Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIB6_LEIBR

TriTrypDb:

LbrM.30.1770 , LBRM2903_300023400

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HIB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.595
CLV_C14_Caspase3-7	83	87	PF00656	0.384
CLV_NRD_NRD_1	122	124	PF00675	0.362
CLV_NRD_NRD_1	199	201	PF00675	0.684
CLV_NRD_NRD_1	220	222	PF00675	0.510
CLV_NRD_NRD_1	316	318	PF00675	0.480
CLV_NRD_NRD_1	358	360	PF00675	0.555
CLV_NRD_NRD_1	79	81	PF00675	0.567
CLV_PCSK_FUR_1	196	200	PF00082	0.527
CLV_PCSK_KEX2_1	198	200	PF00082	0.798
CLV_PCSK_KEX2_1	220	222	PF00082	0.613
CLV_PCSK_KEX2_1	79	81	PF00082	0.567
CLV_PCSK_SKI1_1	386	390	PF00082	0.625
DEG_APCC_KENBOX_2	128	132	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.608
DOC_CYCLIN_RxL_1	117	130	PF00134	0.445
DOC_CYCLIN_RxL_1	217	227	PF00134	0.658
DOC_MAPK_MEF2A_6	374	383	PF00069	0.560
DOC_PP1_RVXF_1	121	128	PF00149	0.537
DOC_PP4_FxxP_1	209	212	PF00568	0.507
DOC_PP4_FxxP_1	216	219	PF00568	0.467
DOC_USP7_MATH_1	113	117	PF00917	0.495
DOC_USP7_MATH_1	202	206	PF00917	0.604
DOC_USP7_MATH_1	212	216	PF00917	0.648
DOC_USP7_MATH_1	235	239	PF00917	0.469
DOC_USP7_MATH_1	48	52	PF00917	0.698
DOC_WW_Pin1_4	183	188	PF00397	0.690
DOC_WW_Pin1_4	222	227	PF00397	0.552
DOC_WW_Pin1_4	287	292	PF00397	0.770
DOC_WW_Pin1_4	41	46	PF00397	0.473
LIG_14-3-3_CanoR_1	110	118	PF00244	0.498
LIG_14-3-3_CanoR_1	123	128	PF00244	0.400
LIG_14-3-3_CanoR_1	352	357	PF00244	0.567
LIG_14-3-3_CanoR_1	79	88	PF00244	0.424
LIG_BIR_III_2	35	39	PF00653	0.660
LIG_EH_1	8	12	PF12763	0.389
LIG_FHA_1	176	182	PF00498	0.719
LIG_FHA_1	269	275	PF00498	0.674
LIG_FHA_1	351	357	PF00498	0.584
LIG_FHA_2	183	189	PF00498	0.576
LIG_FHA_2	212	218	PF00498	0.650
LIG_FHA_2	278	284	PF00498	0.681
LIG_FHA_2	30	36	PF00498	0.553
LIG_FHA_2	353	359	PF00498	0.493
LIG_FHA_2	81	87	PF00498	0.400
LIG_LIR_Apic_2	207	212	PF02991	0.512
LIG_LIR_Apic_2	213	219	PF02991	0.487
LIG_LIR_Apic_2	227	233	PF02991	0.524
LIG_LIR_Gen_1	17	24	PF02991	0.563
LIG_LIR_Gen_1	91	101	PF02991	0.315
LIG_LIR_Nem_3	17	23	PF02991	0.533
LIG_LIR_Nem_3	89	93	PF02991	0.393
LIG_Pex14_2	49	53	PF04695	0.481
LIG_Rb_LxCxE_1	91	107	PF01857	0.344
LIG_SH2_CRK	7	11	PF00017	0.409
LIG_SH2_GRB2like	7	10	PF00017	0.462
LIG_SH2_NCK_1	7	11	PF00017	0.487
LIG_SH2_PTP2	93	96	PF00017	0.319
LIG_SH2_SRC	20	23	PF00017	0.634
LIG_SH2_SRC	7	10	PF00017	0.582
LIG_SH2_STAP1	20	24	PF00017	0.709
LIG_SH2_STAP1	307	311	PF00017	0.378
LIG_SH2_STAP1	90	94	PF00017	0.405
LIG_SH2_STAT5	93	96	PF00017	0.374
LIG_SH3_3	184	190	PF00018	0.670
LIG_SH3_3	35	41	PF00018	0.504
LIG_TRAF2_1	152	155	PF00917	0.492
LIG_TRAF2_1	204	207	PF00917	0.514
LIG_TRAF2_1	323	326	PF00917	0.424
LIG_TYR_ITIM	18	23	PF00017	0.530
LIG_Vh1_VBS_1	146	164	PF01044	0.519
