Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIE8_LEIBR

TriTrypDb:

LbrM.30.2110 , LBRM2903_300027300

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	544	548	PF00656	0.669
CLV_C14_Caspase3-7	551	555	PF00656	0.692
CLV_NRD_NRD_1	384	386	PF00675	0.545
CLV_NRD_NRD_1	404	406	PF00675	0.625
CLV_NRD_NRD_1	465	467	PF00675	0.604
CLV_NRD_NRD_1	597	599	PF00675	0.562
CLV_NRD_NRD_1	603	605	PF00675	0.541
CLV_PCSK_KEX2_1	384	386	PF00082	0.545
CLV_PCSK_KEX2_1	421	423	PF00082	0.607
CLV_PCSK_KEX2_1	465	467	PF00082	0.604
CLV_PCSK_KEX2_1	603	605	PF00082	0.555
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.601
CLV_PCSK_SKI1_1	167	171	PF00082	0.411
CLV_PCSK_SKI1_1	29	33	PF00082	0.510
CLV_PCSK_SKI1_1	311	315	PF00082	0.510
CLV_PCSK_SKI1_1	418	422	PF00082	0.562
CLV_Separin_Metazoa	415	419	PF03568	0.428
DEG_APCC_DBOX_1	302	310	PF00400	0.516
DEG_Nend_UBRbox_2	1	3	PF02207	0.717
DEG_SCF_FBW7_1	247	253	PF00400	0.468
DEG_SCF_FBW7_1	25	30	PF00400	0.488
DOC_CKS1_1	247	252	PF01111	0.469
DOC_CKS1_1	34	39	PF01111	0.522
DOC_CKS1_1	562	567	PF01111	0.677
DOC_MAPK_MEF2A_6	568	577	PF00069	0.477
DOC_MAPK_MEF2A_6	62	70	PF00069	0.561
DOC_PP1_RVXF_1	369	375	PF00149	0.461
DOC_PP2B_LxvP_1	327	330	PF13499	0.414
DOC_PP2B_LxvP_1	479	482	PF13499	0.545
DOC_PP4_FxxP_1	257	260	PF00568	0.627
DOC_PP4_FxxP_1	34	37	PF00568	0.522
DOC_USP7_MATH_1	119	123	PF00917	0.502
DOC_USP7_MATH_1	207	211	PF00917	0.467
DOC_USP7_MATH_1	236	240	PF00917	0.744
DOC_USP7_MATH_1	250	254	PF00917	0.552
DOC_USP7_MATH_1	260	264	PF00917	0.545
DOC_USP7_MATH_1	355	359	PF00917	0.547
DOC_USP7_MATH_1	388	392	PF00917	0.487
DOC_USP7_MATH_1	454	458	PF00917	0.795
DOC_USP7_MATH_1	482	486	PF00917	0.635
DOC_USP7_MATH_1	51	55	PF00917	0.506
DOC_USP7_MATH_1	534	538	PF00917	0.569
DOC_USP7_MATH_1	611	615	PF00917	0.586
DOC_WW_Pin1_4	23	28	PF00397	0.618
DOC_WW_Pin1_4	246	251	PF00397	0.650
DOC_WW_Pin1_4	33	38	PF00397	0.617
DOC_WW_Pin1_4	41	46	PF00397	0.598
DOC_WW_Pin1_4	532	537	PF00397	0.643
DOC_WW_Pin1_4	561	566	PF00397	0.651
LIG_14-3-3_CanoR_1	134	140	PF00244	0.480
LIG_14-3-3_CanoR_1	192	199	PF00244	0.507
LIG_14-3-3_CanoR_1	243	248	PF00244	0.515
LIG_14-3-3_CanoR_1	265	273	PF00244	0.443
LIG_14-3-3_CanoR_1	357	361	PF00244	0.479
LIG_14-3-3_CanoR_1	445	451	PF00244	0.553
LIG_14-3-3_CanoR_1	465	475	PF00244	0.500
LIG_14-3-3_CanoR_1	488	493	PF00244	0.543
LIG_14-3-3_CanoR_1	520	524	PF00244	0.664
LIG_Actin_WH2_2	190	208	PF00022	0.592
LIG_Actin_WH2_2	369	386	PF00022	0.495
LIG_BIR_III_4	558	562	PF00653	0.571
LIG_Clathr_ClatBox_1	226	230	PF01394	0.631
LIG_DLG_GKlike_1	488	495	PF00625	0.451
LIG_eIF4E_1	312	318	PF01652	0.491
LIG_FHA_1	119	125	PF00498	0.571
LIG_FHA_1	127	133	PF00498	0.510
LIG_FHA_1	159	165	PF00498	0.568
LIG_FHA_1	168	174	PF00498	0.427
LIG_FHA_1	192	198	PF00498	0.607
LIG_FHA_1	243	249	PF00498	0.598
LIG_FHA_1	280	286	PF00498	0.514
LIG_FHA_1	313	319	PF00498	0.507
