Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIC4_LEIBR

TriTrypDb:

LbrM.30.1850 , LBRM2903_300024400

Length:

998

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	529	533	PF00656	0.515
CLV_C14_Caspase3-7	716	720	PF00656	0.554
CLV_C14_Caspase3-7	981	985	PF00656	0.551
CLV_NRD_NRD_1	282	284	PF00675	0.530
CLV_NRD_NRD_1	423	425	PF00675	0.537
CLV_NRD_NRD_1	895	897	PF00675	0.437
CLV_NRD_NRD_1	932	934	PF00675	0.540
CLV_PCSK_KEX2_1	282	284	PF00082	0.530
CLV_PCSK_KEX2_1	41	43	PF00082	0.622
CLV_PCSK_KEX2_1	423	425	PF00082	0.537
CLV_PCSK_KEX2_1	931	933	PF00082	0.532
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.622
CLV_PCSK_SKI1_1	297	301	PF00082	0.525
CLV_PCSK_SKI1_1	373	377	PF00082	0.394
CLV_PCSK_SKI1_1	587	591	PF00082	0.521
CLV_PCSK_SKI1_1	671	675	PF00082	0.484
CLV_PCSK_SKI1_1	691	695	PF00082	0.318
CLV_PCSK_SKI1_1	989	993	PF00082	0.646
CLV_Separin_Metazoa	736	740	PF03568	0.510
DEG_APCC_DBOX_1	459	467	PF00400	0.343
DEG_APCC_DBOX_1	586	594	PF00400	0.512
DEG_SCF_FBW7_1	491	498	PF00400	0.367
DEG_SPOP_SBC_1	524	528	PF00917	0.494
DEG_SPOP_SBC_1	702	706	PF00917	0.520
DOC_ANK_TNKS_1	930	937	PF00023	0.412
DOC_CDC14_PxL_1	187	195	PF14671	0.483
DOC_CKS1_1	61	66	PF01111	0.534
DOC_CYCLIN_yCln2_LP_2	837	843	PF00134	0.515
DOC_MAPK_DCC_7	381	389	PF00069	0.592
DOC_MAPK_gen_1	282	289	PF00069	0.499
DOC_MAPK_gen_1	688	698	PF00069	0.638
DOC_MAPK_HePTP_8	279	291	PF00069	0.488
DOC_MAPK_HePTP_8	780	792	PF00069	0.414
DOC_MAPK_MEF2A_6	282	291	PF00069	0.489
DOC_MAPK_MEF2A_6	449	456	PF00069	0.549
DOC_MAPK_MEF2A_6	783	792	PF00069	0.418
DOC_MAPK_MEF2A_6	816	824	PF00069	0.412
DOC_MAPK_RevD_3	270	283	PF00069	0.494
DOC_PP1_RVXF_1	116	122	PF00149	0.520
DOC_PP1_RVXF_1	987	993	PF00149	0.646
DOC_PP2B_LxvP_1	837	840	PF13499	0.439
DOC_PP2B_LxvP_1	912	915	PF13499	0.494
DOC_PP2B_LxvP_1	917	920	PF13499	0.507
DOC_PP4_FxxP_1	159	162	PF00568	0.470
DOC_PP4_FxxP_1	91	94	PF00568	0.510
DOC_USP7_MATH_1	175	179	PF00917	0.470
DOC_USP7_MATH_1	195	199	PF00917	0.622
DOC_USP7_MATH_1	344	348	PF00917	0.552
DOC_USP7_MATH_1	367	371	PF00917	0.644
DOC_USP7_MATH_1	487	491	PF00917	0.412
DOC_USP7_MATH_1	495	499	PF00917	0.442
DOC_USP7_MATH_1	524	528	PF00917	0.726
DOC_USP7_MATH_1	540	544	PF00917	0.620
DOC_USP7_MATH_1	548	552	PF00917	0.633
DOC_USP7_MATH_1	701	705	PF00917	0.526
DOC_USP7_UBL2_3	200	204	PF12436	0.503
DOC_WW_Pin1_4	136	141	PF00397	0.553
DOC_WW_Pin1_4	178	183	PF00397	0.475
DOC_WW_Pin1_4	40	45	PF00397	0.459
DOC_WW_Pin1_4	491	496	PF00397	0.475
DOC_WW_Pin1_4	533	538	PF00397	0.698
DOC_WW_Pin1_4	60	65	PF00397	0.510
DOC_WW_Pin1_4	614	619	PF00397	0.450
DOC_WW_Pin1_4	841	846	PF00397	0.546
DOC_WW_Pin1_4	974	979	PF00397	0.642
