Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIC5_LEIBR

TriTrypDb:

LbrM.30.1860 , LBRM2903_300024500

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.709
CLV_NRD_NRD_1	115	117	PF00675	0.670
CLV_NRD_NRD_1	171	173	PF00675	0.816
CLV_NRD_NRD_1	225	227	PF00675	0.578
CLV_NRD_NRD_1	284	286	PF00675	0.573
CLV_NRD_NRD_1	489	491	PF00675	0.591
CLV_PCSK_FUR_1	169	173	PF00082	0.569
CLV_PCSK_FUR_1	223	227	PF00082	0.500
CLV_PCSK_KEX2_1	115	117	PF00082	0.670
CLV_PCSK_KEX2_1	171	173	PF00082	0.829
CLV_PCSK_KEX2_1	225	227	PF00082	0.578
CLV_PCSK_KEX2_1	274	276	PF00082	0.666
CLV_PCSK_KEX2_1	284	286	PF00082	0.622
CLV_PCSK_KEX2_1	434	436	PF00082	0.757
CLV_PCSK_KEX2_1	488	490	PF00082	0.593
CLV_PCSK_KEX2_1	77	79	PF00082	0.740
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.692
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.746
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.434
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.740
CLV_PCSK_PC7_1	167	173	PF00082	0.823
CLV_PCSK_PC7_1	270	276	PF00082	0.732
CLV_PCSK_PC7_1	484	490	PF00082	0.438
CLV_PCSK_SKI1_1	274	278	PF00082	0.480
CLV_PCSK_SKI1_1	408	412	PF00082	0.451
DEG_APCC_DBOX_1	121	129	PF00400	0.746
DEG_SPOP_SBC_1	11	15	PF00917	0.531
DEG_SPOP_SBC_1	292	296	PF00917	0.560
DOC_ANK_TNKS_1	79	86	PF00023	0.732
DOC_MAPK_gen_1	120	127	PF00069	0.743
DOC_MAPK_gen_1	274	282	PF00069	0.657
DOC_MAPK_gen_1	344	352	PF00069	0.587
DOC_MAPK_MEF2A_6	274	282	PF00069	0.739
DOC_MAPK_MEF2A_6	527	534	PF00069	0.578
DOC_PP1_RVXF_1	458	465	PF00149	0.702
DOC_USP7_MATH_1	10	14	PF00917	0.582
DOC_USP7_MATH_1	242	246	PF00917	0.613
DOC_USP7_MATH_1	41	45	PF00917	0.635
DOC_USP7_MATH_1	495	499	PF00917	0.467
DOC_USP7_MATH_1	590	594	PF00917	0.574
DOC_USP7_MATH_1	65	69	PF00917	0.682
DOC_USP7_MATH_1	92	96	PF00917	0.746
DOC_WW_Pin1_4	176	181	PF00397	0.774
DOC_WW_Pin1_4	215	220	PF00397	0.649
DOC_WW_Pin1_4	238	243	PF00397	0.679
DOC_WW_Pin1_4	26	31	PF00397	0.605
LIG_14-3-3_CanoR_1	115	123	PF00244	0.609
LIG_14-3-3_CanoR_1	124	128	PF00244	0.654
LIG_14-3-3_CanoR_1	253	257	PF00244	0.632
LIG_14-3-3_CanoR_1	344	352	PF00244	0.587
LIG_14-3-3_CanoR_1	449	457	PF00244	0.645
LIG_14-3-3_CanoR_1	551	557	PF00244	0.658
LIG_14-3-3_CanoR_1	564	574	PF00244	0.790
LIG_APCC_ABBA_1	357	362	PF00400	0.424
LIG_BIR_III_4	377	381	PF00653	0.766
LIG_BRCT_BRCA1_1	246	250	PF00533	0.720
LIG_BRCT_BRCA1_1	558	562	PF00533	0.542
LIG_EH1_1	451	459	PF00400	0.439
LIG_FHA_1	47	53	PF00498	0.788
LIG_FHA_1	499	505	PF00498	0.515
LIG_FHA_1	516	522	PF00498	0.503
LIG_FHA_1	529	535	PF00498	0.689
LIG_FHA_1	632	638	PF00498	0.819
