Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIF1_LEIBR

TriTrypDb:

LbrM.30.2140 , LBRM2903_300027600

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HIF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.616
CLV_NRD_NRD_1	415	417	PF00675	0.661
CLV_NRD_NRD_1	65	67	PF00675	0.275
CLV_PCSK_FUR_1	182	186	PF00082	0.614
CLV_PCSK_KEX2_1	182	184	PF00082	0.609
CLV_PCSK_KEX2_1	185	187	PF00082	0.627
CLV_PCSK_KEX2_1	415	417	PF00082	0.661
CLV_PCSK_SKI1_1	149	153	PF00082	0.303
CLV_PCSK_SKI1_1	276	280	PF00082	0.533
CLV_PCSK_SKI1_1	33	37	PF00082	0.329
CLV_PCSK_SKI1_1	56	60	PF00082	0.318
CLV_PCSK_SKI1_1	66	70	PF00082	0.239
CLV_PCSK_SKI1_1	88	92	PF00082	0.565
DEG_APCC_DBOX_1	275	283	PF00400	0.531
DEG_SCF_FBW7_1	242	247	PF00400	0.535
DEG_SCF_FBW7_1	286	292	PF00400	0.520
DOC_CKS1_1	286	291	PF01111	0.667
DOC_MAPK_gen_1	42	51	PF00069	0.503
DOC_PP2B_LxvP_1	258	261	PF13499	0.520
DOC_PP4_FxxP_1	200	203	PF00568	0.621
DOC_PP4_FxxP_1	322	325	PF00568	0.521
DOC_PP4_FxxP_1	392	395	PF00568	0.668
DOC_USP7_MATH_1	250	254	PF00917	0.622
DOC_USP7_MATH_1	263	267	PF00917	0.645
DOC_USP7_MATH_1	318	322	PF00917	0.569
DOC_USP7_MATH_1	334	338	PF00917	0.639
DOC_USP7_MATH_1	395	399	PF00917	0.519
DOC_WW_Pin1_4	130	135	PF00397	0.413
DOC_WW_Pin1_4	240	245	PF00397	0.560
DOC_WW_Pin1_4	285	290	PF00397	0.739
DOC_WW_Pin1_4	320	325	PF00397	0.560
DOC_WW_Pin1_4	329	334	PF00397	0.594
DOC_WW_Pin1_4	364	369	PF00397	0.569
DOC_WW_Pin1_4	391	396	PF00397	0.591
LIG_14-3-3_CanoR_1	13	21	PF00244	0.482
LIG_14-3-3_CanoR_1	257	261	PF00244	0.525
LIG_14-3-3_CanoR_1	276	286	PF00244	0.622
LIG_14-3-3_CanoR_1	430	435	PF00244	0.508
LIG_14-3-3_CanoR_1	483	492	PF00244	0.560
LIG_AP2alpha_2	390	392	PF02296	0.507
LIG_APCC_ABBA_1	21	26	PF00400	0.475
LIG_APCC_ABBA_1	48	53	PF00400	0.475
LIG_BIR_II_1	1	5	PF00653	0.399
LIG_BRCT_BRCA1_1	158	162	PF00533	0.361
LIG_BRCT_BRCA1_1	42	46	PF00533	0.503
LIG_EVH1_1	285	289	PF00568	0.514
LIG_EVH1_2	271	275	PF00568	0.582
LIG_FHA_1	208	214	PF00498	0.602
LIG_FHA_1	243	249	PF00498	0.611
LIG_FHA_1	253	259	PF00498	0.672
LIG_FHA_1	394	400	PF00498	0.521
LIG_FHA_1	407	413	PF00498	0.517
LIG_FHA_1	75	81	PF00498	0.377
LIG_FHA_2	142	148	PF00498	0.478
LIG_FHA_2	305	311	PF00498	0.529
LIG_FHA_2	447	453	PF00498	0.534
LIG_LIR_Apic_2	128	134	PF02991	0.475
LIG_LIR_Apic_2	288	294	PF02991	0.679
