PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HIB7_LEIBR

TriTrypDb:

LbrM.30.1780 , LBRM2903_300023500

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.438
CLV_C14_Caspase3-7	31	35	PF00656	0.488
CLV_C14_Caspase3-7	77	81	PF00656	0.486
CLV_C14_Caspase3-7	92	96	PF00656	0.497
CLV_PCSK_KEX2_1	240	242	PF00082	0.431
CLV_PCSK_KEX2_1	58	60	PF00082	0.558
CLV_PCSK_KEX2_1	86	88	PF00082	0.622
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.394
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.589
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.544
CLV_PCSK_SKI1_1	218	222	PF00082	0.519
CLV_PCSK_SKI1_1	240	244	PF00082	0.411
CLV_PCSK_SKI1_1	55	59	PF00082	0.567
DOC_MAPK_DCC_7	10	20	PF00069	0.532
DOC_SPAK_OSR1_1	252	256	PF12202	0.311
DOC_USP7_MATH_1	16	20	PF00917	0.539
DOC_USP7_MATH_1	68	72	PF00917	0.535
DOC_USP7_UBL2_3	109	113	PF12436	0.416
DOC_USP7_UBL2_3	221	225	PF12436	0.367
DOC_WW_Pin1_4	135	140	PF00397	0.393
DOC_WW_Pin1_4	160	165	PF00397	0.457
DOC_WW_Pin1_4	8	13	PF00397	0.542
LIG_14-3-3_CanoR_1	241	246	PF00244	0.433
LIG_14-3-3_CanoR_1	252	258	PF00244	0.336
LIG_APCC_ABBA_1	154	159	PF00400	0.409
LIG_APCC_ABBAyCdc20_2	153	159	PF00400	0.327
LIG_BRCT_BRCA1_1	205	209	PF00533	0.452
LIG_eIF4E_1	198	204	PF01652	0.269
LIG_FHA_2	191	197	PF00498	0.391
LIG_FHA_2	48	54	PF00498	0.535
LIG_FHA_2	75	81	PF00498	0.524
LIG_LIR_Gen_1	251	260	PF02991	0.378
LIG_LIR_Gen_1	273	281	PF02991	0.403
LIG_LIR_Nem_3	124	129	PF02991	0.415
LIG_LIR_Nem_3	196	201	PF02991	0.370
LIG_LIR_Nem_3	251	257	PF02991	0.396
LIG_LIR_Nem_3	273	278	PF02991	0.396
LIG_LIR_Nem_3	37	43	PF02991	0.602
LIG_LIR_Nem_3	44	48	PF02991	0.537
LIG_Pex14_2	253	257	PF04695	0.361
LIG_SH2_PTP2	198	201	PF00017	0.352
LIG_SH2_STAP1	43	47	PF00017	0.515
LIG_SH2_STAT5	121	124	PF00017	0.306
LIG_SH2_STAT5	155	158	PF00017	0.392
LIG_SH2_STAT5	198	201	PF00017	0.352
LIG_SH2_STAT5	254	257	PF00017	0.357
LIG_SH2_STAT5	274	277	PF00017	0.219
LIG_SH2_STAT5	281	284	PF00017	0.386
LIG_SH2_STAT5	48	51	PF00017	0.448
LIG_SH2_STAT5	56	59	PF00017	0.472
LIG_SH3_2	127	132	PF14604	0.452
LIG_SH3_2	161	166	PF14604	0.334
LIG_SH3_3	124	130	PF00018	0.447
LIG_SH3_3	133	139	PF00018	0.492
LIG_SH3_3	158	164	PF00018	0.461
LIG_SH3_3	24	30	PF00018	0.643
LIG_SUMO_SIM_par_1	202	208	PF11976	0.360
LIG_SUMO_SIM_par_1	25	32	PF11976	0.491
LIG_TRAF2_1	260	263	PF00917	0.384
LIG_TRFH_1	209	213	PF08558	0.464
LIG_WRC_WIRS_1	254	259	PF05994	0.346
LIG_WRC_WIRS_1	75	80	PF05994	0.451
MOD_CDC14_SPxK_1	11	14	PF00782	0.538
MOD_CDC14_SPxK_1	163	166	PF00782	0.296
MOD_CDK_SPK_2	135	140	PF00069	0.363
MOD_CDK_SPxK_1	160	166	PF00069	0.343
MOD_CDK_SPxK_1	8	14	PF00069	0.544
MOD_CK1_1	28	34	PF00069	0.496
MOD_CK1_1	41	47	PF00069	0.437
MOD_CK1_1	60	66	PF00069	0.577
MOD_CK2_1	47	53	PF00069	0.562
MOD_Cter_Amidation	230	233	PF01082	0.386
MOD_Cter_Amidation	84	87	PF01082	0.563
MOD_GlcNHglycan	222	225	PF01048	0.371
MOD_GSK3_1	121	128	PF00069	0.436
MOD_GSK3_1	199	206	PF00069	0.380
MOD_GSK3_1	281	288	PF00069	0.356
MOD_GSK3_1	34	41	PF00069	0.534
MOD_GSK3_1	98	105	PF00069	0.550
MOD_NEK2_1	102	107	PF00069	0.562
MOD_NEK2_1	203	208	PF00069	0.371
MOD_NEK2_1	220	225	PF00069	0.518
MOD_NEK2_1	253	258	PF00069	0.327
MOD_NEK2_1	57	62	PF00069	0.678
MOD_Plk_1	180	186	PF00069	0.379
MOD_Plk_4	102	108	PF00069	0.531
MOD_Plk_4	121	127	PF00069	0.424
MOD_Plk_4	190	196	PF00069	0.397
MOD_Plk_4	199	205	PF00069	0.368
MOD_Plk_4	253	259	PF00069	0.351
MOD_ProDKin_1	135	141	PF00069	0.388
MOD_ProDKin_1	160	166	PF00069	0.451
MOD_ProDKin_1	8	14	PF00069	0.544
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.405
TRG_ENDOCYTIC_2	198	201	PF00928	0.352
TRG_ENDOCYTIC_2	254	257	PF00928	0.357
TRG_ENDOCYTIC_2	274	277	PF00928	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT80	Leptomonas seymouri	59%	100%
A0A3Q8IFU1	Leishmania donovani	68%	92%
A4I5K1	Leishmania infantum	67%	92%
E9B0U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	93%
Q4Q7C0	Leishmania major	67%	100%