Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIE7_LEIBR

TriTrypDb:

LbrM.30.2100 , LBRM2903_300027200

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.414
CLV_C14_Caspase3-7	514	518	PF00656	0.431
CLV_C14_Caspase3-7	61	65	PF00656	0.462
CLV_NRD_NRD_1	255	257	PF00675	0.727
CLV_NRD_NRD_1	441	443	PF00675	0.532
CLV_NRD_NRD_1	452	454	PF00675	0.488
CLV_NRD_NRD_1	635	637	PF00675	0.427
CLV_PCSK_KEX2_1	255	257	PF00082	0.715
CLV_PCSK_KEX2_1	441	443	PF00082	0.620
CLV_PCSK_KEX2_1	635	637	PF00082	0.433
CLV_PCSK_SKI1_1	131	135	PF00082	0.430
CLV_PCSK_SKI1_1	423	427	PF00082	0.502
CLV_PCSK_SKI1_1	441	445	PF00082	0.565
CLV_PCSK_SKI1_1	469	473	PF00082	0.563
CLV_PCSK_SKI1_1	622	626	PF00082	0.394
CLV_PCSK_SKI1_1	723	727	PF00082	0.488
CLV_PCSK_SKI1_1	760	764	PF00082	0.467
CLV_PCSK_SKI1_1	832	836	PF00082	0.524
CLV_Separin_Metazoa	54	58	PF03568	0.310
DEG_APCC_DBOX_1	485	493	PF00400	0.487
DEG_COP1_1	769	779	PF00400	0.396
DEG_SCF_FBW7_2	586	593	PF00400	0.325
DEG_SPOP_SBC_1	12	16	PF00917	0.470
DEG_SPOP_SBC_1	48	52	PF00917	0.343
DOC_CKS1_1	321	326	PF01111	0.478
DOC_MAPK_MEF2A_6	101	109	PF00069	0.510
DOC_PP2B_LxvP_1	268	271	PF13499	0.732
DOC_PP2B_PxIxI_1	784	790	PF00149	0.441
DOC_SPAK_OSR1_1	667	671	PF12202	0.459
DOC_USP7_MATH_1	11	15	PF00917	0.455
DOC_USP7_MATH_1	249	253	PF00917	0.667
DOC_USP7_MATH_1	410	414	PF00917	0.622
DOC_USP7_MATH_1	425	429	PF00917	0.589
DOC_USP7_MATH_1	461	465	PF00917	0.638
DOC_USP7_MATH_1	494	498	PF00917	0.541
DOC_USP7_MATH_1	735	739	PF00917	0.421
DOC_USP7_MATH_1	791	795	PF00917	0.360
DOC_WW_Pin1_4	169	174	PF00397	0.624
DOC_WW_Pin1_4	25	30	PF00397	0.613
DOC_WW_Pin1_4	277	282	PF00397	0.604
DOC_WW_Pin1_4	320	325	PF00397	0.523
DOC_WW_Pin1_4	362	367	PF00397	0.441
DOC_WW_Pin1_4	580	585	PF00397	0.504
DOC_WW_Pin1_4	586	591	PF00397	0.437
LIG_14-3-3_CanoR_1	106	110	PF00244	0.433
LIG_14-3-3_CanoR_1	308	312	PF00244	0.472
LIG_14-3-3_CanoR_1	57	63	PF00244	0.394
LIG_14-3-3_CanoR_1	667	671	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.304
LIG_BIR_III_4	38	42	PF00653	0.622
LIG_BIR_III_4	64	68	PF00653	0.304
LIG_BRCT_BRCA1_1	13	17	PF00533	0.472
LIG_BRCT_BRCA1_1	27	31	PF00533	0.430
LIG_BRCT_BRCA1_1	410	414	PF00533	0.483
LIG_BRCT_BRCA1_1	88	92	PF00533	0.543
LIG_Clathr_ClatBox_1	133	137	PF01394	0.449
LIG_CSL_BTD_1	581	584	PF09270	0.508
LIG_CSL_BTD_1	827	830	PF09270	0.463
LIG_FHA_1	161	167	PF00498	0.560
LIG_FHA_1	188	194	PF00498	0.460
LIG_FHA_1	215	221	PF00498	0.365
LIG_FHA_1	229	235	PF00498	0.345
LIG_FHA_1	308	314	PF00498	0.377
LIG_FHA_1	316	322	PF00498	0.393
LIG_FHA_1	35	41	PF00498	0.444
LIG_FHA_1	372	378	PF00498	0.566
LIG_FHA_1	5	11	PF00498	0.363
LIG_FHA_1	50	56	PF00498	0.596
LIG_FHA_1	502	508	PF00498	0.442
LIG_FHA_1	539	545	PF00498	0.490
LIG_FHA_1	645	651	PF00498	0.585
LIG_FHA_1	739	745	PF00498	0.393
LIG_FHA_1	751	757	PF00498	0.356
LIG_FHA_2	155	161	PF00498	0.463
