Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HID8_LEIBR

TriTrypDb:

LbrM.30.2010 , LBRM2903_300026100

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HID8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.568
CLV_NRD_NRD_1	125	127	PF00675	0.685
CLV_NRD_NRD_1	154	156	PF00675	0.703
CLV_NRD_NRD_1	206	208	PF00675	0.589
CLV_NRD_NRD_1	289	291	PF00675	0.638
CLV_NRD_NRD_1	303	305	PF00675	0.554
CLV_NRD_NRD_1	70	72	PF00675	0.623
CLV_NRD_NRD_1	95	97	PF00675	0.622
CLV_PCSK_FUR_1	123	127	PF00082	0.703
CLV_PCSK_FUR_1	68	72	PF00082	0.720
CLV_PCSK_KEX2_1	12	14	PF00082	0.557
CLV_PCSK_KEX2_1	125	127	PF00082	0.696
CLV_PCSK_KEX2_1	154	156	PF00082	0.703
CLV_PCSK_KEX2_1	289	291	PF00082	0.637
CLV_PCSK_KEX2_1	303	305	PF00082	0.578
CLV_PCSK_KEX2_1	70	72	PF00082	0.624
CLV_PCSK_KEX2_1	95	97	PF00082	0.621
CLV_PCSK_SKI1_1	96	100	PF00082	0.652
DEG_Nend_UBRbox_1	1	4	PF02207	0.632
DEG_SCF_FBW7_1	111	116	PF00400	0.711
DOC_CKS1_1	119	124	PF01111	0.634
DOC_CKS1_1	88	93	PF01111	0.635
DOC_MAPK_DCC_7	196	204	PF00069	0.629
DOC_MAPK_MEF2A_6	196	204	PF00069	0.629
DOC_MAPK_MEF2A_6	244	253	PF00069	0.629
DOC_PP2B_PxIxI_1	273	279	PF00149	0.485
DOC_PP4_MxPP_1	231	234	PF00568	0.518
DOC_USP7_MATH_1	100	104	PF00917	0.760
DOC_USP7_MATH_1	113	117	PF00917	0.672
DOC_USP7_MATH_1	131	135	PF00917	0.508
DOC_USP7_MATH_1	15	19	PF00917	0.556
DOC_USP7_MATH_1	160	164	PF00917	0.672
DOC_USP7_MATH_1	30	34	PF00917	0.682
DOC_USP7_UBL2_3	192	196	PF12436	0.630
DOC_USP7_UBL2_3	205	209	PF12436	0.456
DOC_WW_Pin1_4	109	114	PF00397	0.694
DOC_WW_Pin1_4	118	123	PF00397	0.628
DOC_WW_Pin1_4	132	137	PF00397	0.563
DOC_WW_Pin1_4	255	260	PF00397	0.648
DOC_WW_Pin1_4	278	283	PF00397	0.657
DOC_WW_Pin1_4	297	302	PF00397	0.582
DOC_WW_Pin1_4	62	67	PF00397	0.740
DOC_WW_Pin1_4	87	92	PF00397	0.604
DOC_WW_Pin1_4	96	101	PF00397	0.645
LIG_14-3-3_CanoR_1	114	122	PF00244	0.674
LIG_14-3-3_CanoR_1	162	167	PF00244	0.663
LIG_14-3-3_CanoR_1	173	181	PF00244	0.544
LIG_14-3-3_CanoR_1	218	225	PF00244	0.484
LIG_14-3-3_CanoR_1	303	307	PF00244	0.567
LIG_14-3-3_CanoR_1	48	55	PF00244	0.457
LIG_APCC_ABBA_1	211	216	PF00400	0.486
LIG_deltaCOP1_diTrp_1	243	248	PF00928	0.614
LIG_eIF4E_2	127	133	PF01652	0.471
LIG_FHA_1	303	309	PF00498	0.585
LIG_FHA_2	2	8	PF00498	0.671
LIG_LIR_Gen_1	18	24	PF02991	0.645
LIG_LIR_Gen_1	243	253	PF02991	0.626
LIG_LIR_Gen_1	305	314	PF02991	0.497
LIG_LIR_Nem_3	18	23	PF02991	0.643
LIG_LIR_Nem_3	243	249	PF02991	0.616
LIG_LIR_Nem_3	305	309	PF02991	0.507
LIG_MYND_1	199	203	PF01753	0.544
LIG_MYND_1	283	287	PF01753	0.483
LIG_SH2_PTP2	127	130	PF00017	0.659
LIG_SH2_SRC	127	130	PF00017	0.645
LIG_SH2_STAP1	55	59	PF00017	0.664
LIG_SH2_STAT5	127	130	PF00017	0.670
LIG_SH3_1	133	139	PF00018	0.535
LIG_SH3_1	230	236	PF00018	0.520
LIG_SH3_2	200	205	PF14604	0.631
LIG_SH3_2	284	289	PF14604	0.488
LIG_SH3_3	116	122	PF00018	0.705
