RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HIF0_LEIBR

TriTrypDb:

LbrM.30.2130 , LBRM2903_300027500

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HIF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIF0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.598
CLV_PCSK_FUR_1	181	185	PF00082	0.597
CLV_PCSK_KEX2_1	180	182	PF00082	0.592
CLV_PCSK_KEX2_1	183	185	PF00082	0.573
CLV_PCSK_KEX2_1	186	188	PF00082	0.542
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.592
CLV_PCSK_PC7_1	181	187	PF00082	0.600
CLV_PCSK_SKI1_1	14	18	PF00082	0.332
CLV_PCSK_SKI1_1	150	154	PF00082	0.395
CLV_PCSK_SKI1_1	34	38	PF00082	0.199
DEG_SCF_FBW7_1	347	354	PF00400	0.674
DEG_SCF_FBW7_1	416	422	PF00400	0.681
DEG_SIAH_1	412	420	PF03145	0.675
DEG_SPOP_SBC_1	419	423	PF00917	0.686
DOC_CKS1_1	304	309	PF01111	0.535
DOC_CKS1_1	356	361	PF01111	0.669
DOC_CKS1_1	393	398	PF01111	0.679
DOC_CKS1_1	416	421	PF01111	0.679
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.643
DOC_MAPK_gen_1	43	52	PF00069	0.532
DOC_MAPK_gen_1	64	72	PF00069	0.532
DOC_PP2B_LxvP_1	227	230	PF13499	0.670
DOC_PP2B_LxvP_1	485	488	PF13499	0.667
DOC_USP7_MATH_1	152	156	PF00917	0.517
DOC_USP7_MATH_1	202	206	PF00917	0.593
DOC_USP7_MATH_1	253	257	PF00917	0.563
DOC_USP7_MATH_1	351	355	PF00917	0.674
DOC_USP7_MATH_1	405	409	PF00917	0.615
DOC_USP7_MATH_1	419	423	PF00917	0.655
DOC_USP7_MATH_1	432	436	PF00917	0.552
DOC_USP7_UBL2_3	85	89	PF12436	0.615
DOC_WW_Pin1_4	225	230	PF00397	0.597
DOC_WW_Pin1_4	242	247	PF00397	0.594
DOC_WW_Pin1_4	267	272	PF00397	0.544
DOC_WW_Pin1_4	286	291	PF00397	0.491
DOC_WW_Pin1_4	303	308	PF00397	0.571
DOC_WW_Pin1_4	313	318	PF00397	0.660
DOC_WW_Pin1_4	347	352	PF00397	0.671
DOC_WW_Pin1_4	355	360	PF00397	0.597
DOC_WW_Pin1_4	392	397	PF00397	0.680
DOC_WW_Pin1_4	401	406	PF00397	0.601
DOC_WW_Pin1_4	415	420	PF00397	0.646
DOC_WW_Pin1_4	428	433	PF00397	0.551
DOC_WW_Pin1_4	455	460	PF00397	0.677
LIG_14-3-3_CanoR_1	14	21	PF00244	0.532
LIG_14-3-3_CanoR_1	479	485	PF00244	0.519
LIG_BRCT_BRCA1_1	258	262	PF00533	0.640
LIG_BRCT_BRCA1_1	265	269	PF00533	0.668
LIG_BRCT_BRCA1_1	315	319	PF00533	0.646
LIG_BRCT_BRCA1_1	320	324	PF00533	0.667
LIG_BRCT_BRCA1_1	43	47	PF00533	0.532
LIG_eIF4E_1	439	445	PF01652	0.589
LIG_FHA_1	292	298	PF00498	0.681
LIG_FHA_1	304	310	PF00498	0.754
LIG_FHA_1	392	398	PF00498	0.538
LIG_FHA_1	439	445	PF00498	0.573
LIG_FHA_1	76	82	PF00498	0.307
LIG_FHA_2	15	21	PF00498	0.532
LIG_FHA_2	246	252	PF00498	0.679
LIG_GSK3_LRP6_1	303	308	PF00069	0.526
LIG_IBAR_NPY_1	412	414	PF08397	0.670
LIG_LIR_Gen_1	123	132	PF02991	0.532