LIG_FHA_2	282	288	PF00498	0.497
LIG_FHA_2	397	403	PF00498	0.640
LIG_FHA_2	48	54	PF00498	0.546
LIG_FHA_2	488	494	PF00498	0.492
LIG_FHA_2	512	518	PF00498	0.421
LIG_FHA_2	555	561	PF00498	0.522
LIG_FHA_2	59	65	PF00498	0.530
LIG_Integrin_isoDGR_2	349	351	PF01839	0.453
LIG_LIR_Gen_1	14	23	PF02991	0.477
LIG_LIR_Gen_1	28	39	PF02991	0.572
LIG_LIR_Gen_1	314	325	PF02991	0.473
LIG_LIR_Gen_1	477	484	PF02991	0.504
LIG_LIR_Nem_3	14	20	PF02991	0.453
LIG_LIR_Nem_3	314	320	PF02991	0.549
LIG_LIR_Nem_3	477	481	PF02991	0.508
LIG_LIR_Nem_3	825	831	PF02991	0.378
LIG_Pex14_2	474	478	PF04695	0.490
LIG_SH2_CRK	317	321	PF00017	0.447
LIG_SH2_NCK_1	430	434	PF00017	0.645
LIG_SH2_PTP2	354	357	PF00017	0.357
LIG_SH2_SRC	354	357	PF00017	0.442
LIG_SH2_STAP1	286	290	PF00017	0.237
LIG_SH2_STAP1	317	321	PF00017	0.497
LIG_SH2_STAP1	822	826	PF00017	0.232
LIG_SH2_STAT5	317	320	PF00017	0.446
LIG_SH2_STAT5	354	357	PF00017	0.491
LIG_SH2_STAT5	363	366	PF00017	0.406
LIG_SH2_STAT5	430	433	PF00017	0.699
LIG_SH2_STAT5	619	622	PF00017	0.356
LIG_SH3_3	481	487	PF00018	0.421
LIG_SH3_3	827	833	PF00018	0.487
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.485
LIG_SUMO_SIM_anti_2	6	16	PF11976	0.411
LIG_SUMO_SIM_anti_2	81	90	PF11976	0.465
LIG_SUMO_SIM_par_1	132	138	PF11976	0.413
LIG_SUMO_SIM_par_1	293	300	PF11976	0.429
LIG_SUMO_SIM_par_1	373	379	PF11976	0.376
LIG_SUMO_SIM_par_1	567	572	PF11976	0.510
LIG_SUMO_SIM_par_1	6	16	PF11976	0.413
LIG_SUMO_SIM_par_1	788	794	PF11976	0.336
LIG_SUMO_SIM_par_1	81	90	PF11976	0.398
LIG_TRAF2_1	51	54	PF00917	0.467
MOD_CDK_SPK_2	362	367	PF00069	0.479
MOD_CDK_SPxxK_3	580	587	PF00069	0.577
MOD_CK1_1	214	220	PF00069	0.377
MOD_CK1_1	257	263	PF00069	0.694
MOD_CK1_1	307	313	PF00069	0.526
MOD_CK1_1	315	321	PF00069	0.501
MOD_CK1_1	4	10	PF00069	0.496
MOD_CK1_1	403	409	PF00069	0.656
MOD_CK1_1	417	423	PF00069	0.674
MOD_CK1_1	428	434	PF00069	0.660
MOD_CK1_1	480	486	PF00069	0.368
MOD_CK1_1	608	614	PF00069	0.299
MOD_CK1_1	649	655	PF00069	0.665
MOD_CK1_1	669	675	PF00069	0.345
MOD_CK1_1	72	78	PF00069	0.514
MOD_CK1_1	738	744	PF00069	0.491
MOD_CK1_1	749	755	PF00069	0.479
MOD_CK1_1	821	827	PF00069	0.407
MOD_CK2_1	47	53	PF00069	0.541
MOD_CK2_1	487	493	PF00069	0.493
MOD_CK2_1	692	698	PF00069	0.478
MOD_GlcNHglycan	169	172	PF01048	0.622
MOD_GlcNHglycan	200	203	PF01048	0.563
MOD_GlcNHglycan	314	317	PF01048	0.498
MOD_GlcNHglycan	405	408	PF01048	0.693
MOD_GlcNHglycan	427	430	PF01048	0.587
MOD_GlcNHglycan	463	466	PF01048	0.677
MOD_GlcNHglycan	496	499	PF01048	0.516
MOD_GlcNHglycan	571	574	PF01048	0.292
MOD_GlcNHglycan	607	610	PF01048	0.557
MOD_GlcNHglycan	677	680	PF01048	0.392
MOD_GlcNHglycan	746	749	PF01048	0.454
MOD_GlcNHglycan	82	85	PF01048	0.517
MOD_GlcNHglycan	840	843	PF01048	0.523
MOD_GSK3_1	1	8	PF00069	0.506
MOD_GSK3_1	116	123	PF00069	0.543
MOD_GSK3_1	187	194	PF00069	0.475
MOD_GSK3_1	23	30	PF00069	0.533