LIG_SH3_3	125	131	PF00018	0.690
LIG_SH3_3	133	139	PF00018	0.550
LIG_SH3_3	184	190	PF00018	0.666
LIG_SH3_3	194	200	PF00018	0.555
LIG_SH3_3	229	235	PF00018	0.469
LIG_SH3_3	268	274	PF00018	0.687
LIG_SH3_3	281	287	PF00018	0.498
LIG_SH3_3	85	91	PF00018	0.566
LIG_SH3_4	192	199	PF00018	0.630
LIG_SH3_4	205	212	PF00018	0.459
LIG_SUMO_SIM_par_1	274	279	PF11976	0.674
MOD_CDC14_SPxK_1	135	138	PF00782	0.522
MOD_CDK_SPK_2	109	114	PF00069	0.691
MOD_CDK_SPK_2	118	123	PF00069	0.705
MOD_CDK_SPK_2	87	92	PF00069	0.650
MOD_CDK_SPxK_1	132	138	PF00069	0.534
MOD_CDK_SPxK_1	297	303	PF00069	0.588
MOD_CDK_SPxK_1	62	68	PF00069	0.746
MOD_CDK_SPxxK_3	118	125	PF00069	0.635
MOD_CDK_SPxxK_3	297	304	PF00069	0.541
MOD_CK1_1	109	115	PF00069	0.653
MOD_CK1_1	172	178	PF00069	0.584
MOD_CK1_1	255	261	PF00069	0.583
MOD_CK1_1	28	34	PF00069	0.676
MOD_CK2_1	1	7	PF00069	0.680
MOD_Cter_Amidation	68	71	PF01082	0.618
MOD_GlcNHglycan	220	223	PF01048	0.568
MOD_GlcNHglycan	239	242	PF01048	0.568
MOD_GSK3_1	109	116	PF00069	0.613
MOD_GSK3_1	145	152	PF00069	0.632
MOD_GSK3_1	154	161	PF00069	0.714
MOD_GSK3_1	169	176	PF00069	0.632
MOD_GSK3_1	274	281	PF00069	0.573
MOD_GSK3_1	43	50	PF00069	0.549
MOD_GSK3_1	96	103	PF00069	0.646
MOD_N-GLC_1	109	114	PF02516	0.675
MOD_N-GLC_1	149	154	PF02516	0.664
MOD_N-GLC_1	264	269	PF02516	0.551
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	171	176	PF00069	0.510
MOD_NEK2_1	47	52	PF00069	0.461
MOD_NEK2_2	15	20	PF00069	0.559
MOD_PIKK_1	47	53	PF00454	0.454
MOD_PK_1	162	168	PF00069	0.715
MOD_PKA_1	154	160	PF00069	0.610
MOD_PKA_2	113	119	PF00069	0.646
MOD_PKA_2	154	160	PF00069	0.662
MOD_PKA_2	172	178	PF00069	0.672
MOD_PKA_2	25	31	PF00069	0.578
MOD_PKA_2	302	308	PF00069	0.576
MOD_PKA_2	47	53	PF00069	0.468
MOD_Plk_1	145	151	PF00069	0.590
MOD_Plk_1	264	270	PF00069	0.596
MOD_Plk_4	15	21	PF00069	0.537
MOD_Plk_4	182	188	PF00069	0.679
MOD_Plk_4	50	56	PF00069	0.669
MOD_ProDKin_1	109	115	PF00069	0.693
MOD_ProDKin_1	118	124	PF00069	0.628
MOD_ProDKin_1	132	138	PF00069	0.560
MOD_ProDKin_1	255	261	PF00069	0.648
MOD_ProDKin_1	278	284	PF00069	0.656
MOD_ProDKin_1	297	303	PF00069	0.579
MOD_ProDKin_1	62	68	PF00069	0.746
MOD_ProDKin_1	87	93	PF00069	0.603
MOD_ProDKin_1	96	102	PF00069	0.642
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.539
TRG_ER_diArg_1	122	125	PF00400	0.697
TRG_ER_diArg_1	289	291	PF00400	0.628
TRG_ER_diArg_1	302	304	PF00400	0.685
TRG_ER_diArg_1	67	70	PF00400	0.750
TRG_ER_diArg_1	94	96	PF00400	0.679
TRG_NLS_MonoExtN_4	205	211	PF00514	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P913	Leptomonas seymouri	61%	100%
A0A1X0P1U3	Trypanosomatidae	29%	100%
A0A3Q8IFW1	Leishmania donovani	77%	100%
A0A422P3E4	Trypanosoma rangeli	33%	100%
A4I5N5	Leishmania infantum	77%	100%
E9B0X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q787	Leishmania major	76%	99%
V5BYT6	Trypanosoma cruzi	31%	100%