RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HIC8_LEIBR

TriTrypDb:

LbrM.30.1890 , LBRM2903_300024900

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIC8

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009451	RNA modification	5	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0016072	rRNA metabolic process	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0031118	rRNA pseudouridine synthesis	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0009982	pseudouridine synthase activity	4	9
GO:0016853	isomerase activity	2	9
GO:0016866	intramolecular transferase activity	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	506	510	PF00656	0.307
CLV_NRD_NRD_1	117	119	PF00675	0.475
CLV_NRD_NRD_1	182	184	PF00675	0.771
CLV_NRD_NRD_1	241	243	PF00675	0.291
CLV_NRD_NRD_1	438	440	PF00675	0.577
CLV_NRD_NRD_1	466	468	PF00675	0.496
CLV_PCSK_FUR_1	436	440	PF00082	0.521
CLV_PCSK_FUR_1	464	468	PF00082	0.293
CLV_PCSK_KEX2_1	117	119	PF00082	0.489
CLV_PCSK_KEX2_1	181	183	PF00082	0.683
CLV_PCSK_KEX2_1	331	333	PF00082	0.249
CLV_PCSK_KEX2_1	438	440	PF00082	0.577
CLV_PCSK_KEX2_1	466	468	PF00082	0.374
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.237
CLV_PCSK_PC7_1	462	468	PF00082	0.365
CLV_PCSK_SKI1_1	24	28	PF00082	0.332
CLV_PCSK_SKI1_1	331	335	PF00082	0.251
CLV_PCSK_SKI1_1	467	471	PF00082	0.351
CLV_PCSK_SKI1_1	474	478	PF00082	0.372
CLV_Separin_Metazoa	338	342	PF03568	0.398
DEG_SCF_FBW7_1	174	180	PF00400	0.668
DEG_SCF_FBW7_2	415	422	PF00400	0.430
DOC_CKS1_1	174	179	PF01111	0.680
DOC_CYCLIN_RxL_1	462	473	PF00134	0.465
DOC_MAPK_gen_1	223	233	PF00069	0.456
DOC_MAPK_gen_1	264	272	PF00069	0.640
DOC_MAPK_MEF2A_6	438	447	PF00069	0.532
DOC_PP1_RVXF_1	472	478	PF00149	0.443
DOC_PP2B_LxvP_1	71	74	PF13499	0.415
DOC_PP4_FxxP_1	477	480	PF00568	0.391
DOC_PP4_FxxP_1	65	68	PF00568	0.422
DOC_USP7_MATH_1	14	18	PF00917	0.499
DOC_USP7_MATH_1	235	239	PF00917	0.550
DOC_USP7_MATH_1	258	262	PF00917	0.497
DOC_USP7_MATH_1	271	275	PF00917	0.528
DOC_USP7_MATH_1	319	323	PF00917	0.514
DOC_USP7_MATH_1	347	351	PF00917	0.536
DOC_USP7_MATH_1	524	528	PF00917	0.553
DOC_USP7_MATH_2	356	362	PF00917	0.398
DOC_WW_Pin1_4	173	178	PF00397	0.760
DOC_WW_Pin1_4	211	216	PF00397	0.498
DOC_WW_Pin1_4	415	420	PF00397	0.496
DOC_WW_Pin1_4	480	485	PF00397	0.551
DOC_WW_Pin1_4	490	495	PF00397	0.443
LIG_14-3-3_CanoR_1	118	124	PF00244	0.438
LIG_14-3-3_CanoR_1	266	271	PF00244	0.438
LIG_AP2alpha_2	442	444	PF02296	0.444
LIG_BIR_III_2	206	210	PF00653	0.212
LIG_BRCT_BRCA1_1	22	26	PF00533	0.464
LIG_BRCT_BRCA1_1	273	277	PF00533	0.472
LIG_BRCT_BRCA1_1	509	513	PF00533	0.427
LIG_Clathr_ClatBox_1	280	284	PF01394	0.382
LIG_eIF4E_1	106	112	PF01652	0.404
LIG_eIF4E_1	84	90	PF01652	0.451
LIG_FHA_1	147	153	PF00498	0.655
LIG_FHA_1	154	160	PF00498	0.569
LIG_FHA_1	189	195	PF00498	0.499
LIG_FHA_1	226	232	PF00498	0.477
LIG_FHA_1	254	260	PF00498	0.517
LIG_FHA_1	291	297	PF00498	0.523
LIG_FHA_1	303	309	PF00498	0.523
LIG_FHA_1	318	324	PF00498	0.466
LIG_FHA_1	490	496	PF00498	0.333
LIG_FHA_1	516	522	PF00498	0.490
LIG_FHA_2	132	138	PF00498	0.571
LIG_KLC1_Yacidic_2	430	435	PF13176	0.489
LIG_LIR_Apic_2	4	10	PF02991	0.400
LIG_LIR_Gen_1	23	32	PF02991	0.476
LIG_LIR_Gen_1	291	300	PF02991	0.532
LIG_LIR_Gen_1	305	312	PF02991	0.522
LIG_LIR_Nem_3	23	29	PF02991	0.493
LIG_LIR_Nem_3	274	280	PF02991	0.413
LIG_LIR_Nem_3	291	295	PF02991	0.532
LIG_LIR_Nem_3	305	309	PF02991	0.522
LIG_LIR_Nem_3	361	366	PF02991	0.497
LIG_LIR_Nem_3	441	447	PF02991	0.505
