GPI mannosyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mannosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HID4_LEIBR

TriTrypDb:

LbrM.30.1970 , LBRM2903_300025700

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0031501	mannosyltransferase complex	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:1990529	glycosylphosphatidylinositol-mannosyltransferase I complex	3	1

Expansion

Sequence features

A4HID4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0051751	alpha-1,4-mannosyltransferase activity	6	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	107	113	PF00089	0.214
CLV_NRD_NRD_1	265	267	PF00675	0.472
CLV_NRD_NRD_1	295	297	PF00675	0.261
CLV_NRD_NRD_1	354	356	PF00675	0.338
CLV_NRD_NRD_1	428	430	PF00675	0.382
CLV_PCSK_KEX2_1	265	267	PF00082	0.472
CLV_PCSK_KEX2_1	353	355	PF00082	0.257
CLV_PCSK_SKI1_1	106	110	PF00082	0.290
CLV_PCSK_SKI1_1	115	119	PF00082	0.274
CLV_PCSK_SKI1_1	13	17	PF00082	0.252
CLV_PCSK_SKI1_1	159	163	PF00082	0.447
CLV_PCSK_SKI1_1	23	27	PF00082	0.281
CLV_PCSK_SKI1_1	54	58	PF00082	0.580
CLV_PCSK_SKI1_1	90	94	PF00082	0.300
DEG_APCC_DBOX_1	353	361	PF00400	0.372
DEG_SPOP_SBC_1	202	206	PF00917	0.372
DOC_CYCLIN_RxL_1	103	113	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.333
DOC_MAPK_gen_1	115	125	PF00069	0.471
DOC_MAPK_gen_1	265	272	PF00069	0.333
DOC_MAPK_gen_1	353	362	PF00069	0.372
DOC_MAPK_HePTP_8	134	146	PF00069	0.426
DOC_MAPK_MEF2A_6	115	124	PF00069	0.491
DOC_MAPK_MEF2A_6	137	146	PF00069	0.476
DOC_MAPK_MEF2A_6	265	272	PF00069	0.333
DOC_MAPK_MEF2A_6	355	364	PF00069	0.478
DOC_MAPK_MEF2A_6	415	422	PF00069	0.633
DOC_MAPK_MEF2A_6	69	78	PF00069	0.293
DOC_PP1_RVXF_1	88	94	PF00149	0.315
DOC_PP2B_LxvP_1	368	371	PF13499	0.420
DOC_PP2B_LxvP_1	77	80	PF13499	0.247
DOC_PP4_FxxP_1	219	222	PF00568	0.300
DOC_PP4_FxxP_1	333	336	PF00568	0.292
DOC_USP7_MATH_1	336	340	PF00917	0.501
DOC_WW_Pin1_4	250	255	PF00397	0.247
DOC_WW_Pin1_4	58	63	PF00397	0.293
DOC_WW_Pin1_4	68	73	PF00397	0.265
LIG_14-3-3_CanoR_1	110	119	PF00244	0.554
LIG_14-3-3_CanoR_1	137	146	PF00244	0.447
LIG_14-3-3_CanoR_1	159	167	PF00244	0.447
LIG_14-3-3_CanoR_1	200	209	PF00244	0.509
LIG_14-3-3_CanoR_1	355	361	PF00244	0.475
LIG_14-3-3_CanoR_1	38	48	PF00244	0.284
LIG_14-3-3_CanoR_1	415	419	PF00244	0.582
LIG_14-3-3_CanoR_1	65	69	PF00244	0.290
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	394	398	PF00533	0.293
LIG_eIF4E_1	103	109	PF01652	0.423
LIG_eIF4E_1	68	74	PF01652	0.349
LIG_FHA_1	179	185	PF00498	0.347
LIG_FHA_1	202	208	PF00498	0.533
LIG_FHA_1	367	373	PF00498	0.265
LIG_FHA_1	400	406	PF00498	0.344
LIG_FHA_1	69	75	PF00498	0.263
LIG_FHA_2	3	9	PF00498	0.553
LIG_FHA_2	40	46	PF00498	0.275
LIG_FHA_2	426	432	PF00498	0.528
LIG_FHA_2	59	65	PF00498	0.334
LIG_FHA_2	92	98	PF00498	0.361
LIG_LIR_Apic_2	216	222	PF02991	0.391
LIG_LIR_Gen_1	116	127	PF02991	0.494
LIG_LIR_Gen_1	145	153	PF02991	0.285
LIG_LIR_Gen_1	253	263	PF02991	0.247
LIG_LIR_Gen_1	307	316	PF02991	0.300
LIG_LIR_Gen_1	43	53	PF02991	0.267
LIG_LIR_Nem_3	116	122	PF02991	0.508
LIG_LIR_Nem_3	223	227	PF02991	0.379
