Photolyase/cryptochrome alpha/beta domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIE2_LEIBR

TriTrypDb:

LbrM.30.2050 , LBRM2903_300026700

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.432
CLV_C14_Caspase3-7	780	784	PF00656	0.476
CLV_NRD_NRD_1	129	131	PF00675	0.442
CLV_NRD_NRD_1	257	259	PF00675	0.755
CLV_NRD_NRD_1	274	276	PF00675	0.499
CLV_NRD_NRD_1	371	373	PF00675	0.553
CLV_NRD_NRD_1	531	533	PF00675	0.626
CLV_NRD_NRD_1	571	573	PF00675	0.627
CLV_PCSK_FUR_1	569	573	PF00082	0.510
CLV_PCSK_KEX2_1	129	131	PF00082	0.442
CLV_PCSK_KEX2_1	257	259	PF00082	0.763
CLV_PCSK_KEX2_1	371	373	PF00082	0.513
CLV_PCSK_KEX2_1	531	533	PF00082	0.626
CLV_PCSK_KEX2_1	571	573	PF00082	0.627
CLV_PCSK_KEX2_1	612	614	PF00082	0.395
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.442
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.395
CLV_PCSK_SKI1_1	430	434	PF00082	0.514
CLV_PCSK_SKI1_1	463	467	PF00082	0.538
CLV_PCSK_SKI1_1	612	616	PF00082	0.368
CLV_PCSK_SKI1_1	659	663	PF00082	0.487
CLV_PCSK_SKI1_1	713	717	PF00082	0.414
DEG_MDM2_SWIB_1	446	453	PF02201	0.479
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_SPOP_SBC_1	148	152	PF00917	0.499
DOC_CYCLIN_RxL_1	609	617	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.468
DOC_MAPK_gen_1	128	137	PF00069	0.464
DOC_MIT_MIM_1	687	697	PF04212	0.526
DOC_PP1_RVXF_1	514	521	PF00149	0.463
DOC_PP1_RVXF_1	600	607	PF00149	0.406
DOC_PP2B_LxvP_1	27	30	PF13499	0.435
DOC_PP2B_LxvP_1	35	38	PF13499	0.440
DOC_PP4_FxxP_1	304	307	PF00568	0.647
DOC_PP4_FxxP_1	497	500	PF00568	0.527
DOC_PP4_FxxP_1	606	609	PF00568	0.371
DOC_SPAK_OSR1_1	516	520	PF12202	0.396
DOC_USP7_MATH_1	144	148	PF00917	0.484
DOC_USP7_MATH_1	205	209	PF00917	0.361
DOC_USP7_MATH_1	290	294	PF00917	0.672
DOC_USP7_MATH_1	402	406	PF00917	0.594
DOC_USP7_MATH_1	552	556	PF00917	0.619
DOC_USP7_MATH_1	584	588	PF00917	0.590
DOC_USP7_MATH_1	597	601	PF00917	0.646
DOC_USP7_MATH_1	740	744	PF00917	0.471
DOC_USP7_MATH_1	782	786	PF00917	0.641
DOC_USP7_UBL2_3	125	129	PF12436	0.418
DOC_USP7_UBL2_3	324	328	PF12436	0.401
DOC_WW_Pin1_4	117	122	PF00397	0.400
DOC_WW_Pin1_4	137	142	PF00397	0.448
DOC_WW_Pin1_4	176	181	PF00397	0.433
DOC_WW_Pin1_4	19	24	PF00397	0.471
DOC_WW_Pin1_4	220	225	PF00397	0.497
DOC_WW_Pin1_4	265	270	PF00397	0.735
DOC_WW_Pin1_4	286	291	PF00397	0.659
DOC_WW_Pin1_4	302	307	PF00397	0.648
DOC_WW_Pin1_4	389	394	PF00397	0.378
DOC_WW_Pin1_4	605	610	PF00397	0.420
DOC_WW_Pin1_4	71	76	PF00397	0.479
LIG_14-3-3_CanoR_1	170	175	PF00244	0.445
LIG_14-3-3_CanoR_1	236	245	PF00244	0.612
LIG_14-3-3_CanoR_1	257	265	PF00244	0.720
LIG_14-3-3_CanoR_1	275	281	PF00244	0.617
