Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIB8_LEIBR

TriTrypDb:

LbrM.30.1790 , LBRM2903_300023600

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HIB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.666
CLV_NRD_NRD_1	138	140	PF00675	0.420
CLV_NRD_NRD_1	43	45	PF00675	0.299
CLV_NRD_NRD_1	56	58	PF00675	0.389
CLV_PCSK_FUR_1	75	79	PF00082	0.521
CLV_PCSK_KEX2_1	68	70	PF00082	0.427
CLV_PCSK_KEX2_1	74	76	PF00082	0.455
CLV_PCSK_KEX2_1	77	79	PF00082	0.472
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.427
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.455
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.472
CLV_PCSK_SKI1_1	33	37	PF00082	0.618
CLV_PCSK_SKI1_1	74	78	PF00082	0.408
DOC_CKS1_1	94	99	PF01111	0.703
DOC_PP1_RVXF_1	31	37	PF00149	0.391
DOC_USP7_MATH_1	18	22	PF00917	0.378
DOC_USP7_MATH_1	70	74	PF00917	0.603
DOC_USP7_UBL2_3	68	72	PF12436	0.629
DOC_WW_Pin1_4	24	29	PF00397	0.364
DOC_WW_Pin1_4	93	98	PF00397	0.747
LIG_14-3-3_CanoR_1	33	43	PF00244	0.426
LIG_14-3-3_CanoR_1	75	84	PF00244	0.720
LIG_APCC_ABBA_1	1	6	PF00400	0.400
LIG_BIR_II_1	1	5	PF00653	0.392
LIG_FHA_1	35	41	PF00498	0.412
LIG_LIR_Gen_1	131	137	PF02991	0.598
LIG_LIR_Gen_1	2	12	PF02991	0.383
LIG_LIR_Gen_1	37	46	PF02991	0.372
LIG_LIR_Nem_3	131	136	PF02991	0.598
LIG_LIR_Nem_3	2	7	PF02991	0.389
LIG_LIR_Nem_3	37	42	PF02991	0.301
LIG_NRP_CendR_1	162	165	PF00754	0.397
LIG_PCNA_yPIPBox_3	153	165	PF02747	0.522
LIG_SH2_CRK	60	64	PF00017	0.564
LIG_SH2_PTP2	133	136	PF00017	0.599
LIG_SH2_SRC	111	114	PF00017	0.642
LIG_SH2_SRC	133	136	PF00017	0.599
LIG_SH2_STAP1	4	8	PF00017	0.424
LIG_SH2_STAT5	111	114	PF00017	0.625
LIG_SH2_STAT5	133	136	PF00017	0.599
LIG_SH2_STAT5	52	55	PF00017	0.312
LIG_SH3_3	91	97	PF00018	0.701
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.579
LIG_SUMO_SIM_par_1	15	21	PF11976	0.327
MOD_CDK_SPK_2	93	98	PF00069	0.664
MOD_CK1_1	103	109	PF00069	0.568
MOD_CK1_1	2	8	PF00069	0.425
MOD_CK1_1	21	27	PF00069	0.315
MOD_CK1_1	79	85	PF00069	0.664
MOD_CK1_1	86	92	PF00069	0.666
MOD_CK2_1	86	92	PF00069	0.612
MOD_GlcNHglycan	78	81	PF01048	0.463
MOD_GlcNHglycan	88	91	PF01048	0.461
MOD_GSK3_1	2	9	PF00069	0.439
MOD_GSK3_1	79	86	PF00069	0.627
MOD_N-GLC_1	24	29	PF02516	0.533
MOD_N-GLC_1	86	91	PF02516	0.456
MOD_NEK2_1	63	68	PF00069	0.701
MOD_PIKK_1	26	32	PF00454	0.421
MOD_PK_1	144	150	PF00069	0.635
MOD_PKA_1	68	74	PF00069	0.670
MOD_PKA_2	68	74	PF00069	0.670
MOD_Plk_1	100	106	PF00069	0.588
MOD_Plk_4	100	106	PF00069	0.586
MOD_Plk_4	151	157	PF00069	0.512
MOD_ProDKin_1	24	30	PF00069	0.363
MOD_ProDKin_1	93	99	PF00069	0.745
MOD_SUMO_rev_2	135	142	PF00179	0.612
TRG_DiLeu_BaEn_1	151	156	PF01217	0.569
TRG_DiLeu_BaEn_2	37	43	PF01217	0.303
TRG_ENDOCYTIC_2	133	136	PF00928	0.599
TRG_ENDOCYTIC_2	4	7	PF00928	0.387
TRG_ENDOCYTIC_2	52	55	PF00928	0.312
TRG_ENDOCYTIC_2	60	63	PF00928	0.593
TRG_NLS_Bipartite_1	57	78	PF00514	0.546
TRG_NLS_MonoExtC_3	73	78	PF00514	0.597
TRG_NLS_MonoExtN_4	72	78	PF00514	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q9	Leptomonas seymouri	63%	99%
A0A3Q8IFM8	Leishmania donovani	79%	100%
A4I5K2	Leishmania infantum	78%	100%
E9B0U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7B9	Leishmania major	82%	100%