Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HIB0_LEIBR

TriTrypDb:

LbrM.30.1710 , LBRM2903_300022900

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HIB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HIB0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11
GO:0042026	protein refolding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.528
CLV_NRD_NRD_1	182	184	PF00675	0.436
CLV_NRD_NRD_1	346	348	PF00675	0.502
CLV_NRD_NRD_1	511	513	PF00675	0.474
CLV_PCSK_KEX2_1	182	184	PF00082	0.417
CLV_PCSK_KEX2_1	346	348	PF00082	0.502
CLV_PCSK_KEX2_1	511	513	PF00082	0.474
CLV_PCSK_SKI1_1	116	120	PF00082	0.500
CLV_PCSK_SKI1_1	147	151	PF00082	0.492
CLV_PCSK_SKI1_1	153	157	PF00082	0.420
CLV_PCSK_SKI1_1	174	178	PF00082	0.492
CLV_PCSK_SKI1_1	330	334	PF00082	0.507
CLV_PCSK_SKI1_1	403	407	PF00082	0.541
CLV_PCSK_SKI1_1	511	515	PF00082	0.551
CLV_PCSK_SKI1_1	82	86	PF00082	0.483
DEG_APCC_DBOX_1	190	198	PF00400	0.335
DEG_APCC_DBOX_1	402	410	PF00400	0.537
DEG_Nend_UBRbox_3	1	3	PF02207	0.454
DEG_SCF_FBW7_1	69	76	PF00400	0.479
DEG_SPOP_SBC_1	128	132	PF00917	0.511
DEG_SPOP_SBC_1	592	596	PF00917	0.366
DOC_CKS1_1	117	122	PF01111	0.452
DOC_CKS1_1	416	421	PF01111	0.539
DOC_CKS1_1	519	524	PF01111	0.269
DOC_CKS1_1	70	75	PF01111	0.480
DOC_CKS1_1	97	102	PF01111	0.453
DOC_MAPK_gen_1	151	159	PF00069	0.436
DOC_MAPK_gen_1	188	196	PF00069	0.498
DOC_MAPK_MEF2A_6	151	159	PF00069	0.427
DOC_PP1_RVXF_1	162	169	PF00149	0.469
DOC_PP2B_LxvP_1	157	160	PF13499	0.463
DOC_PP2B_LxvP_1	315	318	PF13499	0.650
DOC_PP2B_LxvP_1	444	447	PF13499	0.402
DOC_PP2B_LxvP_1	67	70	PF13499	0.489
DOC_PP4_FxxP_1	519	522	PF00568	0.554
DOC_PP4_FxxP_1	97	100	PF00568	0.452
DOC_USP7_MATH_1	128	132	PF00917	0.628
DOC_USP7_MATH_1	275	279	PF00917	0.439
DOC_USP7_MATH_1	328	332	PF00917	0.520
DOC_USP7_MATH_1	378	382	PF00917	0.586
DOC_USP7_MATH_1	592	596	PF00917	0.482
DOC_WW_Pin1_4	116	121	PF00397	0.651
DOC_WW_Pin1_4	124	129	PF00397	0.660
DOC_WW_Pin1_4	131	136	PF00397	0.571
DOC_WW_Pin1_4	415	420	PF00397	0.487
DOC_WW_Pin1_4	453	458	PF00397	0.445
DOC_WW_Pin1_4	518	523	PF00397	0.284
DOC_WW_Pin1_4	52	57	PF00397	0.504
DOC_WW_Pin1_4	65	70	PF00397	0.465
DOC_WW_Pin1_4	96	101	PF00397	0.453
LIG_14-3-3_CanoR_1	158	168	PF00244	0.445
LIG_14-3-3_CanoR_1	223	231	PF00244	0.385
LIG_14-3-3_CanoR_1	304	312	PF00244	0.437
LIG_14-3-3_CanoR_1	346	352	PF00244	0.460
LIG_14-3-3_CanoR_1	468	476	PF00244	0.281
LIG_14-3-3_CanoR_1	494	503	PF00244	0.310
LIG_14-3-3_CanoR_1	82	87	PF00244	0.483
LIG_Actin_RPEL_3	181	200	PF02755	0.432
LIG_Actin_WH2_2	152	169	PF00022	0.459
LIG_Actin_WH2_2	97	114	PF00022	0.460
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.504
LIG_FHA_1	11	17	PF00498	0.442
LIG_FHA_1	150	156	PF00498	0.449
LIG_FHA_1	171	177	PF00498	0.291
LIG_FHA_1	205	211	PF00498	0.326
LIG_FHA_1	231	237	PF00498	0.375
LIG_FHA_1	258	264	PF00498	0.519
LIG_FHA_1	375	381	PF00498	0.511
LIG_FHA_1	91	97	PF00498	0.678
LIG_FHA_2	223	229	PF00498	0.451
LIG_FHA_2	288	294	PF00498	0.542
LIG_FHA_2	529	535	PF00498	0.383
LIG_FHA_2	93	99	PF00498	0.453
LIG_GBD_Chelix_1	8	16	PF00786	0.442
LIG_IRF3_LxIS_1	75	81	PF10401	0.486
LIG_LIR_Apic_2	518	522	PF02991	0.564
LIG_LIR_Apic_2	95	100	PF02991	0.451
LIG_LIR_Gen_1	195	204	PF02991	0.377
LIG_LIR_Gen_1	205	214	PF02991	0.362
LIG_LIR_Gen_1	273	284	PF02991	0.453
LIG_LIR_Gen_1	579	589	PF02991	0.459
LIG_LIR_Nem_3	137	141	PF02991	0.494
LIG_LIR_Nem_3	195	199	PF02991	0.390
LIG_LIR_Nem_3	205	209	PF02991	0.346
LIG_LIR_Nem_3	273	279	PF02991	0.485
LIG_LIR_Nem_3	327	332	PF02991	0.476
LIG_LIR_Nem_3	579	585	PF02991	0.457
LIG_MAD2	267	275	PF02301	0.504
LIG_NRBOX	283	289	PF00104	0.542
LIG_Pex14_1	329	333	PF04695	0.497
LIG_Pex14_2	22	26	PF04695	0.601
LIG_REV1ctd_RIR_1	533	542	PF16727	0.534
LIG_SH2_CRK	138	142	PF00017	0.479
LIG_SH2_CRK	342	346	PF00017	0.479
LIG_SH2_NCK_1	138	142	PF00017	0.498
LIG_SH2_SRC	18	21	PF00017	0.447
LIG_SH2_STAT3	249	252	PF00017	0.535
LIG_SH2_STAT5	103	106	PF00017	0.460
LIG_SH2_STAT5	18	21	PF00017	0.447
LIG_SH2_STAT5	344	347	PF00017	0.447
LIG_SH3_1	256	262	PF00018	0.300
LIG_SH3_2	259	264	PF14604	0.444
LIG_SH3_3	114	120	PF00018	0.505
LIG_SH3_3	256	262	PF00018	0.460
LIG_SH3_3	451	457	PF00018	0.411
LIG_SH3_3	503	509	PF00018	0.482
LIG_SH3_3	67	73	PF00018	0.486
LIG_SH3_3	81	87	PF00018	0.443
LIG_SUMO_SIM_par_1	139	146	PF11976	0.441
LIG_SUMO_SIM_par_1	474	480	PF11976	0.420
LIG_TRAF2_1	225	228	PF00917	0.471
LIG_WRC_WIRS_1	19	24	PF05994	0.444
MOD_CK1_1	127	133	PF00069	0.629
MOD_CK1_1	139	145	PF00069	0.730
MOD_CK1_1	169	175	PF00069	0.474
MOD_CK1_1	21	27	PF00069	0.603
MOD_CK1_1	29	35	PF00069	0.656
MOD_CK1_1	291	297	PF00069	0.483
MOD_CK1_1	306	312	PF00069	0.590
MOD_CK1_1	331	337	PF00069	0.505
MOD_CK1_1	348	354	PF00069	0.304
MOD_CK1_1	477	483	PF00069	0.434
MOD_CK1_1	547	553	PF00069	0.520
MOD_CK1_1	562	568	PF00069	0.490
MOD_CK1_1	591	597	PF00069	0.634
MOD_CK1_1	68	74	PF00069	0.481
MOD_CK2_1	209	215	PF00069	0.437
MOD_CK2_1	222	228	PF00069	0.344
MOD_CK2_1	445	451	PF00069	0.358
MOD_CK2_1	551	557	PF00069	0.421
MOD_CK2_1	85	91	PF00069	0.478
MOD_DYRK1A_RPxSP_1	116	120	PF00069	0.508
MOD_GlcNHglycan	211	214	PF01048	0.492
MOD_GlcNHglycan	352	355	PF01048	0.303
MOD_GlcNHglycan	36	39	PF01048	0.454
MOD_GlcNHglycan	479	482	PF01048	0.434
MOD_GlcNHglycan	549	552	PF01048	0.359
MOD_GlcNHglycan	561	564	PF01048	0.347
MOD_GlcNHglycan	57	60	PF01048	0.508
MOD_GlcNHglycan	590	593	PF01048	0.591
MOD_GSK3_1	123	130	PF00069	0.608
MOD_GSK3_1	139	146	PF00069	0.671
MOD_GSK3_1	149	156	PF00069	0.470
MOD_GSK3_1	166	173	PF00069	0.270
MOD_GSK3_1	18	25	PF00069	0.417
MOD_GSK3_1	26	33	PF00069	0.397