LIG_14-3-3_CanoR_1	479	483	PF00244	0.562
LIG_14-3-3_CanoR_1	613	622	PF00244	0.387
LIG_14-3-3_CanoR_1	722	728	PF00244	0.519
LIG_14-3-3_CanoR_1	745	755	PF00244	0.438
LIG_Actin_WH2_2	179	197	PF00022	0.347
LIG_APCC_ABBA_1	14	19	PF00400	0.443
LIG_BIR_III_2	535	539	PF00653	0.561
LIG_BIR_III_4	416	420	PF00653	0.432
LIG_CaM_IQ_9	358	374	PF13499	0.477
LIG_Clathr_ClatBox_1	452	456	PF01394	0.355
LIG_CSL_BTD_1	606	609	PF09270	0.405
LIG_deltaCOP1_diTrp_1	448	455	PF00928	0.438
LIG_deltaCOP1_diTrp_1	645	654	PF00928	0.410
LIG_eIF4E_1	4	10	PF01652	0.438
LIG_FHA_1	153	159	PF00498	0.462
LIG_FHA_1	303	309	PF00498	0.564
LIG_FHA_1	336	342	PF00498	0.595
LIG_FHA_1	362	368	PF00498	0.683
LIG_FHA_1	40	46	PF00498	0.448
LIG_FHA_1	528	534	PF00498	0.657
LIG_FHA_1	79	85	PF00498	0.470
LIG_FHA_2	198	204	PF00498	0.455
LIG_FHA_2	464	470	PF00498	0.545
LIG_Integrin_isoDGR_2	542	544	PF01839	0.666
LIG_LIR_Apic_2	19	23	PF02991	0.435
LIG_LIR_Apic_2	301	307	PF02991	0.655
LIG_LIR_Apic_2	495	500	PF02991	0.532
LIG_LIR_Apic_2	603	609	PF02991	0.379
LIG_LIR_Gen_1	120	127	PF02991	0.409
LIG_LIR_Gen_1	184	194	PF02991	0.500
LIG_LIR_Gen_1	209	219	PF02991	0.462
LIG_LIR_Gen_1	491	500	PF02991	0.451
LIG_LIR_Gen_1	660	668	PF02991	0.477
LIG_LIR_Gen_1	686	694	PF02991	0.540
LIG_LIR_Gen_1	774	782	PF02991	0.562
LIG_LIR_Nem_3	120	126	PF02991	0.409
LIG_LIR_Nem_3	184	190	PF02991	0.407
LIG_LIR_Nem_3	209	215	PF02991	0.427
LIG_LIR_Nem_3	21	27	PF02991	0.434
LIG_LIR_Nem_3	349	354	PF02991	0.582
LIG_LIR_Nem_3	448	453	PF02991	0.446
LIG_LIR_Nem_3	47	52	PF02991	0.450
LIG_LIR_Nem_3	491	497	PF02991	0.462
LIG_LIR_Nem_3	660	665	PF02991	0.496
LIG_LIR_Nem_3	686	690	PF02991	0.485
LIG_LIR_Nem_3	774	779	PF02991	0.514
LIG_LYPXL_yS_3	24	27	PF13949	0.434
LIG_MYND_1	25	29	PF01753	0.431
LIG_NBox_RRM_1	455	465	PF00076	0.498
LIG_NRBOX	162	168	PF00104	0.443
LIG_OCRL_FandH_1	686	698	PF00620	0.407
LIG_Pex14_1	20	24	PF04695	0.438
LIG_Pex14_2	446	450	PF04695	0.497
LIG_SH2_CRK	4	8	PF00017	0.436
LIG_SH2_CRK	93	97	PF00017	0.412
LIG_SH2_GRB2like	776	779	PF00017	0.455
LIG_SH2_NCK_1	123	127	PF00017	0.412
LIG_SH2_NCK_1	776	780	PF00017	0.420
LIG_SH2_SRC	776	779	PF00017	0.575
LIG_SH2_STAP1	168	172	PF00017	0.447
LIG_SH2_STAT5	17	20	PF00017	0.546
LIG_SH2_STAT5	199	202	PF00017	0.485
LIG_SH2_STAT5	206	209	PF00017	0.474
LIG_SH2_STAT5	320	323	PF00017	0.573
LIG_SH2_STAT5	4	7	PF00017	0.486
LIG_SH2_STAT5	48	51	PF00017	0.454
LIG_SH2_STAT5	818	821	PF00017	0.472
LIG_SH2_STAT5	93	96	PF00017	0.409
LIG_SH3_3	138	144	PF00018	0.475
LIG_SH3_3	546	552	PF00018	0.709
LIG_SH3_3	805	811	PF00018	0.567
LIG_SUMO_SIM_anti_2	208	217	PF11976	0.492
LIG_SUMO_SIM_anti_2	753	760	PF11976	0.421
LIG_SUMO_SIM_par_1	338	345	PF11976	0.570
LIG_SUMO_SIM_par_1	769	774	PF11976	0.555
LIG_TRAF2_1	438	441	PF00917	0.528
LIG_TRAF2_1	466	469	PF00917	0.614
LIG_TRAF2_1	637	640	PF00917	0.510
LIG_TRAF2_1	790	793	PF00917	0.580
LIG_TYR_ITIM	91	96	PF00017	0.411
LIG_UBA3_1	321	328	PF00899	0.391
LIG_WW_2	143	146	PF00397	0.474
MOD_CDC14_SPxK_1	310	313	PF00782	0.624
MOD_CDK_SPxK_1	307	313	PF00069	0.636
MOD_CDK_SPxxK_3	302	309	PF00069	0.528
MOD_CDK_SPxxK_3	605	612	PF00069	0.424
MOD_CK1_1	117	123	PF00069	0.403
MOD_CK1_1	147	153	PF00069	0.494
MOD_CK1_1	197	203	PF00069	0.595
MOD_CK1_1	208	214	PF00069	0.391
MOD_CK1_1	237	243	PF00069	0.640
MOD_CK1_1	251	257	PF00069	0.516
MOD_CK1_1	293	299	PF00069	0.668
MOD_CK1_1	326	332	PF00069	0.420
MOD_CK1_1	365	371	PF00069	0.517
MOD_CK1_1	392	398	PF00069	0.450
MOD_CK1_1	585	591	PF00069	0.597
MOD_CK1_1	600	606	PF00069	0.391
MOD_CK1_1	721	727	PF00069	0.496
MOD_CK1_1	74	80	PF00069	0.468
MOD_CK1_1	800	806	PF00069	0.598
MOD_CK2_1	326	332	PF00069	0.570
MOD_CK2_1	333	339	PF00069	0.521
MOD_CK2_1	463	469	PF00069	0.526
MOD_CK2_1	519	525	PF00069	0.536
MOD_CK2_1	605	611	PF00069	0.401
MOD_CK2_1	771	777	PF00069	0.533
MOD_GlcNHglycan	105	108	PF01048	0.410
MOD_GlcNHglycan	112	115	PF01048	0.387
MOD_GlcNHglycan	183	186	PF01048	0.474
MOD_GlcNHglycan	196	199	PF01048	0.409
MOD_GlcNHglycan	248	251	PF01048	0.776
MOD_GlcNHglycan	325	328	PF01048	0.580
MOD_GlcNHglycan	367	370	PF01048	0.686
MOD_GlcNHglycan	404	407	PF01048	0.587
MOD_GlcNHglycan	422	425	PF01048	0.327
MOD_GlcNHglycan	558	561	PF01048	0.688
MOD_GlcNHglycan	62	65	PF01048	0.476
MOD_GlcNHglycan	723	726	PF01048	0.492
MOD_GlcNHglycan	759	762	PF01048	0.533
MOD_GlcNHglycan	773	776	PF01048	0.533
MOD_GlcNHglycan	783	787	PF01048	0.539
MOD_GSK3_1	110	117	PF00069	0.368
MOD_GSK3_1	144	151	PF00069	0.489
MOD_GSK3_1	166	173	PF00069	0.708
MOD_GSK3_1	234	241	PF00069	0.663
MOD_GSK3_1	244	251	PF00069	0.663
MOD_GSK3_1	253	260	PF00069	0.506
MOD_GSK3_1	271	278	PF00069	0.605
MOD_GSK3_1	286	293	PF00069	0.564
MOD_GSK3_1	29	36	PF00069	0.450
MOD_GSK3_1	361	368	PF00069	0.612
MOD_GSK3_1	552	559	PF00069	0.665
MOD_GSK3_1	70	77	PF00069	0.476
MOD_GSK3_1	746	753	PF00069	0.382
MOD_GSK3_1	78	85	PF00069	0.433
MOD_GSK3_1	91	98	PF00069	0.388
MOD_N-GLC_1	290	295	PF02516	0.650
MOD_N-GLC_1	777	782	PF02516	0.468
MOD_NEK2_1	135	140	PF00069	0.491
MOD_NEK2_1	166	171	PF00069	0.444
MOD_NEK2_1	194	199	PF00069	0.487
MOD_NEK2_1	238	243	PF00069	0.451
MOD_NEK2_1	253	258	PF00069	0.498
MOD_NEK2_1	361	366	PF00069	0.632
MOD_NEK2_1	409	414	PF00069	0.498
MOD_NEK2_1	420	425	PF00069	0.406
MOD_NEK2_1	527	532	PF00069	0.533
MOD_NEK2_1	614	619	PF00069	0.391
MOD_NEK2_1	697	702	PF00069	0.597
MOD_NEK2_1	716	721	PF00069	0.440
MOD_NEK2_1	757	762	PF00069	0.403
MOD_NEK2_1	76	81	PF00069	0.464
MOD_NEK2_2	12	17	PF00069	0.444
MOD_PIKK_1	623	629	PF00454	0.532
MOD_PIKK_1	652	658	PF00454	0.606
MOD_PIKK_1	670	676	PF00454	0.382
MOD_PKA_1	257	263	PF00069	0.691
MOD_PKA_1	275	281	PF00069	0.480
MOD_PKA_1	571	577	PF00069	0.500
MOD_PKA_2	257	263	PF00069	0.633
MOD_PKA_2	356	362	PF00069	0.566
MOD_PKA_2	365	371	PF00069	0.560
MOD_PKA_2	478	484	PF00069	0.566
MOD_PKA_2	543	549	PF00069	0.661
MOD_PKA_2	570	576	PF00069	0.648
MOD_PKA_2	585	591	PF00069	0.450
MOD_PKA_2	721	727	PF00069	0.457
MOD_PKA_2	82	88	PF00069	0.427
MOD_PKB_1	569	577	PF00069	0.504
MOD_Plk_1	108	114	PF00069	0.403
MOD_Plk_1	208	214	PF00069	0.531
MOD_Plk_1	290	296	PF00069	0.728
MOD_Plk_1	300	306	PF00069	0.680
MOD_Plk_1	344	350	PF00069	0.522
MOD_Plk_1	430	436	PF00069	0.544
MOD_Plk_1	697	703	PF00069	0.358
MOD_Plk_1	777	783	PF00069	0.470
MOD_Plk_2-3	657	663	PF00069	0.497
MOD_Plk_2-3	777	783	PF00069	0.470
MOD_Plk_4	208	214	PF00069	0.531
MOD_Plk_4	44	50	PF00069	0.454
MOD_Plk_4	657	663	PF00069	0.482
MOD_ProDKin_1	117	123	PF00069	0.403
MOD_ProDKin_1	137	143	PF00069	0.447
MOD_ProDKin_1	176	182	PF00069	0.431
MOD_ProDKin_1	19	25	PF00069	0.465
MOD_ProDKin_1	220	226	PF00069	0.493
MOD_ProDKin_1	265	271	PF00069	0.730
MOD_ProDKin_1	286	292	PF00069	0.659
MOD_ProDKin_1	302	308	PF00069	0.648
MOD_ProDKin_1	389	395	PF00069	0.374
MOD_ProDKin_1	605	611	PF00069	0.423
MOD_ProDKin_1	71	77	PF00069	0.477
MOD_SUMO_for_1	314	317	PF00179	0.554
MOD_SUMO_for_1	96	99	PF00179	0.403
MOD_SUMO_rev_2	655	661	PF00179	0.476
TRG_DiLeu_BaEn_1	317	322	PF01217	0.542
TRG_DiLeu_BaEn_1	448	453	PF01217	0.446
TRG_DiLeu_BaEn_4	468	474	PF01217	0.499
TRG_DiLeu_BaEn_4	639	645	PF01217	0.504
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.551
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.488
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.421
TRG_ENDOCYTIC_2	123	126	PF00928	0.415
TRG_ENDOCYTIC_2	24	27	PF00928	0.434
TRG_ENDOCYTIC_2	776	779	PF00928	0.482
TRG_ENDOCYTIC_2	93	96	PF00928	0.409
TRG_ER_diArg_1	531	533	PF00400	0.626
TRG_NES_CRM1_1	471	483	PF08389	0.482
TRG_NLS_MonoCore_2	128	133	PF00514	0.449
TRG_NLS_MonoExtN_4	128	134	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBM3	Leptomonas seymouri	61%	100%
A0A1X0P209	Trypanosomatidae	33%	100%
A0A3S5H7N2	Leishmania donovani	85%	100%
A4I5N9	Leishmania infantum	85%	100%
E9B0Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q783	Leishmania major	84%	99%
V5BL95	Trypanosoma cruzi	34%	100%