Putative alcohol dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alcohol dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HIE1_LEIBR

TriTrypDb:

LbrM.30.2040 , LBRM2903_300026500

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004022	alcohol dehydrogenase (NAD+) activity	6	6
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	8
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	8
GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	5	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.384
CLV_PCSK_SKI1_1	127	131	PF00082	0.229
CLV_PCSK_SKI1_1	134	138	PF00082	0.476
CLV_PCSK_SKI1_1	198	202	PF00082	0.405
CLV_PCSK_SKI1_1	227	231	PF00082	0.370
CLV_PCSK_SKI1_1	45	49	PF00082	0.352
CLV_PCSK_SKI1_1	78	82	PF00082	0.476
DOC_CDC14_PxL_1	140	148	PF14671	0.476
DOC_CDC14_PxL_1	31	39	PF14671	0.476
DOC_CKS1_1	180	185	PF01111	0.405
DOC_CKS1_1	19	24	PF01111	0.367
DOC_CYCLIN_RxL_1	39	51	PF00134	0.360
DOC_MAPK_gen_1	39	49	PF00069	0.476
DOC_MAPK_gen_1	97	107	PF00069	0.405
DOC_PP1_RVXF_1	136	142	PF00149	0.405
DOC_PP4_FxxP_1	180	183	PF00568	0.476
DOC_USP7_MATH_1	309	313	PF00917	0.473
DOC_WW_Pin1_4	179	184	PF00397	0.352
DOC_WW_Pin1_4	18	23	PF00397	0.377
LIG_14-3-3_CanoR_1	125	132	PF00244	0.229
LIG_14-3-3_CanoR_1	357	361	PF00244	0.229
LIG_AP2alpha_2	178	180	PF02296	0.476
LIG_APCC_ABBA_1	74	79	PF00400	0.405
LIG_EVH1_1	141	145	PF00568	0.476
LIG_FHA_1	11	17	PF00498	0.517
LIG_FHA_1	126	132	PF00498	0.316
LIG_FHA_1	19	25	PF00498	0.421
LIG_FHA_1	208	214	PF00498	0.311
LIG_FHA_1	48	54	PF00498	0.287
LIG_FHA_1	70	76	PF00498	0.229
LIG_FHA_2	153	159	PF00498	0.341
LIG_FHA_2	202	208	PF00498	0.327
LIG_FHA_2	246	252	PF00498	0.229
LIG_LIR_Apic_2	178	183	PF02991	0.476
LIG_LIR_Gen_1	172	181	PF02991	0.300
LIG_LIR_Gen_1	214	222	PF02991	0.318
LIG_LIR_Gen_1	392	399	PF02991	0.282
LIG_LIR_Nem_3	214	219	PF02991	0.318
LIG_LIR_Nem_3	260	265	PF02991	0.229
LIG_LIR_Nem_3	392	398	PF02991	0.457
LIG_MYND_1	179	183	PF01753	0.405
LIG_PCNA_PIPBox_1	233	242	PF02747	0.405
LIG_Pex14_2	137	141	PF04695	0.229
LIG_PTB_Apo_2	374	381	PF02174	0.405
LIG_PTB_Phospho_1	374	380	PF10480	0.405
LIG_SH2_CRK	286	290	PF00017	0.352
LIG_SH2_CRK	380	384	PF00017	0.476
LIG_SH2_GRB2like	216	219	PF00017	0.405
LIG_SH2_GRB2like	292	295	PF00017	0.476
LIG_SH2_SRC	216	219	PF00017	0.238
LIG_SH2_SRC	292	295	PF00017	0.476
LIG_SH2_STAP1	292	296	PF00017	0.394
LIG_SH2_STAT5	103	106	PF00017	0.376
LIG_SH2_STAT5	132	135	PF00017	0.229
LIG_SH2_STAT5	15	18	PF00017	0.498
LIG_SH2_STAT5	216	219	PF00017	0.316
LIG_SH2_STAT5	239	242	PF00017	0.405
LIG_SH2_STAT5	261	264	PF00017	0.383
LIG_SH3_3	136	142	PF00018	0.476
LIG_SH3_3	162	168	PF00018	0.448
LIG_SH3_3	184	190	PF00018	0.422
LIG_SH3_3	191	197	PF00018	0.451
LIG_SH3_3	293	299	PF00018	0.458
LIG_SUMO_SIM_par_1	145	152	PF11976	0.352
LIG_SUMO_SIM_par_1	189	195	PF11976	0.329
LIG_TYR_ITIM	75	80	PF00017	0.229
LIG_WRC_WIRS_1	60	65	PF05994	0.229
MOD_CK1_1	157	163	PF00069	0.352
MOD_CK2_1	152	158	PF00069	0.322
MOD_CK2_1	228	234	PF00069	0.367
MOD_CK2_1	245	251	PF00069	0.406
MOD_GlcNHglycan	230	233	PF01048	0.229
MOD_GlcNHglycan	306	309	PF01048	0.396
MOD_GlcNHglycan	351	354	PF01048	0.305
MOD_GSK3_1	148	155	PF00069	0.352
MOD_GSK3_1	6	13	PF00069	0.444
MOD_N-GLC_2	99	101	PF02516	0.352
MOD_NEK2_1	10	15	PF00069	0.485
MOD_NEK2_1	130	135	PF00069	0.381
MOD_NEK2_1	192	197	PF00069	0.476
MOD_NEK2_1	257	262	PF00069	0.389
