AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIE0_LEIBR

TriTrypDb:

LbrM.30.2030 , LBRM2903_300026300

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HIE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	14	20	PF00089	0.477
CLV_MEL_PAP_1	211	217	PF00089	0.328
CLV_NRD_NRD_1	231	233	PF00675	0.358
CLV_NRD_NRD_1	289	291	PF00675	0.328
CLV_NRD_NRD_1	295	297	PF00675	0.328
CLV_NRD_NRD_1	374	376	PF00675	0.482
CLV_NRD_NRD_1	455	457	PF00675	0.628
CLV_NRD_NRD_1	528	530	PF00675	0.697
CLV_NRD_NRD_1	534	536	PF00675	0.600
CLV_PCSK_FUR_1	287	291	PF00082	0.328
CLV_PCSK_KEX2_1	231	233	PF00082	0.358
CLV_PCSK_KEX2_1	289	291	PF00082	0.328
CLV_PCSK_KEX2_1	295	297	PF00082	0.328
CLV_PCSK_KEX2_1	374	376	PF00082	0.482
CLV_PCSK_KEX2_1	528	530	PF00082	0.706
CLV_PCSK_KEX2_1	534	536	PF00082	0.625
CLV_PCSK_PC7_1	524	530	PF00082	0.542
CLV_PCSK_SKI1_1	224	228	PF00082	0.413
CLV_PCSK_SKI1_1	382	386	PF00082	0.455
CLV_PCSK_SKI1_1	446	450	PF00082	0.464
CLV_PCSK_SKI1_1	456	460	PF00082	0.625
CLV_PCSK_SKI1_1	545	549	PF00082	0.547
DEG_APCC_DBOX_1	231	239	PF00400	0.475
DEG_MDM2_SWIB_1	74	81	PF02201	0.491
DEG_SCF_FBW7_1	260	266	PF00400	0.437
DEG_SPOP_SBC_1	34	38	PF00917	0.687
DOC_ANK_TNKS_1	181	188	PF00023	0.594
DOC_CKS1_1	260	265	PF01111	0.437
DOC_CYCLIN_RxL_1	443	453	PF00134	0.584
DOC_MAPK_FxFP_2	122	125	PF00069	0.278
DOC_MAPK_gen_1	100	109	PF00069	0.535
DOC_MAPK_gen_1	202	211	PF00069	0.422
DOC_MAPK_gen_1	231	238	PF00069	0.358
DOC_MAPK_gen_1	402	411	PF00069	0.422
DOC_MAPK_HePTP_8	399	411	PF00069	0.451
DOC_MAPK_MEF2A_6	204	213	PF00069	0.411
DOC_MAPK_MEF2A_6	402	411	PF00069	0.447
DOC_PP2B_LxvP_1	165	168	PF13499	0.443
DOC_PP4_FxxP_1	122	125	PF00568	0.278
DOC_PP4_FxxP_1	515	518	PF00568	0.666
DOC_USP7_MATH_1	3	7	PF00917	0.733
DOC_USP7_MATH_1	35	39	PF00917	0.659
DOC_USP7_MATH_1	461	465	PF00917	0.472
DOC_USP7_MATH_1	480	484	PF00917	0.540
DOC_USP7_MATH_1	510	514	PF00917	0.533
DOC_USP7_MATH_1	84	88	PF00917	0.540
DOC_WW_Pin1_4	1	6	PF00397	0.683
DOC_WW_Pin1_4	259	264	PF00397	0.467
DOC_WW_Pin1_4	308	313	PF00397	0.344
DOC_WW_Pin1_4	388	393	PF00397	0.425
LIG_14-3-3_CanoR_1	128	137	PF00244	0.570
LIG_14-3-3_CanoR_1	197	201	PF00244	0.466
LIG_14-3-3_CanoR_1	264	268	PF00244	0.423
LIG_14-3-3_CanoR_1	535	544	PF00244	0.601
LIG_14-3-3_CanoR_1	72	81	PF00244	0.476
LIG_Actin_WH2_2	113	130	PF00022	0.409
LIG_APCC_ABBAyCdc20_2	404	410	PF00400	0.410
LIG_BRCT_BRCA1_1	120	124	PF00533	0.265
LIG_deltaCOP1_diTrp_1	542	551	PF00928	0.578
LIG_DLG_GKlike_1	231	238	PF00625	0.223
LIG_FHA_1	114	120	PF00498	0.449
LIG_FHA_1	168	174	PF00498	0.554
LIG_FHA_1	210	216	PF00498	0.328
LIG_FHA_1	244	250	PF00498	0.339
LIG_FHA_1	260	266	PF00498	0.328
LIG_FHA_1	453	459	PF00498	0.392
LIG_FHA_2	138	144	PF00498	0.516
LIG_FHA_2	167	173	PF00498	0.523
LIG_FHA_2	264	270	PF00498	0.344
LIG_FHA_2	320	326	PF00498	0.328
LIG_FHA_2	381	387	PF00498	0.456
LIG_FHA_2	463	469	PF00498	0.619
LIG_FHA_2	486	492	PF00498	0.742
LIG_FHA_2	537	543	PF00498	0.575
LIG_LIR_Apic_2	121	125	PF02991	0.274
LIG_LIR_Apic_2	386	392	PF02991	0.539
