LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HIC2_LEIBR
TriTrypDb:
LbrM.30.1830 , LBRM2903_300024200
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIC2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 50 52 PF00675 0.357
CLV_NRD_NRD_1 96 98 PF00675 0.531
CLV_PCSK_KEX2_1 95 97 PF00082 0.520
CLV_PCSK_SKI1_1 52 56 PF00082 0.441
DEG_Nend_UBRbox_1 1 4 PF02207 0.587
DOC_CYCLIN_yCln2_LP_2 18 21 PF00134 0.531
DOC_MAPK_gen_1 51 62 PF00069 0.472
DOC_MAPK_gen_1 95 102 PF00069 0.539
DOC_MAPK_MEF2A_6 55 64 PF00069 0.434
DOC_PP2B_LxvP_1 18 21 PF13499 0.531
DOC_USP7_UBL2_3 52 56 PF12436 0.534
LIG_Actin_WH2_2 42 60 PF00022 0.527
LIG_LIR_Gen_1 113 118 PF02991 0.428
LIG_LIR_Gen_1 22 33 PF02991 0.449
LIG_LIR_Nem_3 113 118 PF02991 0.674
LIG_LIR_Nem_3 22 28 PF02991 0.446
LIG_LIR_Nem_3 84 90 PF02991 0.487
LIG_PDZ_Class_3 113 118 PF00595 0.638
LIG_SH2_STAT5 4 7 PF00017 0.507
LIG_SH3_3 105 111 PF00018 0.571
MOD_CK2_1 74 80 PF00069 0.486
MOD_Cter_Amidation 49 52 PF01082 0.522
MOD_GlcNHglycan 76 79 PF01048 0.575
MOD_GSK3_1 106 113 PF00069 0.553
MOD_NEK2_1 101 106 PF00069 0.636
MOD_NEK2_1 24 29 PF00069 0.423
MOD_PIKK_1 9 15 PF00454 0.444
MOD_PKA_2 9 15 PF00069 0.444
TRG_ER_diArg_1 35 38 PF00400 0.468
TRG_ER_diArg_1 95 97 PF00400 0.565
TRG_NLS_MonoExtC_3 50 55 PF00514 0.438
TRG_NLS_MonoExtN_4 48 55 PF00514 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCW4 Leptomonas seymouri 73% 91%
A0A0S4JF46 Bodo saltans 37% 100%
A0A1X0P2V6 Trypanosomatidae 57% 100%
A0A3Q8IHY2 Leishmania donovani 86% 100%
A0A3R7NV36 Trypanosoma rangeli 56% 100%
A4I5L4 Leishmania infantum 86% 100%
C9ZQZ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 80%
E9B0V9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q7A7 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS