Putative intraflagellar transport (IFT) protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport (IFT) protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HID3_LEIBR

TriTrypDb:

LbrM.30.1950 , LBRM2903_300025500

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HID3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.354
CLV_PCSK_KEX2_1	34	36	PF00082	0.281
DEG_Nend_UBRbox_2	1	3	PF02207	0.531
DOC_MAPK_gen_1	92	100	PF00069	0.518
DOC_PP1_RVXF_1	3	10	PF00149	0.494
DOC_PP1_RVXF_1	65	72	PF00149	0.554
LIG_Actin_WH2_2	54	69	PF00022	0.465
LIG_Actin_WH2_2	97	113	PF00022	0.465
LIG_APCC_Cbox_2	101	107	PF00515	0.465
LIG_Clathr_ClatBox_1	6	10	PF01394	0.323
LIG_eIF4E_1	107	113	PF01652	0.554
LIG_FHA_1	27	33	PF00498	0.491
LIG_FHA_1	48	54	PF00498	0.447
LIG_LIR_Gen_1	106	113	PF02991	0.442
LIG_LIR_Gen_1	119	127	PF02991	0.447
LIG_LIR_Gen_1	21	30	PF02991	0.451
LIG_LIR_Nem_3	106	110	PF02991	0.442
LIG_LIR_Nem_3	119	124	PF02991	0.447
LIG_LIR_Nem_3	21	26	PF02991	0.451
LIG_LIR_Nem_3	41	46	PF02991	0.318
LIG_LIR_Nem_3	80	86	PF02991	0.481
LIG_PCNA_yPIPBox_3	92	104	PF02747	0.442
LIG_SH2_CRK	107	111	PF00017	0.368
LIG_SH2_STAP1	23	27	PF00017	0.554
LIG_SH2_STAT5	103	106	PF00017	0.439
LIG_SH2_STAT5	36	39	PF00017	0.503
LIG_SUMO_SIM_par_1	28	33	PF11976	0.531
LIG_TRAF2_1	85	88	PF00917	0.465
MOD_CK2_1	74	80	PF00069	0.440
MOD_GlcNHglycan	10	14	PF01048	0.174
MOD_NEK2_1	8	13	PF00069	0.500
MOD_PIKK_1	122	128	PF00454	0.593
MOD_Plk_4	116	122	PF00069	0.504
TRG_DiLeu_BaEn_1	42	47	PF01217	0.531
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.645
TRG_ENDOCYTIC_2	107	110	PF00928	0.442
TRG_ENDOCYTIC_2	23	26	PF00928	0.531
TRG_ER_diArg_1	34	36	PF00400	0.554
TRG_ER_diArg_1	91	94	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N7	Leptomonas seymouri	84%	100%
A0A0S4JMX1	Bodo saltans	58%	99%
A0A1X0P221	Trypanosomatidae	66%	99%
A0A3Q8IHZ1	Leishmania donovani	92%	100%
A0A3R7P3P8	Trypanosoma rangeli	68%	99%
A4I5M7	Leishmania infantum	93%	100%
C9ZR00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	99%
E9B0X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q794	Leishmania major	93%	100%
Q58CS6	Bos taurus	34%	83%
Q61025	Mus musculus	34%	98%
Q640Z7	Xenopus laevis	33%	98%
Q66I67	Danio rerio	31%	98%
Q66KL7	Xenopus tropicalis	32%	98%
Q8IY31	Homo sapiens	34%	98%
Q90WZ0	Xenopus laevis	33%	98%