C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2H2 type zinc-finger (2 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HID1_LEIBR

TriTrypDb:

LbrM.30.1920 , LBRM2903_300025200

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HID1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	275	281	PF00089	0.514
CLV_NRD_NRD_1	219	221	PF00675	0.321
CLV_NRD_NRD_1	237	239	PF00675	0.279
CLV_NRD_NRD_1	277	279	PF00675	0.486
CLV_PCSK_KEX2_1	219	221	PF00082	0.321
CLV_PCSK_KEX2_1	237	239	PF00082	0.331
CLV_PCSK_KEX2_1	277	279	PF00082	0.486
CLV_PCSK_SKI1_1	10	14	PF00082	0.453
CLV_PCSK_SKI1_1	260	264	PF00082	0.321
DEG_COP1_1	312	322	PF00400	0.514
DEG_SPOP_SBC_1	147	151	PF00917	0.607
DOC_USP7_MATH_1	147	151	PF00917	0.638
DOC_USP7_MATH_1	239	243	PF00917	0.544
DOC_USP7_MATH_1	327	331	PF00917	0.573
DOC_WW_Pin1_4	137	142	PF00397	0.600
DOC_WW_Pin1_4	329	334	PF00397	0.421
DOC_WW_Pin1_4	74	79	PF00397	0.500
LIG_14-3-3_CanoR_1	214	218	PF00244	0.505
LIG_14-3-3_CanoR_1	238	247	PF00244	0.552
LIG_14-3-3_CanoR_1	277	287	PF00244	0.534
LIG_APCC_ABBA_1	190	195	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	220	226	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_eIF4E_1	227	233	PF01652	0.388
LIG_FHA_1	138	144	PF00498	0.508
LIG_FHA_1	282	288	PF00498	0.298
LIG_FHA_2	134	140	PF00498	0.603
LIG_FHA_2	299	305	PF00498	0.482
LIG_FHA_2	319	325	PF00498	0.473
LIG_FHA_2	88	94	PF00498	0.562
LIG_LIR_Gen_1	168	179	PF02991	0.672
LIG_LIR_Gen_1	22	28	PF02991	0.325
LIG_LIR_Gen_1	225	235	PF02991	0.430
LIG_LIR_Gen_1	293	300	PF02991	0.464
LIG_LIR_Gen_1	304	314	PF02991	0.586
LIG_LIR_Nem_3	168	174	PF02991	0.660
LIG_LIR_Nem_3	22	27	PF02991	0.406
LIG_LIR_Nem_3	225	230	PF02991	0.430
LIG_LIR_Nem_3	304	309	PF02991	0.570
LIG_LIR_Nem_3	313	319	PF02991	0.457
LIG_NRBOX	66	72	PF00104	0.461
LIG_NRP_CendR_1	335	337	PF00754	0.459
LIG_PCNA_PIPBox_1	36	45	PF02747	0.461
LIG_SH2_CRK	227	231	PF00017	0.429
LIG_SH2_GRB2like	109	112	PF00017	0.388
LIG_SH2_NCK_1	258	262	PF00017	0.367
LIG_SH2_STAP1	258	262	PF00017	0.367
LIG_SH2_STAT5	122	125	PF00017	0.340
LIG_SH2_STAT5	193	196	PF00017	0.486
LIG_SH3_3	285	291	PF00018	0.469
LIG_SH3_3	311	317	PF00018	0.515
LIG_SH3_3	55	61	PF00018	0.503
LIG_TRAF2_1	161	164	PF00917	0.732
LIG_TRAF2_1	262	265	PF00917	0.439
LIG_TRAF2_1	321	324	PF00917	0.581
MOD_CDK_SPxK_1	329	335	PF00069	0.416
MOD_CK1_1	100	106	PF00069	0.550
MOD_CK1_1	127	133	PF00069	0.669
MOD_CK1_1	148	154	PF00069	0.729
MOD_CK2_1	133	139	PF00069	0.604
MOD_CK2_1	298	304	PF00069	0.544
MOD_CK2_1	318	324	PF00069	0.475
MOD_CK2_1	87	93	PF00069	0.468
MOD_GlcNHglycan	129	132	PF01048	0.604
MOD_GlcNHglycan	195	199	PF01048	0.328
MOD_GlcNHglycan	301	304	PF01048	0.583
MOD_GlcNHglycan	67	70	PF01048	0.220
MOD_GSK3_1	123	130	PF00069	0.476
MOD_GSK3_1	133	140	PF00069	0.536
MOD_GSK3_1	142	149	PF00069	0.631
MOD_GSK3_1	277	284	PF00069	0.547
MOD_GSK3_1	294	301	PF00069	0.481
MOD_GSK3_1	325	332	PF00069	0.477
MOD_NEK2_1	142	147	PF00069	0.684
MOD_NEK2_1	213	218	PF00069	0.503
MOD_NEK2_1	298	303	PF00069	0.433
MOD_NEK2_1	325	330	PF00069	0.544
MOD_NEK2_1	5	10	PF00069	0.434
MOD_PKA_1	277	283	PF00069	0.490
MOD_PKA_2	213	219	PF00069	0.503
MOD_PKA_2	277	283	PF00069	0.541
MOD_PKA_2	5	11	PF00069	0.363
MOD_Plk_1	133	139	PF00069	0.658
MOD_Plk_1	87	93	PF00069	0.414
MOD_ProDKin_1	137	143	PF00069	0.602
MOD_ProDKin_1	329	335	PF00069	0.427
MOD_ProDKin_1	74	80	PF00069	0.500
TRG_DiLeu_BaEn_1	139	144	PF01217	0.585
TRG_DiLeu_BaEn_3	22	28	PF01217	0.320
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.472
TRG_ENDOCYTIC_2	227	230	PF00928	0.429
TRG_ER_diArg_1	219	221	PF00400	0.519
TRG_ER_diArg_1	236	238	PF00400	0.531
TRG_ER_diArg_1	276	278	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N5	Leptomonas seymouri	56%	100%
A0A0S4JM68	Bodo saltans	29%	100%
A0A3Q8IJF7	Leishmania donovani	78%	99%
A0A422P3H1	Trypanosoma rangeli	37%	100%
A4I5M4	Leishmania infantum	78%	99%
C9ZQZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B0W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q797	Leishmania major	78%	100%
Q9W1V7	Drosophila melanogaster	24%	75%
V5BYU5	Trypanosoma cruzi	40%	100%