LIG_LIR_Gen_1	142	149	PF02991	0.406
LIG_LIR_Gen_1	259	269	PF02991	0.671
LIG_LIR_Gen_1	321	331	PF02991	0.793
LIG_LIR_Gen_1	60	70	PF02991	0.532
LIG_LIR_Nem_3	135	140	PF02991	0.532
LIG_LIR_Nem_3	142	146	PF02991	0.486
LIG_LIR_Nem_3	22	28	PF02991	0.493
LIG_LIR_Nem_3	259	265	PF02991	0.672
LIG_LIR_Nem_3	321	327	PF02991	0.672
LIG_LIR_Nem_3	342	347	PF02991	0.666
LIG_LIR_Nem_3	44	50	PF02991	0.532
LIG_LIR_Nem_3	60	65	PF02991	0.426
LIG_PCNA_PIPBox_1	1	10	PF02747	0.474
LIG_PCNA_PIPBox_1	109	118	PF02747	0.532
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.532
LIG_Pex14_2	115	119	PF04695	0.532
LIG_Pex14_2	337	341	PF04695	0.684
LIG_PTAP_UEV_1	439	444	PF05743	0.644
LIG_PTB_Apo_2	323	330	PF02174	0.665
LIG_PTB_Apo_2	443	450	PF02174	0.604
LIG_PTB_Apo_2	470	477	PF02174	0.679
LIG_SH2_CRK	414	418	PF00017	0.677
LIG_SH2_GRB2like	162	165	PF00017	0.485
LIG_SH2_NCK_1	143	147	PF00017	0.517
LIG_SH2_NCK_1	414	418	PF00017	0.677
LIG_SH2_SRC	173	176	PF00017	0.640
LIG_SH2_SRC	414	417	PF00017	0.678
LIG_SH2_STAT5	124	127	PF00017	0.568
LIG_SH2_STAT5	162	165	PF00017	0.628
LIG_SH2_STAT5	484	487	PF00017	0.671
LIG_SH2_STAT5	99	102	PF00017	0.573
LIG_SH3_1	353	359	PF00018	0.673
LIG_SH3_1	410	416	PF00018	0.674
LIG_SH3_3	226	232	PF00018	0.649
LIG_SH3_3	275	281	PF00018	0.620
LIG_SH3_3	284	290	PF00018	0.634
LIG_SH3_3	301	307	PF00018	0.511
LIG_SH3_3	353	359	PF00018	0.673
LIG_SH3_3	410	416	PF00018	0.532
LIG_SH3_3	426	432	PF00018	0.524
LIG_SH3_3	437	443	PF00018	0.541
LIG_SH3_3	456	462	PF00018	0.498
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.475
LIG_TRAF2_1	91	94	PF00917	0.554
MOD_CDC14_SPxK_1	270	273	PF00782	0.552
MOD_CDK_SPxK_1	267	273	PF00069	0.548
MOD_CDK_SPxK_1	347	353	PF00069	0.674
MOD_CDK_SPxxK_3	242	249	PF00069	0.575
MOD_CDK_SPxxK_3	392	399	PF00069	0.682
MOD_CK1_1	148	154	PF00069	0.517
MOD_CK1_1	256	262	PF00069	0.565
MOD_CK1_1	379	385	PF00069	0.528
MOD_CK1_1	401	407	PF00069	0.704
MOD_CK1_1	422	428	PF00069	0.544
MOD_CK2_1	105	111	PF00069	0.587
MOD_CK2_1	241	247	PF00069	0.661
MOD_GlcNHglycan	147	150	PF01048	0.332
MOD_GlcNHglycan	320	323	PF01048	0.600
MOD_GlcNHglycan	369	373	PF01048	0.784
MOD_GlcNHglycan	387	391	PF01048	0.552
MOD_GlcNHglycan	405	408	PF01048	0.510
MOD_GSK3_1	128	135	PF00069	0.450
MOD_GSK3_1	148	155	PF00069	0.450
MOD_GSK3_1	198	205	PF00069	0.616
MOD_GSK3_1	235	242	PF00069	0.645
MOD_GSK3_1	252	259	PF00069	0.530
MOD_GSK3_1	263	270	PF00069	0.533
MOD_GSK3_1	291	298	PF00069	0.724
MOD_GSK3_1	313	320	PF00069	0.564
MOD_GSK3_1	325	332	PF00069	0.536
MOD_GSK3_1	347	354	PF00069	0.674
MOD_GSK3_1	37	44	PF00069	0.532
MOD_GSK3_1	397	404	PF00069	0.795