LIG_FHA_2	441	447	PF00498	0.706
LIG_FHA_2	473	479	PF00498	0.707
LIG_FHA_2	57	63	PF00498	0.517
LIG_LIR_Apic_2	251	257	PF02991	0.696
LIG_LIR_Gen_1	353	364	PF02991	0.706
LIG_LIR_Gen_1	59	65	PF02991	0.559
LIG_LIR_Gen_1	95	105	PF02991	0.731
LIG_LIR_LC3C_4	455	459	PF02991	0.671
LIG_LIR_Nem_3	353	359	PF02991	0.705
LIG_LIR_Nem_3	59	64	PF02991	0.561
LIG_LIR_Nem_3	95	100	PF02991	0.731
LIG_MYND_1	2	6	PF01753	0.535
LIG_NRBOX	278	284	PF00104	0.741
LIG_PCNA_PIPBox_1	197	206	PF02747	0.485
LIG_PCNA_PIPBox_1	409	418	PF02747	0.440
LIG_PCNA_yPIPBox_3	194	204	PF02747	0.480
LIG_PCNA_yPIPBox_3	403	416	PF02747	0.444
LIG_SH2_CRK	254	258	PF00017	0.441
LIG_SH2_CRK	510	514	PF00017	0.571
LIG_SH2_GRB2like	373	376	PF00017	0.739
LIG_SH2_NCK_1	103	107	PF00017	0.479
LIG_SH2_NCK_1	254	258	PF00017	0.441
LIG_SH2_SRC	373	376	PF00017	0.508
LIG_SH2_STAP1	110	114	PF00017	0.480
LIG_SH2_STAT3	186	189	PF00017	0.694
LIG_SH2_STAT3	439	442	PF00017	0.787
LIG_SH2_STAT5	210	213	PF00017	0.499
LIG_SH2_STAT5	237	240	PF00017	0.750
LIG_SH2_STAT5	254	257	PF00017	0.570
LIG_SH2_STAT5	373	376	PF00017	0.508
LIG_SH2_STAT5	496	499	PF00017	0.730
LIG_SH2_STAT5	510	513	PF00017	0.441
LIG_SH3_3	349	355	PF00018	0.724
LIG_SH3_3	518	524	PF00018	0.580
LIG_SH3_3	638	644	PF00018	0.747
LIG_SH3_CIN85_PxpxPR_1	640	645	PF14604	0.824
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.466
LIG_TRAF2_1	264	267	PF00917	0.741
LIG_TYR_ITIM	108	113	PF00017	0.479
LIG_TYR_ITIM	508	513	PF00017	0.405
LIG_WW_3	640	644	PF00397	0.819
MOD_CDK_SPxxK_3	26	33	PF00069	0.556
MOD_CK1_1	126	132	PF00069	0.548
MOD_CK1_1	174	180	PF00069	0.804
MOD_CK1_1	209	215	PF00069	0.693
MOD_CK1_1	241	247	PF00069	0.739
MOD_CK1_1	258	264	PF00069	0.468
MOD_CK1_1	31	37	PF00069	0.645
MOD_CK1_1	44	50	PF00069	0.520
MOD_CK1_1	448	454	PF00069	0.742
MOD_CK1_1	498	504	PF00069	0.573
MOD_CK1_1	555	561	PF00069	0.655
MOD_CK1_1	563	569	PF00069	0.585
MOD_CK2_1	56	62	PF00069	0.564
MOD_CMANNOS	195	198	PF00535	0.683
MOD_Cter_Amidation	75	78	PF01082	0.739
MOD_GlcNHglycan	138	141	PF01048	0.589
MOD_GlcNHglycan	183	186	PF01048	0.647
MOD_GlcNHglycan	289	292	PF01048	0.776
MOD_GlcNHglycan	338	341	PF01048	0.566
MOD_GlcNHglycan	36	39	PF01048	0.592
MOD_GlcNHglycan	54	57	PF01048	0.685
MOD_GlcNHglycan	558	561	PF01048	0.728
MOD_GlcNHglycan	570	573	PF01048	0.695
MOD_GlcNHglycan	575	578	PF01048	0.641
MOD_GlcNHglycan	582	585	PF01048	0.650
MOD_GSK3_1	171	178	PF00069	0.742
MOD_GSK3_1	205	212	PF00069	0.705
MOD_GSK3_1	237	244	PF00069	0.663
MOD_GSK3_1	24	31	PF00069	0.653
MOD_GSK3_1	287	294	PF00069	0.704
MOD_GSK3_1	336	343	PF00069	0.811
