LeishMANIAdb
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ATPase_AAA_core domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATPase_AAA_core domain-containing protein
Gene product:
AAA domain (Cdc48 subfamily), putative
Species:
Leishmania braziliensis
UniProt:
A4HIB3_LEIBR
TriTrypDb:
LbrM.30.1740 , LBRM2903_300023100 *
Length:
859

Annotations

LeishMANIAdb annotations

These proteins are apparently divergent members of the greater ClpB family found in both Eukaryota and Prokaryota. The TM segments are unusual additions.. Anchored into the membrane using the very last 3 helical segment (similar to tail-anchored proteins)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HIB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIB3

Function

Biological processes
Term Name Level Count
GO:0006950 response to stress 2 1
GO:0009266 response to temperature stimulus 3 1
GO:0009408 response to heat 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034605 cellular response to heat 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 516 518 PF00675 0.330
CLV_PCSK_FUR_1 86 90 PF00082 0.703
CLV_PCSK_KEX2_1 343 345 PF00082 0.283
CLV_PCSK_KEX2_1 487 489 PF00082 0.277
CLV_PCSK_KEX2_1 516 518 PF00082 0.321
CLV_PCSK_KEX2_1 605 607 PF00082 0.390
CLV_PCSK_KEX2_1 88 90 PF00082 0.750
CLV_PCSK_PC1ET2_1 343 345 PF00082 0.351
CLV_PCSK_PC1ET2_1 487 489 PF00082 0.191
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.390
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.693
CLV_PCSK_SKI1_1 162 166 PF00082 0.495
CLV_PCSK_SKI1_1 285 289 PF00082 0.437
CLV_PCSK_SKI1_1 433 437 PF00082 0.267
CLV_PCSK_SKI1_1 479 483 PF00082 0.332
CLV_PCSK_SKI1_1 526 530 PF00082 0.342
CLV_PCSK_SKI1_1 605 609 PF00082 0.400
CLV_PCSK_SKI1_1 640 644 PF00082 0.549
CLV_PCSK_SKI1_1 752 756 PF00082 0.386
CLV_PCSK_SKI1_1 768 772 PF00082 0.316
CLV_PCSK_SKI1_1 77 81 PF00082 0.700
CLV_PCSK_SKI1_1 826 830 PF00082 0.326
CLV_PCSK_SKI1_1 853 857 PF00082 0.553
DEG_APCC_DBOX_1 161 169 PF00400 0.344
DEG_APCC_DBOX_1 263 271 PF00400 0.606
DEG_SCF_FBW7_2 667 674 PF00400 0.620
DEG_SPOP_SBC_1 135 139 PF00917 0.434
DEG_SPOP_SBC_1 221 225 PF00917 0.717
DOC_CKS1_1 539 544 PF01111 0.522
DOC_CYCLIN_RxL_1 476 484 PF00134 0.463
DOC_CYCLIN_RxL_1 737 747 PF00134 0.581
DOC_CYCLIN_RxL_1 749 759 PF00134 0.524
DOC_CYCLIN_RxL_1 768 782 PF00134 0.448
DOC_CYCLIN_yCln2_LP_2 814 820 PF00134 0.422
DOC_CYCLIN_yCln2_LP_2 831 837 PF00134 0.422
