Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HIE5_LEIBR

TriTrypDb:

LbrM.30.2080 , LBRM2903_300027000

Length:

982

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010941	regulation of cell death	4	1
GO:0016567	protein ubiquitination	7	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0042981	regulation of apoptotic process	6	1
GO:0043067	regulation of programmed cell death	5	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008270	zinc ion binding	6	9
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.523
CLV_C14_Caspase3-7	520	524	PF00656	0.430
CLV_C14_Caspase3-7	607	611	PF00656	0.536
CLV_NRD_NRD_1	163	165	PF00675	0.492
CLV_NRD_NRD_1	533	535	PF00675	0.686
CLV_NRD_NRD_1	570	572	PF00675	0.396
CLV_NRD_NRD_1	659	661	PF00675	0.621
CLV_NRD_NRD_1	7	9	PF00675	0.411
CLV_NRD_NRD_1	838	840	PF00675	0.411
CLV_PCSK_KEX2_1	163	165	PF00082	0.492
CLV_PCSK_KEX2_1	533	535	PF00082	0.686
CLV_PCSK_KEX2_1	7	9	PF00082	0.411
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.411
CLV_PCSK_SKI1_1	200	204	PF00082	0.316
CLV_PCSK_SKI1_1	231	235	PF00082	0.308
CLV_PCSK_SKI1_1	236	240	PF00082	0.284
CLV_PCSK_SKI1_1	249	253	PF00082	0.236
CLV_PCSK_SKI1_1	336	340	PF00082	0.339
CLV_PCSK_SKI1_1	342	346	PF00082	0.309
CLV_PCSK_SKI1_1	408	412	PF00082	0.648
CLV_PCSK_SKI1_1	48	52	PF00082	0.300
CLV_PCSK_SKI1_1	505	509	PF00082	0.667
CLV_PCSK_SKI1_1	571	575	PF00082	0.557
CLV_PCSK_SKI1_1	786	790	PF00082	0.393
CLV_PCSK_SKI1_1	963	967	PF00082	0.411
DEG_APCC_DBOX_1	429	437	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.467
DEG_SPOP_SBC_1	353	357	PF00917	0.336
DOC_ANK_TNKS_1	7	14	PF00023	0.411
DOC_CKS1_1	270	275	PF01111	0.296
DOC_MAPK_gen_1	236	245	PF00069	0.296
DOC_MAPK_gen_1	24	34	PF00069	0.365
DOC_MAPK_gen_1	48	56	PF00069	0.303
DOC_MAPK_gen_1	660	670	PF00069	0.473
DOC_MAPK_MEF2A_6	48	56	PF00069	0.300
DOC_MAPK_MEF2A_6	713	722	PF00069	0.239
DOC_PP2B_LxvP_1	512	515	PF13499	0.646
DOC_PP2B_LxvP_1	548	551	PF13499	0.465
DOC_USP7_MATH_1	136	140	PF00917	0.593
DOC_USP7_MATH_1	309	313	PF00917	0.296
DOC_USP7_MATH_1	353	357	PF00917	0.393
DOC_USP7_MATH_1	380	384	PF00917	0.580
DOC_USP7_MATH_1	515	519	PF00917	0.614
DOC_USP7_MATH_1	653	657	PF00917	0.742
DOC_USP7_MATH_1	81	85	PF00917	0.393
DOC_USP7_MATH_1	859	863	PF00917	0.411
DOC_USP7_MATH_1	87	91	PF00917	0.573
DOC_WW_Pin1_4	269	274	PF00397	0.296
DOC_WW_Pin1_4	366	371	PF00397	0.516
DOC_WW_Pin1_4	443	448	PF00397	0.651
DOC_WW_Pin1_4	464	469	PF00397	0.512
DOC_WW_Pin1_4	580	585	PF00397	0.383
DOC_WW_Pin1_4	598	603	PF00397	0.507
DOC_WW_Pin1_4	608	613	PF00397	0.411