LIG_LIR_Apic_2	320	325	PF02991	0.516
LIG_LIR_Apic_2	390	395	PF02991	0.665
LIG_LIR_Apic_2	437	443	PF02991	0.654
LIG_LIR_Gen_1	141	148	PF02991	0.477
LIG_LIR_Gen_1	75	82	PF02991	0.479
LIG_LIR_Nem_3	117	121	PF02991	0.473
LIG_LIR_Nem_3	133	139	PF02991	0.558
LIG_LIR_Nem_3	141	145	PF02991	0.522
LIG_LIR_Nem_3	25	30	PF02991	0.579
LIG_LIR_Nem_3	356	361	PF02991	0.533
LIG_LIR_Nem_3	43	49	PF02991	0.494
LIG_LIR_Nem_3	75	79	PF02991	0.533
LIG_MLH1_MIPbox_1	158	162	PF16413	0.361
LIG_PCNA_PIPBox_1	108	117	PF02747	0.503
LIG_PCNA_yPIPBox_3	108	116	PF02747	0.500
LIG_Pex14_2	114	118	PF04695	0.503
LIG_PTB_Apo_2	117	124	PF02174	0.475
LIG_PTB_Apo_2	261	268	PF02174	0.534
LIG_PTB_Phospho_1	117	123	PF10480	0.475
LIG_SH2_CRK	131	135	PF00017	0.475
LIG_SH2_CRK	291	295	PF00017	0.521
LIG_SH2_CRK	61	65	PF00017	0.472
LIG_SH2_NCK_1	142	146	PF00017	0.475
LIG_SH2_NCK_1	291	295	PF00017	0.598
LIG_SH2_PTP2	440	443	PF00017	0.498
LIG_SH2_SRC	440	443	PF00017	0.589
LIG_SH2_STAT5	123	126	PF00017	0.503
LIG_SH2_STAT5	161	164	PF00017	0.488
LIG_SH2_STAT5	304	307	PF00017	0.536
LIG_SH2_STAT5	378	381	PF00017	0.499
LIG_SH2_STAT5	421	424	PF00017	0.679
LIG_SH2_STAT5	440	443	PF00017	0.460
LIG_SH2_STAT5	98	101	PF00017	0.503
LIG_SH3_2	271	276	PF14604	0.516
LIG_SH3_3	268	274	PF00018	0.660
LIG_SH3_3	283	289	PF00018	0.519
LIG_SH3_3	322	328	PF00018	0.670
LIG_SH3_3	376	382	PF00018	0.493
LIG_SH3_3	76	82	PF00018	0.374
LIG_Sin3_3	338	345	PF02671	0.513
LIG_SUMO_SIM_anti_2	367	373	PF11976	0.647
LIG_SUMO_SIM_par_1	337	344	PF11976	0.523
LIG_SUMO_SIM_par_1	367	373	PF11976	0.653
LIG_TRAF2_1	475	478	PF00917	0.529
LIG_TRFH_1	378	382	PF08558	0.658
LIG_WRC_WIRS_1	115	120	PF05994	0.468
LIG_WRC_WIRS_1	319	324	PF05994	0.471
MOD_CK1_1	209	215	PF00069	0.633
MOD_CK1_1	231	237	PF00069	0.542
MOD_CK1_1	320	326	PF00069	0.585
MOD_CK1_1	394	400	PF00069	0.602
MOD_CK1_1	406	412	PF00069	0.662
MOD_CK1_1	435	441	PF00069	0.562
MOD_CK2_1	304	310	PF00069	0.538
MOD_CK2_1	436	442	PF00069	0.501
MOD_Cter_Amidation	413	416	PF01082	0.541
MOD_GlcNHglycan	195	198	PF01048	0.608
MOD_GlcNHglycan	30	33	PF01048	0.301
MOD_GlcNHglycan	310	313	PF01048	0.524
MOD_GlcNHglycan	336	339	PF01048	0.581
MOD_GlcNHglycan	343	346	PF01048	0.602
MOD_GlcNHglycan	422	425	PF01048	0.790
MOD_GSK3_1	212	219	PF00069	0.644
MOD_GSK3_1	224	231	PF00069	0.701
MOD_GSK3_1	240	247	PF00069	0.703