LIG_WRC_WIRS_1	254	259	PF05994	0.467
MOD_CDC14_SPxK_1	186	189	PF00782	0.511
MOD_CDK_SPxK_1	183	189	PF00069	0.511
MOD_CK1_1	175	181	PF00069	0.721
MOD_CK1_1	56	62	PF00069	0.500
MOD_CK2_1	113	119	PF00069	0.414
MOD_CK2_1	148	154	PF00069	0.538
MOD_CK2_1	182	188	PF00069	0.643
MOD_CK2_1	211	217	PF00069	0.651
MOD_CK2_1	277	283	PF00069	0.688
MOD_GlcNHglycan	150	153	PF01048	0.492
MOD_GlcNHglycan	165	168	PF01048	0.354
MOD_GlcNHglycan	190	193	PF01048	0.623
MOD_GlcNHglycan	2	5	PF01048	0.558
MOD_GlcNHglycan	226	229	PF01048	0.615
MOD_GlcNHglycan	233	236	PF01048	0.522
MOD_GlcNHglycan	386	389	PF01048	0.457
MOD_GlcNHglycan	50	53	PF01048	0.625
MOD_GlcNHglycan	61	64	PF01048	0.650
MOD_GSK3_1	113	120	PF00069	0.461
MOD_GSK3_1	172	179	PF00069	0.579
MOD_GSK3_1	231	238	PF00069	0.576
MOD_GSK3_1	348	355	PF00069	0.392
MOD_GSK3_1	39	46	PF00069	0.768
MOD_GSK3_1	71	78	PF00069	0.648
MOD_LATS_1	330	336	PF00433	0.350
MOD_N-GLC_1	202	207	PF02516	0.610
MOD_NEK2_1	111	116	PF00069	0.430
MOD_NEK2_1	176	181	PF00069	0.753
MOD_NEK2_1	348	353	PF00069	0.461
MOD_NEK2_2	237	242	PF00069	0.477
MOD_NEK2_2	71	76	PF00069	0.668
MOD_PIKK_1	111	117	PF00454	0.395
MOD_PIKK_1	202	208	PF00454	0.644
MOD_PIKK_1	296	302	PF00454	0.666
MOD_PIKK_1	332	338	PF00454	0.531
MOD_PIKK_1	80	86	PF00454	0.501
MOD_PK_1	39	45	PF00069	0.476
MOD_PKA_1	123	129	PF00069	0.475
MOD_PKA_1	79	85	PF00069	0.435
MOD_PKA_2	162	168	PF00069	0.412
MOD_PKA_2	188	194	PF00069	0.521
MOD_PKA_2	296	302	PF00069	0.590
MOD_PKA_2	53	59	PF00069	0.627
MOD_PKA_2	79	85	PF00069	0.472
MOD_PKB_1	121	129	PF00069	0.462
MOD_PKB_1	350	358	PF00069	0.567
MOD_PKB_1	37	45	PF00069	0.480
MOD_Plk_1	176	182	PF00069	0.704
MOD_Plk_1	212	218	PF00069	0.547
MOD_Plk_1	307	313	PF00069	0.374
MOD_Plk_2-3	22	28	PF00069	0.548
MOD_ProDKin_1	183	189	PF00069	0.694
MOD_ProDKin_1	222	228	PF00069	0.551
MOD_ProDKin_1	287	293	PF00069	0.766
MOD_ProDKin_1	41	47	PF00069	0.474
MOD_SUMO_rev_2	151	160	PF00179	0.455
MOD_SUMO_rev_2	366	376	PF00179	0.499
TRG_DiLeu_BaEn_1	155	160	PF01217	0.551
TRG_DiLeu_BaEn_3	155	161	PF01217	0.502
TRG_ENDOCYTIC_2	20	23	PF00928	0.548
TRG_ENDOCYTIC_2	254	257	PF00928	0.455
TRG_ENDOCYTIC_2	93	96	PF00928	0.319
TRG_ER_diArg_1	142	145	PF00400	0.527
TRG_ER_diArg_1	195	198	PF00400	0.547
TRG_ER_diArg_1	219	221	PF00400	0.755
TRG_ER_diArg_1	37	40	PF00400	0.516
TRG_ER_diArg_1	383	386	PF00400	0.362
TRG_NLS_MonoExtN_4	359	364	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I207	Leptomonas seymouri	43%	100%
A0A3Q8IBZ6	Leishmania donovani	68%	100%
A0A422P3J4	Trypanosoma rangeli	29%	100%
A4I5K0	Leishmania infantum	69%	100%
E9B0U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
Q4Q7C1	Leishmania major	70%	100%
V5B8Y5	Trypanosoma cruzi	26%	100%