DOC_WW_Pin1_4	714	719	PF00397	0.393
DOC_WW_Pin1_4	786	791	PF00397	0.411
LIG_14-3-3_CanoR_1	24	34	PF00244	0.492
LIG_14-3-3_CanoR_1	266	274	PF00244	0.411
LIG_14-3-3_CanoR_1	352	362	PF00244	0.343
LIG_14-3-3_CanoR_1	425	433	PF00244	0.623
LIG_14-3-3_CanoR_1	476	480	PF00244	0.687
LIG_14-3-3_CanoR_1	723	727	PF00244	0.393
LIG_APCC_ABBAyCdc20_2	231	237	PF00400	0.357
LIG_BIR_III_4	809	813	PF00653	0.296
LIG_BRCT_BRCA1_1	503	507	PF00533	0.568
LIG_eIF4E_1	64	70	PF01652	0.296
LIG_FHA_1	12	18	PF00498	0.262
LIG_FHA_1	154	160	PF00498	0.692
LIG_FHA_1	210	216	PF00498	0.211
LIG_FHA_1	259	265	PF00498	0.357
LIG_FHA_1	386	392	PF00498	0.667
LIG_FHA_1	525	531	PF00498	0.512
LIG_FHA_1	580	586	PF00498	0.501
LIG_FHA_1	649	655	PF00498	0.804
LIG_FHA_1	709	715	PF00498	0.439
LIG_FHA_1	787	793	PF00498	0.411
LIG_FHA_1	883	889	PF00498	0.365
LIG_FHA_2	122	128	PF00498	0.612
LIG_FHA_2	302	308	PF00498	0.296
LIG_FHA_2	36	42	PF00498	0.460
LIG_FHA_2	468	474	PF00498	0.500
LIG_FHA_2	669	675	PF00498	0.411
LIG_FHA_2	950	956	PF00498	0.357
LIG_GBD_Chelix_1	176	184	PF00786	0.411
LIG_GBD_Chelix_1	337	345	PF00786	0.393
LIG_LIR_Apic_2	272	278	PF02991	0.296
LIG_LIR_Gen_1	504	515	PF02991	0.599
LIG_LIR_Gen_1	63	71	PF02991	0.296
LIG_LIR_Gen_1	750	759	PF02991	0.411
LIG_LIR_Gen_1	815	823	PF02991	0.411
LIG_LIR_Nem_3	246	251	PF02991	0.377
LIG_LIR_Nem_3	444	448	PF02991	0.703
LIG_LIR_Nem_3	483	488	PF02991	0.502
LIG_LIR_Nem_3	504	510	PF02991	0.598
LIG_LIR_Nem_3	63	67	PF02991	0.296
LIG_LIR_Nem_3	750	754	PF02991	0.411
LIG_LIR_Nem_3	815	819	PF02991	0.411
LIG_LIR_Nem_3	939	943	PF02991	0.243
LIG_LRP6_Inhibitor_1	861	867	PF00058	0.296
LIG_LRP6_Inhibitor_1	907	913	PF00058	0.411
LIG_MAD2	51	59	PF02301	0.357
LIG_NRBOX	298	304	PF00104	0.411
LIG_NRBOX	336	342	PF00104	0.321
LIG_PCNA_TLS_4	621	628	PF02747	0.288
LIG_PCNA_yPIPBox_3	187	200	PF02747	0.414
LIG_Pex14_2	111	115	PF04695	0.486
LIG_Pex14_2	67	71	PF04695	0.296
LIG_PTB_Apo_2	478	485	PF02174	0.505
LIG_SH2_CRK	248	252	PF00017	0.393
LIG_SH2_CRK	816	820	PF00017	0.411
LIG_SH2_NCK_1	816	820	PF00017	0.411
LIG_SH2_STAP1	286	290	PF00017	0.203
LIG_SH2_STAP1	30	34	PF00017	0.411
LIG_SH2_STAP1	333	337	PF00017	0.393
LIG_SH2_STAT5	275	278	PF00017	0.296
LIG_SH2_STAT5	4	7	PF00017	0.247
LIG_SH2_STAT5	64	67	PF00017	0.296
LIG_SH2_STAT5	898	901	PF00017	0.296
LIG_SH3_3	267	273	PF00018	0.296
LIG_SH3_3	449	455	PF00018	0.510
LIG_SH3_3	659	665	PF00018	0.614
LIG_SH3_3	712	718	PF00018	0.415
LIG_SUMO_SIM_par_1	296	301	PF11976	0.296
LIG_SUMO_SIM_par_1	582	589	PF11976	0.434
LIG_SUMO_SIM_par_1	604	611	PF11976	0.435
LIG_TRAF2_1	38	41	PF00917	0.375
LIG_TRFH_1	274	278	PF08558	0.357
LIG_UBA3_1	378	386	PF00899	0.665
LIG_WRC_WIRS_1	112	117	PF05994	0.482
MOD_CDK_SPK_2	786	791	PF00069	0.411
MOD_CDK_SPxxK_3	786	793	PF00069	0.411
MOD_CK1_1	114	120	PF00069	0.510
MOD_CK1_1	157	163	PF00069	0.652
MOD_CK1_1	26	32	PF00069	0.393
MOD_CK1_1	364	370	PF00069	0.482
MOD_CK1_1	424	430	PF00069	0.677
MOD_CK1_1	446	452	PF00069	0.581
MOD_CK1_1	467	473	PF00069	0.704
MOD_CK1_1	487	493	PF00069	0.680
MOD_CK1_1	522	528	PF00069	0.623
MOD_CK1_1	60	66	PF00069	0.411
MOD_CK1_1	663	669	PF00069	0.547
MOD_CK1_1	688	694	PF00069	0.303
MOD_CK1_1	695	701	PF00069	0.307
MOD_CK1_1	724	730	PF00069	0.211
MOD_CK1_1	972	978	PF00069	0.482
MOD_CK2_1	113	119	PF00069	0.641
MOD_CK2_1	205	211	PF00069	0.468
MOD_CK2_1	213	219	PF00069	0.296
MOD_CK2_1	301	307	PF00069	0.407
MOD_CK2_1	35	41	PF00069	0.460
MOD_CK2_1	653	659	PF00069	0.586
MOD_CK2_1	668	674	PF00069	0.452
MOD_CK2_1	680	686	PF00069	0.337
MOD_CK2_1	859	865	PF00069	0.321
MOD_GlcNHglycan	267	270	PF01048	0.411
MOD_GlcNHglycan	374	377	PF01048	0.689
MOD_GlcNHglycan	535	539	PF01048	0.696
MOD_GlcNHglycan	618	621	PF01048	0.410
MOD_GlcNHglycan	655	658	PF01048	0.747
MOD_GlcNHglycan	686	690	PF01048	0.302
MOD_GlcNHglycan	774	777	PF01048	0.361
MOD_GlcNHglycan	809	813	PF01048	0.296
MOD_GlcNHglycan	832	835	PF01048	0.411
MOD_GlcNHglycan	878	881	PF01048	0.326
MOD_GlcNHglycan	89	92	PF01048	0.755
MOD_GlcNHglycan	93	96	PF01048	0.636
MOD_GSK3_1	111	118	PF00069	0.682
MOD_GSK3_1	136	143	PF00069	0.782
MOD_GSK3_1	153	160	PF00069	0.591
MOD_GSK3_1	201	208	PF00069	0.365
MOD_GSK3_1	209	216	PF00069	0.211
MOD_GSK3_1	22	29	PF00069	0.460
MOD_GSK3_1	265	272	PF00069	0.296
MOD_GSK3_1	332	339	PF00069	0.284
MOD_GSK3_1	361	368	PF00069	0.469
MOD_GSK3_1	432	439	PF00069	0.594
MOD_GSK3_1	456	463	PF00069	0.677
MOD_GSK3_1	464	471	PF00069	0.700
MOD_GSK3_1	480	487	PF00069	0.686
MOD_GSK3_1	501	508	PF00069	0.495
MOD_GSK3_1	515	522	PF00069	0.592
MOD_GSK3_1	576	583	PF00069	0.388
MOD_GSK3_1	616	623	PF00069	0.389
MOD_GSK3_1	648	655	PF00069	0.602
MOD_GSK3_1	688	695	PF00069	0.439
MOD_GSK3_1	696	703	PF00069	0.391
MOD_GSK3_1	714	721	PF00069	0.421
MOD_GSK3_1	87	94	PF00069	0.586
MOD_N-GLC_1	431	436	PF02516	0.695
MOD_N-GLC_1	480	485	PF02516	0.722
MOD_N-GLC_1	488	493	PF02516	0.580
MOD_N-GLC_1	577	582	PF02516	0.543
MOD_NEK2_1	111	116	PF00069	0.623
MOD_NEK2_1	201	206	PF00069	0.455
MOD_NEK2_1	258	263	PF00069	0.344
MOD_NEK2_1	331	336	PF00069	0.296
MOD_NEK2_1	372	377	PF00069	0.656
MOD_NEK2_1	403	408	PF00069	0.632
MOD_NEK2_1	460	465	PF00069	0.722
MOD_NEK2_1	472	477	PF00069	0.726
MOD_NEK2_1	585	590	PF00069	0.532
