Autophagy-related protein 13

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIE3_LEIBR

TriTrypDb:

LbrM.30.2060 , LBRM2903_300026800

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.564
CLV_C14_Caspase3-7	9	13	PF00656	0.658
CLV_NRD_NRD_1	210	212	PF00675	0.621
CLV_NRD_NRD_1	363	365	PF00675	0.587
CLV_NRD_NRD_1	414	416	PF00675	0.677
CLV_NRD_NRD_1	422	424	PF00675	0.720
CLV_PCSK_FUR_1	361	365	PF00082	0.586
CLV_PCSK_KEX2_1	210	212	PF00082	0.524
CLV_PCSK_KEX2_1	363	365	PF00082	0.587
CLV_PCSK_KEX2_1	414	416	PF00082	0.677
CLV_PCSK_KEX2_1	469	471	PF00082	0.629
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.532
CLV_PCSK_SKI1_1	127	131	PF00082	0.469
CLV_PCSK_SKI1_1	469	473	PF00082	0.667
DEG_APCC_DBOX_1	80	88	PF00400	0.592
DEG_SPOP_SBC_1	427	431	PF00917	0.565
DEG_SPOP_SBC_1	454	458	PF00917	0.536
DOC_CDC14_PxL_1	308	316	PF14671	0.568
DOC_CKS1_1	184	189	PF01111	0.725
DOC_CKS1_1	303	308	PF01111	0.705
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.807
DOC_MAPK_gen_1	253	261	PF00069	0.566
DOC_MAPK_gen_1	414	420	PF00069	0.542
DOC_MAPK_gen_1	469	477	PF00069	0.540
DOC_MAPK_MEF2A_6	81	90	PF00069	0.421
DOC_PP1_RVXF_1	125	131	PF00149	0.462
DOC_PP4_FxxP_1	346	349	PF00568	0.697
DOC_PP4_FxxP_1	80	83	PF00568	0.514
DOC_USP7_MATH_1	3	7	PF00917	0.499
DOC_USP7_MATH_1	320	324	PF00917	0.771
DOC_USP7_MATH_1	427	431	PF00917	0.672
DOC_USP7_MATH_1	455	459	PF00917	0.567
DOC_USP7_UBL2_3	33	37	PF12436	0.647
DOC_WW_Pin1_4	157	162	PF00397	0.714
DOC_WW_Pin1_4	164	169	PF00397	0.635
DOC_WW_Pin1_4	180	185	PF00397	0.638
DOC_WW_Pin1_4	242	247	PF00397	0.799
DOC_WW_Pin1_4	26	31	PF00397	0.456
DOC_WW_Pin1_4	264	269	PF00397	0.811
DOC_WW_Pin1_4	302	307	PF00397	0.733
DOC_WW_Pin1_4	326	331	PF00397	0.749
DOC_WW_Pin1_4	335	340	PF00397	0.584
DOC_WW_Pin1_4	365	370	PF00397	0.693
DOC_WW_Pin1_4	423	428	PF00397	0.735
DOC_WW_Pin1_4	429	434	PF00397	0.699
DOC_WW_Pin1_4	483	488	PF00397	0.713
DOC_WW_Pin1_4	90	95	PF00397	0.464
LIG_14-3-3_CanoR_1	175	180	PF00244	0.833
LIG_14-3-3_CanoR_1	194	203	PF00244	0.640
LIG_14-3-3_CanoR_1	232	237	PF00244	0.721
LIG_14-3-3_CanoR_1	363	369	PF00244	0.726
LIG_14-3-3_CanoR_1	440	450	PF00244	0.809
LIG_14-3-3_CanoR_1	470	477	PF00244	0.749
LIG_14-3-3_CanoR_1	488	494	PF00244	0.586
LIG_14-3-3_CanoR_1	63	68	PF00244	0.677
LIG_Actin_WH2_2	518	534	PF00022	0.640
LIG_BRCT_BRCA1_1	216	220	PF00533	0.528
LIG_BRCT_BRCA1_1	353	357	PF00533	0.805
LIG_BRCT_BRCA1_1	373	377	PF00533	0.513
LIG_deltaCOP1_diTrp_1	59	67	PF00928	0.649
LIG_FHA_1	202	208	PF00498	0.551
LIG_FHA_1	303	309	PF00498	0.705