LIG_LIR_Nem_3	253	258	PF02991	0.259
LIG_LIR_Nem_3	307	313	PF02991	0.330
LIG_LIR_Nem_3	34	39	PF02991	0.312
LIG_LIR_Nem_3	43	49	PF02991	0.265
LIG_LIR_Nem_3	67	73	PF02991	0.274
LIG_LYPXL_S_1	175	179	PF13949	0.300
LIG_LYPXL_yS_3	176	179	PF13949	0.300
LIG_Pex14_1	256	260	PF04695	0.247
LIG_Pex14_1	324	328	PF04695	0.288
LIG_Pex14_2	169	173	PF04695	0.309
LIG_Pex14_2	215	219	PF04695	0.420
LIG_Pex14_2	252	256	PF04695	0.267
LIG_Pex14_2	281	285	PF04695	0.385
LIG_REV1ctd_RIR_1	195	204	PF16727	0.533
LIG_SH2_CRK	18	22	PF00017	0.418
LIG_SH2_CRK	180	184	PF00017	0.315
LIG_SH2_CRK	46	50	PF00017	0.256
LIG_SH2_CRK	70	74	PF00017	0.274
LIG_SH2_GRB2like	260	263	PF00017	0.247
LIG_SH2_NCK_1	344	348	PF00017	0.372
LIG_SH2_NCK_1	41	45	PF00017	0.275
LIG_SH2_STAP1	344	348	PF00017	0.372
LIG_SH2_STAT3	230	233	PF00017	0.308
LIG_SH2_STAT5	103	106	PF00017	0.302
LIG_SH2_STAT5	160	163	PF00017	0.354
LIG_SH2_STAT5	180	183	PF00017	0.116
LIG_SH2_STAT5	224	227	PF00017	0.345
LIG_SH2_STAT5	234	237	PF00017	0.210
LIG_SH2_STAT5	260	263	PF00017	0.247
LIG_SH2_STAT5	321	324	PF00017	0.300
LIG_SH2_STAT5	36	39	PF00017	0.332
LIG_SH2_STAT5	399	402	PF00017	0.396
LIG_SH2_STAT5	41	44	PF00017	0.262
LIG_SH2_STAT5	70	73	PF00017	0.265
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.358
LIG_SUMO_SIM_par_1	45	51	PF11976	0.275
LIG_TYR_ITIM	16	21	PF00017	0.418
LIG_TYR_ITIM	39	44	PF00017	0.354
LIG_WRC_WIRS_1	143	148	PF05994	0.285
MOD_CDK_SPxxK_3	58	65	PF00069	0.365
MOD_CK1_1	2	8	PF00069	0.426
MOD_CK2_1	425	431	PF00069	0.575
MOD_Cter_Amidation	263	266	PF01082	0.420
MOD_GlcNHglycan	114	118	PF01048	0.343
MOD_GlcNHglycan	273	277	PF01048	0.400
MOD_GSK3_1	109	116	PF00069	0.517
MOD_GSK3_1	133	140	PF00069	0.300
MOD_GSK3_1	336	343	PF00069	0.323
MOD_GSK3_1	64	71	PF00069	0.353
MOD_N-GLC_1	132	137	PF02516	0.357
MOD_N-GLC_1	250	255	PF02516	0.300
MOD_NEK2_1	132	137	PF00069	0.334
MOD_NEK2_1	142	147	PF00069	0.317
MOD_NEK2_1	201	206	PF00069	0.447
MOD_NEK2_1	213	218	PF00069	0.248
MOD_NEK2_1	423	428	PF00069	0.581
MOD_NEK2_1	63	68	PF00069	0.418
MOD_PKA_2	109	115	PF00069	0.524
MOD_PKA_2	337	343	PF00069	0.361
MOD_PKA_2	414	420	PF00069	0.531
MOD_PKA_2	64	70	PF00069	0.359
MOD_PKA_2	8	14	PF00069	0.504
MOD_Plk_1	423	429	PF00069	0.402
MOD_Plk_1	63	69	PF00069	0.415
MOD_Plk_4	2	8	PF00069	0.422
MOD_Plk_4	203	209	PF00069	0.417
MOD_Plk_4	220	226	PF00069	0.264
MOD_Plk_4	304	310	PF00069	0.340
MOD_ProDKin_1	250	256	PF00069	0.300
MOD_ProDKin_1	58	64	PF00069	0.367
MOD_ProDKin_1	68	74	PF00069	0.322
MOD_SUMO_for_1	349	352	PF00179	0.400
TRG_DiLeu_BaEn_2	305	311	PF01217	0.420
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.340
TRG_ENDOCYTIC_2	102	105	PF00928	0.311
TRG_ENDOCYTIC_2	176	179	PF00928	0.300
TRG_ENDOCYTIC_2	18	21	PF00928	0.357
TRG_ENDOCYTIC_2	255	258	PF00928	0.315
TRG_ENDOCYTIC_2	260	263	PF00928	0.315
TRG_ENDOCYTIC_2	29	32	PF00928	0.244
TRG_ENDOCYTIC_2	36	39	PF00928	0.269
TRG_ENDOCYTIC_2	388	391	PF00928	0.361
TRG_ENDOCYTIC_2	41	44	PF00928	0.318
TRG_ENDOCYTIC_2	46	49	PF00928	0.277
TRG_ENDOCYTIC_2	70	73	PF00928	0.324
TRG_ER_diArg_1	353	355	PF00400	0.194

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I387	Leptomonas seymouri	78%	100%
A0A0S4JVL8	Bodo saltans	53%	98%
A0A1X0P1P7	Trypanosomatidae	61%	95%
A0A3Q8IS10	Leishmania donovani	88%	100%
A0A422P3K4	Trypanosoma rangeli	61%	100%
A4I5N0	Leishmania infantum	88%	100%
C9ZR01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B0X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P47088	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q2TXB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	32%	100%
Q4I073	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
Q4Q791	Leishmania major	87%	100%
Q4R4E1	Macaca fascicularis	34%	100%
Q4WAH2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
Q500W7	Arabidopsis thaliana	31%	96%
Q54IA4	Dictyostelium discoideum	33%	98%
Q5AMR5	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q5B7W0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	98%
Q5EA10	Bos taurus	34%	100%
Q5F380	Gallus gallus	34%	100%
Q5RAH7	Pongo abelii	33%	100%
Q66IJ4	Xenopus tropicalis	34%	100%
Q6BHI9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	100%
Q6CRE7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
Q6FXQ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q75C82	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q7S4Z3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	89%
Q7T310	Danio rerio	35%	100%
Q8C2R7	Mus musculus	35%	100%
Q9BPQ5	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	62%	100%
Q9EQY6	Rattus norvegicus	33%	100%
Q9H3S5	Homo sapiens	33%	100%
Q9P6R5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BU12	Trypanosoma cruzi	59%	100%