DOC_WW_Pin1_4	982	987	PF00397	0.717
LIG_14-3-3_CanoR_1	118	122	PF00244	0.370
LIG_14-3-3_CanoR_1	282	288	PF00244	0.645
LIG_14-3-3_CanoR_1	301	309	PF00244	0.337
LIG_14-3-3_CanoR_1	510	519	PF00244	0.435
LIG_14-3-3_CanoR_1	587	593	PF00244	0.580
LIG_14-3-3_CanoR_1	676	682	PF00244	0.426
LIG_14-3-3_CanoR_1	691	696	PF00244	0.369
LIG_14-3-3_CanoR_1	81	86	PF00244	0.544
LIG_14-3-3_CanoR_1	951	960	PF00244	0.493
LIG_Actin_WH2_2	585	600	PF00022	0.590
LIG_Actin_WH2_2	777	793	PF00022	0.544
LIG_BIR_III_4	321	325	PF00653	0.394
LIG_BRCT_BRCA1_1	180	184	PF00533	0.476
LIG_BRCT_BRCA1_1	266	270	PF00533	0.500
LIG_BRCT_BRCA1_1	987	991	PF00533	0.709
LIG_Clathr_ClatBox_1	214	218	PF01394	0.461
LIG_EVH1_2	729	733	PF00568	0.517
LIG_FHA_1	284	290	PF00498	0.560
LIG_FHA_1	321	327	PF00498	0.462
LIG_FHA_1	472	478	PF00498	0.459
LIG_FHA_1	502	508	PF00498	0.528
LIG_FHA_1	548	554	PF00498	0.408
LIG_FHA_1	577	583	PF00498	0.442
LIG_FHA_1	592	598	PF00498	0.480
LIG_FHA_1	682	688	PF00498	0.525
LIG_FHA_1	690	696	PF00498	0.504
LIG_FHA_1	865	871	PF00498	0.439
LIG_FHA_1	962	968	PF00498	0.423
LIG_FHA_2	260	266	PF00498	0.350
LIG_FHA_2	290	296	PF00498	0.353
LIG_FHA_2	676	682	PF00498	0.474
LIG_FHA_2	941	947	PF00498	0.483
LIG_GBD_Chelix_1	251	259	PF00786	0.317
LIG_GBD_Chelix_1	552	560	PF00786	0.501
LIG_GBD_Chelix_1	959	967	PF00786	0.402
LIG_HP1_1	388	392	PF01393	0.503
LIG_LIR_Apic_2	156	162	PF02991	0.362
LIG_LIR_Apic_2	645	651	PF02991	0.363
LIG_LIR_Apic_2	89	94	PF02991	0.529
LIG_LIR_Gen_1	181	192	PF02991	0.482
LIG_LIR_Gen_1	672	682	PF02991	0.340
LIG_LIR_Gen_1	815	825	PF02991	0.476
LIG_LIR_Nem_3	155	161	PF02991	0.479
LIG_LIR_Nem_3	181	187	PF02991	0.484
LIG_LIR_Nem_3	672	677	PF02991	0.339
LIG_LIR_Nem_3	815	820	PF02991	0.504
LIG_LIR_Nem_3	96	102	PF02991	0.594
LIG_LIR_Nem_3	988	994	PF02991	0.658
LIG_MYND_1	191	195	PF01753	0.618
LIG_MYND_1	228	232	PF01753	0.587
LIG_MYND_1	307	311	PF01753	0.513
LIG_MYND_3	219	223	PF01753	0.510
LIG_MYND_3	306	310	PF01753	0.503
LIG_PCNA_yPIPBox_3	802	816	PF02747	0.378
LIG_REV1ctd_RIR_1	671	680	PF16727	0.441
LIG_REV1ctd_RIR_1	989	997	PF16727	0.639
LIG_SH2_CRK	100	104	PF00017	0.583
LIG_SH2_CRK	116	120	PF00017	0.415
LIG_SH2_CRK	648	652	PF00017	0.544
LIG_SH2_GRB2like	99	102	PF00017	0.341
LIG_SH2_NCK_1	100	104	PF00017	0.475
LIG_SH2_STAT3	634	637	PF00017	0.480
LIG_SH2_STAT5	116	119	PF00017	0.590
LIG_SH2_STAT5	144	147	PF00017	0.473
LIG_SH2_STAT5	186	189	PF00017	0.492
LIG_SH2_STAT5	317	320	PF00017	0.463
LIG_SH2_STAT5	629	632	PF00017	0.458
LIG_SH2_STAT5	634	637	PF00017	0.474
LIG_SH3_3	129	135	PF00018	0.411
LIG_SH3_3	177	183	PF00018	0.660
LIG_SH3_3	189	195	PF00018	0.705
LIG_SH3_3	214	220	PF00018	0.506
LIG_SH3_3	226	232	PF00018	0.521