DOC_MAPK_gen_1 160 167 PF00069 0.287
DOC_MAPK_gen_1 513 522 PF00069 0.517
DOC_MAPK_gen_1 74 83 PF00069 0.353
DOC_MAPK_HePTP_8 771 783 PF00069 0.544
DOC_MAPK_JIP1_4 324 330 PF00069 0.544
DOC_MAPK_MEF2A_6 160 169 PF00069 0.311
DOC_MAPK_MEF2A_6 324 331 PF00069 0.453
DOC_MAPK_MEF2A_6 516 524 PF00069 0.502
DOC_MAPK_MEF2A_6 774 783 PF00069 0.495
DOC_MAPK_MEF2A_6 836 845 PF00069 0.422
DOC_PP2B_LxvP_1 352 355 PF13499 0.391
DOC_PP2B_LxvP_1 814 817 PF13499 0.422
DOC_PP4_FxxP_1 330 333 PF00568 0.509
DOC_USP7_MATH_1 135 139 PF00917 0.474
DOC_USP7_MATH_1 187 191 PF00917 0.668
DOC_USP7_MATH_1 214 218 PF00917 0.781
DOC_USP7_MATH_1 221 225 PF00917 0.787
DOC_USP7_MATH_1 253 257 PF00917 0.716
DOC_USP7_MATH_1 295 299 PF00917 0.529
DOC_USP7_MATH_1 438 442 PF00917 0.463
DOC_USP7_MATH_1 456 460 PF00917 0.492
DOC_USP7_MATH_1 532 536 PF00917 0.471
DOC_USP7_MATH_1 598 602 PF00917 0.681
DOC_USP7_MATH_1 646 650 PF00917 0.689
DOC_USP7_MATH_1 701 705 PF00917 0.755
DOC_USP7_MATH_1 849 853 PF00917 0.460
DOC_WW_Pin1_4 468 473 PF00397 0.528
DOC_WW_Pin1_4 538 543 PF00397 0.524
DOC_WW_Pin1_4 605 610 PF00397 0.664
DOC_WW_Pin1_4 64 69 PF00397 0.549
DOC_WW_Pin1_4 667 672 PF00397 0.778
DOC_WW_Pin1_4 696 701 PF00397 0.719
LIG_14-3-3_CanoR_1 189 197 PF00244 0.638
LIG_14-3-3_CanoR_1 220 229 PF00244 0.672
LIG_14-3-3_CanoR_1 254 263 PF00244 0.659
LIG_14-3-3_CanoR_1 264 268 PF00244 0.618
LIG_14-3-3_CanoR_1 274 278 PF00244 0.682
LIG_14-3-3_CanoR_1 344 349 PF00244 0.555
LIG_14-3-3_CanoR_1 440 446 PF00244 0.464
LIG_14-3-3_CanoR_1 551 556 PF00244 0.589
LIG_14-3-3_CanoR_1 9 17 PF00244 0.481
LIG_Actin_WH2_2 589 607 PF00022 0.521
LIG_Actin_WH2_2 783 799 PF00022 0.422
LIG_Actin_WH2_2 806 824 PF00022 0.208
LIG_APCC_ABBA_1 146 151 PF00400 0.462
LIG_BIR_III_4 51 55 PF00653 0.409
LIG_eIF4E_1 835 841 PF01652 0.397
LIG_EVH1_1 709 713 PF00568 0.581
LIG_FHA_1 115 121 PF00498 0.421
LIG_FHA_1 129 135 PF00498 0.477
LIG_FHA_1 143 149 PF00498 0.494
LIG_FHA_1 213 219 PF00498 0.790
LIG_FHA_1 234 240 PF00498 0.665
LIG_FHA_1 310 316 PF00498 0.456
LIG_FHA_1 324 330 PF00498 0.453
LIG_FHA_1 445 451 PF00498 0.474
LIG_FHA_1 564 570 PF00498 0.609
LIG_FHA_1 575 581 PF00498 0.481
LIG_FHA_1 589 595 PF00498 0.622
LIG_FHA_1 704 710 PF00498 0.743
LIG_FHA_1 734 740 PF00498 0.623
LIG_FHA_1 749 755 PF00498 0.583
LIG_FHA_2 107 113 PF00498 0.458
LIG_FHA_2 256 262 PF00498 0.543
LIG_FHA_2 286 292 PF00498 0.604
LIG_FHA_2 491 497 PF00498 0.467
