BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HID0_LEIBR

TriTrypDb:

LbrM.30.1910 , LBRM2903_300025100

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HID0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HID0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.636
CLV_NRD_NRD_1	289	291	PF00675	0.442
CLV_PCSK_KEX2_1	264	266	PF00082	0.788
CLV_PCSK_KEX2_1	289	291	PF00082	0.442
CLV_PCSK_KEX2_1	353	355	PF00082	0.631
CLV_PCSK_KEX2_1	395	397	PF00082	0.543
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.706
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.615
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.543
CLV_PCSK_SKI1_1	105	109	PF00082	0.337
CLV_PCSK_SKI1_1	147	151	PF00082	0.503
CLV_PCSK_SKI1_1	296	300	PF00082	0.503
CLV_PCSK_SKI1_1	392	396	PF00082	0.613
CLV_PCSK_SKI1_1	404	408	PF00082	0.500
CLV_PCSK_SKI1_1	87	91	PF00082	0.355
DEG_APCC_DBOX_1	173	181	PF00400	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.386
DOC_CYCLIN_yClb5_NLxxxL_5	134	143	PF00134	0.491
DOC_MAPK_MEF2A_6	172	180	PF00069	0.531
DOC_PP1_RVXF_1	159	165	PF00149	0.525
DOC_PP1_RVXF_1	402	408	PF00149	0.499
DOC_SPAK_OSR1_1	163	167	PF12202	0.635
DOC_USP7_MATH_1	100	104	PF00917	0.267
DOC_USP7_MATH_1	157	161	PF00917	0.544
DOC_USP7_MATH_1	183	187	PF00917	0.638
DOC_USP7_MATH_1	213	217	PF00917	0.502
DOC_USP7_MATH_1	277	281	PF00917	0.686
DOC_USP7_MATH_1	329	333	PF00917	0.552
DOC_WW_Pin1_4	127	132	PF00397	0.643
DOC_WW_Pin1_4	179	184	PF00397	0.603
DOC_WW_Pin1_4	222	227	PF00397	0.558
DOC_WW_Pin1_4	75	80	PF00397	0.296
LIG_14-3-3_CanoR_1	212	221	PF00244	0.603
LIG_14-3-3_CanoR_1	238	246	PF00244	0.580
LIG_14-3-3_CanoR_1	265	275	PF00244	0.600
LIG_Actin_WH2_2	380	397	PF00022	0.518
LIG_APCC_ABBA_1	83	88	PF00400	0.238
LIG_BRCT_BRCA1_1	215	219	PF00533	0.547
LIG_BRCT_BRCA1_1	247	251	PF00533	0.533
LIG_BRCT_BRCA1_1	294	298	PF00533	0.488
LIG_BRCT_BRCA1_1	36	40	PF00533	0.355
LIG_CtBP_PxDLS_1	131	135	PF00389	0.506
LIG_FHA_1	121	127	PF00498	0.550
LIG_FHA_1	157	163	PF00498	0.524
LIG_FHA_1	24	30	PF00498	0.355
LIG_FHA_1	256	262	PF00498	0.636
LIG_FHA_1	280	286	PF00498	0.550
LIG_FHA_2	182	188	PF00498	0.664
LIG_LIR_Apic_2	145	151	PF02991	0.496
LIG_LIR_Gen_1	197	206	PF02991	0.590
LIG_LIR_Gen_1	88	98	PF02991	0.273
LIG_LIR_Nem_3	197	202	PF02991	0.594
LIG_LIR_Nem_3	2	6	PF02991	0.335
LIG_LIR_Nem_3	208	214	PF02991	0.497
LIG_LIR_Nem_3	269	275	PF02991	0.534
LIG_LIR_Nem_3	37	43	PF02991	0.333
LIG_LIR_Nem_3	88	93	PF02991	0.273
LIG_NRBOX	28	34	PF00104	0.238
LIG_Pex14_2	199	203	PF04695	0.508
LIG_Pex14_2	313	317	PF04695	0.511
LIG_Pex14_2	86	90	PF04695	0.355
LIG_REV1ctd_RIR_1	296	304	PF16727	0.507
LIG_SH2_CRK	272	276	PF00017	0.651
LIG_SH2_SRC	61	64	PF00017	0.238
LIG_SH2_STAT3	153	156	PF00017	0.521
LIG_SH2_STAT3	59	62	PF00017	0.238
LIG_SH2_STAT5	59	62	PF00017	0.296
LIG_SH2_STAT5	84	87	PF00017	0.296
LIG_SH3_3	123	129	PF00018	0.517
LIG_SH3_3	207	213	PF00018	0.490
