Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIC9_LEIBR

TriTrypDb:

LbrM.30.1900 , LBRM2903_300025000

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.512
CLV_NRD_NRD_1	344	346	PF00675	0.571
CLV_NRD_NRD_1	364	366	PF00675	0.413
CLV_NRD_NRD_1	395	397	PF00675	0.497
CLV_NRD_NRD_1	409	411	PF00675	0.558
CLV_NRD_NRD_1	55	57	PF00675	0.632
CLV_PCSK_KEX2_1	241	243	PF00082	0.522
CLV_PCSK_KEX2_1	288	290	PF00082	0.546
CLV_PCSK_KEX2_1	55	57	PF00082	0.402
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.546
CLV_PCSK_SKI1_1	145	149	PF00082	0.491
CLV_PCSK_SKI1_1	201	205	PF00082	0.617
CLV_PCSK_SKI1_1	21	25	PF00082	0.504
CLV_PCSK_SKI1_1	253	257	PF00082	0.390
CLV_PCSK_SKI1_1	365	369	PF00082	0.676
CLV_PCSK_SKI1_1	401	405	PF00082	0.448
CLV_PCSK_SKI1_1	423	427	PF00082	0.554
CLV_PCSK_SKI1_1	44	48	PF00082	0.520
CLV_PCSK_SKI1_1	56	60	PF00082	0.517
CLV_PCSK_SKI1_1	70	74	PF00082	0.459
DEG_APCC_DBOX_1	313	321	PF00400	0.357
DEG_APCC_DBOX_1	340	348	PF00400	0.594
DEG_COP1_1	2	10	PF00400	0.538
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DEG_SCF_FBW7_2	367	372	PF00400	0.446
DOC_CDC14_PxL_1	30	38	PF14671	0.511
DOC_CYCLIN_RxL_1	420	429	PF00134	0.659
DOC_MAPK_gen_1	288	296	PF00069	0.442
DOC_MAPK_gen_1	407	417	PF00069	0.641
DOC_MAPK_MEF2A_6	21	30	PF00069	0.412
DOC_MAPK_MEF2A_6	376	384	PF00069	0.621
DOC_MAPK_MEF2A_6	410	419	PF00069	0.491
DOC_MAPK_MEF2A_6	423	432	PF00069	0.629
DOC_MAPK_RevD_3	352	366	PF00069	0.482
DOC_PP1_RVXF_1	19	25	PF00149	0.533
DOC_USP7_MATH_1	140	144	PF00917	0.648
DOC_USP7_MATH_1	380	384	PF00917	0.397
DOC_USP7_MATH_1	78	82	PF00917	0.543
DOC_WW_Pin1_4	119	124	PF00397	0.673
DOC_WW_Pin1_4	129	134	PF00397	0.744
DOC_WW_Pin1_4	352	357	PF00397	0.618
DOC_WW_Pin1_4	365	370	PF00397	0.634
LIG_14-3-3_CanoR_1	145	154	PF00244	0.697
LIG_14-3-3_CanoR_1	199	204	PF00244	0.602
LIG_14-3-3_CanoR_1	242	252	PF00244	0.592
LIG_14-3-3_CanoR_1	388	392	PF00244	0.543
LIG_14-3-3_CanoR_1	401	409	PF00244	0.615
LIG_14-3-3_CanoR_1	410	417	PF00244	0.545
LIG_14-3-3_CanoR_1	70	76	PF00244	0.576
LIG_BRCT_BRCA1_1	142	146	PF00533	0.516
LIG_CaM_IQ_9	82	97	PF13499	0.400
LIG_Clathr_ClatBox_1	23	27	PF01394	0.432
LIG_deltaCOP1_diTrp_1	209	214	PF00928	0.596
LIG_EH1_1	23	31	PF00400	0.486
LIG_FHA_1	122	128	PF00498	0.701
LIG_FHA_1	202	208	PF00498	0.494
LIG_FHA_1	244	250	PF00498	0.607
LIG_FHA_1	296	302	PF00498	0.501
LIG_FHA_1	349	355	PF00498	0.673
LIG_FHA_2	104	110	PF00498	0.657
LIG_FHA_2	200	206	PF00498	0.452
LIG_FHA_2	252	258	PF00498	0.330
LIG_FHA_2	422	428	PF00498	0.604
LIG_FHA_2	52	58	PF00498	0.615
LIG_LIR_Gen_1	42	50	PF02991	0.517
LIG_LIR_Gen_1	71	78	PF02991	0.575
LIG_LIR_Nem_3	263	267	PF02991	0.489
LIG_LIR_Nem_3	357	362	PF02991	0.498
LIG_LIR_Nem_3	42	48	PF02991	0.512
LIG_LIR_Nem_3	71	75	PF02991	0.510
LIG_Pex14_2	146	150	PF04695	0.470
LIG_SH2_CRK	45	49	PF00017	0.549
LIG_SH2_PTP2	25	28	PF00017	0.374
LIG_SH2_SRC	25	28	PF00017	0.627
LIG_SH2_SRC	299	302	PF00017	0.442
LIG_SH2_STAP1	260	264	PF00017	0.326
LIG_SH2_STAP1	292	296	PF00017	0.532
LIG_SH2_STAP1	92	96	PF00017	0.602
LIG_SH2_STAT3	303	306	PF00017	0.484
LIG_SH2_STAT5	25	28	PF00017	0.481
LIG_SH3_3	5	11	PF00018	0.499
LIG_SUMO_SIM_anti_2	152	161	PF11976	0.574
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.494