LIG_FHA_1	371	377	PF00498	0.462
LIG_FHA_1	378	384	PF00498	0.488
LIG_FHA_1	591	597	PF00498	0.620
LIG_FHA_1	63	69	PF00498	0.552
LIG_FHA_1	75	81	PF00498	0.588
LIG_FHA_1	95	101	PF00498	0.411
LIG_FHA_2	339	345	PF00498	0.543
LIG_FHA_2	360	366	PF00498	0.548
LIG_FHA_2	395	401	PF00498	0.629
LIG_FHA_2	42	48	PF00498	0.674
LIG_FHA_2	540	546	PF00498	0.731
LIG_FHA_2	549	555	PF00498	0.675
LIG_FHA_2	564	570	PF00498	0.527
LIG_FHA_2	576	582	PF00498	0.501
LIG_FHA_2	59	65	PF00498	0.479
LIG_FHA_2	634	640	PF00498	0.566
LIG_LIR_Apic_2	522	526	PF02991	0.702
LIG_LIR_Gen_1	125	135	PF02991	0.669
LIG_LIR_Gen_1	291	296	PF02991	0.473
LIG_LIR_Gen_1	425	434	PF02991	0.487
LIG_LIR_Nem_3	125	130	PF02991	0.668
LIG_LIR_Nem_3	291	295	PF02991	0.462
LIG_LIR_Nem_3	425	430	PF02991	0.479
LIG_NRBOX	579	585	PF00104	0.484
LIG_Pex14_2	84	88	PF04695	0.511
LIG_SH2_CRK	292	296	PF00017	0.466
LIG_SH2_NCK_1	234	238	PF00017	0.479
LIG_SH2_PTP2	301	304	PF00017	0.573
LIG_SH2_STAP1	292	296	PF00017	0.466
LIG_SH2_STAT5	176	179	PF00017	0.562
LIG_SH2_STAT5	301	304	PF00017	0.718
LIG_SH2_STAT5	312	315	PF00017	0.497
LIG_SH2_STAT5	35	38	PF00017	0.521
LIG_SH3_3	120	126	PF00018	0.428
LIG_SH3_3	137	143	PF00018	0.543
LIG_SH3_3	193	199	PF00018	0.500
LIG_SH3_3	219	225	PF00018	0.522
LIG_SH3_3	244	250	PF00018	0.470
LIG_SH3_3	299	305	PF00018	0.526
LIG_SH3_3	390	396	PF00018	0.653
LIG_SH3_3	478	484	PF00018	0.459
LIG_SH3_3	559	565	PF00018	0.711
LIG_SH3_3	589	595	PF00018	0.537
LIG_SUMO_SIM_anti_2	578	584	PF11976	0.637
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.665
LIG_SUMO_SIM_par_1	128	133	PF11976	0.594
LIG_SUMO_SIM_par_1	63	72	PF11976	0.559
LIG_TRAF2_1	361	364	PF00917	0.543
LIG_TRAF2_1	61	64	PF00917	0.636
LIG_TYR_ITIM	217	222	PF00017	0.508
LIG_UBA3_1	66	73	PF00899	0.468
LIG_WW_2	140	143	PF00397	0.498
MOD_CDK_SPK_2	41	46	PF00069	0.541
MOD_CDK_SPxK_1	23	29	PF00069	0.560
MOD_CDK_SPxxK_3	561	568	PF00069	0.531
MOD_CK1_1	246	252	PF00069	0.622
MOD_CK1_1	263	269	PF00069	0.502
MOD_CK1_1	359	365	PF00069	0.462
MOD_CK1_1	448	454	PF00069	0.801
MOD_CK1_1	457	463	PF00069	0.645
MOD_CK1_1	543	549	PF00069	0.687
MOD_CK1_1	552	558	PF00069	0.689
MOD_CK1_1	607	613	PF00069	0.644
MOD_CK2_1	119	125	PF00069	0.574
MOD_CK2_1	359	365	PF00069	0.611
MOD_CK2_1	394	400	PF00069	0.629
MOD_CK2_1	41	47	PF00069	0.692
MOD_CK2_1	436	442	PF00069	0.682
MOD_CK2_1	487	493	PF00069	0.683
MOD_CK2_1	539	545	PF00069	0.677
MOD_CK2_1	563	569	PF00069	0.640
MOD_CK2_1	575	581	PF00069	0.485
MOD_CK2_1	58	64	PF00069	0.557
MOD_CK2_1	633	639	PF00069	0.558
MOD_CK2_1	647	653	PF00069	0.616
MOD_DYRK1A_RPxSP_1	532	536	PF00069	0.641
MOD_GlcNHglycan	238	241	PF01048	0.565
MOD_GlcNHglycan	252	255	PF01048	0.528
MOD_GlcNHglycan	262	265	PF01048	0.640
MOD_GlcNHglycan	266	269	PF01048	0.479
MOD_GlcNHglycan	296	299	PF01048	0.687
MOD_GlcNHglycan	324	327	PF01048	0.673
MOD_GlcNHglycan	350	353	PF01048	0.513