LIG_LIR_Apic_2	513	518	PF02991	0.650
LIG_LIR_Gen_1	136	147	PF02991	0.424
LIG_LIR_Gen_1	311	321	PF02991	0.346
LIG_LIR_Gen_1	391	401	PF02991	0.456
LIG_LIR_Gen_1	491	498	PF02991	0.760
LIG_LIR_Gen_1	76	86	PF02991	0.463
LIG_LIR_LC3C_4	6	10	PF02991	0.488
LIG_LIR_Nem_3	103	107	PF02991	0.435
LIG_LIR_Nem_3	121	127	PF02991	0.308
LIG_LIR_Nem_3	136	142	PF02991	0.417
LIG_LIR_Nem_3	143	149	PF02991	0.342
LIG_LIR_Nem_3	311	317	PF02991	0.346
LIG_LIR_Nem_3	391	396	PF02991	0.368
LIG_LIR_Nem_3	491	497	PF02991	0.762
LIG_LIR_Nem_3	542	547	PF02991	0.603
LIG_LIR_Nem_3	76	81	PF02991	0.402
LIG_MYND_1	56	60	PF01753	0.336
LIG_NRBOX	347	353	PF00104	0.328
LIG_Pex14_2	74	78	PF04695	0.488
LIG_SH2_CRK	389	393	PF00017	0.551
LIG_SH2_CRK	494	498	PF00017	0.785
LIG_SH2_NCK_1	139	143	PF00017	0.542
LIG_SH2_NCK_1	389	393	PF00017	0.565
LIG_SH2_PTP2	408	411	PF00017	0.410
LIG_SH2_SRC	218	221	PF00017	0.449
LIG_SH2_SRC	314	317	PF00017	0.363
LIG_SH2_SRC	408	411	PF00017	0.433
LIG_SH2_STAP1	113	117	PF00017	0.470
LIG_SH2_STAP1	494	498	PF00017	0.649
LIG_SH2_STAP1	85	89	PF00017	0.521
LIG_SH2_STAT5	139	142	PF00017	0.526
LIG_SH2_STAT5	175	178	PF00017	0.535
LIG_SH2_STAT5	218	221	PF00017	0.363
LIG_SH2_STAT5	284	287	PF00017	0.449
LIG_SH2_STAT5	314	317	PF00017	0.344
LIG_SH2_STAT5	408	411	PF00017	0.376
LIG_SH2_STAT5	494	497	PF00017	0.763
LIG_SH2_STAT5	50	53	PF00017	0.425
LIG_SH3_3	257	263	PF00018	0.385
LIG_SH3_5	135	139	PF00018	0.465
LIG_Sin3_3	223	230	PF02671	0.344
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.344
LIG_SUMO_SIM_anti_2	445	453	PF11976	0.539
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.488
LIG_SUMO_SIM_par_1	234	239	PF11976	0.328
LIG_SUMO_SIM_par_1	445	453	PF11976	0.502
LIG_TRAF2_1	321	324	PF00917	0.475
LIG_TRAF2_1	370	373	PF00917	0.472
LIG_UBA3_1	235	240	PF00899	0.395
LIG_UBA3_1	447	454	PF00899	0.511
LIG_WRC_WIRS_1	119	124	PF05994	0.262
LIG_WRC_WIRS_1	85	90	PF05994	0.558
MOD_CDK_SPK_2	259	264	PF00069	0.437
MOD_CK1_1	13	19	PF00069	0.651
MOD_CK1_1	391	397	PF00069	0.488
MOD_CK1_1	462	468	PF00069	0.608
MOD_CK1_1	482	488	PF00069	0.730
MOD_CK1_1	49	55	PF00069	0.563
MOD_CK1_1	70	76	PF00069	0.437
MOD_CK2_1	109	115	PF00069	0.318
MOD_CK2_1	137	143	PF00069	0.462
MOD_CK2_1	166	172	PF00069	0.328
MOD_CK2_1	267	273	PF00069	0.328
MOD_CK2_1	319	325	PF00069	0.344
MOD_CK2_1	367	373	PF00069	0.454
MOD_CK2_1	380	386	PF00069	0.472
MOD_CK2_1	439	445	PF00069	0.556
MOD_CK2_1	485	491	PF00069	0.740
MOD_GlcNHglycan	157	160	PF01048	0.608
MOD_GlcNHglycan	37	40	PF01048	0.650
MOD_GlcNHglycan	420	425	PF01048	0.464
MOD_GlcNHglycan	43	46	PF01048	0.543
MOD_GlcNHglycan	482	485	PF01048	0.801
MOD_GlcNHglycan	501	504	PF01048	0.618
MOD_GlcNHglycan	508	511	PF01048	0.633
MOD_GlcNHglycan	521	524	PF01048	0.782
MOD_GlcNHglycan	65	68	PF01048	0.514
MOD_GlcNHglycan	69	72	PF01048	0.535
MOD_GlcNHglycan	75	78	PF01048	0.501
MOD_GSK3_1	109	116	PF00069	0.420
MOD_GSK3_1	129	136	PF00069	0.424
MOD_GSK3_1	259	266	PF00069	0.383
MOD_GSK3_1	476	483	PF00069	0.742
MOD_GSK3_1	506	513	PF00069	0.787