MOD_GSK3_1	250	257	PF00069	0.678
MOD_GSK3_1	277	284	PF00069	0.628
MOD_GSK3_1	293	300	PF00069	0.452
MOD_GSK3_1	396	403	PF00069	0.517
MOD_GSK3_1	410	417	PF00069	0.503
MOD_GSK3_1	461	468	PF00069	0.712
MOD_GSK3_1	507	514	PF00069	0.387
MOD_GSK3_1	554	561	PF00069	0.430
MOD_GSK3_1	644	651	PF00069	0.628
MOD_GSK3_1	723	730	PF00069	0.482
MOD_GSK3_1	746	753	PF00069	0.520
MOD_GSK3_1	771	778	PF00069	0.507
MOD_GSK3_1	818	825	PF00069	0.453
MOD_N-GLC_1	110	115	PF02516	0.532
MOD_N-GLC_1	214	219	PF02516	0.514
MOD_N-GLC_1	561	566	PF02516	0.286
MOD_N-GLC_1	738	743	PF02516	0.358
MOD_NEK2_1	110	115	PF00069	0.478
MOD_NEK2_1	211	216	PF00069	0.474
MOD_NEK2_1	297	302	PF00069	0.337
MOD_NEK2_1	339	344	PF00069	0.520
MOD_NEK2_1	569	574	PF00069	0.469
MOD_NEK2_1	623	628	PF00069	0.460
MOD_NEK2_1	744	749	PF00069	0.435
MOD_NEK2_1	750	755	PF00069	0.324
MOD_NEK2_1	86	91	PF00069	0.502
MOD_NEK2_2	105	110	PF00069	0.333
MOD_NEK2_2	281	286	PF00069	0.341
MOD_PIKK_1	257	263	PF00454	0.646
MOD_PIKK_1	315	321	PF00454	0.460
MOD_PIKK_1	368	374	PF00454	0.585
MOD_PIKK_1	414	420	PF00454	0.492
MOD_PIKK_1	766	772	PF00454	0.501
MOD_PIKK_1	791	797	PF00454	0.430
MOD_PK_1	120	126	PF00069	0.278
MOD_PKA_2	100	106	PF00069	0.400
MOD_PKA_2	191	197	PF00069	0.431
MOD_PKA_2	254	260	PF00069	0.696
MOD_PKA_2	307	313	PF00069	0.483
MOD_PKA_2	4	10	PF00069	0.300
MOD_PKA_2	485	491	PF00069	0.563
MOD_PKA_2	666	672	PF00069	0.542
MOD_PKA_2	727	733	PF00069	0.587
MOD_Plk_1	110	116	PF00069	0.465
MOD_Plk_1	281	287	PF00069	0.480
MOD_Plk_1	5	11	PF00069	0.584
MOD_Plk_1	592	598	PF00069	0.484
MOD_Plk_1	72	78	PF00069	0.530
MOD_Plk_2-3	376	382	PF00069	0.522
MOD_Plk_4	105	111	PF00069	0.480
MOD_Plk_4	13	19	PF00069	0.495
MOD_Plk_4	204	210	PF00069	0.497
MOD_Plk_4	27	33	PF00069	0.622
MOD_Plk_4	281	287	PF00069	0.444
MOD_Plk_4	396	402	PF00069	0.528
MOD_Plk_4	477	483	PF00069	0.556
MOD_Plk_4	5	11	PF00069	0.472
MOD_Plk_4	705	711	PF00069	0.517
MOD_Plk_4	87	93	PF00069	0.306
MOD_ProDKin_1	169	175	PF00069	0.609
MOD_ProDKin_1	25	31	PF00069	0.623
MOD_ProDKin_1	277	283	PF00069	0.584
MOD_ProDKin_1	320	326	PF00069	0.531
MOD_ProDKin_1	362	368	PF00069	0.437
MOD_ProDKin_1	580	586	PF00069	0.504
TRG_ENDOCYTIC_2	306	309	PF00928	0.502
TRG_ENDOCYTIC_2	317	320	PF00928	0.320
TRG_ENDOCYTIC_2	354	357	PF00928	0.515
TRG_ER_diArg_1	255	258	PF00400	0.719
TRG_ER_diArg_1	265	268	PF00400	0.748
TRG_ER_diArg_1	441	443	PF00400	0.394
TRG_ER_diArg_1	634	636	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P916	Leptomonas seymouri	46%	91%
A0A0S4ILJ2	Bodo saltans	27%	100%
A0A1X0P1Y6	Trypanosomatidae	26%	100%
A0A3S5IQN0	Trypanosoma rangeli	26%	100%
A0A3S7X3K9	Leishmania donovani	74%	100%
A4I5P4	Leishmania infantum	74%	100%
C9ZR12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B0Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q778	Leishmania major	76%	100%
V5BC72	Trypanosoma cruzi	26%	96%