MOD_GSK3_1	287	294	PF00069	0.423
MOD_GSK3_1	331	338	PF00069	0.459
MOD_GSK3_1	374	381	PF00069	0.471
MOD_GSK3_1	445	452	PF00069	0.488
MOD_GSK3_1	46	53	PF00069	0.434
MOD_GSK3_1	547	554	PF00069	0.513
MOD_GSK3_1	555	562	PF00069	0.498
MOD_GSK3_1	588	595	PF00069	0.476
MOD_GSK3_1	65	72	PF00069	0.443
MOD_GSK3_1	74	81	PF00069	0.460
MOD_GSK3_1	8	15	PF00069	0.652
MOD_GSK3_1	92	99	PF00069	0.401
MOD_N-GLC_1	318	323	PF02516	0.513
MOD_N-GLC_1	335	340	PF02516	0.340
MOD_NEK2_1	166	171	PF00069	0.426
MOD_NEK2_1	177	182	PF00069	0.351
MOD_NEK2_1	186	191	PF00069	0.235
MOD_NEK2_1	199	204	PF00069	0.263
MOD_NEK2_1	209	214	PF00069	0.386
MOD_NEK2_1	22	27	PF00069	0.443
MOD_NEK2_1	287	292	PF00069	0.347
MOD_NEK2_1	30	35	PF00069	0.427
MOD_NEK2_1	43	48	PF00069	0.440
MOD_NEK2_1	559	564	PF00069	0.515
MOD_NEK2_1	585	590	PF00069	0.526
MOD_NEK2_1	78	83	PF00069	0.487
MOD_NEK2_2	18	23	PF00069	0.448
MOD_NEK2_2	328	333	PF00069	0.477
MOD_NEK2_2	335	340	PF00069	0.395
MOD_NEK2_2	92	97	PF00069	0.453
MOD_OFUCOSY	465	472	PF10250	0.255
MOD_PIKK_1	199	205	PF00454	0.460
MOD_PKA_2	166	172	PF00069	0.418
MOD_PKA_2	187	193	PF00069	0.477
MOD_PKA_2	222	228	PF00069	0.400
MOD_PKA_2	303	309	PF00069	0.449
MOD_PKA_2	345	351	PF00069	0.424
MOD_PKA_2	467	473	PF00069	0.296
MOD_PKA_2	537	543	PF00069	0.495
MOD_PKA_2	559	565	PF00069	0.434
MOD_PKB_1	151	159	PF00069	0.427
MOD_Plk_1	153	159	PF00069	0.421
MOD_Plk_1	227	233	PF00069	0.406
MOD_Plk_1	335	341	PF00069	0.355
MOD_Plk_2-3	387	393	PF00069	0.687
MOD_Plk_4	227	233	PF00069	0.379
MOD_Plk_4	26	32	PF00069	0.450
MOD_Plk_4	275	281	PF00069	0.528
MOD_Plk_4	328	334	PF00069	0.514
MOD_Plk_4	362	368	PF00069	0.399
MOD_Plk_4	474	480	PF00069	0.432
MOD_Plk_4	92	98	PF00069	0.602
MOD_ProDKin_1	116	122	PF00069	0.652
MOD_ProDKin_1	124	130	PF00069	0.660
MOD_ProDKin_1	131	137	PF00069	0.571
MOD_ProDKin_1	415	421	PF00069	0.500
MOD_ProDKin_1	453	459	PF00069	0.445
MOD_ProDKin_1	518	524	PF00069	0.278
MOD_ProDKin_1	52	58	PF00069	0.508
MOD_ProDKin_1	65	71	PF00069	0.462
MOD_ProDKin_1	96	102	PF00069	0.453
MOD_SUMO_rev_2	390	398	PF00179	0.574
TRG_DiLeu_BaEn_1	439	444	PF01217	0.466
TRG_DiLeu_BaEn_4	227	233	PF01217	0.534
TRG_ENDOCYTIC_2	138	141	PF00928	0.490
TRG_ENDOCYTIC_2	342	345	PF00928	0.384
TRG_ER_diArg_1	150	153	PF00400	0.470
TRG_ER_diArg_1	181	183	PF00400	0.424
TRG_ER_diArg_1	345	347	PF00400	0.490
TRG_ER_diArg_1	510	512	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI4	Leptomonas seymouri	63%	100%
A0A1X0P2N8	Trypanosomatidae	39%	100%
A0A3Q8IES4	Leishmania donovani	78%	100%
A0A422P4Y1	Trypanosoma rangeli	39%	100%
A4I5J4	Leishmania infantum	78%	100%
C9ZQT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B0T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q7C7	Leishmania major	77%	100%
V5DQR0	Trypanosoma cruzi	37%	100%