LIG_SUMO_SIM_par_1	152	161	PF11976	0.581
LIG_SUMO_SIM_par_1	33	39	PF11976	0.503
LIG_SUMO_SIM_par_1	350	355	PF11976	0.647
LIG_TRAF2_1	106	109	PF00917	0.427
LIG_TRAF2_1	224	227	PF00917	0.341
LIG_TRAF2_1	276	279	PF00917	0.613
LIG_TRAF2_1	369	372	PF00917	0.448
LIG_TYR_ITIM	23	28	PF00017	0.379
LIG_UBA3_1	36	44	PF00899	0.551
LIG_WRC_WIRS_1	47	52	PF05994	0.585
MOD_CDK_SPxK_1	352	358	PF00069	0.676
MOD_CK1_1	114	120	PF00069	0.563
MOD_CK1_1	3	9	PF00069	0.718
MOD_CK1_1	51	57	PF00069	0.557
MOD_CK2_1	103	109	PF00069	0.381
MOD_CK2_1	199	205	PF00069	0.442
MOD_CK2_1	309	315	PF00069	0.504
MOD_CK2_1	387	393	PF00069	0.637
MOD_CK2_1	421	427	PF00069	0.636
MOD_CK2_1	46	52	PF00069	0.564
MOD_CK2_1	85	91	PF00069	0.510
MOD_Cter_Amidation	239	242	PF01082	0.449
MOD_GlcNHglycan	129	132	PF01048	0.668
MOD_GlcNHglycan	218	221	PF01048	0.430
MOD_GlcNHglycan	222	225	PF01048	0.429
MOD_GlcNHglycan	404	407	PF01048	0.672
MOD_GlcNHglycan	41	44	PF01048	0.484
MOD_GSK3_1	100	107	PF00069	0.624
MOD_GSK3_1	2	9	PF00069	0.715
MOD_GSK3_1	216	223	PF00069	0.433
MOD_GSK3_1	348	355	PF00069	0.565
MOD_GSK3_1	409	416	PF00069	0.561
MOD_GSK3_1	60	67	PF00069	0.590
MOD_GSK3_1	78	85	PF00069	0.451
MOD_N-GLC_1	114	119	PF02516	0.547
MOD_N-GLC_1	127	132	PF02516	0.736
MOD_N-GLC_1	78	83	PF02516	0.622
MOD_NEK2_1	111	116	PF00069	0.627
MOD_NEK2_1	127	132	PF00069	0.667
MOD_NEK2_1	319	324	PF00069	0.606
MOD_NEK2_1	402	407	PF00069	0.585
MOD_NEK2_1	64	69	PF00069	0.608
MOD_NEK2_1	82	87	PF00069	0.411
MOD_PIKK_1	140	146	PF00454	0.668
MOD_PIKK_1	193	199	PF00454	0.476
MOD_PIKK_1	82	88	PF00454	0.439
MOD_PKA_2	111	117	PF00069	0.583
MOD_PKA_2	387	393	PF00069	0.568
MOD_PKA_2	395	401	PF00069	0.549
MOD_PKA_2	409	415	PF00069	0.522
MOD_PKB_1	199	207	PF00069	0.368
MOD_Plk_1	174	180	PF00069	0.412
MOD_Plk_1	267	273	PF00069	0.520
MOD_Plk_1	277	283	PF00069	0.453
MOD_Plk_1	78	84	PF00069	0.393
MOD_Plk_2-3	251	257	PF00069	0.331
MOD_Plk_2-3	309	315	PF00069	0.504
MOD_Plk_4	100	106	PF00069	0.649
MOD_Plk_4	380	386	PF00069	0.522
MOD_Plk_4	60	66	PF00069	0.423
MOD_Plk_4	78	84	PF00069	0.635
MOD_ProDKin_1	119	125	PF00069	0.676
MOD_ProDKin_1	129	135	PF00069	0.741
MOD_ProDKin_1	352	358	PF00069	0.622
MOD_ProDKin_1	365	371	PF00069	0.627
MOD_SUMO_for_1	255	258	PF00179	0.329
MOD_SUMO_for_1	281	284	PF00179	0.604
MOD_SUMO_rev_2	247	255	PF00179	0.424
MOD_SUMO_rev_2	363	368	PF00179	0.477
MOD_SUMO_rev_2	88	97	PF00179	0.554
TRG_DiLeu_BaEn_1	315	320	PF01217	0.610
TRG_DiLeu_BaEn_2	141	147	PF01217	0.513
TRG_DiLeu_BaEn_4	108	114	PF01217	0.538
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.448
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.421
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.386
TRG_ENDOCYTIC_2	25	28	PF00928	0.585
TRG_ENDOCYTIC_2	359	362	PF00928	0.501
TRG_ENDOCYTIC_2	45	48	PF00928	0.333
TRG_ER_diArg_1	289	292	PF00400	0.585
TRG_NLS_MonoExtC_3	287	293	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD9	Leptomonas seymouri	57%	100%
A0A1X0P1Q4	Trypanosomatidae	38%	95%
A0A3S5H7N1	Leishmania donovani	76%	100%
A0A3S5ISM8	Trypanosoma rangeli	35%	93%
A4I5M2	Leishmania infantum	76%	100%
E9B0W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q799	Leishmania major	73%	100%
V5B8X3	Trypanosoma cruzi	34%	93%