LIG_FHA_2 510 516 PF00498 0.425
LIG_FHA_2 54 60 PF00498 0.521
LIG_FHA_2 557 563 PF00498 0.643
LIG_FHA_2 597 603 PF00498 0.695
LIG_FHA_2 671 677 PF00498 0.771
LIG_FHA_2 762 768 PF00498 0.505
LIG_FHA_2 96 102 PF00498 0.582
LIG_GBD_Chelix_1 776 784 PF00786 0.297
LIG_GBD_Chelix_1 806 814 PF00786 0.355
LIG_LIR_Apic_2 503 507 PF02991 0.419
LIG_LIR_Gen_1 108 116 PF02991 0.495
LIG_LIR_Gen_1 375 386 PF02991 0.453
LIG_LIR_Gen_1 645 654 PF02991 0.642
LIG_LIR_Gen_1 729 739 PF02991 0.630
LIG_LIR_Nem_3 143 149 PF02991 0.486
LIG_LIR_Nem_3 375 381 PF02991 0.453
LIG_LIR_Nem_3 503 508 PF02991 0.484
LIG_LIR_Nem_3 645 650 PF02991 0.679
LIG_LIR_Nem_3 729 735 PF02991 0.644
LIG_NRBOX 523 529 PF00104 0.581
LIG_NRBOX 779 785 PF00104 0.373
LIG_PCNA_PIPBox_1 475 484 PF02747 0.544
LIG_PCNA_yPIPBox_3 160 168 PF02747 0.353
LIG_PCNA_yPIPBox_3 475 488 PF02747 0.561
LIG_Pex14_1 422 426 PF04695 0.453
LIG_SH2_CRK 539 543 PF00017 0.586
LIG_SH2_GRB2like 271 274 PF00017 0.488
LIG_SH2_GRB2like 467 470 PF00017 0.475
LIG_SH2_NCK_1 378 382 PF00017 0.453
LIG_SH2_NCK_1 511 515 PF00017 0.558
LIG_SH2_NCK_1 539 543 PF00017 0.586
LIG_SH2_SRC 467 470 PF00017 0.475
LIG_SH2_SRC 732 735 PF00017 0.496
LIG_SH2_STAP1 149 153 PF00017 0.470
LIG_SH2_STAP1 176 180 PF00017 0.559
LIG_SH2_STAP1 271 275 PF00017 0.488
LIG_SH2_STAP1 730 734 PF00017 0.522
LIG_SH2_STAT3 300 303 PF00017 0.490
LIG_SH2_STAT5 300 303 PF00017 0.490
LIG_SH2_STAT5 365 368 PF00017 0.485
LIG_SH2_STAT5 43 46 PF00017 0.404
LIG_SH2_STAT5 467 470 PF00017 0.453
LIG_SH2_STAT5 504 507 PF00017 0.466
LIG_SH2_STAT5 511 514 PF00017 0.527
LIG_SH2_STAT5 734 737 PF00017 0.517
LIG_SH3_1 504 510 PF00018 0.412
LIG_SH3_3 213 219 PF00018 0.751
LIG_SH3_3 272 278 PF00018 0.625
LIG_SH3_3 28 34 PF00018 0.483
LIG_SH3_3 378 384 PF00018 0.453
LIG_SH3_3 504 510 PF00018 0.480
LIG_SH3_3 591 597 PF00018 0.554
LIG_SH3_3 648 654 PF00018 0.699
LIG_SH3_3 707 713 PF00018 0.632
LIG_SH3_3 718 724 PF00018 0.744
LIG_SUMO_SIM_anti_2 240 245 PF11976 0.688
LIG_SUMO_SIM_anti_2 402 409 PF11976 0.455
LIG_SUMO_SIM_anti_2 591 596 PF11976 0.605
LIG_SUMO_SIM_anti_2 767 773 PF11976 0.604
LIG_SUMO_SIM_par_1 112 117 PF11976 0.380
LIG_SUMO_SIM_par_1 402 409 PF11976 0.455
LIG_SUMO_SIM_par_1 577 584 PF11976 0.532
LIG_SUMO_SIM_par_1 630 639 PF11976 0.752
LIG_SUMO_SIM_par_1 740 745 PF11976 0.643
LIG_SUMO_SIM_par_1 777 782 PF11976 0.365
LIG_TRAF2_1 100 103 PF00917 0.396
LIG_TRAF2_1 473 476 PF00917 0.502