MOD_GSK3_1	519	526	PF00069	0.661
MOD_GSK3_1	63	70	PF00069	0.476
MOD_GSK3_1	73	80	PF00069	0.395
MOD_GSK3_1	84	91	PF00069	0.371
MOD_N-GLC_1	308	313	PF02516	0.344
MOD_N-GLC_1	377	382	PF02516	0.503
MOD_N-GLC_1	499	504	PF02516	0.682
MOD_N-GLC_1	506	511	PF02516	0.684
MOD_NEK2_1	109	114	PF00069	0.312
MOD_NEK2_1	137	142	PF00069	0.384
MOD_NEK2_1	209	214	PF00069	0.385
MOD_NEK2_1	236	241	PF00069	0.334
MOD_NEK2_1	243	248	PF00069	0.336
MOD_NEK2_1	339	344	PF00069	0.328
MOD_NEK2_1	46	51	PF00069	0.553
MOD_NEK2_2	113	118	PF00069	0.472
MOD_NEK2_2	77	82	PF00069	0.299
MOD_PIKK_1	129	135	PF00454	0.536
MOD_PIKK_1	137	143	PF00454	0.512
MOD_PIKK_1	330	336	PF00454	0.344
MOD_PIKK_1	482	488	PF00454	0.633
MOD_PIKK_1	523	529	PF00454	0.745
MOD_PKA_1	231	237	PF00069	0.358
MOD_PKA_2	155	161	PF00069	0.581
MOD_PKA_2	196	202	PF00069	0.427
MOD_PKA_2	231	237	PF00069	0.449
MOD_PKA_2	263	269	PF00069	0.449
MOD_PKA_2	523	529	PF00069	0.715
MOD_PKB_1	375	383	PF00069	0.499
MOD_Plk_1	137	143	PF00069	0.289
MOD_Plk_1	297	303	PF00069	0.358
MOD_Plk_1	46	52	PF00069	0.547
MOD_Plk_1	476	482	PF00069	0.800
MOD_Plk_1	506	512	PF00069	0.791
MOD_Plk_2-3	319	325	PF00069	0.449
MOD_Plk_4	118	124	PF00069	0.382
MOD_Plk_4	196	202	PF00069	0.433
MOD_Plk_4	231	237	PF00069	0.335
MOD_Plk_4	244	250	PF00069	0.305
MOD_Plk_4	263	269	PF00069	0.328
MOD_Plk_4	3	9	PF00069	0.667
MOD_Plk_4	380	386	PF00069	0.472
MOD_Plk_4	46	52	PF00069	0.547
MOD_Plk_4	492	498	PF00069	0.756
MOD_Plk_4	84	90	PF00069	0.552
MOD_ProDKin_1	1	7	PF00069	0.684
MOD_ProDKin_1	259	265	PF00069	0.467
MOD_ProDKin_1	308	314	PF00069	0.344
MOD_ProDKin_1	388	394	PF00069	0.428
MOD_SUMO_rev_2	540	550	PF00179	0.685
MOD_SUMO_rev_2	98	107	PF00179	0.407
TRG_DiLeu_BaEn_1	115	120	PF01217	0.351
TRG_DiLeu_BaEn_1	172	177	PF01217	0.428
TRG_DiLeu_BaEn_1	435	440	PF01217	0.545
TRG_DiLeu_BaEn_1	445	450	PF01217	0.531
TRG_DiLeu_BaEn_3	491	497	PF01217	0.532
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.580
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.457
TRG_ENDOCYTIC_2	139	142	PF00928	0.526
TRG_ENDOCYTIC_2	314	317	PF00928	0.344
TRG_ENDOCYTIC_2	408	411	PF00928	0.362
TRG_ENDOCYTIC_2	494	497	PF00928	0.790
TRG_ENDOCYTIC_2	85	88	PF00928	0.518
TRG_ER_diArg_1	14	17	PF00400	0.517
TRG_ER_diArg_1	201	204	PF00400	0.446
TRG_ER_diArg_1	287	290	PF00400	0.328
TRG_ER_diArg_1	294	296	PF00400	0.328
TRG_ER_diArg_1	374	377	PF00400	0.483
TRG_ER_diArg_1	534	536	PF00400	0.694
TRG_NES_CRM1_1	438	453	PF08389	0.404
TRG_NLS_MonoExtN_4	454	460	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	446	451	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P0	Leptomonas seymouri	66%	98%
A0A0S4JQC6	Bodo saltans	50%	100%
A0A1X0P383	Trypanosomatidae	51%	100%
A0A3Q8IFP8	Leishmania donovani	81%	100%
A0A422P3G0	Trypanosoma rangeli	63%	100%
A4I5N7	Leishmania infantum	81%	100%
C9ZR06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B0Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q785	Leishmania major	81%	100%
V5DQJ7	Trypanosoma cruzi	59%	94%