LIG_LYPXL_yS_3	406	409	PF13949	0.420
LIG_PTB_Apo_2	49	56	PF02174	0.326
LIG_PTB_Phospho_1	49	55	PF10480	0.327
LIG_SH2_CRK	292	296	PF00017	0.481
LIG_SH2_CRK	7	11	PF00017	0.427
LIG_SH2_NCK_1	124	128	PF00017	0.329
LIG_SH2_SRC	84	87	PF00017	0.469
LIG_SH2_STAP1	292	296	PF00017	0.523
LIG_SH2_STAT5	106	109	PF00017	0.476
LIG_SH2_STAT5	124	127	PF00017	0.517
LIG_SH2_STAT5	158	161	PF00017	0.461
LIG_SH2_STAT5	21	24	PF00017	0.360
LIG_SH2_STAT5	28	31	PF00017	0.417
LIG_SH2_STAT5	292	295	PF00017	0.482
LIG_SH2_STAT5	433	436	PF00017	0.381
LIG_SH2_STAT5	55	58	PF00017	0.482
LIG_SH2_STAT5	7	10	PF00017	0.482
LIG_SH3_3	202	208	PF00018	0.682
LIG_SH3_3	350	356	PF00018	0.519
LIG_SH3_3	440	446	PF00018	0.554
LIG_SH3_3	518	524	PF00018	0.542
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.456
LIG_SUMO_SIM_anti_2	85	93	PF11976	0.480
LIG_TYR_ITIM	404	409	PF00017	0.420
LIG_UBA3_1	18	25	PF00899	0.459
LIG_UBA3_1	218	226	PF00899	0.398
LIG_WW_3	66	70	PF00397	0.477
MOD_CDK_SPxK_1	415	421	PF00069	0.624
MOD_CK1_1	122	128	PF00069	0.616
MOD_CK1_1	351	357	PF00069	0.466
MOD_CK1_1	493	499	PF00069	0.328
MOD_CK2_1	131	137	PF00069	0.518
MOD_GlcNHglycan	167	170	PF01048	0.657
MOD_GlcNHglycan	200	203	PF01048	0.567
MOD_GlcNHglycan	227	231	PF01048	0.270
MOD_GSK3_1	125	132	PF00069	0.553
MOD_GSK3_1	140	147	PF00069	0.750
MOD_GSK3_1	173	180	PF00069	0.747
MOD_GSK3_1	20	27	PF00069	0.493
MOD_GSK3_1	249	256	PF00069	0.560
MOD_GSK3_1	341	348	PF00069	0.529
MOD_GSK3_1	354	361	PF00069	0.407
MOD_GSK3_1	454	461	PF00069	0.583
MOD_GSK3_1	486	493	PF00069	0.466
MOD_GSK3_1	503	510	PF00069	0.419
MOD_GSK3_1	515	522	PF00069	0.362
MOD_GSK3_1	524	531	PF00069	0.569
MOD_N-GLC_1	51	56	PF02516	0.327
MOD_NEK2_1	366	371	PF00069	0.525
MOD_NEK2_1	380	385	PF00069	0.429
MOD_NEK2_1	413	418	PF00069	0.443
MOD_NEK2_1	451	456	PF00069	0.531
MOD_NEK2_1	470	475	PF00069	0.422
MOD_NEK2_1	488	493	PF00069	0.373
MOD_NEK2_1	90	95	PF00069	0.468
MOD_NEK2_2	119	124	PF00069	0.304
MOD_PIKK_1	325	331	PF00454	0.550
MOD_PIKK_1	351	357	PF00454	0.479
MOD_PKA_1	117	123	PF00069	0.398
MOD_PKA_1	24	30	PF00069	0.327
MOD_PKA_2	117	123	PF00069	0.578
MOD_PKA_2	458	464	PF00069	0.445
MOD_PKB_1	264	272	PF00069	0.360
MOD_Plk_1	107	113	PF00069	0.401
MOD_Plk_1	14	20	PF00069	0.509
MOD_Plk_1	153	159	PF00069	0.636
MOD_Plk_1	185	191	PF00069	0.657
MOD_Plk_1	51	57	PF00069	0.317
MOD_Plk_1	84	90	PF00069	0.489
MOD_Plk_4	107	113	PF00069	0.406
MOD_Plk_4	119	125	PF00069	0.500
MOD_Plk_4	14	20	PF00069	0.474
MOD_Plk_4	258	264	PF00069	0.420
MOD_Plk_4	302	308	PF00069	0.523
MOD_Plk_4	493	499	PF00069	0.345
MOD_Plk_4	51	57	PF00069	0.480
MOD_ProDKin_1	173	179	PF00069	0.760
MOD_ProDKin_1	211	217	PF00069	0.498
MOD_ProDKin_1	415	421	PF00069	0.503
MOD_ProDKin_1	480	486	PF00069	0.545
MOD_ProDKin_1	490	496	PF00069	0.449
TRG_DiLeu_BaEn_1	85	90	PF01217	0.454
TRG_DiLeu_BaEn_2	301	307	PF01217	0.523
TRG_DiLeu_BaEn_2	439	445	PF01217	0.468
TRG_ENDOCYTIC_2	292	295	PF00928	0.456
TRG_ENDOCYTIC_2	406	409	PF00928	0.420
TRG_ER_diArg_1	181	183	PF00400	0.716
TRG_ER_diArg_1	370	373	PF00400	0.480
TRG_ER_diArg_1	436	439	PF00400	0.474
TRG_ER_diArg_1	463	466	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME7	Leptomonas seymouri	50%	100%
A0A0S4JCR9	Bodo saltans	29%	89%
A0A3Q8IFN9	Leishmania donovani	75%	100%
A4I5M1	Leishmania infantum	74%	100%
C9ZQZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B0W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q7A0	Leishmania major	76%	100%