LIG_TRAF2_1 559 562 PF00917 0.599
LIG_UBA3_1 741 746 PF00899 0.633
LIG_UBA3_1 769 774 PF00899 0.629
LIG_UBA3_1 789 797 PF00899 0.346
LIG_WRC_WIRS_1 107 112 PF05994 0.505
LIG_WRC_WIRS_1 368 373 PF05994 0.453
LIG_WRC_WIRS_1 552 557 PF05994 0.532
MOD_CDK_SPK_2 64 69 PF00069 0.413
MOD_CDK_SPxxK_3 64 71 PF00069 0.540
MOD_CK1_1 106 112 PF00069 0.371
MOD_CK1_1 206 212 PF00069 0.653
MOD_CK1_1 223 229 PF00069 0.740
MOD_CK1_1 370 376 PF00069 0.464
MOD_CK1_1 441 447 PF00069 0.454
MOD_CK1_1 616 622 PF00069 0.792
MOD_CK1_1 638 644 PF00069 0.672
MOD_CK1_1 680 686 PF00069 0.702
MOD_CK1_1 782 788 PF00069 0.393
MOD_CK2_1 175 181 PF00069 0.613
MOD_CK2_1 189 195 PF00069 0.550
MOD_CK2_1 253 259 PF00069 0.649
MOD_CK2_1 285 291 PF00069 0.559
MOD_CK2_1 410 416 PF00069 0.544
MOD_CK2_1 431 437 PF00069 0.485
MOD_CK2_1 490 496 PF00069 0.548
MOD_CK2_1 509 515 PF00069 0.479
MOD_CK2_1 527 533 PF00069 0.504
MOD_CK2_1 556 562 PF00069 0.514
MOD_CK2_1 596 602 PF00069 0.688
MOD_CK2_1 670 676 PF00069 0.767
MOD_CK2_1 723 729 PF00069 0.597
MOD_GlcNHglycan 12 15 PF01048 0.666
MOD_GlcNHglycan 207 211 PF01048 0.507
MOD_GlcNHglycan 280 284 PF01048 0.459
MOD_GlcNHglycan 333 336 PF01048 0.214
MOD_GlcNHglycan 358 362 PF01048 0.271
MOD_GlcNHglycan 389 392 PF01048 0.284
MOD_GlcNHglycan 394 397 PF01048 0.255
MOD_GlcNHglycan 423 426 PF01048 0.269
MOD_GlcNHglycan 46 49 PF01048 0.652
MOD_GlcNHglycan 577 580 PF01048 0.364
MOD_GlcNHglycan 618 621 PF01048 0.598
MOD_GlcNHglycan 714 717 PF01048 0.504
MOD_GlcNHglycan 721 724 PF01048 0.537
MOD_GlcNHglycan 853 856 PF01048 0.653
MOD_GlcNHglycan 92 95 PF01048 0.755
MOD_GSK3_1 136 143 PF00069 0.441
MOD_GSK3_1 175 182 PF00069 0.508
MOD_GSK3_1 208 215 PF00069 0.732
MOD_GSK3_1 219 226 PF00069 0.752
MOD_GSK3_1 309 316 PF00069 0.521
MOD_GSK3_1 39 46 PF00069 0.542
MOD_GSK3_1 436 443 PF00069 0.451
MOD_GSK3_1 445 452 PF00069 0.455
MOD_GSK3_1 575 582 PF00069 0.620
MOD_GSK3_1 605 612 PF00069 0.721
MOD_GSK3_1 616 623 PF00069 0.799
MOD_GSK3_1 676 683 PF00069 0.741
MOD_GSK3_1 684 691 PF00069 0.739
MOD_GSK3_1 701 708 PF00069 0.636
MOD_GSK3_1 719 726 PF00069 0.648
MOD_GSK3_1 84 91 PF00069 0.498
MOD_GSK3_1 849 856 PF00069 0.331
MOD_N-GLC_1 468 473 PF02516 0.377
MOD_N-GLC_1 667 672 PF02516 0.495
MOD_NEK2_1 140 145 PF00069 0.350
MOD_NEK2_1 263 268 PF00069 0.594
MOD_NEK2_1 314 319 PF00069 0.477
MOD_NEK2_1 357 362 PF00069 0.519
MOD_NEK2_1 39 44 PF00069 0.424
MOD_NEK2_1 410 415 PF00069 0.544