LIG_SH3_3	282	288	PF00018	0.477
LIG_SH3_3	402	408	PF00018	0.499
LIG_SH3_3	48	54	PF00018	0.229
LIG_SUMO_SIM_anti_2	102	111	PF11976	0.372
LIG_SUMO_SIM_par_1	106	111	PF11976	0.465
LIG_UBA3_1	106	113	PF00899	0.405
MOD_CK1_1	116	122	PF00069	0.567
MOD_CK1_1	124	130	PF00069	0.546
MOD_CK1_1	137	143	PF00069	0.604
MOD_CK1_1	182	188	PF00069	0.571
MOD_CK1_1	205	211	PF00069	0.740
MOD_CK1_1	268	274	PF00069	0.601
MOD_CK1_1	276	282	PF00069	0.541
MOD_CK1_1	309	315	PF00069	0.553
MOD_CK1_1	318	324	PF00069	0.588
MOD_CK2_1	236	242	PF00069	0.535
MOD_GlcNHglycan	239	242	PF01048	0.557
MOD_GlcNHglycan	247	250	PF01048	0.522
MOD_GlcNHglycan	253	256	PF01048	0.489
MOD_GlcNHglycan	275	278	PF01048	0.548
MOD_GlcNHglycan	331	334	PF01048	0.594
MOD_GlcNHglycan	357	360	PF01048	0.645
MOD_GlcNHglycan	398	401	PF01048	0.455
MOD_GlcNHglycan	55	58	PF01048	0.493
MOD_GSK3_1	116	123	PF00069	0.544
MOD_GSK3_1	133	140	PF00069	0.649
MOD_GSK3_1	179	186	PF00069	0.555
MOD_GSK3_1	251	258	PF00069	0.574
MOD_GSK3_1	273	280	PF00069	0.562
MOD_GSK3_1	309	316	PF00069	0.556
MOD_GSK3_1	394	401	PF00069	0.441
MOD_N-GLC_1	132	137	PF02516	0.702
MOD_NEK2_1	101	106	PF00069	0.524
MOD_NEK2_1	108	113	PF00069	0.585
MOD_NEK2_1	120	125	PF00069	0.526
MOD_NEK2_1	132	137	PF00069	0.590
MOD_NEK2_1	164	169	PF00069	0.518
MOD_NEK2_1	251	256	PF00069	0.541
MOD_NEK2_1	299	304	PF00069	0.622
MOD_NEK2_1	317	322	PF00069	0.696
MOD_NEK2_1	394	399	PF00069	0.550
MOD_PIKK_1	124	130	PF00454	0.516
MOD_PIKK_1	72	78	PF00454	0.355
MOD_PKA_1	265	271	PF00069	0.540
MOD_PKA_2	237	243	PF00069	0.533
MOD_PKA_2	251	257	PF00069	0.486
MOD_PKA_2	265	271	PF00069	0.499
MOD_PKA_2	299	305	PF00069	0.607
MOD_PKA_2	323	329	PF00069	0.732
MOD_PKB_1	386	394	PF00069	0.398
MOD_Plk_1	101	107	PF00069	0.438
MOD_Plk_1	121	127	PF00069	0.520
MOD_Plk_1	137	143	PF00069	0.438
MOD_Plk_1	205	211	PF00069	0.543
MOD_Plk_1	309	315	PF00069	0.611
MOD_Plk_1	72	78	PF00069	0.355
MOD_Plk_4	121	127	PF00069	0.614
MOD_Plk_4	205	211	PF00069	0.488
MOD_Plk_4	360	366	PF00069	0.523
MOD_ProDKin_1	127	133	PF00069	0.646
MOD_ProDKin_1	179	185	PF00069	0.605
MOD_ProDKin_1	222	228	PF00069	0.560
MOD_ProDKin_1	75	81	PF00069	0.296
MOD_SUMO_for_1	352	355	PF00179	0.513
MOD_SUMO_rev_2	389	397	PF00179	0.408
TRG_DiLeu_BaEn_2	1	7	PF01217	0.405
TRG_DiLeu_BaEn_4	389	395	PF01217	0.521
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.353
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.518
TRG_ENDOCYTIC_2	272	275	PF00928	0.534
TRG_ENDOCYTIC_2	61	64	PF00928	0.355
TRG_ER_diArg_1	161	164	PF00400	0.616
TRG_ER_diArg_1	288	290	PF00400	0.464
TRG_ER_diArg_1	383	386	PF00400	0.388
TRG_ER_diArg_1	402	405	PF00400	0.499
TRG_NES_CRM1_1	375	389	PF08389	0.390
TRG_NLS_MonoExtN_4	262	268	PF00514	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML8	Leptomonas seymouri	31%	92%
A0A3Q8IEA2	Leishmania donovani	54%	95%
A4I5M3	Leishmania infantum	54%	96%
E9B0W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	98%