Ferric reductase transmembrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HID6_LEIBR

TriTrypDb:

LbrM.30.1990 , LBRM2903_300025900

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HID6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0140575	transmembrane monodehydroascorbate reductase activity	3	11
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.259
CLV_NRD_NRD_1	28	30	PF00675	0.252
CLV_NRD_NRD_1	77	79	PF00675	0.409
CLV_NRD_NRD_1	87	89	PF00675	0.523
CLV_PCSK_KEX2_1	175	177	PF00082	0.346
CLV_PCSK_KEX2_1	180	182	PF00082	0.187
CLV_PCSK_KEX2_1	28	30	PF00082	0.251
CLV_PCSK_KEX2_1	77	79	PF00082	0.422
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.346
CLV_PCSK_PC7_1	176	182	PF00082	0.187
CLV_PCSK_SKI1_1	166	170	PF00082	0.382
DOC_ANK_TNKS_1	28	35	PF00023	0.433
DOC_MAPK_gen_1	28	35	PF00069	0.531
DOC_USP7_MATH_1	87	91	PF00917	0.598
DOC_WW_Pin1_4	14	19	PF00397	0.675
DOC_WW_Pin1_4	167	172	PF00397	0.387
DOC_WW_Pin1_4	83	88	PF00397	0.626
LIG_Actin_WH2_2	152	168	PF00022	0.461
LIG_Actin_WH2_2	66	82	PF00022	0.414
LIG_EH1_1	56	64	PF00400	0.279
LIG_FHA_1	187	193	PF00498	0.374
LIG_FHA_1	217	223	PF00498	0.455
LIG_FHA_2	2	8	PF00498	0.715
LIG_Integrin_RGD_1	20	22	PF01839	0.296
LIG_LIR_Gen_1	129	137	PF02991	0.270
LIG_LIR_Gen_1	47	58	PF02991	0.283
LIG_LIR_Nem_3	129	133	PF02991	0.324
LIG_LIR_Nem_3	134	140	PF02991	0.347
LIG_LIR_Nem_3	47	53	PF02991	0.298
LIG_PDZ_Class_2	230	235	PF00595	0.201
LIG_SH2_CRK	56	60	PF00017	0.239
LIG_SH2_NCK_1	50	54	PF00017	0.287
LIG_SH2_PTP2	130	133	PF00017	0.187
LIG_SH2_STAP1	207	211	PF00017	0.371
LIG_SH2_STAP1	50	54	PF00017	0.287
LIG_SH2_STAT5	130	133	PF00017	0.288
LIG_SH2_STAT5	167	170	PF00017	0.546
LIG_SH2_STAT5	185	188	PF00017	0.298
LIG_SH2_STAT5	50	53	PF00017	0.413
LIG_SH3_2	171	176	PF14604	0.488
LIG_SH3_3	165	171	PF00018	0.483
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.201
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.349
LIG_SUMO_SIM_par_1	219	225	PF11976	0.201
LIG_TRFH_1	167	171	PF08558	0.407
LIG_TYR_ITIM	128	133	PF00017	0.344
LIG_WRC_WIRS_1	112	117	PF05994	0.344
LIG_WRC_WIRS_1	23	28	PF05994	0.537
MOD_CDC14_SPxK_1	17	20	PF00782	0.424
MOD_CDC14_SPxK_1	86	89	PF00782	0.515
MOD_CDK_SPK_2	83	88	PF00069	0.420
MOD_CDK_SPxK_1	14	20	PF00069	0.442
MOD_CDK_SPxK_1	83	89	PF00069	0.491
MOD_CK1_1	225	231	PF00069	0.292
MOD_CK2_1	1	7	PF00069	0.685
MOD_CK2_1	99	105	PF00069	0.359
MOD_GlcNHglycan	186	189	PF01048	0.292
MOD_GlcNHglycan	224	227	PF01048	0.201
MOD_GlcNHglycan	46	49	PF01048	0.413
MOD_GSK3_1	139	146	PF00069	0.391
MOD_GSK3_1	212	219	PF00069	0.344
MOD_GSK3_1	222	229	PF00069	0.246
MOD_GSK3_1	44	51	PF00069	0.440
MOD_GSK3_1	83	90	PF00069	0.427
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	143	148	PF00069	0.221
MOD_NEK2_1	216	221	PF00069	0.371
MOD_NEK2_1	44	49	PF00069	0.443
MOD_PKA_2	87	93	PF00069	0.468
MOD_Plk_4	111	117	PF00069	0.399
MOD_Plk_4	151	157	PF00069	0.325
MOD_Plk_4	212	218	PF00069	0.355
MOD_ProDKin_1	14	20	PF00069	0.601
MOD_ProDKin_1	167	173	PF00069	0.202
MOD_ProDKin_1	83	89	PF00069	0.543
MOD_SUMO_rev_2	17	26	PF00179	0.343
MOD_SUMO_rev_2	170	177	PF00179	0.209
TRG_ENDOCYTIC_2	130	133	PF00928	0.470
TRG_ENDOCYTIC_2	137	140	PF00928	0.344
TRG_ENDOCYTIC_2	50	53	PF00928	0.384
TRG_ENDOCYTIC_2	56	59	PF00928	0.306
TRG_ER_diArg_1	179	181	PF00400	0.201
TRG_ER_diArg_1	28	30	PF00400	0.293
TRG_ER_diArg_1	76	78	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNM4	Bodo saltans	27%	99%
A0A1X0P2F3	Trypanosomatidae	24%	95%
A0A3Q8IC17	Leishmania donovani	64%	100%
A0A3R7RSY6	Trypanosoma rangeli	28%	98%
A4I5N2	Leishmania infantum	66%	100%
C9ZR03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	98%
E9B0X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q789	Leishmania major	68%	96%
V5BPF8	Trypanosoma cruzi	27%	98%