0.371
DOC_MAPK_MEF2A_6	80	87	PF00069	0.441
DOC_PP1_RVXF_1	111	117	PF00149	0.596
DOC_PP4_FxxP_1	116	119	PF00568	0.614
DOC_USP7_MATH_1	134	138	PF00917	0.524

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM2	Leptomonas seymouri	68%	99%
A0A0N1PGD1	Leptomonas seymouri	37%	94%
A0A3S7X3I3	Leishmania donovani	89%	100%
A4I5P9	Leishmania infantum	89%	100%
E9B0Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q773	Leishmania major	89%	100%

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