MOD_GSK3_1	415	422	PF00069	0.513
MOD_GSK3_1	423	430	PF00069	0.606
MOD_N-GLC_1	14	19	PF02516	0.332
MOD_N-GLC_1	163	168	PF02516	0.541
MOD_N-GLC_1	222	227	PF02516	0.531
MOD_N-GLC_1	242	247	PF02516	0.573
MOD_N-GLC_1	325	330	PF02516	0.677
MOD_N-GLC_1	332	337	PF02516	0.675
MOD_N-GLC_1	339	344	PF02516	0.612
MOD_N-GLC_1	360	365	PF02516	0.687
MOD_N-GLC_1	401	406	PF02516	0.684
MOD_N-GLC_1	480	485	PF02516	0.518
MOD_N-GLC_1	65	70	PF02516	0.332
MOD_N-GLC_2	376	378	PF02516	0.548
MOD_NEK2_1	105	110	PF00069	0.517
MOD_NEK2_1	163	168	PF00069	0.495
MOD_NEK2_1	325	330	PF00069	0.713
MOD_NEK2_1	360	365	PF00069	0.729
MOD_NEK2_1	368	373	PF00069	0.701
MOD_NEK2_1	37	42	PF00069	0.532
MOD_NEK2_1	386	391	PF00069	0.555
MOD_NEK2_1	433	438	PF00069	0.670
MOD_NEK2_1	449	454	PF00069	0.521
MOD_NEK2_1	65	70	PF00069	0.532
MOD_NEK2_2	152	157	PF00069	0.517
MOD_PIKK_1	105	111	PF00454	0.532
MOD_PIKK_1	253	259	PF00454	0.567
MOD_PK_1	128	134	PF00069	0.431
MOD_PKA_2	398	404	PF00069	0.682
MOD_Plk_1	128	134	PF00069	0.431
MOD_Plk_1	163	169	PF00069	0.532
MOD_Plk_1	222	228	PF00069	0.531
MOD_Plk_1	235	241	PF00069	0.565
MOD_Plk_1	325	331	PF00069	0.603
MOD_Plk_1	332	338	PF00069	0.566
MOD_Plk_1	339	345	PF00069	0.539
MOD_Plk_1	360	366	PF00069	0.677
MOD_Plk_1	480	486	PF00069	0.520
MOD_Plk_1	65	71	PF00069	0.547
MOD_Plk_2-3	142	148	PF00069	0.532
MOD_Plk_4	132	138	PF00069	0.539
MOD_Plk_4	222	228	PF00069	0.531
MOD_Plk_4	305	311	PF00069	0.712
MOD_Plk_4	320	326	PF00069	0.708
MOD_Plk_4	480	486	PF00069	0.520
MOD_ProDKin_1	225	231	PF00069	0.597
MOD_ProDKin_1	242	248	PF00069	0.595
MOD_ProDKin_1	267	273	PF00069	0.548
MOD_ProDKin_1	286	292	PF00069	0.495
MOD_ProDKin_1	303	309	PF00069	0.575
MOD_ProDKin_1	313	319	PF00069	0.661
MOD_ProDKin_1	347	353	PF00069	0.674
MOD_ProDKin_1	355	361	PF00069	0.597
MOD_ProDKin_1	392	398	PF00069	0.680
MOD_ProDKin_1	401	407	PF00069	0.603
MOD_ProDKin_1	415	421	PF00069	0.648
MOD_ProDKin_1	428	434	PF00069	0.552
MOD_ProDKin_1	455	461	PF00069	0.675
MOD_SUMO_for_1	179	182	PF00179	0.445
MOD_SUMO_rev_2	84	91	PF00179	0.554
MOD_SUMO_rev_2	93	98	PF00179	0.408
TRG_DiLeu_BaEn_2	110	116	PF01217	0.532
TRG_DiLeu_BaEn_4	93	99	PF01217	0.479
TRG_ENDOCYTIC_2	124	127	PF00928	0.552
TRG_ENDOCYTIC_2	143	146	PF00928	0.492
TRG_ENDOCYTIC_2	344	347	PF00928	0.678
TRG_ENDOCYTIC_2	414	417	PF00928	0.678
TRG_ENDOCYTIC_2	62	65	PF00928	0.532
TRG_ER_diArg_1	183	186	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L2	Leishmania donovani	72%	99%
A4I5P7	Leishmania infantum	72%	99%
E9B0Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q775	Leishmania major	73%	99%