MOD_GSK3_1	252	259	PF00069	0.537
MOD_GSK3_1	285	292	PF00069	0.723
MOD_GSK3_1	304	311	PF00069	0.548
MOD_GSK3_1	320	327	PF00069	0.590
MOD_GSK3_1	343	350	PF00069	0.686
MOD_GSK3_1	360	367	PF00069	0.564
MOD_GSK3_1	390	397	PF00069	0.605
MOD_GSK3_1	401	408	PF00069	0.607
MOD_GSK3_1	420	427	PF00069	0.710
MOD_GSK3_1	432	439	PF00069	0.704
MOD_GSK3_1	446	453	PF00069	0.569
MOD_GSK3_1	483	490	PF00069	0.639
MOD_N-GLC_1	13	18	PF02516	0.282
MOD_N-GLC_1	157	162	PF02516	0.399
MOD_N-GLC_1	361	366	PF02516	0.599
MOD_N-GLC_1	385	390	PF02516	0.496
MOD_NEK2_1	114	119	PF00069	0.485
MOD_NEK2_1	162	167	PF00069	0.502
MOD_NEK2_1	308	313	PF00069	0.540
MOD_NEK2_1	341	346	PF00069	0.572
MOD_NEK2_1	360	365	PF00069	0.468
MOD_PIKK_1	186	192	PF00454	0.503
MOD_PIKK_1	224	230	PF00454	0.580
MOD_PIKK_1	280	286	PF00454	0.595
MOD_PIKK_1	403	409	PF00454	0.606
MOD_PK_1	430	436	PF00069	0.509
MOD_PKA_1	66	72	PF00069	0.451
MOD_PKA_2	250	256	PF00069	0.673
MOD_PKA_2	482	488	PF00069	0.580
MOD_PKB_1	184	192	PF00069	0.500
MOD_Plk_1	157	163	PF00069	0.605
MOD_Plk_1	280	286	PF00069	0.522
MOD_Plk_1	436	442	PF00069	0.710
MOD_Plk_1	459	465	PF00069	0.669
MOD_Plk_2-3	141	147	PF00069	0.503
MOD_Plk_4	157	163	PF00069	0.577
MOD_Plk_4	407	413	PF00069	0.677
MOD_Plk_4	424	430	PF00069	0.500
MOD_Plk_4	436	442	PF00069	0.473
MOD_ProDKin_1	130	136	PF00069	0.413
MOD_ProDKin_1	240	246	PF00069	0.559
MOD_ProDKin_1	285	291	PF00069	0.742
MOD_ProDKin_1	320	326	PF00069	0.564
MOD_ProDKin_1	329	335	PF00069	0.592
MOD_ProDKin_1	364	370	PF00069	0.570
MOD_ProDKin_1	391	397	PF00069	0.592
MOD_SUMO_for_1	170	173	PF00179	0.406
MOD_SUMO_rev_2	141	151	PF00179	0.475
MOD_SUMO_rev_2	173	181	PF00179	0.423
MOD_SUMO_rev_2	233	243	PF00179	0.691
MOD_SUMO_rev_2	52	58	PF00179	0.529
TRG_DiLeu_BaEn_4	92	98	PF01217	0.448
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.639
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.485
TRG_ENDOCYTIC_2	123	126	PF00928	0.503
TRG_ENDOCYTIC_2	142	145	PF00928	0.503
TRG_ENDOCYTIC_2	61	64	PF00928	0.503
TRG_ER_diArg_1	182	185	PF00400	0.604
TRG_NLS_MonoExtC_3	178	183	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q0	Leptomonas seymouri	56%	100%
A0A3Q8II02	Leishmania donovani	70%	99%
A4I5P8	Leishmania infantum	70%	99%
E9B0Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q774	Leishmania major	67%	99%