LIG_SH3_3	359	365	PF00018	0.497
LIG_SH3_3	562	568	PF00018	0.494
LIG_SH3_3	58	64	PF00018	0.520
LIG_SH3_3	706	712	PF00018	0.722
LIG_SH3_3	935	941	PF00018	0.404
LIG_SUMO_SIM_anti_2	692	697	PF11976	0.430
LIG_SUMO_SIM_par_1	213	218	PF11976	0.463
LIG_SUMO_SIM_par_1	588	595	PF11976	0.517
LIG_SUMO_SIM_par_1	957	964	PF11976	0.471
LIG_TRAF2_1	613	616	PF00917	0.587
LIG_TRAF2_1	617	620	PF00917	0.546
LIG_TYR_ITIM	766	771	PF00017	0.549
LIG_UBA3_1	8	14	PF00899	0.488
LIG_WRC_WIRS_1	247	252	PF05994	0.441
LIG_WRC_WIRS_1	453	458	PF05994	0.387
LIG_WRC_WIRS_1	882	887	PF05994	0.480
MOD_CDK_SPK_2	60	65	PF00069	0.535
MOD_CDK_SPK_2	841	846	PF00069	0.406
MOD_CDK_SPxK_1	491	497	PF00069	0.474
MOD_CDK_SPxxK_3	982	989	PF00069	0.656
MOD_CK1_1	178	184	PF00069	0.540
MOD_CK1_1	246	252	PF00069	0.360
MOD_CK1_1	334	340	PF00069	0.504
MOD_CK1_1	432	438	PF00069	0.451
MOD_CK1_1	469	475	PF00069	0.349
MOD_CK1_1	526	532	PF00069	0.588
MOD_CK1_1	533	539	PF00069	0.532
MOD_CK1_1	551	557	PF00069	0.331
MOD_CK1_1	576	582	PF00069	0.567
MOD_CK1_1	718	724	PF00069	0.550
MOD_CK1_1	864	870	PF00069	0.360
MOD_CK1_1	985	991	PF00069	0.645
MOD_CK2_1	235	241	PF00069	0.609
MOD_CK2_1	289	295	PF00069	0.363
MOD_CK2_1	414	420	PF00069	0.533
MOD_CK2_1	614	620	PF00069	0.442
MOD_CK2_1	729	735	PF00069	0.590
MOD_CK2_1	748	754	PF00069	0.567
MOD_CK2_1	940	946	PF00069	0.496
MOD_GlcNHglycan	108	111	PF01048	0.622
MOD_GlcNHglycan	177	180	PF01048	0.511
MOD_GlcNHglycan	267	270	PF01048	0.451
MOD_GlcNHglycan	434	437	PF01048	0.411
MOD_GlcNHglycan	468	471	PF01048	0.424
MOD_GlcNHglycan	497	500	PF01048	0.528
MOD_GlcNHglycan	51	54	PF01048	0.596
MOD_GlcNHglycan	512	515	PF01048	0.599
MOD_GlcNHglycan	532	535	PF01048	0.575
MOD_GlcNHglycan	542	545	PF01048	0.669
MOD_GlcNHglycan	565	568	PF01048	0.643
MOD_GlcNHglycan	582	585	PF01048	0.405
MOD_GlcNHglycan	598	601	PF01048	0.518
MOD_GlcNHglycan	705	708	PF01048	0.569
MOD_GlcNHglycan	88	91	PF01048	0.529
MOD_GlcNHglycan	956	959	PF01048	0.407
MOD_GlcNHglycan	980	983	PF01048	0.672
MOD_GSK3_1	117	124	PF00069	0.425
MOD_GSK3_1	178	185	PF00069	0.512
MOD_GSK3_1	195	202	PF00069	0.593
MOD_GSK3_1	235	242	PF00069	0.587
MOD_GSK3_1	246	253	PF00069	0.382
MOD_GSK3_1	255	262	PF00069	0.379
MOD_GSK3_1	316	323	PF00069	0.450
MOD_GSK3_1	327	334	PF00069	0.366
MOD_GSK3_1	344	351	PF00069	0.369
MOD_GSK3_1	452	459	PF00069	0.519
MOD_GSK3_1	487	494	PF00069	0.451
MOD_GSK3_1	495	502	PF00069	0.455
MOD_GSK3_1	524	531	PF00069	0.631
MOD_GSK3_1	547	554	PF00069	0.523
MOD_GSK3_1	573	580	PF00069	0.474
MOD_GSK3_1	588	595	PF00069	0.465
MOD_GSK3_1	881	888	PF00069	0.542
MOD_GSK3_1	936	943	PF00069	0.536
MOD_GSK3_1	974	981	PF00069	0.686
MOD_LATS_1	281	287	PF00433	0.512