MOD_NEK2_1 421 426 PF00069 0.469
MOD_NEK2_1 449 454 PF00069 0.458
MOD_NEK2_1 481 486 PF00069 0.508
MOD_NEK2_1 527 532 PF00069 0.562
MOD_NEK2_1 748 753 PF00069 0.592
MOD_NEK2_1 796 801 PF00069 0.313
MOD_PIKK_1 114 120 PF00454 0.514
MOD_PIKK_1 295 301 PF00454 0.576
MOD_PIKK_1 481 487 PF00454 0.467
MOD_PIKK_1 527 533 PF00454 0.595
MOD_PIKK_1 563 569 PF00454 0.618
MOD_PIKK_1 680 686 PF00454 0.623
MOD_PK_1 344 350 PF00069 0.544
MOD_PKA_1 88 94 PF00069 0.520
MOD_PKA_2 219 225 PF00069 0.715
MOD_PKA_2 253 259 PF00069 0.686
MOD_PKA_2 263 269 PF00069 0.617
MOD_PKA_2 273 279 PF00069 0.583
MOD_PKA_2 445 451 PF00069 0.515
MOD_PKA_2 849 855 PF00069 0.455
MOD_PKA_2 88 94 PF00069 0.520
MOD_Plk_1 103 109 PF00069 0.502
MOD_Plk_1 638 644 PF00069 0.622
MOD_Plk_1 676 682 PF00069 0.756
MOD_Plk_2-3 103 109 PF00069 0.502
MOD_Plk_2-3 761 767 PF00069 0.530
MOD_Plk_4 12 18 PF00069 0.384
MOD_Plk_4 323 329 PF00069 0.488
MOD_Plk_4 344 350 PF00069 0.544
MOD_Plk_4 373 379 PF00069 0.461
MOD_Plk_4 39 45 PF00069 0.402
MOD_Plk_4 445 451 PF00069 0.476
MOD_Plk_4 456 462 PF00069 0.457
MOD_Plk_4 779 785 PF00069 0.343
MOD_Plk_4 796 802 PF00069 0.192
MOD_Plk_4 816 822 PF00069 0.150
MOD_ProDKin_1 468 474 PF00069 0.528
MOD_ProDKin_1 538 544 PF00069 0.521
MOD_ProDKin_1 605 611 PF00069 0.666
MOD_ProDKin_1 64 70 PF00069 0.542
MOD_ProDKin_1 667 673 PF00069 0.778
MOD_ProDKin_1 696 702 PF00069 0.719
MOD_SUMO_rev_2 147 153 PF00179 0.485
TRG_DiLeu_BaEn_2 514 520 PF01217 0.551
TRG_DiLeu_BaEn_4 102 108 PF01217 0.508
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.582
TRG_ENDOCYTIC_2 365 368 PF00928 0.481
TRG_ENDOCYTIC_2 378 381 PF00928 0.383
TRG_ENDOCYTIC_2 732 735 PF00928 0.632
TRG_ER_diArg_1 68 71 PF00400 0.547
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.253
TRG_Pf-PMV_PEXEL_1 479 483 PF00026 0.326
TRG_Pf-PMV_PEXEL_1 526 531 PF00026 0.297
TRG_Pf-PMV_PEXEL_1 640 645 PF00026 0.511
TRG_Pf-PMV_PEXEL_1 740 745 PF00026 0.409
TRG_Pf-PMV_PEXEL_1 752 756 PF00026 0.350

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHZ4 Leptomonas seymouri 56% 87%
A0A1X0P2X6 Trypanosomatidae 35% 97%
A0A3Q8IEX3 Leishmania donovani 81% 100%
A0A422P3I3 Trypanosoma rangeli 39% 100%
A4I5J7 Leishmania infantum 81% 100%
C9ZQX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9B0U2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q7C4 Leishmania major 82% 100%
V5BPI4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS