Oligomerization domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Oligomerisation domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HIE4_LEIBR

TriTrypDb:

LbrM.30.2070 , LBRM2903_300026900

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HIE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE4

PDB structure(s): 7am2_CB

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0031123	RNA 3'-end processing	7	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071076	RNA 3' uridylation	8	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0017148	negative regulation of translation	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090069	regulation of ribosome biogenesis	5	1
GO:0090071	negative regulation of ribosome biogenesis	5	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0050265	RNA uridylyltransferase activity	4	4
GO:0070569	uridylyltransferase activity	5	4
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043023	ribosomal large subunit binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.396
CLV_NRD_NRD_1	119	121	PF00675	0.309
CLV_NRD_NRD_1	87	89	PF00675	0.274
CLV_PCSK_FUR_1	87	91	PF00082	0.221
CLV_PCSK_KEX2_1	87	89	PF00082	0.309
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.221
CLV_PCSK_SKI1_1	142	146	PF00082	0.485
CLV_PCSK_SKI1_1	168	172	PF00082	0.403
DEG_APCC_DBOX_1	19	27	PF00400	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.329
DOC_MAPK_gen_1	37	46	PF00069	0.309
DOC_MAPK_MEF2A_6	102	109	PF00069	0.309
DOC_USP7_UBL2_3	85	89	PF12436	0.274
LIG_14-3-3_CanoR_1	87	97	PF00244	0.436
LIG_CaM_IQ_9	71	87	PF13499	0.309
LIG_Clathr_ClatBox_1	2	6	PF01394	0.406
LIG_eIF4E_1	166	172	PF01652	0.403
LIG_FHA_1	149	155	PF00498	0.412
LIG_FHA_1	89	95	PF00498	0.423
LIG_FHA_2	12	18	PF00498	0.552
LIG_LIR_Gen_1	50	58	PF02991	0.309
LIG_LIR_Gen_1	92	103	PF02991	0.440
LIG_LIR_Nem_3	50	56	PF02991	0.423
LIG_LIR_Nem_3	92	98	PF02991	0.440
LIG_SH2_STAT5	166	169	PF00017	0.409
LIG_SH2_STAT5	55	58	PF00017	0.221
LIG_UBA3_1	32	37	PF00899	0.309
LIG_WRC_WIRS_1	109	114	PF05994	0.309
MOD_CK1_1	47	53	PF00069	0.370
MOD_CK2_1	108	114	PF00069	0.309
MOD_GSK3_1	44	51	PF00069	0.309
MOD_NEK2_1	108	113	PF00069	0.396
MOD_PKA_1	88	94	PF00069	0.274
MOD_PKA_2	81	87	PF00069	0.326
MOD_Plk_1	11	17	PF00069	0.433
MOD_Plk_1	114	120	PF00069	0.484
MOD_Plk_2-3	114	120	PF00069	0.309
MOD_SUMO_rev_2	114	123	PF00179	0.309
MOD_SUMO_rev_2	24	29	PF00179	0.385
TRG_ENDOCYTIC_2	55	58	PF00928	0.414
TRG_ER_diArg_1	20	23	PF00400	0.327
TRG_ER_diArg_1	86	88	PF00400	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L3	Leishmania donovani	93%	87%
Q96EH3	Homo sapiens	31%	75%
Q9NE59	Leishmania major	91%	100%