MOD_N-GLC_1	121	126	PF02516	0.604
MOD_N-GLC_1	136	141	PF02516	0.553
MOD_N-GLC_1	820	825	PF02516	0.441
MOD_NEK2_1	239	244	PF00069	0.627
MOD_NEK2_1	250	255	PF00069	0.428
MOD_NEK2_1	414	419	PF00069	0.570
MOD_NEK2_1	456	461	PF00069	0.517
MOD_NEK2_1	49	54	PF00069	0.478
MOD_NEK2_1	501	506	PF00069	0.492
MOD_NEK2_1	577	582	PF00069	0.597
MOD_NEK2_1	592	597	PF00069	0.489
MOD_NEK2_1	621	626	PF00069	0.396
MOD_NEK2_1	769	774	PF00069	0.459
MOD_NEK2_1	812	817	PF00069	0.462
MOD_NEK2_1	874	879	PF00069	0.483
MOD_NEK2_1	885	890	PF00069	0.405
MOD_NEK2_1	992	997	PF00069	0.636
MOD_NEK2_2	898	903	PF00069	0.546
MOD_NEK2_2	908	913	PF00069	0.420
MOD_PKA_2	117	123	PF00069	0.484
MOD_PKA_2	49	55	PF00069	0.477
MOD_PKA_2	675	681	PF00069	0.412
MOD_PKA_2	952	958	PF00069	0.536
MOD_PKA_2	992	998	PF00069	0.525
MOD_Plk_1	548	554	PF00069	0.381
MOD_Plk_1	689	695	PF00069	0.496
MOD_Plk_1	769	775	PF00069	0.459
MOD_Plk_1	820	826	PF00069	0.440
MOD_Plk_1	874	880	PF00069	0.455
MOD_Plk_1	885	891	PF00069	0.431
MOD_Plk_1	908	914	PF00069	0.467
MOD_Plk_4	125	131	PF00069	0.445
MOD_Plk_4	246	252	PF00069	0.394
MOD_Plk_4	402	408	PF00069	0.418
MOD_Plk_4	435	441	PF00069	0.532
MOD_Plk_4	548	554	PF00069	0.448
MOD_Plk_4	588	594	PF00069	0.510
MOD_Plk_4	820	826	PF00069	0.422
MOD_Plk_4	861	867	PF00069	0.583
MOD_ProDKin_1	136	142	PF00069	0.544
MOD_ProDKin_1	178	184	PF00069	0.476
MOD_ProDKin_1	40	46	PF00069	0.447
MOD_ProDKin_1	491	497	PF00069	0.474
MOD_ProDKin_1	533	539	PF00069	0.694
MOD_ProDKin_1	60	66	PF00069	0.511
MOD_ProDKin_1	614	620	PF00069	0.442
MOD_ProDKin_1	841	847	PF00069	0.542
MOD_ProDKin_1	974	980	PF00069	0.646
MOD_ProDKin_1	982	988	PF00069	0.718
MOD_SUMO_for_1	380	383	PF00179	0.431
MOD_SUMO_for_1	687	690	PF00179	0.499
MOD_SUMO_rev_2	543	548	PF00179	0.499
MOD_SUMO_rev_2	681	689	PF00179	0.552
TRG_DiLeu_BaEn_1	421	426	PF01217	0.563
TRG_DiLeu_BaEn_1	861	866	PF01217	0.503
TRG_DiLeu_BaEn_3	924	930	PF01217	0.510
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.482
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.558
TRG_ENDOCYTIC_2	116	119	PF00928	0.424
TRG_ENDOCYTIC_2	640	643	PF00928	0.452
TRG_ENDOCYTIC_2	768	771	PF00928	0.523
TRG_ENDOCYTIC_2	99	102	PF00928	0.600
TRG_ER_diArg_1	130	133	PF00400	0.473
TRG_ER_diArg_1	300	303	PF00400	0.528
TRG_ER_diArg_1	423	425	PF00400	0.537
TRG_ER_diArg_1	657	660	PF00400	0.504
TRG_ER_diArg_1	930	933	PF00400	0.500
TRG_ER_diArg_1	950	953	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM5	Leptomonas seymouri	54%	88%
A0A3Q8IEY3	Leishmania donovani	74%	98%
A0A3R7KYM3	Trypanosoma rangeli	31%	95%
A4I5L6	Leishmania infantum	74%	98%
E9B0W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q7A5	Leishmania major	73%	100%