MOD_GlcNHglycan	4	7	PF01048	0.495
MOD_GlcNHglycan	438	441	PF01048	0.580
MOD_GlcNHglycan	450	453	PF01048	0.760
MOD_GlcNHglycan	456	459	PF01048	0.586
MOD_GlcNHglycan	468	471	PF01048	0.476
MOD_GlcNHglycan	551	554	PF01048	0.612
MOD_GlcNHglycan	609	612	PF01048	0.581
MOD_GlcNHglycan	97	100	PF01048	0.473
MOD_GSK3_1	114	121	PF00069	0.509
MOD_GSK3_1	126	133	PF00069	0.519
MOD_GSK3_1	23	30	PF00069	0.501
MOD_GSK3_1	242	249	PF00069	0.486
MOD_GSK3_1	260	267	PF00069	0.538
MOD_GSK3_1	318	325	PF00069	0.574
MOD_GSK3_1	338	345	PF00069	0.556
MOD_GSK3_1	355	362	PF00069	0.503
MOD_GSK3_1	483	490	PF00069	0.617
MOD_GSK3_1	521	528	PF00069	0.824
MOD_GSK3_1	534	541	PF00069	0.629
MOD_GSK3_1	545	552	PF00069	0.747
MOD_GSK3_1	58	65	PF00069	0.569
MOD_GSK3_1	590	597	PF00069	0.803
MOD_GSK3_1	607	614	PF00069	0.579
MOD_N-GLC_2	137	139	PF02516	0.639
MOD_NEK2_1	130	135	PF00069	0.596
MOD_NEK2_1	294	299	PF00069	0.455
MOD_NEK2_1	338	343	PF00069	0.467
MOD_NEK2_1	370	375	PF00069	0.497
MOD_NEK2_1	436	441	PF00069	0.512
MOD_NEK2_1	519	524	PF00069	0.557
MOD_NEK2_1	539	544	PF00069	0.844
MOD_PIKK_1	312	318	PF00454	0.567
MOD_PK_1	243	249	PF00069	0.482
MOD_PKA_2	149	155	PF00069	0.609
MOD_PKA_2	191	197	PF00069	0.528
MOD_PKA_2	242	248	PF00069	0.651
MOD_PKA_2	264	270	PF00069	0.447
MOD_PKA_2	356	362	PF00069	0.482
MOD_PKA_2	377	383	PF00069	0.480
MOD_PKA_2	487	493	PF00069	0.539
MOD_PKA_2	519	525	PF00069	0.697
MOD_Plk_1	130	136	PF00069	0.614
MOD_Plk_1	150	156	PF00069	0.424
MOD_Plk_1	400	406	PF00069	0.639
MOD_Plk_1	425	431	PF00069	0.483
MOD_Plk_1	51	57	PF00069	0.582
MOD_Plk_1	62	68	PF00069	0.507
MOD_Plk_2-3	426	432	PF00069	0.645
MOD_Plk_2-3	613	619	PF00069	0.604
MOD_Plk_4	119	125	PF00069	0.447
MOD_Plk_4	208	214	PF00069	0.578
MOD_Plk_4	243	249	PF00069	0.482
MOD_Plk_4	388	394	PF00069	0.502
MOD_Plk_4	408	414	PF00069	0.449
MOD_Plk_4	534	540	PF00069	0.561
MOD_Plk_4	62	68	PF00069	0.622
MOD_ProDKin_1	23	29	PF00069	0.621
MOD_ProDKin_1	246	252	PF00069	0.653
MOD_ProDKin_1	33	39	PF00069	0.619
MOD_ProDKin_1	41	47	PF00069	0.598
MOD_ProDKin_1	532	538	PF00069	0.644
MOD_ProDKin_1	561	567	PF00069	0.647
MOD_SUMO_for_1	420	423	PF00179	0.596
TRG_AP2beta_CARGO_1	125	134	PF09066	0.593
TRG_DiLeu_BaEn_1	291	296	PF01217	0.428
TRG_DiLeu_BaEn_1	569	574	PF01217	0.635
TRG_DiLeu_BaEn_1	579	584	PF01217	0.536
TRG_DiLeu_BaEn_1	63	68	PF01217	0.563
TRG_DiLeu_BaEn_2	475	481	PF01217	0.445
TRG_DiLeu_BaEn_4	363	369	PF01217	0.565
TRG_ENDOCYTIC_2	219	222	PF00928	0.670
TRG_ENDOCYTIC_2	292	295	PF00928	0.471
TRG_ENDOCYTIC_2	301	304	PF00928	0.522
TRG_ER_diArg_1	383	385	PF00400	0.497
TRG_ER_diArg_1	464	466	PF00400	0.666
TRG_NES_CRM1_1	571	585	PF08389	0.635
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E3	Leptomonas seymouri	36%	98%
A0A3Q8IJH1	Leishmania donovani	68%	100%
A4I5P5	Leishmania infantum	68%	100%
E9B0Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q777	Leishmania major	68%	99%