MOD_NEK2_1	700	705	PF00069	0.300
MOD_NEK2_1	722	727	PF00069	0.393
MOD_NEK2_1	762	767	PF00069	0.411
MOD_NEK2_1	875	880	PF00069	0.296
MOD_NEK2_1	920	925	PF00069	0.300
MOD_NEK2_2	718	723	PF00069	0.211
MOD_OFUCOSY	401	407	PF10250	0.474
MOD_PIKK_1	11	17	PF00454	0.211
MOD_PIKK_1	209	215	PF00454	0.211
MOD_PIKK_1	524	530	PF00454	0.582
MOD_PK_1	361	367	PF00069	0.524
MOD_PK_1	57	63	PF00069	0.411
MOD_PKA_1	163	169	PF00069	0.489
MOD_PKA_1	660	666	PF00069	0.547
MOD_PKA_2	163	169	PF00069	0.489
MOD_PKA_2	23	29	PF00069	0.393
MOD_PKA_2	265	271	PF00069	0.296
MOD_PKA_2	351	357	PF00069	0.211
MOD_PKA_2	424	430	PF00069	0.619
MOD_PKA_2	475	481	PF00069	0.688
MOD_PKA_2	663	669	PF00069	0.520
MOD_PKA_2	680	686	PF00069	0.195
MOD_PKA_2	722	728	PF00069	0.441
MOD_Plk_1	2	8	PF00069	0.247
MOD_Plk_1	431	437	PF00069	0.669
MOD_Plk_1	480	486	PF00069	0.582
MOD_Plk_1	522	528	PF00069	0.623
MOD_Plk_2-3	301	307	PF00069	0.296
MOD_Plk_4	106	112	PF00069	0.659
MOD_Plk_4	154	160	PF00069	0.679
MOD_Plk_4	213	219	PF00069	0.296
MOD_Plk_4	309	315	PF00069	0.361
MOD_Plk_4	336	342	PF00069	0.409
MOD_Plk_4	354	360	PF00069	0.254
MOD_Plk_4	374	380	PF00069	0.655
MOD_Plk_4	432	438	PF00069	0.660
MOD_Plk_4	480	486	PF00069	0.543
MOD_Plk_4	543	549	PF00069	0.461
MOD_Plk_4	57	63	PF00069	0.307
MOD_Plk_4	747	753	PF00069	0.357
MOD_Plk_4	972	978	PF00069	0.447
MOD_ProDKin_1	269	275	PF00069	0.296
MOD_ProDKin_1	366	372	PF00069	0.524
MOD_ProDKin_1	443	449	PF00069	0.651
MOD_ProDKin_1	464	470	PF00069	0.513
MOD_ProDKin_1	580	586	PF00069	0.381
MOD_ProDKin_1	598	604	PF00069	0.500
MOD_ProDKin_1	608	614	PF00069	0.405
MOD_ProDKin_1	714	720	PF00069	0.393
MOD_ProDKin_1	786	792	PF00069	0.411
MOD_SUMO_for_1	784	787	PF00179	0.292
MOD_SUMO_rev_2	246	251	PF00179	0.296
MOD_SUMO_rev_2	655	663	PF00179	0.610
MOD_SUMO_rev_2	890	895	PF00179	0.292
TRG_DiLeu_BaEn_1	49	54	PF01217	0.296
TRG_ENDOCYTIC_2	248	251	PF00928	0.357
TRG_ENDOCYTIC_2	64	67	PF00928	0.296
TRG_ENDOCYTIC_2	816	819	PF00928	0.411
TRG_ENDOCYTIC_2	940	943	PF00928	0.296
TRG_ER_diArg_1	790	793	PF00400	0.411
TRG_NES_CRM1_1	291	301	PF08389	0.387
TRG_NLS_MonoExtC_3	6	12	PF00514	0.411
TRG_NLS_MonoExtN_4	836	843	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	886	890	PF00026	0.211

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFF2	Leptomonas seymouri	70%	99%
A0A1X0P1U2	Trypanosomatidae	45%	100%
A0A3Q8IEB1	Leishmania donovani	85%	99%
A0A422N709	Trypanosoma rangeli	48%	100%
A4I5P2	Leishmania infantum	85%	99%
E9B0Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q9NE58	Leishmania major	84%	99%
V5DCX1	Trypanosoma cruzi	46%	100%