MOD_NEK2_1	265	270	PF00069	0.348
MOD_NEK2_1	304	309	PF00069	0.392
MOD_NEK2_1	59	64	PF00069	0.291
MOD_NEK2_1	95	100	PF00069	0.229
MOD_NEK2_2	356	361	PF00069	0.229
MOD_PKA_2	356	362	PF00069	0.229
MOD_PKB_1	18	26	PF00069	0.307
MOD_Plk_1	157	163	PF00069	0.352
MOD_Plk_4	108	114	PF00069	0.389
MOD_Plk_4	11	17	PF00069	0.483
MOD_Plk_4	20	26	PF00069	0.381
MOD_Plk_4	257	263	PF00069	0.458
MOD_Plk_4	59	65	PF00069	0.291
MOD_ProDKin_1	179	185	PF00069	0.352
MOD_ProDKin_1	18	24	PF00069	0.375
TRG_DiLeu_BaEn_1	340	345	PF01217	0.229
TRG_DiLeu_BaEn_4	90	96	PF01217	0.476
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.476
TRG_ENDOCYTIC_2	216	219	PF00928	0.316
TRG_ENDOCYTIC_2	77	80	PF00928	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM0	Leptomonas seymouri	64%	98%
A0A0N1P9Y7	Leptomonas seymouri	36%	100%
A0A0S1X9S7	Thermococcus barophilus	31%	100%
A0A1X0P6U8	Trypanosomatidae	37%	100%
A0A3R7LCK2	Trypanosoma rangeli	36%	100%
A0A3S7X3G7	Leishmania donovani	81%	100%
A4I5N8	Leishmania infantum	81%	100%
A4IP64	Geobacillus thermodenitrificans (strain NG80-2)	36%	100%
A4ISB9	Geobacillus thermodenitrificans (strain NG80-2)	27%	100%
A6QP15	Bos taurus	28%	86%
A6ZTT5	Saccharomyces cerevisiae (strain YJM789)	33%	100%
A8WTJ7	Caenorhabditis briggsae	30%	86%
B1VB76	Citrobacter freundii	31%	100%
C5MRT8	Mycobacterium sp. (strain DSM 3803 / JC1)	34%	94%
E5Y946	Bilophila wadsworthia (strain 3_1_6)	27%	100%
E9B0Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
F8DVL8	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	39%	100%
O05239	Bacillus subtilis (strain 168)	29%	100%
O05240	Bacillus subtilis (strain 168)	28%	100%
O30847	Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13)	25%	100%
O87612	Pseudomonas aeruginosa	25%	100%
P0A9S1	Escherichia coli (strain K12)	34%	100%
P0A9S2	Escherichia coli O157:H7	34%	100%
P0DJA2	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	39%	100%
P10127	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P13604	Clostridium saccharobutylicum	32%	100%
P27101	Pseudomonas sp. (strain P51)	25%	100%
P27137	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	24%	100%
P31005	Bacillus methanolicus	34%	100%
P37686	Escherichia coli (strain K12)	38%	100%
P41795	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P45513	Citrobacter freundii	37%	100%
P71017	Bacillus subtilis (strain 168)	36%	99%
P76553	Escherichia coli (strain K12)	33%	100%
Q08B39	Xenopus laevis	28%	86%
Q09669	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	95%
Q17EN4	Aedes aegypti	27%	86%
Q24857	Entamoeba histolytica	24%	100%
Q28XT3	Drosophila pseudoobscura pseudoobscura	30%	86%
Q45072	Burkholderia cepacia	25%	100%
Q46856	Escherichia coli (strain K12)	28%	100%
Q4Q784	Leishmania major	80%	100%
Q4QQW3	Rattus norvegicus	28%	85%
Q53062	Rhodococcus erythropolis	32%	94%
Q54GJ7	Dictyostelium discoideum	26%	73%
Q59104	Cupriavidus necator	35%	100%
Q59477	Klebsiella pneumoniae	37%	100%
Q5RF11	Pongo abelii	28%	85%
Q6P371	Xenopus tropicalis	29%	86%
Q7Q547	Anopheles gambiae	28%	86%
Q8IWW8	Homo sapiens	28%	85%
Q8R0N6	Mus musculus	29%	86%
Q93T12	Delftia acidovorans	25%	100%
Q9F282	Thermoanaerobacter ethanolicus	30%	100%
Q9RCG0	Amycolatopsis methanolica	32%	93%
Q9U2M4	Caenorhabditis elegans	32%	86%
Q9W265	Drosophila melanogaster	28%	86%
Q9XDN0	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
V5BRQ8	Trypanosoma cruzi	39%	100%