NFACT-R_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF814), putative

Species:

Leishmania braziliensis

UniProt:

A4HID9_LEIBR

TriTrypDb:

LbrM.30.2020 , LBRM2903_300026200

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HID9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.498
CLV_NRD_NRD_1	143	145	PF00675	0.632
CLV_NRD_NRD_1	155	157	PF00675	0.460
CLV_PCSK_KEX2_1	115	117	PF00082	0.498
CLV_PCSK_KEX2_1	155	157	PF00082	0.573
CLV_PCSK_KEX2_1	177	179	PF00082	0.657
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.657
CLV_PCSK_PC7_1	173	179	PF00082	0.704
CLV_PCSK_SKI1_1	125	129	PF00082	0.633
DEG_APCC_DBOX_1	124	132	PF00400	0.637
DEG_APCC_KENBOX_2	73	77	PF00400	0.408
DOC_CKS1_1	89	94	PF01111	0.288
DOC_MAPK_gen_1	135	143	PF00069	0.561
DOC_PIKK_1	174	182	PF02985	0.450
DOC_PP4_FxxP_1	30	33	PF00568	0.408
DOC_USP7_UBL2_3	129	133	PF12436	0.637
DOC_WW_Pin1_4	59	64	PF00397	0.288
DOC_WW_Pin1_4	88	93	PF00397	0.288
LIG_14-3-3_CanoR_1	115	121	PF00244	0.411
LIG_eIF4E_1	22	28	PF01652	0.288
LIG_FHA_1	196	202	PF00498	0.701
LIG_FHA_1	60	66	PF00498	0.364
LIG_FHA_2	132	138	PF00498	0.589
LIG_LIR_Gen_1	91	97	PF02991	0.203
LIG_LIR_Nem_3	140	146	PF02991	0.575
LIG_LIR_Nem_3	184	188	PF02991	0.438
LIG_LIR_Nem_3	34	40	PF02991	0.288
LIG_LIR_Nem_3	91	96	PF02991	0.288
LIG_SH2_CRK	117	121	PF00017	0.649
LIG_SH2_CRK	185	189	PF00017	0.455
LIG_SH2_GRB2like	22	25	PF00017	0.288
LIG_SH2_PTP2	49	52	PF00017	0.345
LIG_SH2_STAT5	4	7	PF00017	0.304
LIG_SH2_STAT5	49	52	PF00017	0.288
LIG_SH2_STAT5	90	93	PF00017	0.288
LIG_SH3_3	47	53	PF00018	0.304
LIG_SH3_3	86	92	PF00018	0.288
LIG_TYR_ITIM	2	7	PF00017	0.304
LIG_UBA3_1	127	133	PF00899	0.555
MOD_CK2_1	131	137	PF00069	0.608
MOD_GlcNHglycan	44	47	PF01048	0.288
MOD_NEK2_1	131	136	PF00069	0.545
MOD_NEK2_1	3	8	PF00069	0.345
MOD_PK_1	74	80	PF00069	0.288
MOD_Plk_1	131	137	PF00069	0.623
MOD_Plk_1	74	80	PF00069	0.354
MOD_ProDKin_1	59	65	PF00069	0.288
MOD_ProDKin_1	88	94	PF00069	0.288
MOD_SUMO_rev_2	169	179	PF00179	0.590
TRG_AP2beta_CARGO_1	140	150	PF09066	0.622
TRG_DiLeu_BaEn_1	23	28	PF01217	0.288
TRG_DiLeu_BaEn_1	68	73	PF01217	0.435
TRG_DiLeu_BaEn_4	153	159	PF01217	0.464
TRG_DiLeu_BaEn_4	174	180	PF01217	0.447
TRG_ENDOCYTIC_2	117	120	PF00928	0.522
TRG_ENDOCYTIC_2	185	188	PF00928	0.552
TRG_ENDOCYTIC_2	4	7	PF00928	0.300
TRG_ENDOCYTIC_2	49	52	PF00928	0.288
TRG_ER_diArg_1	114	116	PF00400	0.511
TRG_NLS_Bipartite_1	144	160	PF00514	0.723
TRG_NLS_MonoExtC_3	121	126	PF00514	0.448
TRG_NLS_MonoExtC_3	155	161	PF00514	0.708
TRG_NLS_MonoExtN_4	155	160	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME9	Leptomonas seymouri	83%	100%
A0A0S4JLK1	Bodo saltans	69%	100%
A0A1X0P1Z6	Trypanosomatidae	67%	100%
A0A3S7X3G6	Leishmania donovani	91%	100%
A0A422P3G2	Trypanosoma rangeli	66%	100%
A4I5N6	Leishmania infantum	91%	100%
C9ZR05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B0Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P40206	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q3SZX8	Bos taurus	50%	100%
Q4Q786	Leishmania major	91%	100%
Q55D55	Dictyostelium discoideum	49%	100%
Q5R9S1	Pongo abelii	50%	100%
Q6GLE1	Xenopus tropicalis	50%	100%
Q78PG9	Mus musculus	50%	100%
Q7T312	Danio rerio	50%	100%
Q86WR0	Homo sapiens	50%	100%
V5BU08	Trypanosoma cruzi	67%	100%