MOD_GSK3_1	37	44	PF00069	0.606
MOD_GSK3_1	472	479	PF00069	0.717
MOD_GSK3_1	48	55	PF00069	0.623
MOD_GSK3_1	494	501	PF00069	0.464
MOD_GSK3_1	551	558	PF00069	0.680
MOD_GSK3_1	562	569	PF00069	0.505
MOD_GSK3_1	580	587	PF00069	0.457
MOD_GSK3_1	620	627	PF00069	0.528
MOD_GSK3_1	66	73	PF00069	0.635
MOD_N-GLC_1	134	139	PF02516	0.523
MOD_N-GLC_1	286	291	PF02516	0.512
MOD_N-GLC_1	302	307	PF02516	0.501
MOD_N-GLC_1	340	345	PF02516	0.559
MOD_N-GLC_1	566	571	PF02516	0.537
MOD_NEK2_1	101	106	PF00069	0.546
MOD_NEK2_1	368	373	PF00069	0.697
MOD_NEK2_1	385	390	PF00069	0.594
MOD_NEK2_1	480	485	PF00069	0.569
MOD_NEK2_1	515	520	PF00069	0.597
MOD_NEK2_1	562	567	PF00069	0.724
MOD_NEK2_1	620	625	PF00069	0.646
MOD_NEK2_1	631	636	PF00069	0.715
MOD_NEK2_2	552	557	PF00069	0.685
MOD_NEK2_2	56	61	PF00069	0.565
MOD_PIKK_1	350	356	PF00454	0.754
MOD_PIKK_1	590	596	PF00454	0.574
MOD_PK_1	171	177	PF00069	0.561
MOD_PKA_1	171	177	PF00069	0.818
MOD_PKA_2	114	120	PF00069	0.634
MOD_PKA_2	123	129	PF00069	0.591
MOD_PKA_2	171	177	PF00069	0.818
MOD_PKA_2	252	258	PF00069	0.640
MOD_PKA_2	448	454	PF00069	0.742
MOD_PKA_2	556	562	PF00069	0.682
MOD_PKA_2	563	569	PF00069	0.801
MOD_PKB_1	169	177	PF00069	0.562
MOD_Plk_1	11	17	PF00069	0.533
MOD_Plk_1	362	368	PF00069	0.600
MOD_Plk_1	590	596	PF00069	0.574
MOD_Plk_1	66	72	PF00069	0.490
MOD_Plk_2-3	268	274	PF00069	0.473
MOD_Plk_2-3	440	446	PF00069	0.705
MOD_Plk_4	123	129	PF00069	0.708
MOD_Plk_4	206	212	PF00069	0.560
MOD_Plk_4	244	250	PF00069	0.469
MOD_Plk_4	368	374	PF00069	0.702
MOD_Plk_4	48	54	PF00069	0.538
MOD_Plk_4	528	534	PF00069	0.590
MOD_Plk_4	56	62	PF00069	0.550
MOD_Plk_4	92	98	PF00069	0.490
MOD_ProDKin_1	176	182	PF00069	0.768
MOD_ProDKin_1	215	221	PF00069	0.647
MOD_ProDKin_1	238	244	PF00069	0.676
MOD_ProDKin_1	26	32	PF00069	0.609
MOD_SUMO_for_1	108	111	PF00179	0.521
TRG_DiLeu_BaEn_1	363	368	PF01217	0.570
TRG_DiLeu_BaEn_1	84	89	PF01217	0.762
TRG_DiLeu_BaEn_4	267	273	PF01217	0.684
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.652
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.693
TRG_ENDOCYTIC_2	110	113	PF00928	0.477
TRG_ENDOCYTIC_2	509	512	PF00928	0.552
TRG_ER_diArg_1	114	116	PF00400	0.690
TRG_ER_diArg_1	169	172	PF00400	0.800
TRG_ER_diArg_1	222	225	PF00400	0.600
TRG_ER_diArg_1	283	285	PF00400	0.585
TRG_ER_diArg_1	642	645	PF00400	0.847
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JB52	Bodo saltans	22%	100%
A0A3Q8IRZ9	Leishmania donovani	69%	100%
A4I5L7	Leishmania infantum	70%	100%
E9B0W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q7A4	Leishmania major	70%	100%