LIG_FHA_1	442	448	PF00498	0.551
LIG_FHA_1	497	503	PF00498	0.495
LIG_FHA_2	495	501	PF00498	0.690
LIG_FHA_2	7	13	PF00498	0.543
LIG_FHA_2	97	103	PF00498	0.497
LIG_GBD_Chelix_1	125	133	PF00786	0.457
LIG_LIR_Apic_2	102	106	PF02991	0.548
LIG_LIR_Apic_2	305	310	PF02991	0.725
LIG_LIR_Apic_2	344	349	PF02991	0.700
LIG_LIR_Gen_1	115	122	PF02991	0.514
LIG_LIR_Gen_1	137	147	PF02991	0.350
LIG_LIR_Gen_1	217	227	PF02991	0.496
LIG_LIR_LC3C_4	245	250	PF02991	0.561
LIG_LIR_Nem_3	115	119	PF02991	0.555
LIG_LIR_Nem_3	137	142	PF02991	0.467
LIG_LIR_Nem_3	217	223	PF02991	0.510
LIG_LIR_Nem_3	41	47	PF02991	0.524
LIG_MYND_1	306	310	PF01753	0.711
LIG_MYND_1	312	316	PF01753	0.725
LIG_NRBOX	501	507	PF00104	0.613
LIG_Rb_pABgroove_1	351	359	PF01858	0.558
LIG_SH2_CRK	139	143	PF00017	0.479
LIG_SH2_GRB2like	89	92	PF00017	0.489
LIG_SH2_NCK_1	55	59	PF00017	0.528
LIG_SH2_SRC	55	58	PF00017	0.497
LIG_SH2_STAP1	139	143	PF00017	0.328
LIG_SH2_STAT5	213	216	PF00017	0.592
LIG_SH2_STAT5	307	310	PF00017	0.713
LIG_SH2_STAT5	89	92	PF00017	0.489
LIG_SH3_3	155	161	PF00018	0.689
LIG_SH3_3	166	172	PF00018	0.642
LIG_SH3_3	181	187	PF00018	0.481
LIG_SH3_3	200	206	PF00018	0.625
LIG_SH3_3	327	333	PF00018	0.822
LIG_SUMO_SIM_anti_2	245	252	PF11976	0.561
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.555
LIG_SUMO_SIM_par_1	245	252	PF11976	0.561
LIG_SUMO_SIM_par_1	93	99	PF11976	0.467
LIG_TRAF2_1	54	57	PF00917	0.629
LIG_TRFH_1	346	350	PF08558	0.693
LIG_UBA3_1	502	511	PF00899	0.624
MOD_CDK_SPK_2	483	488	PF00069	0.582
MOD_CDK_SPxxK_3	168	175	PF00069	0.723
MOD_CDK_SPxxK_3	26	33	PF00069	0.480
MOD_CK1_1	145	151	PF00069	0.576
MOD_CK1_1	171	177	PF00069	0.613
MOD_CK1_1	178	184	PF00069	0.598
MOD_CK1_1	302	308	PF00069	0.783
MOD_CK1_1	318	324	PF00069	0.791
MOD_CK1_1	362	368	PF00069	0.776
MOD_CK1_1	426	432	PF00069	0.794
MOD_CK1_1	441	447	PF00069	0.726
MOD_CK1_1	492	498	PF00069	0.619
MOD_CK1_1	6	12	PF00069	0.507
MOD_CK1_1	65	71	PF00069	0.685
MOD_CK2_1	195	201	PF00069	0.539
MOD_CK2_1	494	500	PF00069	0.702
MOD_CK2_1	51	57	PF00069	0.503
MOD_CK2_1	90	96	PF00069	0.477
MOD_Cter_Amidation	435	438	PF01082	0.829
MOD_GlcNHglycan	197	200	PF01048	0.596
MOD_GlcNHglycan	323	326	PF01048	0.668
MOD_GlcNHglycan	440	443	PF01048	0.763
MOD_GlcNHglycan	462	465	PF01048	0.684
MOD_GlcNHglycan	491	494	PF01048	0.716
MOD_GlcNHglycan	68	71	PF01048	0.593
MOD_GSK3_1	142	149	PF00069	0.417
MOD_GSK3_1	164	171	PF00069	0.768
MOD_GSK3_1	174	181	PF00069	0.698
MOD_GSK3_1	223	230	PF00069	0.587
MOD_GSK3_1	238	245	PF00069	0.538
MOD_GSK3_1	264	271	PF00069	0.733
MOD_GSK3_1	284	291	PF00069	0.776
MOD_GSK3_1	294	301	PF00069	0.690
MOD_GSK3_1	314	321	PF00069	0.690
MOD_GSK3_1	365	372	PF00069	0.692
MOD_GSK3_1	419	426	PF00069	0.769
MOD_GSK3_1	449	456	PF00069	0.692
MOD_GSK3_1	45	52	PF00069	0.600
MOD_GSK3_1	483	490	PF00069	0.824
MOD_GSK3_1	492	499	PF00069	0.528
MOD_GSK3_1	62	69	PF00069	0.381
MOD_N-GLC_1	175	180	PF02516	0.725
MOD_N-GLC_1	227	232	PF02516	0.391
MOD_N-GLC_1	90	95	PF02516	0.509
MOD_NEK2_1	223	228	PF00069	0.489
MOD_NEK2_1	298	303	PF00069	0.756
MOD_NEK2_1	371	376	PF00069	0.840
MOD_NEK2_1	377	382	PF00069	0.815
MOD_NEK2_1	419	424	PF00069	0.821
MOD_NEK2_1	49	54	PF00069	0.498
MOD_NEK2_2	3	8	PF00069	0.490
MOD_NEK2_2	45	50	PF00069	0.625
MOD_PIKK_1	238	244	PF00454	0.783
MOD_PIKK_1	284	290	PF00454	0.748
MOD_PIKK_1	441	447	PF00454	0.687
MOD_PKA_2	174	180	PF00069	0.616
MOD_PKA_2	321	327	PF00069	0.580
MOD_PKA_2	362	368	PF00069	0.730
MOD_PKA_2	487	493	PF00069	0.588
MOD_PKA_2	49	55	PF00069	0.464
MOD_PKA_2	62	68	PF00069	0.495
MOD_Plk_1	108	114	PF00069	0.556
MOD_Plk_1	175	181	PF00069	0.739
MOD_Plk_1	223	229	PF00069	0.466
MOD_Plk_2-3	51	57	PF00069	0.532
MOD_Plk_2-3	96	102	PF00069	0.481
MOD_Plk_4	121	127	PF00069	0.470
MOD_Plk_4	137	143	PF00069	0.479
MOD_Plk_4	232	238	PF00069	0.735
MOD_Plk_4	372	378	PF00069	0.613
MOD_Plk_4	449	455	PF00069	0.700
MOD_ProDKin_1	157	163	PF00069	0.714
MOD_ProDKin_1	164	170	PF00069	0.636
MOD_ProDKin_1	180	186	PF00069	0.632
MOD_ProDKin_1	242	248	PF00069	0.803
MOD_ProDKin_1	26	32	PF00069	0.467
MOD_ProDKin_1	264	270	PF00069	0.811
MOD_ProDKin_1	302	308	PF00069	0.734
MOD_ProDKin_1	326	332	PF00069	0.749
MOD_ProDKin_1	335	341	PF00069	0.586
MOD_ProDKin_1	365	371	PF00069	0.693
MOD_ProDKin_1	423	429	PF00069	0.735
MOD_ProDKin_1	483	489	PF00069	0.715
MOD_ProDKin_1	90	96	PF00069	0.459
TRG_DiLeu_BaEn_2	523	529	PF01217	0.480
TRG_DiLeu_BaEn_4	56	62	PF01217	0.535
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.496
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.454
TRG_ENDOCYTIC_2	139	142	PF00928	0.473
TRG_ER_diArg_1	179	182	PF00400	0.579
TRG_ER_diArg_1	361	364	PF00400	0.586
TRG_ER_diArg_1	413	415	PF00400	0.662
TRG_NES_CRM1_1	466	479	PF08389	0.538
TRG_NLS_Bipartite_1	423	441	PF00514	0.823
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.748

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W6	Leptomonas seymouri	46%	98%
A0A3S7X3G8	Leishmania donovani	78%	100%
A4I5P0	Leishmania infantum	78%	100%
E9B0Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q9NE60	Leishmania major	78%	100%